SCOPUS 정보 검색 플랫폼

Journal of Computer-Aided Molecular Design

Volumn 23, Issue 2, 2009, Pages 97-103

Structural pairwise comparisons of HLM stability of phenyl derivatives: Introduction of the Pfizer metabolism index (PMI) and metabolism-lipophilicity efficiency (MLE)

(2) Lewis, Mark L a Cucurull Sanchez, Lourdes a

a PFIZER GLOBAL RESEARCH AND DEVELOPMENT (United Kingdom)

Author keywords

Human liver microsome; Metabolism lipophilicity efficiency; Pairwise comparison; Pfizer metabolism index; Topliss analysis

Indexed keywords

DATA MINING; EFFICIENCY; PHYSIOLOGY;

AUTOMATED TOOLS; CLEARANCE VALUE; HUMAN LIVER MICROSOMES; LIPOPHILICITY; METABOLISM-LIPOPHILICITY EFFICIENCY; NEW PARAMETERS; PAIR-WISE COMPARISON; PFIZER METABOLISM INDEX; PROBABILITY TABLES; TOPLISS ANALYSE;

METABOLISM;

BENZENE DERIVATIVE;

ARTICLE; DATA MINING; DRUG METABOLISM; DRUG POTENCY; INTERMETHOD COMPARISON; LIPOPHILICITY; LIVER MICROSOME METABOLISM; METABOLIC CLEARANCE RATE; METABOLISM LIPOPHILICITY EFFICIENCY; MOLECULAR STABILITY; PFIZER METABOLISM INDEX; PRIORITY JOURNAL; PROBABILITY; STRUCTURE ANALYSIS; STRUCTURE METABOLISM RELATIONSHIP; SURFACE PROPERTY;

EID: 58149343803 PISSN: 0920654X EISSN: 15734951 Source Type: Journal
DOI: 10.1007/s10822-008-9242-3 Document Type: Article

Times cited : (55)

References (10)

1
- 33845996187
- Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: Reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver
- doi: 10.2174/138920007779315053
- Barter ZE, Bayliss MK, Beaune PH, Boobis AR, Carlile DJ, Edwards RJ, Houston JB, Lake BG, Lipscomb JC, Pelkonen OR, Tucker GT, Rostami-Hodjegan A (2007) Scaling factors for the extrapolation of in vivo metabolic drug clearance from in vitro data: Reaching a consensus on values of human microsomal protein and hepatocellularity per gram of liver. Curr Drug Metab 8:33-45. doi: 10.2174/ 138920007779315053
- (2007) Curr Drug Metab , vol.8 , pp. 33-45
- Barter, Z.E.¹ Bayliss, M.K.² Beaune, P.H.³ Boobis, A.R.⁴ Carlile, D.J.⁵ Edwards, R.J.⁶ Houston, J.B.⁷ Lake, B.G.⁸ Lipscomb, J.C.⁹ Pelkonen, O.R.¹⁰ Tucker, G.T.¹¹ Rostami-Hodjegan, A.¹²

2
- 0015417053
- Utlization of operational schemes for analog synthesis in drug design
- doi: 10.1021/jm00280a002
- Topliss JG (1972) Utlization of operational schemes for analog synthesis in drug design. J Med Chem 15:1006-1011. doi: 10.1021/jm00280a002
- (1972) J Med Chem , vol.15 , pp. 1006-1011
- Topliss, J.G.¹

3
- 0029895323
- A Topliss tree analysis of the HIV-protease inhibitory activity of 6-phenyl-4-hydroxypyran-2-ones
- doi: 10.1016/0960-894X(96)00180-1
- Steinbaugh BA, Hamilton HW, Prasad JVNV, Para KS, Tummino PJ, Ferguson D et al (1996) A Topliss tree analysis of the HIV-protease inhibitory activity of 6-phenyl-4-hydroxypyran-2-ones. Bioorg Med Chem Lett 6:1099-1104. doi: 10.1016/0960-894X(96)00180-1
- (1996) Bioorg Med Chem Lett , vol.6 , pp. 1099-1104
- Steinbaugh, B.A.¹ Hamilton, H.W.² Prasad, J.V.N.V.³ Para, K.S.⁴ Tummino, P.J.⁵ Ferguson, D.⁶

4
- 0035352673
- Structure-metabolism relationships: Steric effects and the enzymatic hydrolysis of carboxylic esters
- doi: 10.2174/1389557013407403
- Buchwald P (2001) Structure-metabolism relationships: Steric effects and the enzymatic hydrolysis of carboxylic esters. Mini Rev Med Chem 1:101-111. doi: 10.2174/1389557013407403
- (2001) Mini Rev Med Chem , vol.1 , pp. 101-111
- Buchwald, P.¹

5
- 33750976700
- Matched molecular pairs as a guide in the optimization of pharmaceutical properties; a study of aqueous solubility, plasma protein binding and oral exposure
- doi: 10.1021/jm0605233
- Leach AG, Jones HD, Cosgrove DA, Kenny PW, Ruston L, MacFaul P et al (2006) Matched molecular pairs as a guide in the optimization of pharmaceutical properties; a study of aqueous solubility, plasma protein binding and oral exposure. J Med Chem 49:6672-6682. doi: 10.1021/ jm0605233
- (2006) J Med Chem , vol.49 , pp. 6672-6682
- Leach, A.G.¹ Jones, H.D.² Cosgrove, D.A.³ Kenny, P.W.⁴ Ruston, L.⁵ MacFaul, P.⁶

6
- 58149346914
- SciTegic Inc (a wholly-owned subsidiary of Accelrys, Inc.) 10188 Telesis Court, Suite 100, San Diego, CA 92121-4779, USA
- SciTegic Inc (a wholly-owned subsidiary of Accelrys, Inc.) (2007) 10188 Telesis Court, Suite 100, San Diego, CA 92121-4779, USA, PipeLine Pilot 6.1.5, version 6.1.5. www.scitegic.com
- (2007) PipeLine Pilot 6.1.5, Version 6.1.5

7
- 58149343100
- MDL Information Systems 2440 Camino Ramon Suite 300, San Ramon, CA 94583, USA
- MDL Information Systems 2440 Camino Ramon (1990-2002) Suite 300, San Ramon, CA 94583, USA, ISIS/Draw 2.5 Standalone, version 2.5. www.mdl.com
- (1990) ISIS/Draw 2.5 Standalone, Version 2.5

8
- 58149352111
- Adobe Systems Inc 345 Park Avenue, San Jose, CA 95110-2704, USA
- Adobe Systems Inc (1987-2003) 345 Park Avenue, San Jose, CA 95110-2704, USA, Adobe Acrobat 6.0 Standard, version 6.0.4. www.adobe.com
- (1987) Adobe Acrobat 6.0 Standard, Version 6.0.4

9
- 3042556959
- Biobyte Corporation. 201 W. 4th St.,#204, Claremont CA 91711-4707
- Biobyte Corporation. 201 W. 4th St.,#204, Claremont CA 91711-4707, CLOGP version 4.3. www.biobyte.com
- CLOGP Version 4.3

10
- 35748934487
- The influence of drug-like concepts on decision-making in medicinal chemistry
- doi: 10.1038/nrd2445
- Leeson PD, Springthorpe B (2007) The influence of drug-like concepts on decision-making in medicinal chemistry. Nat Rev Drug Discov 6:881-890. doi: 10.1038/nrd2445
- (2007) Nat Rev Drug Discov , vol.6 , pp. 881-890
- Leeson, P.D.¹ Springthorpe, B.²

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.