Anti-resorptive saurolactam exhibits in vitro anti-inflammatory activity via ERK-NF-κB signaling pathway

International Immunopharmacology

Volumn 10, Issue 3, 2010, Pages 298-303

  Lee, Su Ui ^a,b   Choi, Yeon Hee ^a,c   Kim, Young Sup ^a   Min, Yong Ki ^a   Rhee, Myungchull ^b   Kim, Seong Hwan ^a  

^a Korea Research Institute of Chemical Technology   (South Korea)

^b Chungnam National University   (South Korea)

^c Sungkyunkwan University   (South Korea)

Author keywords

Extracellular signal regulated kinase; Inflammation; Mitogen activated protein kinase; Nuclear factor B; Saurolactam

Indexed keywords

ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PROSTAGLANDIN E2; SAUROLACTAM; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL NUCLEUS; CELL VIABILITY; CYTOKINE PRODUCTION; DRUG ACTIVATION; DRUG INHIBITION; DRUG ISOLATION; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; MACROPHAGE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE; SAURURACEAE; SAURURUS CHINENSIS; WESTERN BLOTTING;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; CYCLOOXYGENASE 2 INHIBITORS; CYTOKINES; DINOPROSTONE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENES, REPORTER; INFLAMMATION MEDIATORS; ISOINDOLES; LIPOPOLYSACCHARIDES; LUCIFERASES; MACROPHAGES; MICE; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RNA, MESSENGER; SAURURACEAE; SIGNAL TRANSDUCTION;

EID: 76849095499     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2009.11.014     Document Type: Article

References (44)

1. Lawrence T., Willoughby D.A., and Gilroy D.W. Anti-inflammatory lipid mediators and insights into resolution of inflammation. Nat Rev Immunol 2 (2002) 787-795
2. Kaplanski G., Marin V., Montero-Julian F., Mantovani A., and Farnarier C. IL-6: a regulator of the transition from neutrophil to monocyte recruitment during inflammation. Trends Immunol 24 (2003) 25-29
3. Nathan C., and Xie Q.W. Nitric oxide synthases: roles, tolls, and controls. Cell 78 (1994) 915-918
4. Korhonen R., Lahti A., Kankaanranta H., and Moilanen E. Nitric oxide production and signaling in inflammation. Curr Drug Targets Inflamm Allergy 4 (2005) 471-479
5. Bertolini A., Ottani A., and Sandrini M. Selective COX-2 inhibitors and dual acting anti-inflammatory drugs: critical remarks. Curr Med Chem 9 (2002) 1033-1043
6. Parente L., and Perretti M. Advances in the pathophysiology of constitutive and inducible cyclooxygenases: two enzymes in the spotlight. Biochem Pharmacol 65 (2003) 153-159
7. Dinarello C.A. Cytokines as endogenous pyrogens. J Infect Dis 179 (1999) S294-S304
8. Feldmann M., Brennan F.M., and Maini R.N. Role of cytokines in rheumatoid arthritis. Annu Rev Immunol 14 (1999) 397-440
9. Hagan P., Poole S., and Bristow A.F. Endotoxin-stimulated production of rat hypothalamic interleukin-1beta in vivo and in vitro, measured by specific immunoradiometric assay. J Mol Endocrinol 11 (1993) 31-36
10. Sautebin L. Prostaglandins and nitric oxide as molecular targets for anti-inflammatory therapy. Fitoterapia 71 (2000) S48-S57
11. Guha M., and Mackman N. LPS induction of gene expression in human monocytes. Cell Signal 13 (2001) 85-94
12. Liu S.F., and Malik A.B. NF-K{green}B activation as a pathological mechanism of septic shock and inflammation. Am J Physiol Lung Cell Mol Physiol 290 (2006) L622-L645
13. Baeuerle P.A., and Henkel T. Function and activation of NF-kappa B in the immune system. Annu Rev Immunol 12 (1994) 141-179
14. Pahl H.L. Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 18 (1999) 6853-6866
15. Celec P. Nuclear factor kappa B-molecular biomedicine: the next generation. Biomed Pharmacother 58 (2004) 365-371
16. Chung B.S. Dictionary of Korean folk medicine. Young Lim Sa: Seoul (1998) 813-814
17. Lee A.K., Sung S.H., Kim Y.C., and Kim S.G. Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2 expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation. Br J Pharmacol 139 (2003) 11-20
18. Hwang B.Y., Lee J.H., Nam J.B., Hong Y.S., and Lee J.J. Lignans from Saururus chinensis inhibiting the transcription factor NF-kappaB. Phytochemistry 64 (2003) 765-771
19. Park H.J., Kim R.G., Seo B.R., Ha J., Ahn B.T., Bok S.H., et al. Saucernetin-7 and saucernetin-8 isolated from Saururus chinensis inhibit the LPS-induced production of nitric oxide and prostaglandin E2 in macrophage RAW264.7 cells. Planta Med 69 (2003) 947-950
20. Moon T.C., Seo C.S., Haa K., Kim J.C., Hwang N.K., Hong T.G., et al. Meso-dihydroguaiaretic acid isolated from Saururus chinensis inhibits cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. Arch Pharm Res 31 (2008) 606-610
21. Kim M.H., Ryu S.Y., Choi J.S., Min Y.K., and Kim S.H. Saurolactam inhibits osteoclast differentiation and stimulates apoptosis of mature osteoclasts. J Cell Physiol 221 (2009) 618-628
22. Rozen S., and Skaletsky H. Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol 132 (2000) 365-386
23. Kim S.N., Kim M.H., Kim Y.S., Ryu S.Y., Min Y.K., and Kim S.H. Inhibitory effect of (-)-saucerneol on osteoclast differentiation and bone pit formation. Phytother Res 23 (2009) 185-191
24. - ΔΔCT method. Methods 25 (2001) 402-408
25. Ding A., Nathan C.F., and Stuehr D.J. Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. J Immunol 141 (1988) 2407-2412
26. de Jager W., te Velthuis H., Prakken B.J., Kuis W., and Rijkers G.T. Simultaneous detection of 15 human cytokines in a single sample of stimulated peripheral blood mononuclear cells. Clin Diagn Lab Immunol 10 (2003) 133-139
27. Salerno L., Sorrenti V., Di Giacomo C., Romeo G., and Siracusa M.A. Progress in the development of selective nitric oxide synthase inhibitors. Curr Pharm Des 8 (2002) 177-200
28. Hinz B., and Brune K. Cyclooxygenase-2-10 years later. J Pharmacol Exp Ther 300 (2002) 367-375
29. Yun K.J., Kim J.Y., Kim J.B., Lee K.W., Jeong S.Y., Park H.J., et al. Inhibition of LPS-induced NO and PGE2 production by asiatic acid via NF-κB inactivation in RAW 264.7 macrophages: Possible involvement of the IKK and MAPK pathways. Int Immunopharmacol 8 (2008) 431-441
30. Han K.Y., Yang D., Chang E.J., Lee Y., Huang H., Sung S.H., et al. Inhibition of osteoclast differentiation and bone resorption by sauchinone. Biochem Pharmacol 74 (2007) 911-923
31. Nam N.H. Naturally occurring NF-kappaB inhibitors. Mini Rev Med Chem 6 (2006) 945-951
32. Takayanagi H.J. Inflammatory bone destruction and osteoimmunology. Periodontal Res 40 (2005) 287-293
33. Koide M., Okahashi N., Tanaka R., Kazuno K., Shibasaki K., Yamazaki Y., et al. Inhibition of experimental bone resorption and osteoclast formation and survival by 2-aminoethanesulphonic acid. Arch Oral Biol 44 (1999) 711-719
34. Inada M., Matsumoto C., Uematsu S., Akira S., and Miyaura C. Membrane-bound prostaglandin E synthase-1-mediated prostaglandin E2 production by osteoblast plays a critical role in lipopolysaccharide-induced bone loss associated with inflammation. J Immunol 177 (2006) 1879-1885
35. Nilforoushan D., Gramoun A., Glogauer M., and Manolson M.F. Nitric oxide enhances osteoclastogenesis possibly by mediating cell fusion. Nitric Oxide 21 (2009) 27-36
36. McCartney-Francis N.L., Song X., Mizel D.E., and Wahl S.M. Selective inhibition of inducible nitric oxide synthase exacerbates erosive joint disease. J Immunol 166 (2001) 2734-2740
37. Barnes P.J., and Karin M. Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336 (1997) 1066-1071
38. Lam J., Takeshita S., Barker J.E., Kanagawa O., Ross F.P., and Teitelbaum S.L. TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J Clin Invest 106 (2000) 1481-1488
39. van der Bruggen T., Nijenhuis S., van Raaij E., Verhoef J., and van Asbeck B.S. Lipopolysaccharide-induced tumor necrosis factor α production by human monocytes involves the raf-1/MEK1-MEK2/ERK1-ERK2 pathway. Infect Immun 67 (1999) 3824-3829
40. Means T.K., Pavlovich R.P., Roca D., Vermeulen M.W., and Fenton M.J. Activation of TNF-α transcription utilizes distinct MAP kinase pathways in different macrophage populations. J Leukocyte Biol 67 (2000) 885-893
41. Carter A.B., Monick M.M., and Hunninghake G.W. Both Erk and p38 kinases are necessary for cytokine gene transcription. Am J Respir Cell Mol Biol 20 (1999) 751-758
42. Ajizian S.J., English B.K., and Meals E.A. Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-γ. J Infect Dis 179 (1999) 939-944
43. Tsatsanis C., Androulidaki A., Venihaki M., and Margioris A.N. Signalling networks regulating cyclooxygenase-2. Int J Biochem Cell Biol 38 (2006) 1654-1661
44. Choi Y.L., Kim J.K., Choi S.U., Min Y.K., Bae M.A., Kim B.T., et al. Synthesis of aristolactam analogues and evaluation of their antitumor activity. Bioorg Med Chem Lett 19 (2009) 3036-3040