Novel peptide-peptide cooperation may transform feeding behavior

Peptides

Volumn 23, Issue 12, 2002, Pages 2189-2196

  Kastin, Abba J ^a   Pan, Weihong ^a   Akerstrom, Victoria ^a   Hackler, Laszlo ^a   Wang, Chuanfeng ^b   Kotz, Catherine M ^b  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

Author keywords

Blood brain barrier; Feeding behavior; Leptin; Peptide peptide cooperation; Transport; Urocortin

Indexed keywords

LEPTIN; UROCORTIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD BRAIN BARRIER; CONTROLLED STUDY; FEEDING BEHAVIOR; FOOD INTAKE; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN INTERACTION; RAT; SATIETY;

ANIMALS; BLOOD-BRAIN BARRIER; CHROMATOGRAPHY, GEL; CORTICOTROPIN-RELEASING HORMONE; ELECTROPHORESIS, CAPILLARY; FEEDING BEHAVIOR; LEPTIN; MALE; RATS; RATS, SPRAGUE-DAWLEY; REGRESSION ANALYSIS;

EID: 0036953198     PISSN: 01969781     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0196-9781(02)00247-4     Document Type: Article

References (14)

1. Caro J.F., Kolaczynski J.W., Nyce M.R., Ohannesian J.P., Opentanova I., Goldman W.H.et al. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet. 348:1996;159-161.
2. Kastin A.J., Akerstrom V., Hackler L. Food deprivation decreases blood galanin-like peptide and its rapid entry into the brain. Neuroendocrinology. 74:2001;423-432.
3. 19-melanin-concentrating hormone and the blood-brain barrier: role of protein binding. J. Neurochem. 74:2000;385-391.
4. Kastin A.J., Akerstrom V., Pan W. Validity of multiple-time regression analysis in measurement of tritiated and iodinated leptin crossing the blood-brain barrier: meaningful controls. Peptides. 22:2001;2127-2136.
5. Kastin A.J., Akerstrom V., Pan W. Activation of urocortin transport into brain by leptin. Peptides. 21:2000;1811-1818.
6. Kastin A.J., Pan W., Maness L.M., Koletsky R.J., Ernsberger P. Decreased transport of leptin across the blood-brain barrier in rats lacking the short form of the leptin receptor. Peptides. 20:1999;1449-1453.
7. Koistinen H.A., Karonen S.-L., Iivanainen M., Koivisto V.A. Circulating leptin has saturable transport into intrathecal space in humans. Eur. J. Clin. Invest. 28:1998;894-897.
8. Patlak C.S., Blasberg R.G., Fenstermacher J.D. Graphical evaluation of blood-to-brain transfer constants from multiple time uptake data. J. Cereb. Blood Flow Metab. 3:1983;1-7.
9. Schwartz M.W., Peskind E., Raskind M., Boyko E.J., Porte D. Jr. Cerebrospinal fluid leptin levels: relationship to plasma levels and to adiposity in humans. Nat. Med. 2:1996;589-593.
10. 2 receptors in corticotropin-releasing factor- and urocortin-induced anorexia. Neuroreport. 9:1998;1601-1606.
11. Spina M., Merlo-Pich E., Chan R.K.W., Basso A.M., Rivier J., Vale W.et al. Appetite-suppressing effects of urocortin, a CRF-related neuropeptide. Science. 273:1996;1561-1564.
12. Van Heek M., Compton D.S., France C.F., Tedesco R.P., Fawzi A.B., Graziano M.P.et al. Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J. Clin. Invest. 99:1997;385-390.
13. Vaughan J., Donaldson C., Bittencourt J., Perrin M.H., Lewis K., Sutton S.et al. Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature. 378:1995;287-292.
14. Wu-Peng X.S., Chua S.C. Jr., Okada N., Liu S.-M., Nicolson M., Leibel R.L. Phenotype of obese Koletsky (f) rat due to Tyr763 stop mutation in the extracellular domain of the leptin receptor (lepr). Diabetes. 46:1997;513-518.