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Volumn 29, Issue 2, 1999, Pages 199-212

Trichomonads, hydrogenosomes and drug resistance

Author keywords

Anaerobic protozoa; Changes in energy metabolism; Hydrogenosome; Mechanisms; Metronidazole resistance; Trichomonas vaginalis; Trichomoniasis; Tritrichomonas foetus

Indexed keywords

5 NITROIMIDAZOLE DERIVATIVE; METRONIDAZOLE; PYRUVATE SYNTHASE; PYRUVIC ACID;

EID: 0033033761     PISSN: 00207519     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0020-7519(98)00155-6     Document Type: Article
Times cited : (154)

References (73)
  • 1
    • 0031978286 scopus 로고    scopus 로고
    • Clinical and microbiological aspects of Trichomonas vaginalis
    • Petrin D, Delgaty K, Bhatt R, Garber G. Clinical and microbiological aspects of Trichomonas vaginalis. Clin Microbiol Rev 1998;11:300-317.
    • (1998) Clin Microbiol Rev , vol.11 , pp. 300-317
    • Petrin, D.1    Delgaty, K.2    Bhatt, R.3    Garber, G.4
  • 2
    • 0000602237 scopus 로고
    • Trichomonads of veterinary importance
    • Kreier JP, editor. San Antonio: Academic Press
    • BonDurant RH, Honigberg BM. Trichomonads of veterinary importance. In: Kreier JP, editor. Parasitic protozoa, vol. 9. San Antonio: Academic Press, 1994;111-188.
    • (1994) Parasitic Protozoa , vol.9 , pp. 111-188
    • BonDurant, R.H.1    Honigberg, B.M.2
  • 3
    • 0015731174 scopus 로고
    • Hydrogenosome, a cytoplasmic organelle of the anaerobic flagellate Tritrichomonas foetus, and its role in pyruvate metabolism
    • Lindmark DG, Müller M. Hydrogenosome, a cytoplasmic organelle of the anaerobic flagellate Tritrichomonas foetus, and its role in pyruvate metabolism. J Biol Chem 1973;248:7724-7728.
    • (1973) J Biol Chem , vol.248 , pp. 7724-7728
    • Lindmark, D.G.1    Müller, M.2
  • 4
    • 0027787578 scopus 로고
    • The hydrogenosome
    • Müller M. The hydrogenosome. J Gen Microbiol 1993;139:2879-2889.
    • (1993) J Gen Microbiol , vol.139 , pp. 2879-2889
    • Müller, M.1
  • 5
    • 0027241047 scopus 로고
    • Small subunit ribosomal RNA of Hexamita inflata and the quest for the first branch in the eukaryotic tree
    • Leipe DD, Gunderson JH, Nerad TA, Sogin ML. Small subunit ribosomal RNA of Hexamita inflata and the quest for the first branch in the eukaryotic tree. Mol Biochem Parasitol 1993;59:41-48.
    • (1993) Mol Biochem Parasitol , vol.59 , pp. 41-48
    • Leipe, D.D.1    Gunderson, J.H.2    Nerad, T.A.3    Sogin, M.L.4
  • 8
    • 0029963676 scopus 로고    scopus 로고
    • Presence of a mitochondrial-type HSP70 in Trichomonas suggests a very early mitochondrial endosymbiosis in eukaryotes
    • Germot A, Philippe H, Le Guyader H. Presence of a mitochondrial-type HSP70 in Trichomonas suggests a very early mitochondrial endosymbiosis in eukaryotes. Proc Natl Acad Sci USA 1996;93:14614-14617.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 14614-14617
    • Germot, A.1    Philippe, H.2    Le Guyader, H.3
  • 9
    • 0031010331 scopus 로고    scopus 로고
    • Targeting and translocation of proteins into the hydrogenosome of the protist Trichomonas: Similarities with mitochondrial protein import
    • Bradley PJ, Lathi CJ, Plümper E, Johnson P. Targeting and translocation of proteins into the hydrogenosome of the protist Trichomonas: similarities with mitochondrial protein import. EMBO J 1997;16:3484-3494.
    • (1997) EMBO J , vol.16 , pp. 3484-3494
    • Bradley, P.J.1    Lathi, C.J.2    Plümper, E.3    Johnson, P.4
  • 10
    • 0030976907 scopus 로고    scopus 로고
    • Evolutionary origins of trichomonad hydrogenosomes
    • Müller M. Evolutionary origins of trichomonad hydrogenosomes. Parasitol Today 1997;13:166-167.
    • (1997) Parasitol Today , vol.13 , pp. 166-167
    • Müller, M.1
  • 11
    • 0022796133 scopus 로고
    • Epidemiologic and economic analyses of an unusually long epizootic of trichomoniasis in a large California dairy herd
    • Goodger WJ, Skirrow SZ. Epidemiologic and economic analyses of an unusually long epizootic of trichomoniasis in a large California dairy herd. J Am Vet Med Assoc 1986;189:772-776.
    • (1986) J Am Vet Med Assoc , vol.189 , pp. 772-776
    • Goodger, W.J.1    Skirrow, S.Z.2
  • 12
    • 0027447473 scopus 로고
    • Non ulcerative sexually transmitted diseases as risk factor for HIV-1 transmission in women: Results from a cohort study
    • Laga M, Manoko A, Kivuvu M et al. Non ulcerative sexually transmitted diseases as risk factor for HIV-1 transmission in women: results from a cohort study. AIDS 1993;7:95-102.
    • (1993) AIDS , vol.7 , pp. 95-102
    • Laga, M.1    Manoko, A.2    Kivuvu, M.3
  • 13
    • 0027522732 scopus 로고
    • Nitroimidazole drugs - Action and resistance mechanisms. I. Mechanisms of action
    • Edwards DI. Nitroimidazole drugs - action and resistance mechanisms. I. Mechanisms of action. J Antimicrob Chemother 1993;31:9-20.
    • (1993) J Antimicrob Chemother , vol.31 , pp. 9-20
    • Edwards, D.I.1
  • 14
    • 0022615157 scopus 로고
    • Reductive activation of nitroimidazoles in anaerobic microorganisms
    • Müller M. Reductive activation of nitroimidazoles in anaerobic microorganisms. Biochem Pharmacol 1986;35:37-41.
    • (1986) Biochem Pharmacol , vol.35 , pp. 37-41
    • Müller, M.1
  • 16
    • 0005577556 scopus 로고
    • Metronidazole resistant trichomonads: Mechanisms of in vitro developed anaerobic resistance
    • Lloyd D, Coombs GH, Paget TA, editors. Chur: Harwood Academic
    • Kulda J, Kabicková H, Tachezy J, Čerkasovová A, Čerkasov J. Metronidazole resistant trichomonads: mechanisms of in vitro developed anaerobic resistance. In: Lloyd D, Coombs GH, Paget TA, editors. Biochemistry and molecular biology of anaerobic protozoa. Chur: Harwood Academic, 1988;137-160.
    • (1988) Biochemistry and Molecular Biology of Anaerobic Protozoa , pp. 137-160
    • Kulda, J.1    Kabicková, H.2    Tachezy, J.3    Čerkasovová, A.4    Čerkasov, J.5
  • 17
    • 0027481272 scopus 로고
    • Nitroimidazole drugs - Action and resistance mechanisms. II. Mechanisms of resistance
    • Edwards DI. Nitroimidazole drugs - action and resistance mechanisms. II. Mechanisms of resistance. J Antimicrob Chemother 1993;31:201-210.
    • (1993) J Antimicrob Chemother , vol.31 , pp. 201-210
    • Edwards, D.I.1
  • 18
    • 0027156517 scopus 로고
    • Metronidazole and drug resistance
    • Johnson PJ. Metronidazole and drug resistance. Parasitol Today 1993;9:183-6.
    • (1993) Parasitol Today , vol.9 , pp. 183-186
    • Johnson, P.J.1
  • 20
    • 0031282415 scopus 로고    scopus 로고
    • Molecular mechanisms underlying metronidazole resistance in trichomonads
    • Land KM, Johnson PJ. Molecular mechanisms underlying metronidazole resistance in trichomonads. Exp Parasitol 1997;87:305-308.
    • (1997) Exp Parasitol , vol.87 , pp. 305-308
    • Land, K.M.1    Johnson, P.J.2
  • 21
    • 0000143331 scopus 로고    scopus 로고
    • Enzymes and compartmentation of core energy metabolism of anaerobic protists - A special case in eukaryotic evolution?
    • Coombs GH, Vickerman K, Sleigh MA, Warren A, editors. London: Chapman and Hall
    • Müller M. Enzymes and compartmentation of core energy metabolism of anaerobic protists - a special case in eukaryotic evolution? In: Coombs GH, Vickerman K, Sleigh MA, Warren A, editors. Evolutionary relationships among Protozoa. London: Chapman and Hall, 1998;108-32.
    • (1998) Evolutionary Relationships among Protozoa , pp. 108-132
    • Müller, M.1
  • 22
    • 0024445334 scopus 로고
    • Presence of a fructose-2,6-bisphosphate-insensitive pyrophosphate: Fructose-6-phosphate phosphotransferase in the anaerobic protozoa Tritrichomonas foetus, Trichomonas vaginalis and Isotricha prostoma
    • Mertens M, Van Schaftingen E, Müller M. Presence of a fructose-2,6-bisphosphate-insensitive pyrophosphate: fructose-6-phosphate phosphotransferase in the anaerobic protozoa Tritrichomonas foetus, Trichomonas vaginalis and Isotricha prostoma. Mol Biochem Parasitol 1989;37:183-190.
    • (1989) Mol Biochem Parasitol , vol.37 , pp. 183-190
    • Mertens, M.1    Van Schaftingen, E.2    Müller, M.3
  • 23
    • 0027393935 scopus 로고
    • Identification, purification and separation of different isozymes of NADH-specific malic enzyme from Tritrichomonas foetus
    • Hrdý I, Mertens M, Van Schaftingen E. Identification, purification and separation of different isozymes of NADH-specific malic enzyme from Tritrichomonas foetus. Mol Biochem Parasitol 1993;57:253-260.
    • (1993) Mol Biochem Parasitol , vol.57 , pp. 253-260
    • Hrdý, I.1    Mertens, M.2    Van Schaftingen, E.3
  • 24
    • 0023404189 scopus 로고
    • Purification and characterization of pyruvate:ferredoxin oxidoreductase from the anaerobic protozoon Trichomonas vaginalis
    • Williams K, Lowe PN, Leadlay PF. Purification and characterization of pyruvate:ferredoxin oxidoreductase from the anaerobic protozoon Trichomonas vaginalis. Biochem J 1987;246:529-536.
    • (1987) Biochem J , vol.246 , pp. 529-536
    • Williams, K.1    Lowe, P.N.2    Leadlay, P.F.3
  • 25
    • 0028874227 scopus 로고
    • Primary structure and eubacterial relationships of the pyruvate:ferredoxin oxidoreductase of the amitochondrial eukaryote Trichomonas vaginalis
    • Hrdý I, Müller M. Primary structure and eubacterial relationships of the pyruvate:ferredoxin oxidoreductase of the amitochondrial eukaryote Trichomonas vaginalis. J Mol Evol 1995;41:388-396.
    • (1995) J Mol Evol , vol.41 , pp. 388-396
    • Hrdý, I.1    Müller, M.2
  • 27
    • 0026641622 scopus 로고
    • β-Succinyl-coenzyme a synthetase from Trichomonas vaginalis is a soluble hydrogenosomal protein with an amino-terminal sequence that resembles mitochondrial presequence
    • Lathi CJ, d'Oliveira CE, Johnson P. β-Succinyl-coenzyme A synthetase from Trichomonas vaginalis is a soluble hydrogenosomal protein with an amino-terminal sequence that resembles mitochondrial presequence. J Bacteriol 1992;174:6822-6830.
    • (1992) J Bacteriol , vol.174 , pp. 6822-6830
    • Lathi, C.J.1    D'Oliveira, C.E.2    Johnson, P.3
  • 28
    • 0028168012 scopus 로고
    • Molecular characterization of the α-subunit of Trichomonas vaginalis hydrogenosomal succinyl CoA synthetase
    • Lathi CJ, Bradley P, Johnson PJ. Molecular characterization of the α-subunit of Trichomonas vaginalis hydrogenosomal succinyl CoA synthetase. Mol Biochem Parasitol 1994;66:309-318.
    • (1994) Mol Biochem Parasitol , vol.66 , pp. 309-318
    • Lathi, C.J.1    Bradley, P.2    Johnson, P.J.3
  • 29
    • 0021112709 scopus 로고
    • Hydrogenosomal ferredoxin of the anaerobic protozoon Tritrichomonas foetus
    • Marczak R, Gorrell TE, Müller M. Hydrogenosomal ferredoxin of the anaerobic protozoon Tritrichomonas foetus. J Biol Chem 1983;258:12427-12433.
    • (1983) J Biol Chem , vol.258 , pp. 12427-12433
    • Marczak, R.1    Gorrell, T.E.2    Müller, M.3
  • 30
    • 0000936375 scopus 로고
    • Isolation and characterization of Trichomonas vaginalis ferredoxin
    • Gorrell T, Yarlett N, Müller M. Isolation and characterization of Trichomonas vaginalis ferredoxin. Carlsberg Res Commun 1984;49:259-268.
    • (1984) Carlsberg Res Commun , vol.49 , pp. 259-268
    • Gorrell, T.1    Yarlett, N.2    Müller, M.3
  • 31
    • 0025180595 scopus 로고
    • Molecular analysis of the hydrogenosomal ferredoxin of the anaerobic protist Trichomonas vaginalis
    • Johnson PJ, d'Oliveira CE, Gorrell TH, Müller M. Molecular analysis of the hydrogenosomal ferredoxin of the anaerobic protist Trichomonas vaginalis. Proc Natl Acad Sci USA 1990;87:6097-6101.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 6097-6101
    • Johnson, P.J.1    D'Oliveira, C.E.2    Gorrell, T.H.3    Müller, M.4
  • 32
    • 0027533463 scopus 로고
    • Evidence for a [Fe]-type hydrogenase in the parasitic protozoan Trichomonas vaginalis
    • Payne MJ, Chapman A, Cammack R. Evidence for a [Fe]-type hydrogenase in the parasitic protozoan Trichomonas vaginalis. FEBS Lett 1993;317:101-104.
    • (1993) FEBS Lett , vol.317 , pp. 101-104
    • Payne, M.J.1    Chapman, A.2    Cammack, R.3
  • 33
    • 0029881944 scopus 로고    scopus 로고
    • Identification and characterization of [Fe]-hydrogenase in the hydrogenosome of Trichomonas vaginalis
    • Bui ETN, Johnson PJ. Identification and characterization of [Fe]-hydrogenase in the hydrogenosome of Trichomonas vaginalis. Mol Biochem Parasitol 1996;76:305-310.
    • (1996) Mol Biochem Parasitol , vol.76 , pp. 305-310
    • Bui, E.T.N.1    Johnson, P.J.2
  • 34
    • 0027438109 scopus 로고
    • Purification and partial characterization of malate dehydrogenase (decarboxylating) from Tritrichomonas foetus hydrogenosomes
    • Hrdý I, Mertens M. Purification and partial characterization of malate dehydrogenase (decarboxylating) from Tritrichomonas foetus hydrogenosomes. Parasitology 1993;107:379-385.
    • (1993) Parasitology , vol.107 , pp. 379-385
    • Hrdý, I.1    Mertens, M.2
  • 35
    • 0029372609 scopus 로고
    • Primary structure of the hydrogenosomal malic enzyme of Trichomonas vaginalis and its relationship to homologous enzymes
    • Hrdý I, Müller M. Primary structure of the hydrogenosomal malic enzyme of Trichomonas vaginalis and its relationship to homologous enzymes. J Eukaryot Microbiol 1995;42:593-603.
    • (1995) J Eukaryot Microbiol , vol.42 , pp. 593-603
    • Hrdý, I.1    Müller, M.2
  • 36
    • 0030596212 scopus 로고    scopus 로고
    • Iron-ascorbate cleavable malic enzyme from hydrogenosomes of Trichomonas vaginalis: Purification and characterization
    • Drmota T, Proost P, Van Ranst M, Weyda F, Kulda J, Tachezy J. Iron-ascorbate cleavable malic enzyme from hydrogenosomes of Trichomonas vaginalis: purification and characterization. Mol Biochem Parasitol 1996;83:221-234.
    • (1996) Mol Biochem Parasitol , vol.83 , pp. 221-234
    • Drmota, T.1    Proost, P.2    Van Ranst, M.3    Weyda, F.4    Kulda, J.5    Tachezy, J.6
  • 37
    • 0022744840 scopus 로고
    • Anaerobic pyruvate metabolism of Tritrichomonas foetus and Trichomonas vaginalis hydrogenosomes
    • Steinbüchel A, Müller M. Anaerobic pyruvate metabolism of Tritrichomonas foetus and Trichomonas vaginalis hydrogenosomes. Mol Biochem Parasitol 1989;20:57-65.
    • (1989) Mol Biochem Parasitol , vol.20 , pp. 57-65
    • Steinbüchel, A.1    Müller, M.2
  • 38
    • 0022270676 scopus 로고
    • 13C-NMR reveals glycerol as an unexpected major metabolite of the protozoan parasite Trichomonas vaginalis
    • 13C-NMR reveals glycerol as an unexpected major metabolite of the protozoan parasite Trichomonas vaginalis. FEBS Lett 1985;191:287-292.
    • (1985) FEBS Lett , vol.191 , pp. 287-292
    • Chapman, A.1    Linstead, D.J.2    Lloyd, D.3    Williams, J.4
  • 39
    • 0022747671 scopus 로고
    • Glycerol, a metabolic endproduct of Trichomonas vaginalis and Tritrichomonas foetus
    • Steinbüchel A, Müller M. Glycerol, a metabolic endproduct of Trichomonas vaginalis and Tritrichomonas foetus. Mol Biochem Parasitol 1986;20:45-55.
    • (1986) Mol Biochem Parasitol , vol.20 , pp. 45-55
    • Steinbüchel, A.1    Müller, M.2
  • 40
    • 0001296330 scopus 로고
    • Studies on the metabolism of the protozoa. 5. Metabolism of the parasitic flagellate Trichomonas foetus
    • Ryley JF. Studies on the metabolism of the protozoa. 5. Metabolism of the parasitic flagellate Trichomonas foetus. Biochem J 1955;59:361-369.
    • (1955) Biochem J , vol.59 , pp. 361-369
    • Ryley, J.F.1
  • 41
    • 0004630080 scopus 로고
    • Carbohydrate and and energy metabolism of Tritrichomonas foetus
    • Van den Boshe H, editor. Amsterdam: North Holland
    • Müller M. Carbohydrate and and energy metabolism of Tritrichomonas foetus. In: Van den Boshe H, editor. Biochemistry of parasites and host-parasite relationships. Amsterdam: North Holland, 1976;3-14.
    • (1976) Biochemistry of Parasites and Host-parasite Relationships , pp. 3-14
    • Müller, M.1
  • 42
    • 0001910082 scopus 로고
    • Biochemistry of Trichomonas vaginalis
    • Honigberg BM, editor. New York: Springer-Verlag
    • Müller M. Biochemistry of Trichomonas vaginalis. In: Honigberg BM, editor. Trichomonads parasitic in humans. New York: Springer-Verlag, 1989;53-83.
    • (1989) Trichomonads Parasitic in Humans , pp. 53-83
    • Müller, M.1
  • 43
    • 0040692338 scopus 로고
    • Energy metabolism of anaerobic protists
    • Coombs GH, North M, editors. London: Taylor and Francis
    • Müller M. Energy metabolism of anaerobic protists. In: Coombs GH, North M, editors. Biochemical protozoology. London: Taylor and Francis, 1991;80-91.
    • (1991) Biochemical Protozoology , pp. 80-91
    • Müller, M.1
  • 44
    • 0002439035 scopus 로고
    • Energy metabolism in anaerobic protozoa
    • Marr JJ, Müller M, editors. London: Academic Press
    • Coombs GH, Müller M. Energy metabolism in anaerobic protozoa. In: Marr JJ, Müller M, editors. Biochemistry and molecular biology of parasites. London: Academic Press, 1995;33-47.
    • (1995) Biochemistry and Molecular Biology of Parasites , pp. 33-47
    • Coombs, G.H.1    Müller, M.2
  • 45
    • 0021796772 scopus 로고
    • Metronidazole inhibition of hydrogen production in vivo in drug-sensitive and resistant strains of Trichomonas vaginalis
    • Lloyd D, Kristensen B. Metronidazole inhibition of hydrogen production in vivo in drug-sensitive and resistant strains of Trichomonas vaginalis. J Gen Microbiol 1985;131:489-853.
    • (1985) J Gen Microbiol , vol.131 , pp. 489-853
    • Lloyd, D.1    Kristensen, B.2
  • 46
    • 0022272171 scopus 로고
    • Mechanism of toxicity of nitro compounds used in the chemotherapy of trichomoniasis
    • Moreno SNJ, Docampo R. Mechanism of toxicity of nitro compounds used in the chemotherapy of trichomoniasis. Environ Health Perspect 1985;64:199-208.
    • (1985) Environ Health Perspect , vol.64 , pp. 199-208
    • Moreno, S.N.J.1    Docampo, R.2
  • 47
    • 0020532158 scopus 로고
    • Generation of free radicals from metronidazole and other nitroimidazoles by Tritrichomonas foetus
    • Moreno SNJ, Mason RP, Muniz RPA, Cruz FC, Docampo R. Generation of free radicals from metronidazole and other nitroimidazoles by Tritrichomonas foetus. J Biol Chem 1983;258:4051-4054.
    • (1983) J Biol Chem , vol.258 , pp. 4051-4054
    • Moreno, S.N.J.1    Mason, R.P.2    Muniz, R.P.A.3    Cruz, F.C.4    Docampo, R.5
  • 48
    • 0021279661 scopus 로고
    • Distinct reduction of nitrofurans and metronidazole to free radical metabolites by Tritrichomonas foetus hydrogenosomal and cytosolic enzymes
    • Moreno SNJ, Mason RP, Docampo R. Distinct reduction of nitrofurans and metronidazole to free radical metabolites by Tritrichomonas foetus hydrogenosomal and cytosolic enzymes. J Biol Chem 1984;259:8252-8259.
    • (1984) J Biol Chem , vol.259 , pp. 8252-8259
    • Moreno, S.N.J.1    Mason, R.P.2    Docampo, R.3
  • 49
    • 0022412781 scopus 로고
    • The generation of metronidazole radicals in hydrogenosomes isolated from Trichomonas vaginalis
    • Chapman A, Cammack R, Linstead D, Lloyd D. The generation of metronidazole radicals in hydrogenosomes isolated from Trichomonas vaginalis. J Gen Microbiol 1985;131:2141-2144.
    • (1985) J Gen Microbiol , vol.131 , pp. 2141-2144
    • Chapman, A.1    Cammack, R.2    Linstead, D.3    Lloyd, D.4
  • 50
    • 0021914743 scopus 로고
    • Metronidazole radical anion generation in vivo in Trichomonas vaginalis: Oxygen quenching is enhanced in a drug-resistant strain
    • Lloyd D, Pedersen JZ. Metronidazole radical anion generation in vivo in Trichomonas vaginalis: oxygen quenching is enhanced in a drug-resistant strain. J Gen Microbiol 1985;131:87-92.
    • (1985) J Gen Microbiol , vol.131 , pp. 87-92
    • Lloyd, D.1    Pedersen, J.Z.2
  • 51
    • 0023260123 scopus 로고
    • Nitroimidazole and oxygen derived radicals detected by electron spin resonance in hydrogenosomal and cytosolic fractions from Trichomonas vaginalis
    • Yarlett N, Rowlands CC, Evans JC, Yarlett NC, Lloyd D. Nitroimidazole and oxygen derived radicals detected by electron spin resonance in hydrogenosomal and cytosolic fractions from Trichomonas vaginalis. Mol Biochem Parasitol 1987;24:255-261.
    • (1987) Mol Biochem Parasitol , vol.24 , pp. 255-261
    • Yarlett, N.1    Rowlands, C.C.2    Evans, J.C.3    Yarlett, N.C.4    Lloyd, D.5
  • 52
    • 0014690360 scopus 로고
    • Resistance to metronidazole by Trichomonas foetus in hamsters infected intravaginally
    • Actor P, Ziv DS, Pagano JF. Resistance to metronidazole by Trichomonas foetus in hamsters infected intravaginally. Science 1969;164:439-440.
    • (1969) Science , vol.164 , pp. 439-440
    • Actor, P.1    Ziv, D.S.2    Pagano, J.F.3
  • 53
    • 0017239957 scopus 로고
    • Cross-resistance of trichomonads to 5-nitroimidazole derivatives
    • Meingassner JG, Mieth H. Cross-resistance of trichomonads to 5-nitroimidazole derivatives. Experientia 1976;32:183-184.
    • (1976) Experientia , vol.32 , pp. 183-184
    • Meingassner, J.G.1    Mieth, H.2
  • 54
    • 0021289020 scopus 로고
    • Tritrichomonas foetus: Stable anaerobic resistance to metronidazole in vitro
    • Kulda J, Cerkasov J, Demeš P, Čerkasovová A. Tritrichomonas foetus: stable anaerobic resistance to metronidazole in vitro. Exp Parasitol 1984;57:93-103.
    • (1984) Exp Parasitol , vol.57 , pp. 93-103
    • Kulda, J.1    Cerkasov, J.2    Demeš, P.3    Čerkasovová, A.4
  • 55
    • 0027598223 scopus 로고
    • In vitro induced anaerobic resistance to metronidazole in Trichomonas vaginalis
    • Kulda J, Tachezy J, Čerkasovová A. In vitro induced anaerobic resistance to metronidazole in Trichomonas vaginalis. J Eukaryot Microbiol 1993;40:262-269.
    • (1993) J Eukaryot Microbiol , vol.40 , pp. 262-269
    • Kulda, J.1    Tachezy, J.2    Čerkasovová, A.3
  • 56
    • 0027389954 scopus 로고
    • Aerobic resistance of Trichomonas vaginalis to metronidazole induced in vitro
    • Tachezy J, Kulda J, Tomkova E. Aerobic resistance of Trichomonas vaginalis to metronidazole induced in vitro. Parasitology 1993;106:31-37.
    • (1993) Parasitology , vol.106 , pp. 31-37
    • Tachezy, J.1    Kulda, J.2    Tomkova, E.3
  • 57
    • 0018408557 scopus 로고
    • Strain of Trichomonas vaginalis resistant to metronidazole and other 5-nitroimidazoles
    • Meingassner JG, Thurner J. Strain of Trichomonas vaginalis resistant to metronidazole and other 5-nitroimidazoles. Antimicrob Agents Chemother 1979;15:254-257.
    • (1979) Antimicrob Agents Chemother , vol.15 , pp. 254-257
    • Meingassner, J.G.1    Thurner, J.2
  • 58
    • 0019215030 scopus 로고
    • Three metronidazole resistant strains of Trichomonas vaginalis from the United States
    • Müller M, Meingassner JG, Miller WA, Ledger WJ. Three metronidazole resistant strains of Trichomonas vaginalis from the United States. Am J Obstet Gynecol 1980;138:808-812.
    • (1980) Am J Obstet Gynecol , vol.138 , pp. 808-812
    • Müller, M.1    Meingassner, J.G.2    Miller, W.A.3    Ledger, W.J.4
  • 59
    • 0020354034 scopus 로고
    • Metronidazole resistance of Trichomonas vaginalis as a cause of treatment failure in trichomoniasis
    • Kulda J, Vojtechovská M, Tachezy J, Demeš P, Kunzová E. Metronidazole resistance of Trichomonas vaginalis as a cause of treatment failure in trichomoniasis. Br J Vener Dis 1982;58:394-399.
    • (1982) Br J Vener Dis , vol.58 , pp. 394-399
    • Kulda, J.1    Vojtechovská, M.2    Tachezy, J.3    Demeš, P.4    Kunzová, E.5
  • 60
    • 0022649496 scopus 로고
    • In vitro drug susceptibility and doses of metronidazole required for cure in cases of refractory vaginal trichomoniasis
    • Lossick JG, Müller M, Gorrell TE. In vitro drug susceptibility and doses of metronidazole required for cure in cases of refractory vaginal trichomoniasis. J Infect Dis 1986;153:948-955.
    • (1986) J Infect Dis , vol.153 , pp. 948-955
    • Lossick, J.G.1    Müller, M.2    Gorrell, T.E.3
  • 61
    • 0014096389 scopus 로고
    • Drug tolerance by Tritrichomonas foetus
    • McLoughlin DK. Drug tolerance by Tritrichomonas foetus. J Parasitol 1967;53:646-648.
    • (1967) J Parasitol , vol.53 , pp. 646-648
    • McLoughlin, D.K.1
  • 63
    • 0022531328 scopus 로고
    • Metronidazole-resistant clinical isolates of Trichomonas vaginalis have lowered oxygen affinities
    • Yarlett N, Yarlet NC, Lloyd D. Metronidazole-resistant clinical isolates of Trichomonas vaginalis have lowered oxygen affinities. Mol Biochem Parasitol 1986;19:111-116.
    • (1986) Mol Biochem Parasitol , vol.19 , pp. 111-116
    • Yarlett, N.1    Yarlet, N.C.2    Lloyd, D.3
  • 64
    • 84912910475 scopus 로고
    • Metronidazole resistant clinical isolates of Trichomonas vaginalis maintain low metronidazole radical anion levels as consequence of defective oxygen scavenging
    • Lloyd D, Yarlett N, Yarlett NC, Pedersen JZ, Kristensen B. Metronidazole resistant clinical isolates of Trichomonas vaginalis maintain low metronidazole radical anion levels as consequence of defective oxygen scavenging. Acta Univ Carolinae - Biol 1988;30:533-545.
    • (1988) Acta Univ Carolinae - Biol , vol.30 , pp. 533-545
    • Lloyd, D.1    Yarlett, N.2    Yarlett, N.C.3    Pedersen, J.Z.4    Kristensen, B.5
  • 65
    • 0021287491 scopus 로고
    • Metabolic differences between metronidazole resistant and susceptible strains of Tritrichomonas foetus
    • Cerkasovova A, Cerkasov J, Kulda J. Metabolic differences between metronidazole resistant and susceptible strains of Tritrichomonas foetus. Mol Biochem Parasitol 1984;11:105-118.
    • (1984) Mol Biochem Parasitol , vol.11 , pp. 105-118
    • Cerkasovova, A.1    Cerkasov, J.2    Kulda, J.3
  • 66
    • 0001152381 scopus 로고
    • Metronidazole resistant Tritrichomonas foetus: Activities of hydrogenosomal enzymes in course of development of anaerobic resistance
    • Kabíčková H, Kulda J, Čerkasovová A, Pecková H. Metronidazole resistant Tritrichomonas foetus: activities of hydrogenosomal enzymes in course of development of anaerobic resistance. Acta Univ Carolinae - Biol 1988;30:513-519.
    • (1988) Acta Univ Carolinae - Biol , vol.30 , pp. 513-519
    • Kabíčková, H.1    Kulda, J.2    Čerkasovová, A.3    Pecková, H.4
  • 67
    • 0000432761 scopus 로고
    • Metabolic properties of Trichomonas vaginalis resistant to metronidazole under anaerobic conditions
    • Cerkasovova A, Novák J, Čerkasov J, Kulda J, Tachezy J. Metabolic properties of Trichomonas vaginalis resistant to metronidazole under anaerobic conditions. Acta Univ Carolinae - Biol 1988;30:505-512.
    • (1988) Acta Univ Carolinae - Biol , vol.30 , pp. 505-512
    • Cerkasovova, A.1    Novák, J.2    Čerkasov, J.3    Kulda, J.4    Tachezy, J.5
  • 68
    • 0022501379 scopus 로고
    • Ferredoxin-dependent reduction of nitroimidazole derivatives in drug-resistant and susceptible strains of Trichomonas vaginalis
    • Yarlett N, Yarlett NC, Lloyd D. Ferredoxin-dependent reduction of nitroimidazole derivatives in drug-resistant and susceptible strains of Trichomonas vaginalis. Biochem Pharmacol 1986;35:1703-1708.
    • (1986) Biochem Pharmacol , vol.35 , pp. 1703-1708
    • Yarlett, N.1    Yarlett, N.C.2    Lloyd, D.3
  • 69
    • 0026583186 scopus 로고
    • Reduced transcription of the ferredoxin gene in metronidazole-resistant Trichomonas vaginalis
    • Quon DVK, d'Oliveira CE, Johnson PJ. Reduced transcription of the ferredoxin gene in metronidazole-resistant Trichomonas vaginalis. Proc Natl Acad Sci USA 1992;89:4402-4406.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4402-4406
    • Quon, D.V.K.1    D'Oliveira, C.E.2    Johnson, P.J.3
  • 70
    • 0002590441 scopus 로고
    • Chemotherapy of nitroimidazole resistant vaginal trichomonisasis
    • Lossick JG. Chemotherapy of nitroimidazole resistant vaginal trichomonisasis. Acta Univ Carolinae - Biol 1988;30:533-545.
    • (1988) Acta Univ Carolinae - Biol , vol.30 , pp. 533-545
    • Lossick, J.G.1
  • 72
    • 0017178336 scopus 로고
    • Uptake of metronidazole and its effect on viability in trichomonads and Entamoeba invadens under anaerobic and aerobic conditions
    • Müller M, Lindmark DG. Uptake of metronidazole and its effect on viability in trichomonads and Entamoeba invadens under anaerobic and aerobic conditions. Antimicrob Agents Chemother 1976;9:696-700.
    • (1976) Antimicrob Agents Chemother , vol.9 , pp. 696-700
    • Müller, M.1    Lindmark, D.G.2
  • 73
    • 0026717685 scopus 로고
    • Pyruvate kinase from Trichomonas vaginalis an allosteric enzyme stimulated by ribose 5-phosphate and glycerate-3-phosphate
    • Mertens E, Van Schaftingen E, Müller M. Pyruvate kinase from Trichomonas vaginalis an allosteric enzyme stimulated by ribose 5-phosphate and glycerate-3-phosphate. Mol Biochem Parasitol 1992;54:13-20.
    • (1992) Mol Biochem Parasitol , vol.54 , pp. 13-20
    • Mertens, E.1    Van Schaftingen, E.2    Müller, M.3


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