Dickkopf-1 is down-regulated by MYCN and inhibits neuroblastoma cell proliferation

Cancer Letters

Volumn 256, Issue 2, 2007, Pages 218-228

  Koppen, Arjen ^a   Ait Aissa, Rachida ^a   Hopman, Saskia ^a   Koster, Jan ^a   Haneveld, Franciska ^a   Versteeg, Rogier ^a   Valentijn, Linda J ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

Dickkopf; DKK1; MYCN; Neuroblastoma

Indexed keywords

ACTIN BINDING PROTEIN; BETA CATENIN; DICKKOPF 1 PROTEIN; PROTEIN; UNCLASSIFIED DRUG; WNT PROTEIN;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; GENE ACTIVITY; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENETIC CODE; HUMAN; HUMAN CELL; MOLECULAR CLONING; NEURAL CREST CELL; NEUROBLASTOMA; ONCOGENE C MYB; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TUMOR CELL LINE; UPREGULATION;

BETA CATENIN; CELL PROLIFERATION; DOWN-REGULATION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MICROFILAMENT PROTEINS; NEUROBLASTOMA; NUCLEAR PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ONCOGENE PROTEINS; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION; WNT PROTEINS;

EID: 34548693211     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.canlet.2007.06.011     Document Type: Article

References (44)

1. LeDouarin N.M. The Neural Crest (1982), Cambridge University Press, New York
2. Brodeur G.M., Seeger R.C., Schwab M., Varmus E., and Bishop J.M. Amplification of N-myc in untreated human neuroblastomas correlates with advanced disease stage. Science 224 (1984) 1121-1124
3. Seeger R.C., Brodeur G.M., Sather H., Dalton A., Siegel S.E., and Wong K.Y. Association of multiple copies of the N-myc oncogene with rapid progression of neuroblastomas. N. Engl. J. Med. 313 (1985) 1111-1116
4. Bernards R., Dessain S.K., and Weinberg R.A. N-myc amplification causes down-modulation of MHC class I antigen expression in neuroblastoma. Cell 47 (1986) 667-674
5. Lutz W., Stohr M., Schurmann J., Wenzel A., Lohr A., and Schwab M. Conditional expression of N-myc in human neuroblastoma cells increases expression of alpha-prothymosin and ornithine decarboxylase and accelerates progression into S-phase early after mitogenic stimulation of quiescent cells. Oncogene 13 (1996) 803-812
6. Negroni A., Scarpa S., Romeo A., Ferrari S., Modesti A., and Raschella G. Decrease of proliferation rate and induction of differentiation by A Mycn antisense Dna oligomer in a human neuroblastoma cell-line. Cell Growth Differ. 2 (1991) 511-518
7. Schmidt M.L., Salwen H.R., Manohar C.F., Ikegaki N., and Cohn S.L. The biological effects of antisense N-Myc expression in human neuroblastoma. Cell Growth Differ. 5 (1994) 171-178
8. Weiss M.J., Guo C., Shusterman S., Hii G., Mirensky T.L., White P.S., Hogarty M.D., Rebbeck T.R., Teare D., Urbanek M., Brodeur G.M., and Maris J.M. Localization of a hereditary neuroblastoma predisposition gene to 16p12-p13. Med. Pediatr. Oncol. 35 (2000) 526-530
9. Nesbit C.E., Tersak J.M., and Prochownik E.V. MYC oncogenes and human neoplastic disease. Oncogene 18 (1999) 3004-3016
10. Blackwood E.M., and Eisenman R.N. Max - A Helix-Loop-Helix zipper protein that forms a sequence-specific Dna-binding complex with Myc. Science 251 (1991) 1211-1217
11. Prendergast G.C., Lawe D., and Ziff E.B. Association of Myn, the Murine homolog of Max, with C-Myc stimulates methylation-sensitive Dna-binding and Ras cotransformation. Cell 65 (1991) 395-407
12. Boon K., Caron H.N., van Asperen R., Valentijn L., Hermus M.C., van Sluis P., Roobeek I., Weis I., Voute P.A., Schwab M., and Versteeg R. N-myc enhances the expression of a large set of genes functioning in ribosome biogenesis and protein synthesis. EMBO J. 20 (2001) 1383-1393
13. Godfried M.B., Veenstra M., Von Sluis P., Boon K., Von Asperen R., Hermus M.C., Von Schaik B.D.C., Voute T.P.A., Schwab M., Versteeg R., and Caron H.N. The N-myc and c-myc downstream pathways include the chromosome 17q genes nm23-H1 and nm23-H2. Oncogene 21 (2002) 2097-2101
14. Seoane J., Le H.V., and Massague J. Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature 419 (2002) 729-734
15. Staller P., Peukert K., Kiermaier A., Seoane J., Lukas J., Karsunky H., Moroy T., Bartek J., Massague J., Hanel F., and Eilers M. Repression of p15(INK4b) expression by Myc through association with Miz-1. Nat. Cell Biol. 3 (2001) 392-399
16. Wanzel M., Herold S., and Eilers M. Transcriptional repression by Myc. Trends Cell Biol. 13 (2003) 146-150
17. Valentijn L.J., Koppen A., van Asperen R., Root H.A., Haneveld F., and Versteeg R. Inhibition of a new differentiation pathway in neuroblastoma by copy number defects of N-myc, Cdc42, and nm23 genes. Cancer Res. 65 (2005) 3136-3145
18. Logan C.Y., and Nusse R. The Wnt signaling pathway in development and disease. Annu. Rev. Cell Dev. Biol. 20 (2004) 781-810
19. Mao B.Y., Wu W., Davidson G., Marhold J., Li M.F., Mechler B.M., Delius H., Hoppe D., Stannek P., Walter C., Glinka A., and Niehrs C. Kremen proteins are Dickkopf receptors that regulate Wnt/beta-catenin signalling. Nature 417 (2002) 664-667
20. Mao B.Y., Wu W., Li Y., Hoppe D., Stannek P., Glinka A., and Niehrs C. LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature 411 (2001) 321-325
21. Mukhopadhyay M., Shtrom S., Rodriguez-Esteban C., Chen L., Tsukui T., Gomer L., Dorward D.W., Glinka A., Grinberg A., Huang S.P., Niehrs C., Belmonte J.C.I., and Westphal H. Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev. Cell 1 (2001) 423-434
22. Auffray C., and Rougeon F. Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumour RNA. Eur. J. Biochem. 107 (1980) 303-314
23. Li Z.R., Van Calcar S., Qu C.X., Cavenee W.K., Zhang M.Q., and Ren B. A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells. Proc. Natl. Acad. Sci. USA 100 (2003) 8164-8169
24. Li Z.R., Van Calcar S., Qu C.X., Cavenee W.K., Zhang M.Q., and Ren B. A global transcriptional regulatory role for c-Myc in Burkitt's lymphoma cells. Proc. Natl. Acad. Sci. 100 (2003) 8164-8169
25. Glinka A., Wu W., Delius H., Monaghan A.P., Blumenstock C., and Niehrs C. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 391 (1998) 357-362
26. Lee A.Y., He B., You L., Xu Z.D., Mazieres J., Reguart N., Mikami I., Batra S., and Jablons D.M. Dickkopf-1 antagonizes Wnt signaling independent of beta-catenin in human mesothelioma. Biochem. Biophys. Res. Commun. 323 (2004) 1246-1250
27. Kuhnert F., Davis C.R., Wang H.T., Chu P., Lee M., Yuan J., Nusse R., and Kuo C.J. Essential requirement for Wnt signaling in proliferation of adult small intestine and colon revealed by adenoviral expression of Dickkopf-1. Proc. Natl. Acad. Sci. USA 101 (2004) 266-271
28. Pinto D., Gregorieff A., Begthel H., and Clevers H. Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev. 17 (2003) 1709-1713
29. Korinek V., Barker N., Morin P.J., vanWichen D., deWeger R., Kinzler K.W., Vogelstein B., and Clevers H. Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC(-/-) colon carcinoma. Science 275 (1997) 1784-1787
30. Luchtenborg M., Weijenberg M.P., Roemen G.M.J.M., de Bruine A.P., van den Brandt P.A., Lentjes M.H.F.M., Brink M., van Engeland M., Goldbohm R.A., and de Goeij A.F.P.M. APC mutations in sporadic colorectal carcinomas from The Netherlands Cohort Study. Carcinogenesis 25 (2004) 1219-1226
31. C.W. Woo, F. Tan, J. Lee, K.C. Lee, C.J. Thiele, Use of RNA interference to elucidate the effect of MYCN on cell cycle in neuroblastoma, Pediatr. Blood Cancer (2007) (Epub ahead of print).
32. Shohet J.M., Hicks M.J., Plon S.E., Burlingame S.M., Stuart S., Chen S.Y., Brenner M.K., and Nuchtern J.G. Minichromosome maintenance protein MCM7 is a direct target of the MYCN transcription factor in neuroblastoma. Cancer Res. 62 (2002) 1123-1128
33. Barrow J.R. Wnt/PCP signaling: a veritable polar star in establishing patterns of polarity in embryonic tissues. Semin. Cell Dev. Biol. 17 (2006) 185-193
34. Kohn A.D., and Moon R.T. Wnt and calcium signaling: beta-catenin-independent pathways. Cell Calcium 38 (2005) 439-446
35. Blanc E., Le Roux G., Benard J., and Raguenez G. Low expression of Wnt-5a gene is associated with high-risk neuroblastoma. Oncogene 24 (2005) 1277-1283
36. Raible D.W., and Ragland J.W. Reiterated Wnt and BMP signals in neural crest development. Semin. Cell Dev. Biol. 16 (2005) 673-682
37. de Melker A.A., Desban N., and Duband J.L. Cellular localization and signaling activity of beta-catenin in migrating neural crest cells. Dev. Dyn. 230 (2004) 708-726
38. De Calisto J., Araya C., Marchant L., Riaz C.F., and Mayor R. Essential role of non-canonical Wnt signalling in neural crest migration. Development 132 (2005) 2587-2597
39. Wakamatsu Y., Watanabe Y., Nakamura H., and Kondoh H. Regulation of the neural crest cell fate by N-myc: promotion of ventral migration and neuronal differentiation. Development 124 (1997) 1953-1962
40. Weins A., Schwarz K., Faul C., Barisoni L., Linke W.A., and Mundel P. Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein. J. Cell Biol. 155 (2001) 393-403
41. Lin F., Yu Y.P., Woods J., Cieply K., Gooding B., Finkelstein P., Dhir R., Krill D., Becich M.J., Michalopoulos G., Finkelstein S., and Luo J.H. Myopodin, a synaptopodin homologue, is frequently deleted in invasive prostate cancers. Am. J. Pathol. 159 (2001) 1603-1612
42. Jing L., Yu Y.P., and Luo J.H. Expression of myopodin induces suppression of tumor growth and metastasis. FASEB J. 18 (2004) A937
43. Yu Y.P., and Luo J.H. Myopodin-mediated suppression of prostate cancer cell migration involves interaction with zyxin. Cancer Res. 66 (2006) 7414-7419
44. Yu Y.P., Tseng G.C., and Luo J.H. Inactivation of myopodin expression associated with prostate cancer relapse. Urology 68 (2006) 578-582