Synthesis and biological evaluation of bengacarboline derivatives

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 3, 2008, Pages 1212-1216

  Pouilhès, Annie ^a   Kouklovsky, Cyrille ^a   Langlois, Yves ^a   Baltaze, Jean Pierre ^a   Vispé, Stéphane ^b   Annereau, Jean Philippe ^b   Barret, Jean Marc ^b   Kruczynski, Anna ^b   Bailly, Christian ^b  

^a UNIVERSITÉ PARIS SUD   (France)

^b INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

Bengacarboline; Cytotoxicity; DNA damages; Indole; Marine alakaloid

Indexed keywords

CARBOLINE DERIVATIVE; DNA; DNA TOPOISOMERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL CYCLE ARREST; CELL CYCLE S PHASE; CONTROLLED STUDY; CYTOTOXICITY; DNA DAMAGE; DNA SYNTHESIS; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA; NONHUMAN;

EID: 38849204313     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.11.113     Document Type: Article

References (11)

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4. 3): 136.9 (C2 and C2″), 136.7 (C2a and C2″a), 136.6 (C2′a), 127.3 (C3a and C3″a), 126.7 (C3′a), 123.3 (C2′), 122.5 (C4′), 121.7 (C5 and C5″), 119.8 (C6′), 119.5 (C5′), 119.4 (C4 and C4″), 115.4 (C3′), 114.5 (C6 and C6″), 113.6 (C7 and C7″), 111,1 (C7′), 109.2 (C3 and C3″), 41.5 (C9 and C9″), 34.5 (C1), 26.2 (C8 and C8″). MS (ESI+) m/z: 604 (M + 1), 606, 608.
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8. 50 values correspond to the dose required to reduce 50% of ATP release by the cell population.
9. Topoisomerase inhibition assays were performed as previously described:. Bailly C. Methods Enzymol. 340 (2001) 610
10. Comet experiments were performed as previously described:. Barret J.-M., Hill B.T., and Olive P. Br. J. Cancer 83 (2000) 1740
11. 2. Cells were treated as reported previously (van Hille, B.; Etiévant, C.; Barret, J.-M.; Kruczynski, A.; Hill, B.T. Anticancer Drugs 2000, 11, 829) prior to the flow cytometry analysis. Fluorescence of propidium iodide was monitored by the Coulter Epics XL flow cytometer on the FL-1 channel. Distribution of the cell populations in G1, S, and G2/M phases was calculated using a deconvolution algorithm (McCycle software).