Corticotropin-releasing hormone receptor-1 in cerebral microvessels changes during development and influences urocortin transport across the blood-brain barrier

Endocrinology

Volumn 151, Issue 3, 2010, Pages 1221-1227

  Hsuchou, Hung ^a   Kastin, Abba J ^a   Wu, Xiaojun ^a   Tu, Hong ^a   Pan, Weihong ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CORTICOTROPIN RELEASING FACTOR RECEPTOR 1; CORTICOTROPIN RELEASING FACTOR RECEPTOR 2; MESSENGER RNA; RADIOACTIVE MATERIAL; UNCLASSIFIED DRUG; UROCORTIN; UROCORTIN 125I;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN BLOOD VESSEL; ENDOCYTOSIS; FEMALE; HYPOTHALAMUS; MALE; MOUSE; NONHUMAN; OBESITY; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; REAL TIME POLYMERASE CHAIN REACTION;

AGING; ANIMALS; ANIMALS, NEWBORN; BLOOD-BRAIN BARRIER; FEMALE; HYPOTHALAMUS; IODINE RADIOISOTOPES; MALE; MICE; MICE, INBRED C57BL; MICROVESSELS; PROTEIN ISOFORMS; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; UROCORTINS;

EID: 77149126400     PISSN: 00137227     EISSN: 00137227     Source Type: Journal    
DOI: 10.1210/en.2009-1039     Document Type: Article

References (35)

1. Pan W, Kastin AJ 2008 Urocortin and the brain. Prog Neurobiol 84:148-156
2. Kastin AJ, Akerstrom V, Pan W 2000 Activation of urocortin transport into brain by leptin. Peptides 21:1811-1817
3. Kastin AJ, Pan W, Akerstrom V, Hackler L, Wang C, Kotz CM 2002 Novel peptide-peptide cooperation may transform feeding behavior. Peptides 23:2189-2196
4. Pan W, Akerstrom V, Zhang J, Pejovic V, Kastin AJ 2004 Modulation of feeding-related peptide/protein signals by the blood-brain barrier. J Neurochem 90:455-461
5. Tu H, Kastin AJ, Pan W 2007 CRH-R1 and CRH-R2 are both trafficking and signaling receptors for urocortin. Mol Endocrinol 21:700-711
6. Tu H, Kastin AJ, Bjorbaek C, Pan W 2007 Urocortin trafficking in cerebral microvessel endothelial cells. J Mol Neurosci 31:171-181
7. Pan W, Tu H, Hsuchou H, Daniel J, Kastin AJ 2007 Unexpected amplification of leptin-induced Stat3 signaling by urocortin: implications for obesity. J Mol Neurosci 33:232-238
8. Swinny JD, Kalicharan D, Brouwer N, Biber K, Shi F, Gramsbergen A, van der Want JJ 2004 The postnatal developmental expression pattern of urocortin in the rat olivocerebellar system. JCompNeurol 472:40-51
9. Schmidt MV, Enthoven L, van der Mark M, Levine S, de Kloet ER, Oitzl MS 2003 The postnatal development of the hypothalamicpituitary-adrenal axis in the mouse. Int J Dev Neurosci 21:125-132
10. Jamieson PM, Li C, Kukura C, Vaughan J, Vale W 2006 Urocortin 3 modulates the neuroendocrine stress response and is regulated in rat amygdala and hypothalamus by stress and glucocorticoids. Endocrinology 147:4578-4588
11. Walker CD, Scribner KA, Cascio CS, Dallman MF 1991 The pituitary-adrenocortical system of neonatal rats is responsive to stress throughout development in a time-dependent and stressor-specific fashion. Endocrinology 128:1385-1395
12. Pan W, Hsuchou H, He Y, Sakharkar A, Cain C, Yu C, Kastin AJ 2008 Astrocyte leptin receptor (ObR) and leptin transport in adult-onset obese mice. Endocrinology 149:2798-2806
13. Kastin AJ, Akerstrom V, Pan W 2001 Validity of multiple-time regression analysis in measurement of tritiated and iodinated leptin crossing the blood-brain barrier: meaningful controls. Peptides 22: 2127-2136
14. Banks WA, Burney BO, Robinson SM 2008 Effects of triglycerides, obesity, and starvation on ghrelin transport across the blood-brain barrier. Peptides 29:2061-2065
15. Pan W, Ding Y, Yu Y, Ohtaki H, Nakamachi T, Kastin AJ 2006 Stroke upregulates TNF α transport across the blood-brain barrier. Exp Neurol 198:222-233
16. Yu C, Kastin AJ, Ding Y, Pan W 2007 γ Glutamyl transpeptidase is a dynamic indicator of endothelial response to stroke. Exp Neurol 203:116-122
17. Bouret SG, Simerly RB 2006 Developmental programming of hypothalamic feeding circuits. Clin Genet 70:295-301
18. Bouret SG 2008 Crossing the border: developmental regulation of leptin transport to the brain. Endocrinology 149:875-876
19. Ahima RS, Prabakaran D, Flier JS 1998 Postnatal leptin surge and regulation of circadian rhythm of leptin by feeding. Implications for energy homeostasis and neuroendocrine function. J Clin Invest 101: 1020-1027
20. Matsuda J, Yokota I, Iida M, Murakami T, Yamada M, Saijo T, Naito E, Ito M, Shima K, Kuroda Y 1999 Dynamic changes in serum leptin concentrations during the fetal and neonatal periods. Pediatr Res 45:71-75
21. Hytinantti TK, Juntunen M, Koistinen HA, Koivisto VA, Karonen SL, Andersson S 2001 Postnatal changes in concentrations of free and bound leptin. Arch Dis Child Fetal Neonatal Ed 85:F123-F126
22. Alexe DM, Syridou G, Petridou ET 2006 Determinants of early life leptin levels and later life degenerative outcomes. Clin Med Res 4:326-335
23. Pan W, Hsuchou H, Tu H, Kastin AJ 2008 Developmental changes of leptin receptors in cerebral microvessels: unexpected relation to leptin transport. Endocrinology 149:877-885
24. Tu H, Pan W, Feucht L, Kastin AJ 2007 Convergent trafficking pattern of leptin after endocytosis mediated by ObRa-ObRd. J Cell Physiol 212:215-222
25. Tu H, Kastin AJ, Hsuchou H, Pan W 2008 Soluble receptor inhibits leptin transport. J Cell Physiol 214:301-305
26. Urayama A, Grubb JH, Sly WS, Banks WA 2004 Developmentally regulated mannose 6-phosphate receptor-mediated transport of a lysosomal enzyme across the blood-brain barrier. Proc Natl Acad Sci USA 101:12658-12663
27. Aguilera G, Nikodemova M, Wynn PC, Catt KJ 2004 Corticotropin releasing hormone receptors: two decades later. Peptides 25:319-329
28. Hashimoto K, NishiyamaM,Tanaka Y, Noguchi T, Asaba K, Hossein PN,NishiokaT,Makino S 2004 Urocortins and corticotropin releasing factor type 2 receptors in the hypothalamus and the cardiovascular system. Peptides 25:1711-1721
29. Nishiyama M, Makino S, Asaba K, Hashimoto K 1999 Leptin effects on the expression of type-2 CRH receptor mRNA in the ventromedial hypothalamus in the rat. J Neuroendocrinol 11:307-314
30. Fekete EM, Inoue K, Zhao Y, Rivier JE, Vale WW, Szücs A, Koob GF, Zorrilla EP 2007 Delayed satiety-like actions and altered feeding microstructure by a selective type 2 corticotropin-releasing factor agonist in rats: intra-hypothalamic urocortin 3 administration reduces food intake by prolonging the post-meal interval. Neuro-psychopharmacology 32:1052-1068
31. Hsuchou H, He Y, Kastin AJ, Tu H, Markadakis EN, Rogers RC, Fossier PB, Pan W 2009 Obesity induces functional astrocytic leptin receptors in hypothalamus. Brain 132:889-902
32. Hsuchou H, Pan W, Barnes MJ, Kastin AJ 2009 Leptin receptor mRNA in rat brain astrocytes. Peptides 30:2275-2280
33. Marsh DJ, Hollopeter G, Huszar D, Laufer R, Yagaloff KA, Fisher SL, Burn P, Palmiter RD 1999 Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat Genet 21: 119-122
34. Lu XY, Barsh GS, Akil H, Watson SJ 2003 Interaction between α-melanocyte-stimulating hormone and corticotropin-releasing hormone in the regulation of feeding and hypothalamo-pituitary-adrenal responses. J Neurosci 23:7863-7872
35. Pan W, Kastin AJ 2007 Mahogany, blood-brain barrier, and fat mass surge in A(VY) mice. Int J Obes 31:1030-1032