Homozygous deletion of CDKN2A (pl6INK4a/p14ARF) but not within 1p36 or at other tumor suppressor loci in neuroblastoma

Cancer Research

Volumn 61, Issue 2, 2001, Pages 679-686

  Thompson, Patricia M ^a   Maris, John M ^a,b   Hogarty, Michael D ^a,b   Seeger, Robert C ^c,d   Reynolds, C Patrick ^c,d   Brodeur, Garrett M ^a,b   White, Peter S ^a,b  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c CHILDREN S HOSPITAL LOS ANGELES   (United States)

^d UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN; PROTEIN CDKN2A; PROTEIN P14; PROTEIN P16; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME 1P; GENE DELETION; GENE INACTIVATION; GENE LOCUS; HUMAN; HUMAN CELL; NEUROBLASTOMA CELL; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

BLOTTING, SOUTHERN; CHROMOSOMES, HUMAN, PAIR 1; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA MUTATIONAL ANALYSIS; DNA, NEOPLASM; GENE DELETION; GENES, TUMOR SUPPRESSOR; GENOTYPE; HOMOZYGOTE; HUMANS; LOSS OF HETEROZYGOSITY; MICROSATELLITE REPEATS; NEUROBLASTOMA; TUMOR CELLS, CULTURED;

EID: 0035863312     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (74)

1. Patient with 13 chromosome deletion: Evidence that the retinoblastoma gene is a recessive cancer gene
2. Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping
3. A cell cycle regulator potentially involved in genesis of many tumor types
4. Allelic loss and neumblastoma suppressor genes
5. Detailed molecular analysis of lp36 in neuroblastoma
6. Significance of chromosome 1p loss of heterozygosity in neuroblastoma
7. Loss of heterozygosity at lp36 independently predicts for disease relapse in neuroblastoma patients: A Children's Cancer Group study
8. Deletion of chromosome lp loci and microsatellite instability in neuroblastomas analyzed with short-tandem repeat polymorphisms
9. A region of consistent deletion in neuroblastoma maps within human chromosome lp36.2-36.3
10. Constitutional translocation t(1;17)(p36;q12-21) in a patient with neuroblastoma
11. Evidence for two tumour suppressor loci on chromosomal bands lp35-36 involved in neumblastoma: One probably imprinted, another associated with N-myc amplification
12. p73 at chromosome 1p36.3 is lost in advanced stage neuroblastoma but its mutation is infrequent
13. Neurofibromatosis type 1 gene mutations in neuroblastoma
14. The p16 and pl8 tumor suppressor genes in neuroblastoma: Implications for drug resistance
15. Delimitation of a critical tumour suppressor region at distal lp in neumblastoma tumors
16. Caspase 8 is deleted or silenced preferentially in childhood neumblastomas with amplification of MYCN
17. The emerging p53 gene family
18. The 1NK4A/4ARF locus and its two gene products
19. Drug resistance patterns of human neuroblastoma cell lines derived from patients at different phases of therapy
20. Model system for removing neuroblastoma cells from bone marrow using monoclonal antibodies and magnetic immunobeads
21. An integrated transcript map of human chromosome lp35-p36
22. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers
23. Human Krdppel-Related 3 (HKR3). A candidate for the lp36 neuroblastoma tumor suppressor gene
24. Duplication of the DR3 gene on human chromosome lp36 and its deletion in human neuroblastoma
25. Reciprocal translocation at 1 p36.2/D1S160 in a neumblastoma cell line: Isolation of a YAC clone at the break
26. Homozygous loss of the MTS1/p16 and MTS2/p15 genes in lymphoma and lymphoblastic leukaemia cell lines
27. Crystal structure of the complex of the cyclin D-dependent kinase Cdk6 bound to the cell-cycle inhibitor pl9INK4d
28. Report of the Fifth International Workshop on Human Chromosome l Mapping 1999
29. Balanced translocation in a neuroblastoma patient disrupts a cluster of small nuclear RNA UI and tRNA genes in chromosomal band lp36
30. There may be two tumor suppressor genes on chromosome arm lp closely associated with biologically distinct subtypes of neuroblastoma
31. p53, the cellular gatekeeper for growth and division
32. Homozygous deletion of the neurofibromatosis-l gene in the tumor of a patient with neuroblastoma
33. The 1NK4a/ARF tumor suppressor: One gene-two products-two pathways
34. Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest
35. Cooperative effects of INK4a and ras in melanoma susceptibility in vivo
36. Role of the INK4a locus in tumor suppression and cell mortality
37. Cancer cell cycles
38. Structural and functional analysis of cyclin-dependent kinase inhibitor genes (CDKN2A, CDKN2B, and CDKN2C) in neuroblastoma
39. No CDKN2 mutations in neuroblastomas
40. Loss of heterozygosity at chromosome 9p21 in primary neuroblastomas: Evidence for two deleted regions
41. Deletion map of chromosome 9 and p16 (CDKN2A) gene alterations in neuroblastoma
42. Molecular analysis of the cyclin-dependent kinase inhibitor family: P16(CDKN2/MTSI/INK4A), p18(INK4C) and p27(Kipl) genes in neuroblastomas
43. Mutational analysis of the p16 gene in human neuroblastomas
44. Methylation of the 5' CpG island of the p16/CDKN2 tumor suppressor gene in normal and transformed human tissues correlates with gene silencing
45. 5′ CpG island methylafion is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers
46. Hypermethylation-associated inactivation indicates a tumor suppressor role for pI5INK4B
47. Frequent deregulation of p16 and the p 16/G cell cycle-regulatory pathway in neuroblastoma
48. Disruption of the cyclin D/cyclin-dependent kinase/INK4/retinoblastoma protein regulatory pathway in human neuroblastoma
49. Novel mutations in the p16/CDKN2A binding region of the cyclin-dependent kinase-4 gene
50. Non-syntenic amplification of MDM2 and MYCN in human neuroblastoma
51. Identification of two distinct chromosome 12-derived amplification units in neuroblastoma cell line NGP
52. Molecular cytogenetic characterization and physical mapping of 12q13-15 amplification in human cancers
53. Cytoplasmic sequestration of wild-type p53 protein impairs the G checkpoint after DNA damage
54. Differential subcellular p53 localization and function in N- and S-type neuroblastoma cell lines
55. Cross-resistance of topoisomerase 1 and 11 inhibitors in neuroblastoma cell lines
56. Synergism of buthionine sulfoximine and melphalan against neuroblastoma cell lines derived after disease progression
57. Establishment and characterization of human neuroblastoma cell lines
58. Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour
59. Human neuroblastomas and abnormalities of chromosomes 1 and 17
60. Definition of a thy-I determinant on human neuroblastoma, glioma, sarcoma, and teratoma cells with a monoclonal antibody
61. Biological classification of cell lines derived from human extra-cranial neural tumors
62. Translocation involving 1p and 17q is a recurrent genetic alteration of human neuroblastoma cells
63. Characterization of human neuroblastoma cell lines that lack N-myc gene amplification
64. N-myc expression switched off and class I human leukocyte antigen expression switched on after somatic cell fusion of neuroblastoma cells
65. 1;17 translocations and other chromosome 17 rearrangements in human primary neuroblastoma tumors and cell lines
66. Clonal evolution in a human neuroblastoma
67. The biological effects of antisense N-rnyc expression in human neuroblastoma
68. Chromosomal aberrations in human neuroblastomas
69. Cytogenetic studies of primary human neuroblastomas
70. A novel chromosome abnormality in human neuroblastoma and antifolate-resistant Chinese hamster cell lines in culture
71. Human neuroblastoma cytogenetics: Search for significance of homogeneously staining regions and double minute chromosomes
72. Biological markers in neuroblastoma and other pediatric neoplasias
73. Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture
74. Characterization of human neuroblastoma cell lines established before and after therapy