Rescue of F508del-CFTR by RXR motif inactivation triggers proteome modulation associated with the unfolded protein response

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1804, Issue 4, 2010, Pages 856-865

  Gomes Alves, Patrícia ^a,b   Couto, Francisco ^c   Pesquita, Cátia ^c   Coelho, Ana V ^b   Penque, Deborah ^a  

^a NATIONAL INSTITUTE OF HEALTH DR RICARDO JORGE   (Portugal)

^b INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^c UNIVERSITY OF LISBON   (Portugal)

Author keywords

CFTR; Cystic fibrosis; Protein trafficking; RXR motif; Therapeutic target; Unfolded protein response

Indexed keywords

CALCIUM BINDING PROTEIN; CALCIUM ION; GLUCOSE REGULATED PROTEIN 94; HEAT SHOCK PROTEIN; PROTEOME; TRANSMEMBRANE CONDUCTANCE REGULATOR;

ANIMAL CELL; ARTICLE; CELL STRAIN BHK; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; GENE OVEREXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEOMICS; TWO DIMENSIONAL ELECTROPHORESIS; UPREGULATION; WESTERN BLOTTING; WILD TYPE;

14-3-3 PROTEINS; AMINO ACID MOTIFS; ANIMALS; BLOTTING, WESTERN; CELL LINE; CRICETINAE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENDOPLASMIC RETICULUM; GENE EXPRESSION; HUMANS; MODELS, BIOLOGICAL; MUTANT PROTEINS; PROTEIN ARRAY ANALYSIS; PROTEOME; RECOMBINANT PROTEINS; SEQUENCE DELETION; STRESS, PHYSIOLOGICAL; TANDEM MASS SPECTROMETRY; UNFOLDED PROTEIN RESPONSE;

EID: 76849090407     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2009.12.013     Document Type: Article

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