Leptin effects on the expression of type-2 CRH receptor mRNA in the ventromedial hypothalamus in the rat

Journal of Neuroendocrinology

Volumn 11, Issue 4, 1999, Pages 307-314

  Nishiyama, Mitsuru ^a   Makino, S ^a   Asaba, K ^a   Hashimoto, K ^a  

^a KOCHI MEDICAL SCHOOL   (Japan)

Author keywords

Corticotropin releasing hormone; Leptin; Paraventricular nucleus; Receptor; Ventromedial hypothalamus

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR RECEPTOR; LEPTIN; MESSENGER RNA; NEUROPEPTIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; BODY WEIGHT; CONTROLLED STUDY; FOOD INTAKE; HISTOCHEMISTRY; HYPOTHALAMUS; IN SITU HYBRIDIZATION; MALE; NONHUMAN; OSMOTIC MINIPUMP; PRIORITY JOURNAL; RAT; ZONA INCERTA;

ANIMALS; BODY WEIGHT; CORTICOTROPIN-RELEASING HORMONE; FEEDING BEHAVIOR; HUMANS; HYPOTHALAMUS, MIDDLE; IN SITU HYBRIDIZATION; LEPTIN; MALE; NEUROPEPTIDE Y; OBESITY; PRO-OPIOMELANOCORTIN; PROTEINS; RATS; RATS, WISTAR; RECEPTORS, CORTICOTROPIN-RELEASING HORMONE; RECOMBINANT PROTEINS; RNA, MESSENGER;

EID: 0033022644     PISSN: 09538194     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2826.1999.00331.x     Document Type: Article

References (47)

1. Richard D. Involvement of corticotropin-releasing factor in the control of food intake and energy expenditure. Ann NY Acad Sci 1993; 697: 155-172.
2. Morley JE, Levine AS. Corticotropin-releasing factor and ingestive behaviors. In: De Souza EB, Nemeroff CB, eds. Corticotropin-Releasing Factor Basic and Clinical Studies of a Neuropeptide. Boca Raton, FL: CRC Press, 1990: 267-274.
3. Arase K, York DA, Shimizu H, Shargil NS, Bray GA. Effect of corticotropin-releasing factor on food intake and brown adipose tissue thermogenesis in rats. Am J Physiol 1988; 255: E255-E259.
4. Glowa J, Gold PW. Corticotropin-releasing hormone produces profound anorexigenic effects in the rhesus monkey. Neuropeptides 1991; 18: 55-61.
5. Lovenberg TW, Liaw CW, Grigoriadis DE, Clevenger W, Chalmers DT, De Souza EB, Oltersdorf T. Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain. Proc Natl Acad Sci USA 1995; 92: 836-840.
6. Chalmers DT, Lovenberg TW, De Souza EB. Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression. J Neurosci 1995; 15: 6340-6350.
7. Spina M, Merlo-Pich E, Chen RKW, Basso AM, Rivier J, Vale W, Koob GF. Appetite-suppressing effects of urocortin, a CRF-related neuropeptide. Science 1996; 273: 1561-1564.
8. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425-432.
9. Campfield LA, Smith FJ, Burn P. The OB protein (leptin) pathway: a link between adipose tissue mass and central neural networks. Horm Metab Res 1996; 28: 619-632.
10. Caro JF, Sinha MK, Kolaczynski JW, Zhang PL, Considinc RV. Leptin: the tale of an obesity gene. Diabetes 1996; 45: 1455-1462.
11. Schwartz MW, Seeley RJ, Campficld LA, Burn P, Baskin DG. Identification of targets of leptin action in rat hypothalamus. J Clin Invest 1996; 98: 1101-1106.
12. Wang Q, Bing C, Al-Barazanji K, Mossakowaska DE, Wang X, McBay DL, Neville WA, Taddayon M, Pickavance L, Dryden S, Thomas MEA, McHale MT, Gloyer IS, Wilson S, Buckingham R, Arch JRS, Trayhurn P, Williams G. Interactions between leptin and hypothalamic neuropeptide Y neurons in the control of food intake and energy homeostasis in the rat. Diabetes 1997; 46: 335-341.
13. Schwartz MW, Seeley RJ, Woods SC, Weigle DS, Campfield LA, Burn P, Baskin DG. Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 1997; 46: 2119-2123.
14. Costa A, Poma A, Martignoni E, Nappi G, Ur E, Grossman A. Stimulation of corticotrophin-releasing hormone release by the obese (ob) gene product, leptin, from hypothalamic explants. Neuroreport 1997; 8: 1131-1134.
15. Raber J, Chen S, Mucke L, Feng L. Corticotropin-releasing factor and adrenocorticotrophic hormone as potential central mediators of ob effects. J Biolog Chemist 1997; 272: 15057-15060.
16. Heiman ML, Ahima RS, Craft LS, Schoner B, Stephens TW, Flier JS. Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress. Enderinology 1997; 138: 3859-3863.
17. Makino S, Nishiyama M, Asaba K, Gold PW, Hashimoto K. Altered expression of type 2 CRH receptor mRNA in the VMH by glucocorticoids and starvation. Am J Physiol 1998; 44: R1138-R1145.
18. Emilsson V, Liu YL, Cawthorne MA, Morton NM, Davenport M. Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes 1997; 46: 313-316.
19. Tanizawa Y, Okuya S, Ishihara H, Asano T, Yada T, Oka Y. Direct stimulation of basal insulin secretion by physiological concentration of leptin in pancreatic β cells. Endocrinology 1997; 138: 4513-4516.
20. Sivitz WI, Walsh SA, Morgan DA, Thomas MJ, Haynes WG. Effects of leptin on insulin sensitivity in normal rats. Endocrinology 1997; 138: 3395-3401.
21. Uehara Y, Shimizu H, Ohtani K, Sato N, Mori M. Hypothalamic corticotropin-releasing hormone is a mediator of the anorexigenic effect of leptin. Diabetes 1998; 47: 890-893.
22. Masuzaki H, Ogawa Y, Isse N, Satoh N, Okazaki T, Shigemoto M, Mori K, Tamura N, Hosoda K, Yoshimasa Y, Jingami H, Kawada T, Nakao K. Human obese gene expression: adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 1995; 44: 855-858.
23. Banks WA, Kastin AJ, Huang W, Jaspan JB, Maness LM. Leptin enters the brain by a saturable system independent of insulin. Peptide 1996; 17: 305-311.
24. Satoh N, Ogawa Y, Katsuura G, Tsuji T, Masuzaki H, Hiraoka J, Okazaki T, Takaki M, Hayase M, Yoshimasa Y, Nishi S, Hosoda K, Nakao K. Pathophysiological significance of the obese gene product, leptin, in ventromedial hypothalamus (VMH)-lesioned rats; evidence for loss of its satiety effect in VMH-lesioned rats. Endocrinology 1997; 138: 947-954.
25. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, Mckee LJ, Bauer TL, Caro JF. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N Engl J Med 1996; 334: 292-295.
26. Elmquist JK, Ahima RS, Elias CF, Flier JS, Saper CB. Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei. Proc Natl Acad Sci USA 1998; 95: 741-746.
27. Richard D, Rivest R, Naimi N, Timofeeva E, Rivest S. Expression of corticotropin-releasing factor and its receptors in the brain of lean and obese Zucker rats. Endocrinology 1996; 137: 4786-4795.
28. Phillips MS, Liu Q, Hammond HA, Dugan V, Hey PJ, Caskey CT, Hess JF. Leptin receptor missense mutation in the fatty Zucker rat. Nat Genet 1996; 13: 18-19.
29. lida M, Murakami T, Ishida K, Mizuno A, Kuwajima M, Shima K. Phenotype-linked amino acid alteration in leptin receptor cDNA from Zucker fatty (fa/fa) rat. Biochem Biophys Res Commun 1996; 222: 19-26.
30. Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Trayhurn P. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett 1996; 387: 113-116.
31. Elmquist JK, Ahima RS, Maratos-f, lier E, Flier JS, Saper CB. Leptin activates neurons in ventromedial hypothalamus and brainstem. Endcrinology 1997; 138: 839-842.
32. Vaughan J, Donaldson C. Bittencourt J, Perrin MH, Lewis K, Sutton S, Chan R, Turnbull AV, Lovejoy D, Rivier C, Rivier J, Sawchenko PE, Vale W. Urocortin, a mammalian neuropeptide related to fish urotensin I and to corticotropin-releasing factor. Nature 1995; 378: 287-292.
33. Ambach G, Palkovits M. Blood supply of the rat hypothalamus. V. The medial hypothalamus (nucleus ventromedialis, nucleus dorsomedialis, nucleus perifornicalis). Acta Morphol Acad Sci Hung 1977; 25: 259-278.
34. Ambach G, Palkovits M, Szentagothai J. Blood supply of the rat hypothalamus. IV. Retrochiasmatic area, median eminence, arcuate nucleus. Acta Morphol Acad Sci Hung 1976; 24: 93-119.
35. Mansi JA, Rivest S, Drolet G. Regulation of corticotropin-releasing factor type 1 (CRFI ) receptor messenger ribonucleic acid in the paraventricular nucleus of rat hypothalamus by exogenous CRF. Endocrinology 1996; 137:4619-4629.
36. Imaki T, Naruse M, Harada S, Chikada N, Imaki J, Onodera H, Demura H, Vale W. Corticotropin-releasing factor up-regulates its own receptor mRNA in the paraventricular nucleus of the hypothalamus. Mol Brain Res 1996; 38: 166-170.
37. Jacob RJ, Dziura J, Medwick MB, Leone P, Caprio S, During M, Shulman GI, Sherwin RS. The effect of leptin is enhanced by microinjection into the ventromedial hypothalamus. Diabetes 1997; 46: 150-152.
38. Spanswick D, Smith MA, Groppi VE, Logan SD, Ashfold MLJ. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channnels. Nature 1997; 390: 521-525.
39. Fisher LA, Brown MR. Central regulation of stress responses-regulation of the autonomie nervous system and visceral function by corticotrophin releasing factor-41. Bailliere Clin Endocrinol Metab 1991; 5: 35-50.
40. Steffens AB, Scheurink AJW, Luiten PGM, Bohus B. Hypothalamic food intake regulating areas are involved in the homeostasis of blood glucose and plasma FFA levels. Physiol Behav 1988; 44: 581-589.
41. Cheung CC, Clifton DK, Steiner RA. Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology 1997; 138: 4489-4492.
42. Seeley RJ, Thiele TE, van Dijk G, Baskin DG, Yagaloff KA, Fisher SL, Burn P, Schwartz MW. Melanocortin receptors in leptin effects. Nature 1997; 390: 349.
43. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS. Role of leptin in the neuroendocrine response to fasting. Nature 1996; 382: 250-252.
44. Larhammer DL, Ericsson A, Persson H. Structure and expression of the rat neuropeptide Y gene. Proc Natl Acad Sci USA 1987; 84: 2068-2072.
45. Drouin J, Chamberland M, Charron J, Jeannotte L, Nemer M. Structure of the rat pro-opiomelanocortin (POMC) gene. FEBS Lett 1985; 193: 54-58.
46. Jingami H, Mizuno N, Takahashi H, Shibahara S, Furutani Y, Imura H, Numa S. Cloning and sequence analysis of cDNA for rat corticotropin-releasing factor precursor. FEBS Lett 1985; 191: 63-66.
47. Makino S, Smith MA, Gold PW. Increased expression of corticotropin-releasing hormone and vasopressin messenger ribonucleic acid (mRNA) in the hypothalamic paraventricular nucleus during repeated stress: association with reduction in glucocorticoid receptor mRNA levels. Enderinology 1995; 136: 3299-3309.