Antiproliferative limonoids of a Malleastrum sp. from the madagascar rainforest

Journal of Natural Products

Volumn 71, Issue 3, 2008, Pages 325-329

  Murphy, Brian T ^a   Brodie, Peggie ^a   Slebodnick, Carla ^a   Miller, James S ^b   Birkinshaw, Chris ^c   Randrianjanaka, Lucien M ^c   Andriantsiferana, Rabodo ^d   Rasamison, Vincent E ^d   TenDyke, Karen ^e   Suh, Edward M ^e   Kingston, David G I ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b MISSOURI BOTANICAL GARDEN   (United States)

^c MISSOURI BOTANICAL GARDEN   (Madagascar)

^d Centre National d'Application des Recherches Pharmaceutiques   (Madagascar)

^e EISAI RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIMONOID; MALLEASTRONE EXTRACT; PLANT EXTRACT; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; MALLEASTRONE; MEDICINAL PLANT; NUCLEAR MAGNETIC RESONANCE; X RAY DIFFRACTION;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; LIMONINS; MADAGASCAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE;

MALLEASTRUM;

EID: 42249112271     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np070487q     Document Type: Article

References (16)

1. Biodiversity Conservation and Drug Discovery in Madagascar, Part 31. For Part 30, see: Murphy, B. T.; Cao, S.; Brodie, P. J.; Miller, J. S.; Birkinshaw. C.; Ratovoson, F.; Birkinshaw, C.; Rakotobe, E.; Rasamison, V. E.; TenDyke, K.; Suh, E. M.; Kingston, D. G. I. Nat. Prod. Res., in press.
2. (a) Cao, S.; Guza, R. C.; Wisse, J. H.; Evans, R.; van der Werff, H.; Miller, J. S.; Kingston, D. G. I. J. Nat. Prod. 2005, 68, 487-492.
3. (b) Cao, S.; Brodie, P. J.; Miller, J. S.; Ratovoson, F.; Callmander, M.; Randrianasolo, S.; Rakotobe, E.; Rasamison, V. E.; Kingston, D. G. I. J. Nat. Prod. 2007, 70, 1064-1066.
4. Mulholland, D. A.; Parel, B.; Coombes, P. H. Curr. Org. Chem. 2000, 4, 1011-1054.
5. Champagne, D. E.; Koul, O.; Isman, M. B.; Scudder, G. G. E.; Towers, G. H. N. Phytochemistry 1992, 31, 377-394.
6. Siddiqui, S.; Ghiasuddin; Siddiqui, B. S.; Faizi, S. Pak. Sci. J. Ind. Res. 1989, 32, 435-438.
7. Rajab, M. S.; Bentley, M. D.; Fort, R. C. J. Nat. Prod. 1988, 51, 1291-1293.
8. The ChemDraw program assigned the stereochemistry at C-17 as R, but a careful application of the Cahn-Ingold-Prelog priority rules (Smith, M. B.; March, J. March's Advanced Organic Chemistry, 5th ed.; John Wiley and Sons, Inc.: New York, 2001; pp 139-141) indicates that the configuration is S.
9. Dewick, P. M. Medicinal Natural Products; A Biosynthetic Approach; John Wiley & Sons: West Sussex, England, 1981; p 255.
10. Ley, S. V.; Denholm, A. A.; Wood, A. Nat. Prod. Rep. 1993, 10, 109-157.
11. Roy, A.; Saraf, S. Biol. Pharm. Bull. 2006, 29, 191-201.
12. Cao, S.; Brodie, P. J.; Miller, J. S.; Randrianaivo, R.; Ratovoson, F.; Birkinshaw, C.; Andriantsiferana, R.; Rasamison, V. E.; Kingston, D. G. I. J. Nat. Prod. 2007, 70, 679-681.
13. CrysAlisPro v1.171; Oxford Diffraction: Wroclaw, Poland, 2006.
14. Sheldrick, G. M. SHELXTL NT ver. 6.12; Broker Analytical X-ray Systems, Inc.: Madison, WI, 2001.
15. Spek, A. L. J. Appl. Crystallogr. 2003, 36, 7-13.
16. Hooft, R. W. W.; Straver, L. H.; Spek, A. L. Abstracts of Papers, Annual Meeting of the American Crystallographic Association: Salt Lake City, UT; 2007; Abstract 10.07.02.