Induction of HIV-1-specific cellular and humoral immune responses following immunization with HIV-DNA adjuvanted with activated apoptotic lymphocytes

Vaccine

Volumn 28, Issue 9, 2010, Pages 2080-2087

  Brave, Andreas ^a,b   Johansson, Ulrika ^d   Hallengärd, David ^a,b   Heidari, Shirin ^d   Gullberg, Hanna ^d   Wahren, Britta ^a,b   Hinkula, Jorma ^a,b,c   Spetz, Anna Lena ^d  

^a KAROLINSKA INSTITUTE   (Sweden)

^b SWEDISH INSTITUTE FOR INFECTIOUS DISEASE CONTROL   (Sweden)

^c LINKÖPING UNIVERSITY   (Sweden)

^d KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Adjuvant; Apoptosis; HIV 1

Indexed keywords

DNA VACCINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

ANIMAL CELL; APOPTOSIS; ARTICLE; B LYMPHOCYTE; CELL FUNCTION; CELLULAR IMMUNITY; COMPARATIVE STUDY; CONTROLLED STUDY; DNA IMMUNIZATION; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMORAL IMMUNITY; LYMPHOCYTE; MOUSE; MUCOSA; NONHUMAN; NUCLEOTIDE SEQUENCE; PLASMID; PRIORITY JOURNAL;

ADJUVANTS, IMMUNOLOGIC; AIDS VACCINES; ANIMALS; APOPTOSIS; B-LYMPHOCYTES; GRANULOCYTE MACROPHAGE COLONY-STIMULATING FACTORS, RECOMBINANT; HIV ANTIBODIES; HIV INFECTIONS; HIV-1; HUMANS; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; PLASMIDS; T-LYMPHOCYTES; TRANSFECTION; VACCINES, DNA;

EID: 76949089970     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2009.12.040     Document Type: Article

References (39)

1. Ulmer J.B., Wahren B., and Liu M.A. Gene-based vaccines: recent technical and clinical advances. Trends Mol Med 12 5 (2006) 216-222
2. Levine M.M., and Sztein M.B. Vaccine development strategies for improving immunization: the role of modern immunology. Nat Immunol 5 5 (2004) 460-464
3. Pulendran B., and Ahmed R. Translating innate immunity into immunological memory: implications for vaccine development. Cell 124 4 (2006) 849-863
4. Pashine A., Valiante N.M., and Ulmer J.B. Targeting the innate immune response with improved vaccine adjuvants. Nat Med 11 4 Suppl. (2005) S63-S68
5. Brewer J.M. (How) do aluminium adjuvants work?. Immunol Lett 102 1 (2006) 10-15
6. Rhee E.G., and Barouch D.H. Translational mini-review series on vaccines for HIV: harnessing innate immunity for HIV vaccine development. Clin Exp Immunol 157 2 (2009) 174-180
7. Banchereau J., Briere F., Caux C., Davoust J., Lebecque S., Liu Y.J., et al. Immunobiology of dendritic cells. Annu Rev Immunol 18 (2000) 767-811
8. Johansson U., Walther-Jallow L., Smed-Sorensen A., and Spetz A.L. Triggering of dendritic cell responses after exposure to activated, but not resting, apoptotic PBMCs. J Immunol 179 3 (2007) 1711-1720
9. Spetz A.L., Sorensen A.S., Walther-Jallow L., Wahren B., Andersson J., Holmgren L., et al. Induction of HIV-1-specific immunity after vaccination with apoptotic HIV-1/murine leukemia virus-infected cells. J Immunol 169 10 (2002) 5771-5779
10. Spector D.H., Wade E., Wright D.A., Koval V., Clark C., Jaquish D., et al. Human immunodeficiency virus pseudotypes with expanded cellular and species tropism. J Virol 64 5 (1990) 2298-2308
11. Andang M., Hinkula J., Hotchkiss G., Larsson S., Britton S., Wong-Staal F., et al. Dose-response resistance to HIV-1/MuLV pseudotype virus ex vivo in a hairpin ribozyme transgenic mouse model. Proc Natl Acad Sci USA 96 22 (1999) 12749-12753
12. Hinkula J., Walther-Jallow L., Lauren A., Makitalo B., Oberg M., Wahren B., et al. Neutralizing activity and cellular immune responses induced in mice after immunization with apoptotic HIV-1/murine leukemia virus infected cells. Vaccine 27 46 (2009) 6424-6431
13. Sandstrom E., Nilsson C., Hejdeman B., Brave A., Bratt G., Robb M., et al. Broad immunogenicity of a multigene, multiclade HIV-1 DNA vaccine boosted with heterologous HIV-1 recombinant modified vaccinia virus Ankara. J Infect Dis 198 10 (2008) 1482-1490
14. Brave A., Ljungberg K., Boberg A., Rollman E., Isaguliants M., Lundgren B., et al. Multigene/multisubtype HIV-1 vaccine induces potent cellular and humoral immune responses by needle-free intradermal delivery. Mol Ther 12 6 (2005) 1197-1205
15. Zuber A.K., Brave A., Engstrom G., Zuber B., Ljungberg K., Fredriksson M., et al. Topical delivery of imiquimod to a mouse model as a novel adjuvant for human immunodeficiency virus (HIV) DNA. Vaccine 22 13-14 (2004) 1791-1798
16. Isaguliants M.G., Petrakova N.N., Zuber B., Pokrovskaya K., Gizatullin R., Kostyuk D.A., et al. DNA-encoding enzymatically active HIV-1 reverse transcriptase, but not the inactive mutant, confers resistance to experimental HIV-1 challenge. Intervirology 43 4-6 (2000) 288-293
17. Ljungberg K., Rollman E., Eriksson L., Hinkula J., and Wahren B. Enhanced immune responses after DNA vaccination with combined envelope genes from different HIV-1 subtypes. Virology 302 1 (2002) 44-57
18. Kjerrstrom A., Hinkula J., Engstrom G., Ovod V., Krohn K., Benthin R., et al. Interactions of single and combined human immunodeficiency virus type 1 (HIV-1) DNA vaccines. Virology 284 1 (2001) 46-61
19. Holmgren L., Szeles A., Rajnavolgyi E., Folkman J., Klein G., Ernberg I., et al. Horizontal transfer of DNA by the uptake of apoptotic bodies. Blood 93 11 (1999) 3956-3963
20. Lundholm P., Asakura Y., Hinkula J., Lucht E., and Wahren B. Induction of mucosal IgA by a novel jet delivery technique for HIV-1 DNA. Vaccine 17 15-16 (1999) 2036-2042
21. Hinkula J., Rosen J., Sundqvist V.A., Stigbrand T., and Wahren B. Epitope mapping of the HIV-1 gag region with monoclonal antibodies. Mol Immunol 27 5 (1990) 395-403
22. Belyakov I.M., Ahlers J.D., Clements J.D., Strober W., and Berzofsky J.A. Interplay of cytokines and adjuvants in the regulation of mucosal and systemic HIV-specific CTL. J Immunol 165 11 (2000) 6454-6462
23. Xu R., Megati S., Roopchand V., Luckay A., Masood A., Garcia-Hand D., et al. Comparative ability of various plasmid-based cytokines and chemokines to adjuvant the activity of HIV plasmid DNA vaccines. Vaccine 26 37 (2008) 4819-4829
24. Haut L.H., and Ertl H.C. Obstacles to the successful development of an efficacious T cell-inducing HIV-1 vaccine. J Leukoc Biol (2009)
25. Plotkin S.A. Sang Froid in a time of trouble: is a vaccine against HIV possible?. J Int AIDS Soc 12 1 (2009) 2
26. Rerks-Ngarm S., Pitisuttithum P., Nitayaphan S., Kaewkungwal J., Chiu J., Paris R., et al. Vaccination with ALVAC and AIDSVAX to prevent HIV-1 infection in Thailand. N Engl J Med 361 23 (2009) 2209-2220
27. Belyakov I.M., and Ahlers J.D. Functional CD8+ CTLs in mucosal sites and HIV infection: moving forward toward a mucosal AIDS vaccine. Trends Immunol 29 11 (2008) 574-585
28. Guo L., Wang J., Zhou H., Si H., Wang M., Song J., et al. Intranasal administration of a recombinant adenovirus expressing the norovirus capsid protein stimulates specific humoral, mucosal, and cellular immune responses in mice. Vaccine 26 4 (2008) 460-468
29. Brave A., Hallengard D., Schroder U., Blomberg P., Wahren B., and Hinkula J. Intranasal immunization of young mice with a multigene HIV-1 vaccine in combination with the N3 adjuvant induces mucosal and systemic immune responses. Vaccine 26 40 (2008) 5075-5078
30. Alsharifi M., Furuya Y., Bowden T.R., Lobigs M., Koskinen A., Regner M., et al. Intranasal flu vaccine protective against seasonal and H5N1 avian influenza infections. PLoS One 4 4 (2009) e5336
31. Green D.R., Ferguson T., Zitvogel L., and Kroemer G. Immunogenic and tolerogenic cell death. Nat Rev Immunol 9 5 (2009) 353-363
32. Schulz O., Diebold S.S., Chen M., Naslund T.I., Nolte M.A., Alexopoulou L., et al. Toll-like receptor 3 promotes cross-priming to virus-infected cells. Nature 433 7028 (2005) 887-892
33. Torchinsky M.B., Garaude J., Martin A.P., and Blander J.M. Innate immune recognition of infected apoptotic cells directs T(H)17 cell differentiation. Nature 458 7234 (2009) 78-82
34. Dharmapuri S., Aurisicchio L., Biondo A., Welsh N., Ciliberto G., and La Monica N. Antiapoptotic small interfering RNA as potent adjuvant of DNA vaccination in a mouse mammary tumor model. Hum Gene Ther 20 6 (2009) 589-597
35. Alexopoulou L., Holt A.C., Medzhitov R., and Flavell R.A. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 413 6857 (2001) 732-738
36. Hornung V., Guenthner-Biller M., Bourquin C., Ablasser A., Schlee M., Uematsu S., et al. Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7. Nat Med 11 3 (2005) 263-270
37. Motta I., Andre F., Lim A., Tartaglia J., Cox W.I., Zitvogel L., et al. Cross-presentation by dendritic cells of tumor antigen expressed in apoptotic recombinant canarypox virus-infected dendritic cells. J Immunol 167 3 (2001) 1795-1802
38. Sarukhan A., Camugli S., Gjata B., von Boehmer H., Danos O., and Jooss K. Successful interference with cellular immune responses to immunogenic proteins encoded by recombinant viral vectors. J Virol 75 1 (2001) 269-277
39. Gasteiger G., Kastenmuller W., Ljapoci R., Sutter G., and Drexler I. Cross-priming of cytotoxic T cells dictates antigen requisites for modified vaccinia virus Ankara vector vaccines. J Virol 81 21 (2007) 11925-11936