Simultaneous determination of LogD, LogP, and pKa of drugs by using a reverse phase HPLC coupled with a 96-well plate auto injector

Combinatorial Chemistry and High Throughput Screening

Volumn 12, Issue 3, 2009, Pages 250-257

  Chiang, Po Chang ^a   Hu, Yiding ^a  

^a PFIZER INC   (United States)

Author keywords

Drug candidates; In vivo; LogD; LogP; pKa; Reverse phase HPLC

Indexed keywords

ACICLOVIR; AMITRIPTYLINE; AMLODIPINE; BACLOFEN; CARBAMAZEPINE; CELECOXIB; CHLORAMPHENICOL; CHLOROQUINE; CIMETIDINE; CIPROFLOXACIN; DILTIAZEM; DOFETILIDE; DOXEPIN; DOXYCYCLINE; HALOPERIDOL; IBUPROFEN; IMIPRAMINE; INDOMETACIN; KETOPROFEN; LIDOCAINE; LINEZOLID; METHOTREXATE; METOPROLOL; NADOLOL; NAPROXEN; NORFLOXACIN; OCTANOL; OFLOXACIN; PARACETAMOL; UNINDEXED DRUG; DRUG;

ARTICLE; CONSTANTS AND COEFFICIENTS; DISTRIBUTION COEFFICIENT; DRUG DETERMINATION; IONIC STRENGTH; LIPOPHILICITY; PARTITION COEFFICIENT; PH; PKA; PRIORITY JOURNAL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLUBILITY; TANDEM MASS SPECTROMETRY; CHEMISTRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METHODOLOGY; MICROARRAY ANALYSIS; PHARMACOKINETICS; STATIC ELECTRICITY; STRUCTURE ACTIVITY RELATION; TECHNIQUE;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HYDROGEN-ION CONCENTRATION; METHODS; MICROARRAY ANALYSIS; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; STATIC ELECTRICITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 65549137535     PISSN: 13862073     EISSN: None     Source Type: Journal    
DOI: 10.2174/138620709787581693     Document Type: Article

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