Biodiversity conservation and drug discovery: Can they be combined? the Suriname and Madagascar experiences

Pharmaceutical Biology

Volumn 47, Issue 8, 2009, Pages 809-823

  Cao, Shugeng ^a,b   Kingston, David G I ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Alkaloids; Bioactive compounds; Biodiversity conservation; Cardenolides; Madagascar; Marine metabolites; Suriname; Terpenoids

Indexed keywords

9 METHOXYCAMPTOTHECIN; ALKALOID; AROMATIC COMPOUND; BENZOPHENONE DERIVATIVE; BENZOQUINONE DERIVATIVE; CAMPTOTHECIN; CARDENOLIDE DERIVATIVE; COUMARIN DERIVATIVE; CRYPTOLEPINE; DIDYMOCHLAENONE A; DIDYMOCHLAENONE B; FLAVONOID; GUTTIFERONE K; LIGNAN DERIVATIVE; NATURAL PRODUCT; OCHROCARPIN B; PHENOL DERIVATIVE; PITTOVIRIDOSIDE; PLANT MEDICINAL PRODUCT; QUINONE DERIVATIVE; ROTENOLONE; SAPONIN; SCHWEINFURTHIN E; SESQUITERPENOID; STILBENE DERIVATIVE; TERPENOID DERIVATIVE; THOUVENOL A; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERAZINE; XANTHONE DERIVATIVE;

BIOASSAY; CONFERENCE PAPER; CONSERVATION BIOLOGY; DRUG ACTIVITY; DRUG INDUSTRY; DRUG MECHANISM; DRUG RESEARCH; ENVIRONMENTAL PROTECTION; HUMAN; MADAGASCAR; NONHUMAN; RAIN FOREST; SOCIOECONOMICS; STRUCTURE ACTIVITY RELATION; SURINAME;

EID: 77149154696     PISSN: 13880209     EISSN: 17445116     Source Type: Journal    
DOI: 10.1080/13880200902988629     Document Type: Conference Paper

References (60)

1. Abdel-Kader M, Berger JM, Slebodnick C, Hoch J, Malone S, Wisse JH, Werkhoven MCM, Neddermann KM, Mamber S, Kingston DGI (2002): Isolation and absolute configuration of ent-halimane diterpenoids from Hymenaea courbaril from the Suriname rain forest. J Nat Prod 65: 11-15.
2. Abdel-Kader M, Hoch J, Berger JM, Evans R, Miller JS, Wisse JH, Mamber SW, Dalton JM, Kingston DGI (2001): Two bioactive saponins from Albizia subdimidiata from the Suriname rainforest. J Nat Prod 64: 536-539.
3. Abdel-Kader MS, Bahler BD, Malone S, Werkhoven MCM, van Troon F, David M, Wisse JH, Burkuser I, Neddermann KM, Mamber SW, Kingston DGI (1998): DNA-damaging steroidal alkaloids from Eclipta alba from the Suriname rain forest. J Nat Prod 61: 1202-1208.
4. Abdel-Kader MS, Bahler BD, Malone S, Werkhoven MCM, Wisse JH, Neddermann KM, Bursuker I, Kingston DGI (2000): Bioactive saponins from Swartzia schomburgkii from the Suriname rain-forest. J Nat Prod 63: 1461-1464.
5. Abdel-Kader MS, Wisse J, Evans R, van der Werff H, Kingston DGI (1997): Bioactive iridoids and a new lignan from Allamanda cathartica and Himatanthus fallax from the Suriname rain forest. J Nat Prod 60: 1294-1297.
6. Adou E, Williams RB, Schilling JK, Malone S, Meyer J, Wisse JH, Frederik D, Koese D, Werkhoven MCM, Snipes CE, Werk TL, Kingston DGI (2005): Cytotoxic diterpenoids from two lianas from the Suriname rainforest. Bioorg Med Chem 18: 6009-6014.
7. Anonymous (1997): New map of "Biodiversity Hotspots" aids targeting of conservation efforts. Diversity 13(1): 27-29.
8. Bhakuni DS, Rawat DS (2005): Bioactive Marine Natural Products. New Delhi, Anamaya Publisher, pp. 1-382.
9. Caldecott JO, Jenkins MD, Johnson T, Groombridge B (1994): Priorities for conserving global species richness and endemism. In: Collins NM, ed., World Conservation Monitoring Centre, Biodiversity Series No. 3. Cambridge, UK, World Conservation Press, p. 17.
10. Cao S, Al-Rehaily AJ, Brodie P, Wisse JH, Moniz E, Malone S, Kingston DGI (2008): Furoquinoline alkaloids of Ertela (monnieria) trifolia (L.) Kuntze from the Suriname rainforest. Phytochemistry 69: 553-557.
11. Cao S, Brodie P, Miller JS, Ratovoson F, Birkinshaw C, Randrianasolo S, Takotobe E, Rasamison VE, Kingston DGI (2007a): Guttiferones K and L, antiproliferative compounds of Rheedia calcicola from the Madagascar rain forest. J Nat Prod 70: 686-688.
12. Cao S, Brodie PJ, Miller JS, Randrianaivo R, Ratovoson F, Birkinshaw C, Andriantsiferana R, Rasamison VE, Kingston DGI (2007b): Antiproliferative xanthones of Terminalia calcicola from the Madagascar rain forest. J Nat Prod 70: 679-681.
13. Cao S, Brodie PJ, Miller JS, Ratovoson F, Callmander MW, Randrianasolo S, Rakotobe E, Rasamison VE, Suh EM, TenDyke K, Kingston DGI (2007c): Antiproliferative cardenolides of an Elaeodendron sp from the Madagascar rain forest. J Nat Prod 70: 1064-1067.
14. Cao S, Guza RC, Wisse JH, Miller JS, Evans R, Kingston DGI (2005): Ipomoeassins A-E, cytotoxic macrocyclic glycoresins from the leaves of Ipomoea squamosa from the Suriname rainforest. J Nat Prod 68: 487-492.
15. Cao S, Norris A, Miller JS, Ratovoson F, Razafitsalama J, Andriantsiferana R, Rasamison VE, TenDyke K, Suh T, Kingston DGI (2007d): Cytotoxic triterpenoid saponins from Albizia gummifera from the Madagascar rain forest. J Nat Prod 70: 361-366.
16. Cao S, Norris A, Wisse JH, Miller JS, Evans R, Kingston DGI (2007e): Ipomoeassin F, a new cytotoxic macrocyclic glycoresin from the leaves of Ipomoea squamosa from the Suriname rainforest. Nat Prod Res 21: 872-876.
17. Cao S, Radwan MM, Norris A, Miller JS, Ratovoson F, Mamisoa A, Andriantsiferana R, Rasamison VE, Rakotonandrasana S, Kingston DGI (2006a): Cytotoxic and other compounds from Didymochlaena truncatula from the Madagascar rain forest. J Nat Prod 69: 284-286.
18. Cao S, Ranarivelo L, Ratsimbason M, Randrianasolo S, Ratovoson F, Andrianjafy M, Kingston DGI (2006b): Antiplasmodial activity of compounds from Sloanea rhodantha (Baker) Capuron var. rhodantha from the Madagascar rain forest. Planta Med 72: 1438-1439.
19. Cao S, Schilling JK, Guza RC, Miller JS, Andriantsiferana R, Rasamison VE, Kingston DGI (2004a): New cytotoxic triterpenoids from Acridocarpus vivy from the Madagascar rain forest. J Nat Prod 67: 986-989.
20. Cao S, Schilling JK, Miller JS, Randrianasolo A, Andriantsiferana R, Rasamison VE, Kingston DGI (2004b): New cytotoxic alkyl phloroglucinols from Protorhus thouvenotii. Planta Med 70: 683-684.
21. Cao S, Schilling JK, Miller JS, Andriantsiferana R, Rasamison VE, Kingston DGI (2004c): Cytotoxic compounds from Mundulea chapelieri from the Madagascar rainforest. J Nat Prod 67: 454-456.
22. Chaturvedula VSP, Schilling JK, Kingston DGI (2002): New cytotoxic coumarins and prenylated benzophenone derivatives from the bark of Ochrocarpus punctatus from the Madagascar rainforest. J Nat Prod 65: 965-972.
23. Chaturvedula VSP, Schilling JK, Miller JS, Andriantsiferana R, Rasamison VE, Kingston DGI (2004): New cytotoxic terpenoids from the wood of Vepris punctata from the Madagascar rainforest. J Nat Prod 67: 895-898.
24. Chaturvedula VSP, Schilling JK, Wisse JH, Miller JS, Evans R, Kingston DGI, (2003a): A new cytotoxic limonoid from Odontadenia macrantha from the Suriname rainforest. Mag Res Chem 41: 139-142.
25. Chaturvedula VSP, Sprague S, Schilling JK, Kingston DGI (2003b): New cytotoxic indole alkaloids from Tabernaemontana calcarea from the Madagascar rainforest. J Nat Prod 66: 528-531.
26. Cragg GM, Newman DJ (2001): Natural product drug discovery in the next millennium. Pharm Biol 39(Suppl.): 8-17.
27. Cragg GM, Newman DJ (2005a) Biodiversity: a continuing source of novel drug leads. Pure Appl Chem 77: 7-24.
28. Cragg GM, Newman DJ (2005b): International collaboration in drug discovery and development from natural sources. Pure Appl Chem 77: 1923-1942.
29. Cragg GM, Newman DJ, Snader K (1997): Natural products in drug discovery and development. J Nat Prod 60: 52-60.
30. Dabydeen DA, Burnett JC, Bai R, Verdier-Pinard P, Hickford SJH, Pettit GR, Blunt JW, Munro MHG, Gussio R, Hamel E (2006): Comparison of the activities of the truncated halichondrin B analog NSC 707389 (E7389) with those of the parent compound and a proposed binding site on tubulin. Mol Pharmacol 70: 1866-1875.
31. de Rasolohery A (2006): Inventaire des Fougeres de Zahamena, Madagascar. Antananarivo, Madagascar, Missouri Botanical Garden.
32. Fuerstner A, Nagano T (2007): Total syntheses of ipomoeassin B and E. J Am Chem Soc 129: 1906-1907.
33. Gunatilaka AAL, Berger JM, Evans R, Miller JS, Wisse JH, Neddermann KM, Bursuker I, Kingston DGI (2001): Isolation, synthesis, and structure-activity relationships of bioactive benzoquinones from Miconia lepidota from the Suriname rain forest. J Nat Prod 64: 2-5.
34. Karkare S, Adou E, Cao S, Brodie PJ, Miller JS, Ratovoson F, Andriantsiferana R, Rasamison VE, Kingston DGI (2007): Antiproliferative cardenolide glycosides of Strophanthus boivinii from Madagascar rainforest. J Nat Prod 70: 1766-1770.
35. Kingston DGI (2001): Biodiversity conservation and drug discovery in Suriname. Explorations in nature's combinatorial library. Pure Appl Chem 73: 595-599.
36. Kingston DGI (2004): Biodiversity conservation and drug discovery in Madagascar and Suriname: explorations in Nature's combinatorial library. In: Yayli N, Küçük M, eds., Proceedings of the 1st International Conference on the Chemistry of Natural Products (ICNP-2002), Trabzon, Turkey, Karadeniz Technical University, pp. 1-7.
37. Kingston DGI, Abdel-Kader M, Zhou B-N, Yang S-W, Berger JM, van der Werff H, Evans R, Mittermeier R, Malone S, Famolare L, Guerin-McManus M, Wisse JH, Miller JS (2000): Biodiversity conservation, economic development, and drug discovery in Suriname. In: Cutler SJ, Cutler HG, eds., Biologically Active Natural Products: Pharmaceuticals. Boca Raton, CRC Press, pp. 39-49.
38. Kingston DGI, Abdel-Kader M, Zhou B-N, Yang S-W, Berger JM, van der Werff H, Miller JS, Evans R, Mittermeier R, Famolare L, Guerin-McManus M, Malone S, Nelson R, Moniz E, Wisse JH, Vyas DM, Wright JJK. Aboikonie S (1999): The Suriname International Cooperative Biodiversity Group program: lessons from the first five years. Pharm Biol 37: 22-34.
39. Klein LE, Freeze BS, Smith ABIII, Horwitz SB (2005): The microtubule stabilizing agent discodermolide is a potent inducer of accelerated cell senescence. Cell Cycle 4: 501-507.
40. Mittermeier RA, Plotkin MJ, Werner TB, Malone SA, Baal F, MacKnight J, Mohadin K, Werkhooven M (1990): Conservation action plan for Suriname. Report prepared by Conservation International, Suriname Forest Service, World Wildlife Fund, Foundation for Nature Preservation in Suriname, and University of Suriname.
41. Murphy BT, Slebodnick C, Brodie PJ, Miller JS, Rasamison VE, Tendyke K, Suh EM, Kingston DGI (2008): Antiproliferative compounds of Malleastrum sp. from the Madagascar rainforest. J Nat Prod 71: 235-329.
42. Murphy BT, Cao SG, Brodie P, Maharavo J, Kingston DGI (2007): Antiproliferative bistramides from the Ascidian Trididemnum sp. from Madagascar. Presented at: The 48th Annual Meeting of the American Society of Pharmacognosy, Portland, ME, USA, July 14-18.
43. Murphy BT, Cao SG, Brodie P, Maharavo J, Andriamanantoanina H, Ravelonandro P, Kingston DGI (2009): Antiproliferative bistramides from a Trididemnum sp. from Madagascar. J Nat Prod In Press.
44. Newman, S (2007): Eribulin, a simplified ketone analog of the tubulin inhibitor halichondrin B, for the potential treatment of cancer. Curr Opin Invest Drugs 8: 1057-1066.
45. Newman DJ (2008): Natural products as leads to potential drugs: an old process or the new hope for drug discovery? J Med Chem 51: 2589-2599.
46. Newman DJ, Cragg GM (2004): Marine natural products and related compounds in clinical and advanced preclinical trials. J Nat Prod 67: 1216-1238.
47. Newman DJ, Cragg GM (2007): Natural products as sources of new drugs over the last 25 years. J Nat Prod 70: 461-477.
48. Prakash CVS, Hoch JM, Kingston DGI (2002): Structure and stereochemistry of new cytotoxic clerodane diterpenoids from the bark of Casearia lucida from the Madagascar rainforest. J Nat Prod 65: 100-107.
49. Prakash CVS, Schilling JK, Miller JS, Andriantsiferana R, Rasamison VE, Kingston DGI (2003): New cytotoxic oleanane saponins from the infructescences of Polyscias amplifolia from the Madagascar rainforest. Planta Med 69: 440-444.
50. Reynolds M, Chaturvedula VSP, Ratovoson F, Andriantsiferana R, Rasamison VE, Guza RC, Kingston DGI (2006): Cytotoxic diterpenoids from Podocarpus madagascariensis from the Madagascar rainforest. Nat Prod Res 20: 606-610.
51. Rizvi S, Tereshko V, Kossiakoff AA, Kozmin SA (2006): Structure of actin-bistramide A complex at 1.35 Å resolution. J Am Chem Soc 128: 3882-3883.
52. Schulz JP, Reichert H, Mittermeier RA (1977): Wildlife in Suriname. Oryx 14(2): 133-144.
53. Seo Y, Berger JM, Hoch J, Neddermann KM, Bursuker I, Mamber SW, Kingston DGI (2002a): A new bioactive triterpenoid saponin from Pittosporum viridiflorum from the Madagascar rainforest. J Nat Prod 65: 65-68.
54. Seo Y, Hoch J, Abdel-Kader M, Malone S, Derveld I, Adams H, Werkhoven MCM, Wisse JH, Mamber SW, Dalton JM, Kingston DGI (2002b): Bioactive saponins from Acacia tenuifolia from the Suriname rainforest. J Nat Prod 65: 170-174.
55. Simmons TL, Andrianasolo E, McPhail K, Flatt P, Gerwixk WH (2005): Marine natural products as anticancer drugs. Mol Cancer Ther 4: 333-342.
56. Williams RB, Norris A, Slebodnick C, Merola J, Miller JS, Andriantsiferana R, Rasamison VE, Kingston DGI (2005): Cytotoxic sesquiterpene lactones from Vernonia pachyclada from the Madagascar rainforest. J Nat Prod 68: 1371-1374.
57. Yang S-W, Abdel-Kader M, Malone S, Werkhoven MCM, Wisse JH, Bursuker I, Nedermann K, Fairchild C, Raventos-Suarez C, Menendez AT, Lane K, Kingston DGI (1999a): Synthesis and biological evaluation of analogues of cryptolepine, an alkaloid isolated from the Suriname rainforest. J Nat Prod 62: 976-983.
58. Yang S-W, Zhou B-N, Malone S, Werkhoven MCM, van Troon F, Wisse JH, Kingston DGI (1999b): A new labdane diterpenoid from Renealmia alpinia collected in the Suriname rain forest. J Nat Prod 62: 1173-1174.
59. Yoder BJ, Cao, S, Norris A, Miller JS, Ratovoson F, Razafitsalama J, Andriantsiferana R, Rasamison VE, Kingston DGI (2007): Antiproliferative prenylated stilbenes and flavonoids from Macaranga alnifolia from the Madagascar rainforest. J Nat Prod 70: 342-346.
60. Zhou B-N, Baj NJ, Glass TE, Malone S, Werkhoven MCM, van Troon F, David M, Wisse JH, Kingston DGI (1997) Bioactive labdane diterpenoids from Renealmia alpinia collected in the Suriname rain forest. J Nat Prod 60: 1287-1293.