Pulmonary inflammation after intraperitoneal administration of ultrafine titanium dioxide (TiO2) at rest or in lungs primed with lipopolysaccharide

Journal of Toxicology and Environmental Health - Part A: Current Issues

Volumn 73, Issue 5-6, 2010, Pages 396-409

  Moon, Changsuk ^a   Park, Hyun Jeong ^a   Choi, Youn Hee ^a   Park, Eun Mi ^a   Castranova, Vincent ^b   Kang, Jihee Lee ^a  

^a Ewha Womans University School of Medicine   (South Korea)

^b NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; MACROPHAGE INFLAMMATORY PROTEIN 2; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; NANOPARTICLE; REACTIVE OXYGEN METABOLITE; TITANIUM DIOXIDE; TRANSCRIPTION FACTOR AP 1; TUMOR NECROSIS FACTOR ALPHA;

ACUTE TOXICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; HISTOPATHOLOGY; LUNG LAVAGE; LUNG PARENCHYMA; MALE; MOUSE; NANOTOXICOLOGY; NEUTROPHIL CHEMOTAXIS; NONHUMAN; ONCOGENE SRC; PARTICLE SIZE; PNEUMONIA; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; BRONCHI; BRONCHOALVEOLAR LAVAGE FLUID; CHEMOKINE CXCL2; DRUG SYNERGISM; INJECTIONS, INTRAPERITONEAL; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; LUNG; MACROPHAGES, ALVEOLAR; MALE; METAL NANOPARTICLES; MICE; MICE, INBRED BALB C; PARTICULATE MATTER; PNEUMONIA; PULMONARY ALVEOLI; REACTIVE OXYGEN SPECIES; REST; RNA, MESSENGER; TITANIUM; TUMOR NECROSIS FACTOR-ALPHA;

MUS;

EID: 77149158798     PISSN: 15287394     EISSN: 10872620     Source Type: Journal    
DOI: 10.1080/15287390903486543     Document Type: Article

References (46)

1. Abu-Amer, Y., Ross, F., McHugh, K., Livolsi, A., Peyron, J. F., and Teitelbaum, S. 1998. Tumor necrosis factor-alpha activation of nuclear transcription factor-kappaB in marrow macrophages is mediated by c-Src tyrosine phosphorylation of Ikappa B alpha. J. Biol. Chem. 273:29417-29423.
2. Ayon, A. A., Cantu, M., Chava, K., Agrawal, C. M., Feldman, M. D., Johnson, D., Patel, D., and Marton, D. 2006. Drug loading of nanoporous TiO2 films. Biomed. Mater. 1:L11-L15.
3. Bermudez, E., Mangum, J. B., Wong, B. A., Asgharian, B., Hext, P. M., Warheit, D. B., and Everitt, J. I. 2004. Pulmonary responses of mice, rats, and hamsters to subchronic inhalation of ultrafine titanium dioxide particles. Toxicol. Sci. 77:347-357.
4. Blackwell, T. S., Blackwell, T. R., Holden, E. P., Christman, B. W., and Christman, J. W. 1996. In vivo antioxidant treatment suppresses nuclear factor-kappa B activation and neutrophilic lung inflammation. J. Immunol. 157:1630-1637.
5. Castranova, V., Jones, T., Barger, M. W., Afshari, A., and Frazer, D. J. 1990. Pulmonary responses of guinea pigs to consecutive exposures to cotton dust. In Proceedings of the 14th Cotton Dust Research Conference, eds. R. R. Jacobs, P. J. Wakelyn, and L. N. Domelsmith, pp. 131-135. Memphis, TN: National Cotton Council.
6. Denis, M., Guojian, L., Widmer, M., and Cantin, A. 1994. A mouse model of lung injury induced by microbial products: Implication of tumor necrosis factor. Am. J. Respir. Cell Mol. Biol.10:658-664.
7. Ding, M., Shi, X., Dong, Z., Chen, F., Lu, Y., Castranova, V., and Vallyathan, V. 1999. Freshly fractured crystalline silica induces activator protein-1 activation through ERKs and p38 MAPK. J. Biol. Chem. 274:30611-30616.
8. Dockery, D. W, and Pope, C. A. 1994. Acute respiratory effects of particulate air pollution. Annu. Rev. Public Health 15:107-132.
9. Drouet, C., Shakhov, A. N., and Jongeneel, C. V. 1991. Enhancers and transcription factors controlling the inducibility of the tumor necrosis factor-a promoter in primary macrophages. J. Immunol. 147:1694-1700.
10. Fabian, E., Landsiedel, R., and Ma-Hock, L. 2008. Tissue distribution and toxicity of intravenously administered titanium dioxide nanoparticles in rats. Arch. Toxicol. 82:151-157.
11. Friedland, J. S., Constantin, D., Shaw, T. C., and Stylianou, E. 2001. Regulation of interleukin-8 gene expression after phagocytosis of zymosan by human monocytic cells. J. Leukocyte Biol. 70:447-454.
12. Hartree, E. F. 1972. Determination of protein: A modification of the Lowry method that gives a linear photometric response. Anal. Biochem. 48:422-427.
13. Huynh, M. L., Malcolm, K. C., Kotaru, C., Tilstra, J. A., Westcott, J. Y., Fadok, V. A., and Wenzel, S. E. 2005. Defective apoptotic cell phagocytosis attenuates prostaglandin E2 and 15-hydroxyeicosatetraenoic acid in severe asthma alveolar macrophages. Am. J. Respir. Crit. Care Med.172:972-979.
14. Kang, J. L., Jung, H. J., Lee, K., and Kim, H. R. 2006. Src tyrosine kinases mediate crystalline silica-induced NF-kB activation through tyrosine phosphorylation of IkB-a and p65 NF-kB in RAW 264.7 macrophages. Toxicol. Sci. 90:470-477.
15. Kang, J. L., Lee, H. W., Kim, H. J., Lee, H. S., Castranova, V., Lim, C. M., and Koh, Y. 2005. Inhibition of Src tyrosine kinases suppresses activation of nuclear factor-kB, and serine and tyrosine phosphorylation of IkB-a in lipopolysaccharide-stimulated RAW 264.7 macrophages. J. Toxicol. Environ. Health A 68:1-20.
16. Kang, J. L., Moon, C., Lee, H. S., Lee, H. W., Park, E. M., Kim, H. S., and Castranova, V. 2008. Comparison of the biological activity between ultrafine and fine titanium dioxide particles in RAW 264.7 cells associated with oxidative stress. J. Toxicol. Environ. Health A 71:478-485.
17. Khadaroo, R. G., Kapus, A., Powers, K. A., Cybulsky, M. I., Marshall, J. C., and Rotstein, O. D. 2003. Oxidative stress reprograms lipopolysaccharide signaling via Src kinasedependent pathway in RAW 264.7, macrophage cell line. J. Biol. Chem. 278:47834-47841.
18. Kim, H. J., Lee, H. S., Chong, Y. H., and Kang, J. L. 2006. P38 mitogen-activated protein kinase up-regulates LPS-induced NF-kB activation in the development of lung injury and RAW 264.7 macrophages. Toxicology 225:36-47.
19. Krewski, D., Burnett, R., Jerrett, M., Pope, C.A., Rainham, D., Calle, E., Thurston, G., and Thun, M. 2005. Mortality and long-term exposure to ambient air pollution: Ongoing analyses based on the American Cancer Society cohort. J. Toxicol. Environ. Health A 68: 1093-1109.
20. Kristof, A. S., Goldberg, P., Laubach, V., and Hussain, S. N. 1998. A role of inducible nitric oxide synthase in endotoxin-induced acute lung injury. Am. J. Respir. Crit. Care Med. 158:1883-1889.
21. Lane, F. C., and Mehta, J. R. 1990. In vitro human tumor sensitivity assay using cell counting and sizing. Am. Biotechnol. Lab. 8:12-27.
22. Lee, H. S., Moon, C., Lee, H. Y., Park, E. M., Cho, M. S., and Kang, J. L. 2007. Src tyrosine kinases mediate activations of NF-kB and integrin signal during lipopolysaccharideinduced acute lung injury. J. Immunol. 179:7001-7011.
23. López, T., Navarrete, J., Conde, R., Ascencio, J. A., Manjarrez, J., and Gonzalez, R. D. 2006. Molecular vibrational analysis and MAS-NMR spectroscopy study of epilepsy drugs encapsulated in TiO2-sol-gel reservoirs. J. Biomed. Mater. Res. 78A:441-448.
24. López, T., Recillas, S., Guevara, P., Sotelo, J., Alvarez, M., and Odriozola, J. A. 2008. Pt/ TiO2 brain biocompatible nanoparticles: GBM treatment using the C6 model in Wistar rats. Acta Biomater. 4:2037-2044.
25. López, T., Ortiz, E., Quintana, P., and González, R. D. 2007. A nanostructured titania bioceramic implantable device capable of drug delivery to the temporal lobe of the brain. Colloids Surfaces A 300:3-10.
26. Monteiller, C., Tran, L., MacNee, W., Faux, S., Jones, A., Niller, B., and Donalson, K. 2007. The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: The role of surface area. Occup. Environ. Med. 64:609-615. (Pubitemid 47345256)
27. Muhlfeld, C., Geiser, M., Kapp, N., Gehr, P., and Rothen-Rutishauser, B. 2007. Reevaluation of pulmonary titanium dioxide nanoparticle distribution using the relative deposition index: Evidence for clearance through microvasculature. Particle Fibre Toxicol. 4:7-14.
28. Nishida, M., Maruyama, Y., Tanaka, R., Kontani, K., Nagaro, T., and Kurose, H. G. 2000. Alpha(i) and G alpha(o) are target proteins of reactive oxygen species. Nature 408:492-495.
29. Oberdörster, G., Oberdörster, E., and Oberdörster, J. 2005. Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. 113:823-839.
30. Olmedo, D. G., Tasat, D. R., Evelson, P., Guglielmotti, M. B., and Cabrini, R. L. 2008a. Biological response of tissue with macrophagic ativity to titanium dioxide. J. Biomed. Mater. Res. 84A:1087-1093.
31. Olmedo, D. G., Tasat, D. R., Guglielmotti, M. B., and Cabrini, R. L. 2008b. Biodistribution of titanium dioxide from biologic compartments. J. Mater. Sci. 19:3049-3056.
32. Pope, C. A., Thun, M. J., Namboodiri, M. M., Dockery, D. W., Evans, J. S., Speizer, F. E., and Heath, C. W. J. 1995a. Particulate air pollution as a predictor of mortality in a prospective study of U.S. adults. Am. J. Respir. Crit. Care Med. 151:669-674.
33. Pope, C. A., Bates, D., and Raizenne, M. 1995b. Health effects of particulate air pollution: Time for reassessment? Environ. Health Perspect. 103:472-480.
34. Renwick, L. C., Brown, D., Clouter, A., and Donaldson, K. 2004. Increased inflammation and altered macrophage chemotactic responses caused two ultrafine particle types. Occup. Environ. Med. 61:442-447.
35. Rhoades, K. L., Golub, S. H., and Economou, J. S. 1992. The regulation of the human tumor necrosis factor-a promoter region in macrophage, T cell, and B cell lines. J. Biol. Chem. 267:22102-22107.
36. Sager, T. M., Kommineni, D., and Castranova, V. 2008. Pulmonary response to intratracheal instillation of ultrafine versus fine titanium dioxide: Role of particle surface area. Particle Fibre Toxicol. 5:17-31.
37. Sager, T. M., Porter, D. W., Robinson, V. A., Lyndsley, W. G., Schwegler-Berry, D. E., and Castranova, V. 2007. Improved method to disperse nanoparticles for in vitro and in vivo investigation of toxicity. Nanotoxicology 1:118-129.
38. Schwartz, J., 1994. What are people dying of on high pollution days? Environ. Res. 64:26-35.
39. Schwartz, J., Dockery, D. W., and Neas, I. M. 1996. Is daily mortality associated specifically with fine particles? J. Air Waste Manage. Assoc. 46:927-939.
40. Severgnini, M., Takahashi, S., Tu, P., Perides, G., Homer, R. J., Jhung, J. W., Bhavsar, D., Cochran, B. H., and Simon, A. R. 2005. Inhibition of the Src and Jak kinases protects against lipopolysaccharide-induced acute lung injury. Am. J. Respir. Crit. Care Med. 171:858-867.
41. Shaulian, E., and Karin, M. 2002. AP-1 as a regulator of cell life and death. Nat. Cell Biol. 4a:E131-E136.
42. Urban, R., Jacobs, J., Tomlinson, M., Gavrilovic, J., Black, J., and Peoc'h M. 2000. Dissemination of wear particles to the liver, spleen, and abdominal lymph nodes of patients with hip or knee replacement. J. Bone Joint Surg. 82-Aa:457-476.
43. Wang, J., Zhou, G., Chen, C., Yu, H., Wang, T., Ma, Y., Jia, G., Gao, Y., Li, B., Sun, J., Li, Y., Jiao, F., Zhao, Y., and Chai, Z. 2007. Acute toxicity and biodistribution of different sized titanium dioxide particles in mice after oral administration. Toxicol. Lett. 168:176-185.
44. Warheit, D. B., Hoke, R. A., Finlay, C., Maria Donner, E, Reed, K. L., and Sayes, C. M. 2007. Development of a base set of toxicity tests using ultrafine TiO2 particles as a component of nanoparticle risk management. Toxicol. Lett.171:99-110.
45. Warheit, D. B., Webb, T. R., Sayes, C. M., Colvin, V. L., and Reed, K. 2006. Pulmonary instillation studies with nanoparticle TiO2 rods and dots in rats: Toxicity is not dependent upon particle size and surface area. Toxicol. Sci. 91:227-236.
46. Xu, J., Sun, Y., Huang, J., Chen, C., Liu, G., Jiang, Y., Zhao, Y., and Jiang, Z. 2007. Phorokilling cancer cells using highly cell-specific antibody-TiO2 bioconjugates and electroporation. Bioelectrochemistry 71:217-222.