Biophysical characterization and mutational analysis of the antibiotic resistance protein NimA from Deinococcus radiodurans

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1804, Issue 4, 2010, Pages 967-976

  Leiros, Hanna Kirsti S ^a   Brandsdal, Bjørn Olav ^a   McSweeney, Seán M ^b  

^a UNIVERSITY OF TROMSØ   (Norway)

^b EUROPEAN SYNCHROTRON RADIATION FACILITY   (France)

Author keywords

5 Nitroimidazole drugs; Antibiotic resistance; Association constants; Isothermal titration calorimetry; Molecular dynamic simulations; Protein structure

Indexed keywords

BACTERIAL PROTEIN; METRONIDAZOLE; NIMA PROTEIN; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; BINDING SITE; CALCULATION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; DEINOCOCCUS RADIODURANS; DIFFERENTIAL SCANNING CALORIMETRY; ENTHALPY; ISOTHERMAL TITRATION CALORIMETRY; MASS SPECTROMETRY; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; ULTRAVIOLET RADIATION;

AMINO ACID SUBSTITUTION; ANIMALS; BACTERIAL PROTEINS; BASE SEQUENCE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DEINOCOCCUS; DNA PRIMERS; DNA, BACTERIAL; DRUG RESISTANCE, BACTERIAL; HUMANS; METRONIDAZOLE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTANT PROTEINS; MUTATION; NITROIMIDAZOLES; PROTEIN STABILITY; THERMODYNAMICS;

ANIMALIA; BACTERIA (MICROORGANISMS); DEINOCOCCUS RADIODURANS;

EID: 76849089840     PISSN: 15709639     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbapap.2010.01.010     Document Type: Article

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