AhR and ARNT modulate ER signaling

Toxicology

Volumn 268, Issue 3, 2010, Pages 132-138

  Swedenborg, Elin ^a   Pongratz, Ingemar ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

2,3,7,8 Tetrachlorodibenzo p dioxin; 3 Methylcholanthrene; ARNT; Endocrine disruption; Estrogen receptors; Metabolism

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 3 METHYLCHOLANTHRENE; 3,3',4,4',5 PENTACHLOROBIPHENYL; AROMATIC HYDROCARBON RECEPTOR; CYCLIN D1; ENDOCRINE DISRUPTOR; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; HALOGENATED HYDROCARBON; HISTONE ACETYLTRANSFERASE PCAF; HYPOXIA INDUCIBLE FACTOR 1BETA; MESSENGER RNA; PESTICIDE; PHTHALIC ACID; POLYCYCLIC AROMATIC HYDROCARBON; VASCULOTROPIN;

COMPLEX FORMATION; GENE EXPRESSION REGULATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; XENOBIOTIC STRESS;

ANIMALS; ARYL HYDROCARBON RECEPTOR NUCLEAR TRANSLOCATOR; ENDOCRINE DISRUPTORS; ENVIRONMENTAL POLLUTANTS; HUMANS; METHYLCHOLANTHRENE; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, ESTROGEN; SIGNAL TRANSDUCTION; TETRACHLORODIBENZODIOXIN; XENOBIOTICS;

EID: 76749166159     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2009.09.007     Document Type: Review

References (61)

1. Abdelrahim M., Ariazi E., Kim K., Khan S., Barhoumi R., Burghardt R., Liu S., Hill D., Finnell R., Wlodarczyk B., Jordan V.C., and Safe S. 3-Methylcholanthrene and other aryl hydrocarbon receptor agonists directly activate estrogen receptor alpha. Cancer Res. 66 (2006) 2459-2467
2. Adachi J., Mori Y., Matsui S., Takigami H., Fujino J., Kitagawa H., Miller III C.A., Kato T., Saeki K., and Matsuda T. Indirubin and indigo are potent aryl hydrocarbon receptor ligands present in human urine. J. Biol. Chem. 276 (2001) 31475-31478
3. Amakura Y., Tsutsumi T., Nakamura M., Kitagawa H., Fujino J., Sasaki K., Toyoda M., Yoshida T., and Maitani T. Activation of the aryl hydrocarbon receptor by some vegetable constituents determined using in vitro reporter gene assay. Biol. Pharm. Bull. 26 (2003) 532-539
4. Amakura Y., Tsutsumi T., Sasaki K., Nakamura M., Yoshida T., and Maitani T. Influence of food polyphenols on aryl hydrocarbon receptor-signaling pathway estimated by in vitro bioassay. Phytochemistry (2007)
5. Antonsson C., Arulampalam V., Whitelaw M.L., Pettersson S., and Poellinger L. Constitutive function of the basic helix-loop-helix/PAS factor Arnt. Regulation of target promoters via the E box motif. J. Biol. Chem. 270 (1995) 13968-13972
6. Beischlag T.V., Luis Morales J., Hollingshead B.D., and Perdew G.H. The aryl hydrocarbon receptor complex and the control of gene expression. Crit. Rev. Eukaryot. Gene Expr. 18 (2008) 207-250
7. Bergander L., Wincent E., Rannug A., Foroozesh M., Alworth W., and Rannug U. Metabolic fate of the Ah receptor ligand 6-formylindolo[3,2-b]carbazole. Chem. Biol. Interact. 149 (2004) 151-164
8. Brunnberg S., Pettersson K., Rydin E., Matthews J., Hanberg A., and Pongratz I. The basic helix-loop-helix-PAS protein ARNT functions as a potent coactivator of estrogen receptor-dependent transcription. Proc. Natl. Acad. Sci. U.S.A. 100 (2003) 6517-6522
9. Delaunay F., Pettersson K., Tujague M., and Gustafsson J.A. Functional differences between the amino-terminal domains of estrogen receptors alpha and beta. Mol. Pharmacol. 58 (2000) 584-590
10. Denison M.S., and Nagy S.R. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annu. Rev. Pharmacol. Toxicol. 43 (2003) 309-334
11. Denison M.S., Pandini A., Nagy S.R., Baldwin E.P., and Bonati L. Ligand binding and activation of the Ah receptor. Chem. Biol. Interact. 141 (2002) 3-24
12. Diamanti-Kandarakis E., Bourguignon J.P., Giudice L.C., Hauser R., Prins G.S., Soto A.M., Zoeller R.T., and Gore A.C. Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocr. Rev. 30 (2009) 293-342
13. Dougherty E.J., and Pollenz R.S. Analysis of Ah receptor-ARNT and Ah receptor-ARNT2 complexes in vitro and in cell culture. Toxicol. Sci. 103 (2008) 191-206
14. Duffy C., Perez K., and Partridge A. Implications of phytoestrogen intake for breast cancer. CA Cancer J. Clin. 57 (2007) 260-277
15. Duncan D.M., Burgess E.A., and Duncan I. Control of distal antennal identity and tarsal development in Drosophila by spineless-aristapedia, a homolog of the mammalian dioxin receptor. Genes Dev. 12 (1998) 1290-1303
16. Enmark E., Pelto-Huikko M., Grandien K., Lagercrantz S., Lagercrantz J., Fried G., Nordenskjold M., and Gustafsson J.A. Human estrogen receptor beta-gene structure, chromosomal localization, and expression pattern. J. Clin. Endocrinol. Metab. 82 (1997) 4258-4265
17. Gronemeyer H., Gustafsson J.A., and Laudet V. Principles for modulation of the nuclear receptor superfamily. Nat. Rev. 3 (2004) 950-964
18. Gu Y.Z., Hogenesch J.B., and Bradfield C.A. The PAS superfamily: sensors of environmental and developmental signals. Annu. Rev. Pharmacol. Toxicol. 40 (2000) 519-561
19. Gunton J.E., Kulkarni R.N., Yim S., Okada T., Hawthorne W.J., Tseng Y.H., Roberson R.S., Ricordi C., O'Connell P.J., Gonzalez F.J., and Kahn C.R. Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes. Cell 122 (2005) 337-349
20. Hahn M.E. Aryl hydrocarbon receptors: diversity and evolution. Chem. Biol. Interact. 141 (2002) 131-160
21. Hankinson O. Why does ARNT2 behave differently from ARNT?. Toxicol. Sci. 103 (2008) 1-3
22. Heldring N., Pike A., Andersson S., Matthews J., Cheng G., Hartman J., Tujague M., Strom A., Treuter E., Warner M., and Gustafsson J.-A. Estrogen receptors: how do they signal and what are their targets. Physiol. Rev. 87 (2007) 905-931
23. Hirose K., Morita M., Ema M., Mimura J., Hamada H., Fujii H., Saijo Y., Gotoh O., Sogawa K., and Fujii-Kuriyama Y. cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS factor (Arnt2) with close sequence similarity to the aryl hydrocarbon receptor nuclear translocator (Arnt). Mol. Cell. Biol. 16 (1996) 1706-1713
24. IPCS/WHO, 2002. Global assessment on the state of the science of endocrine disruptors. IPCS/WHO.
25. Karmaus W., Huang S., and Cameron L. Parental concentration of dichlorodiphenyl dichloroethene and polychlorinated biphenyls in Michigan fish eaters and sex ratio in offspring. J. Occup. Environ. Med. 44 (2002) 8-13
26. Keith B., Adelman D.M., and Simon M.C. Targeted mutation of the murine arylhydrocarbon receptor nuclear translocator 2 (Arnt2) gene reveals partial redundancy with Arnt. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 6692-6697
27. Kerkvliet N.I. AHR-mediated immunomodulation: the role of altered gene transcription. Biochem. Pharmacol. 77 (2009) 746-760
28. Kimura A., Naka T., Nohara K., Fujii-Kuriyama Y., and Kishimoto T. Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells. Proc. Natl. Acad. Sci. U.S.A. 105 (2008) 9721-9726
29. Kobayashi A., Numayama-Tsuruta K., Sogawa K., and Fujii-Kuriyama Y. CBP/p300 functions as a possible transcriptional coactivator of Ah receptor nuclear translocator (Arnt). J. Biochem. 122 (1997) 703-710
30. Kobayashi Y., Kitamoto T., Masuhiro Y., Watanabe M., Kase T., Metzger D., Yanagisawa J., and Kato S. p300 mediates functional synergism between AF-1 and AF-2 of estrogen receptor alpha and beta by interacting directly with the N-terminal A/B domains. J. Biol. Chem. 275 (2000) 15645-15651
31. Kohle C., and Bock K.W. Coordinate regulation of phase I and II xenobiotic metabolisms by the Ah receptor and Nrf2. Biochem. Pharmacol. 73 (2007) 1853-1862
32. Kozak K.R., Abbott B., and Hankinson O. ARNT-deficient mice and placental differentiation. Dev. Biol. 191 (1997) 297-305
33. Liu Z.H., Kanjo Y., and Mizutani S. A review of phytoestrogens: their occurrence and fate in the environment. Water Res. (2009)
34. Maltepe E., Schmidt J.V., Baunoch D., Bradfield C.A., and Simon M.C. Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT. Nature 386 (1997) 403-407
35. Matthews J., and Gustafsson J.A. Estrogen receptor and aryl hydrocarbon receptor signaling pathways. Nucl. Recept. Signal 4 (2006) e016
36. Mocarelli P., Gerthoux P.M., Ferrari E., Patterson Jr. D.G., Kieszak S.M., Brambilla P., Vincoli N., Signorini S., Tramacere P., Carreri V., Sampson E.J., Turner W.E., and Needham L.L. Paternal concentrations of dioxin and sex ratio of offspring. Lancet 355 (2000) 1858-1863
37. Mukai M., and Tischkau S.A. Effects of tryptophan photoproducts in the circadian timing system: searching for a physiological role for aryl hydrocarbon receptor. Toxicol. Sci. 95 (2007) 172-181
38. Ohtake F., Baba A., Takada I., Okada M., Iwasaki K., Miki H., Takahashi S., Kouzmenko A., Nohara K., Chiba T., Fujii-Kuriyama Y., and Kato S. Dioxin receptor is a ligand-dependent E3 ubiquitin ligase. Nature 446 (2007) 562-566
39. Ohtake F., Fujii-Kuriyama Y., and Kato S. AhR acts as an E3 ubiquitin ligase to modulate steroid receptor functions. Biochem. Pharmacol. 77 (2009) 474-484
40. Ohtake F., Takeyama K., Matsumoto T., Kitagawa H., Yamamoto Y., Nohara K., Tohyama C., Krust A., Mimura J., Chambon P., Yanagisawa J., Fujii-Kuriyama Y., and Kato S. Modulation of oestrogen receptor signalling by association with the activated dioxin receptor. Nature 423 (2003) 545-550
41. Oseni T., Patel R., Pyle J., and Jordan V.C. Selective estrogen receptor modulators and phytoestrogens. Planta Med. 74 (2008) 1656-1665
42. Penttinen P., Jaehrling J., Damdimopoulos A.E., Inzunza J., Lemmen J.G., van der Saag P., Pettersson K., Gauglitz G., Makela S., and Pongratz I. Diet-derived polyphenol metabolite enterolactone is a tissue-specific estrogen receptor activator. Endocrinology 148 (2007) 4875-4886
43. Poland A., and Knutson J.C. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Annu. Rev. Pharmacol. Toxicol. 22 (1982) 517-554
44. Powell-Coffman J.A., Bradfield C.A., and Wood W.B. Caenorhabditis elegans orthologs of the aryl hydrocarbon receptor and its heterodimerization partner the aryl hydrocarbon receptor nuclear translocator. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 2844-2849
45. Quintana F.J., Basso A.S., Iglesias A.H., Korn T., Farez M.F., Bettelli E., Caccamo M., Oukka M., and Weiner H.L. Control of T(reg) and T(H)17 cell differentiation by the aryl hydrocarbon receptor. Nature 453 (2008) 65-71
46. Rannug U., Rannug A., Sjoberg U., Li H., Westerholm R., and Bergman J. Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands. Chem. Biol. 2 (1995) 841-845
47. Reen R.K., Cadwallader A., and Perdew G.H. The subdomains of the transactivation domain of the aryl hydrocarbon receptor (AhR) inhibit AhR and estrogen receptor transcriptional activity. Arch. Biochem. Biophys. 408 (2002) 93-102
48. Ruegg J., Swedenborg E., Wahlstrom D., Escande A., Balaguer P., Pettersson K., and Pongratz I. The transcription factor aryl hydrocarbon receptor nuclear translocator functions as an estrogen receptor beta-selective coactivator, and its recruitment to alternative pathways mediates antiestrogenic effects of dioxin. Mol. Endocrinol. (Baltimore, Md) 22 (2008) 304-316
49. Safe S., and Wormke M. Inhibitory aryl hydrocarbon receptor-estrogen receptor alpha cross-talk and mechanisms of action. Chem. Res. Toxicol. 16 (2003) 807-816
50. Safe S., Wormke M., and Samudio I. Mechanisms of inhibitory aryl hydrocarbon receptor-estrogen receptor crosstalk in human breast cancer cells. J. Mammary Gland Biol. Neoplasia 5 (2000) 295-306
51. Shipley J.M., and Waxman D.J. Aryl hydrocarbon receptor-independent activation of estrogen receptor-dependent transcription by 3-methylcholanthrene. Toxicol. Appl. Pharmacol. 213 (2006) 87-97
52. Sogawa K., Nakano R., Kobayashi A., Kikuchi Y., Ohe N., Matsushita N., and Fujii-Kuriyama Y. Possible function of Ah receptor nuclear translocator (Arnt) homodimer in transcriptional regulation. Proc. Natl. Acad. Sci. U.S.A. 92 (1995) 1936-1940
53. Swedenborg E., Ruegg J., Hillenweck A., Rehnmark S., Faulds M.H., Zalko D., Pongratz I., and Pettersson K. 3-Methylcholanthrene displays dual effects on estrogen receptor (ER) alpha and ER beta signaling in a cell-type specific fashion. Mol. Pharmacol. 73 (2008) 575-586
54. Swedenborg E., Ruegg J., Makela S., and Pongratz I. Endocrine disruptive chemicals: mechanisms of action and involvement in metabolic disorders. J. Mol. Endocrinol. 43 (2009) 1-10
55. Tanguay R.L., Abnet C.C., Heideman W., and Peterson R.E. Cloning and characterization of the zebrafish (Danio rerio) aryl hydrocarbon receptor. Biochim. Biophys. Acta 1444 (1999) 35-48
56. Tomita S., Jiang H.B., Ueno T., Takagi S., Tohi K., Maekawa S., Miyatake A., Furukawa A., Gonzalez F.J., Takeda J., Ichikawa Y., and Takahama Y. T cell-specific disruption of arylhydrocarbon receptor nuclear translocator (Arnt) gene causes resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin-induced thymic involution. J. Immunol. 171 (2003) 4113-4120
57. Veldhoen M., Hirota K., Westendorf A.M., Buer J., Dumoutier L., Renauld J.C., and Stockinger B. The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins. Nature 453 (2008) 106-109
58. Wang X.L., Suzuki R., Lee K., Tran T., Gunton J.E., Saha A.K., Patti M.E., Goldfine A., Ruderman N.B., Gonzalez F.J., and Kahn C.R. Ablation of ARNT/HIF1beta in liver alters gluconeogenesis, lipogenic gene expression, and serum ketones. Cell Metab. 9 (2009) 428-439
59. Whitelaw M.L., Gustafsson J.A., and Poellinger L. Identification of transactivation and repression functions of the dioxin receptor and its basic helix-loop-helix/PAS partner factor Arnt: inducible versus constitutive modes of regulation. Mol. Cell. Biol. 14 (1994) 8343-8355
60. Whitlock Jr. J.P. Genetic and molecular aspects of 2,3,7,8-tetrachlorodibenzo-p-dioxin action. Annu. Rev. Pharmacol. Toxicol. 30 (1990) 251-277
61. Zhang S., Lei P., Liu X., Li X., Walker K., Kotha L., Rowlands C., and Safe S. The aryl hydrocarbon receptor as a target for estrogen receptor-negative breast cancer chemotherapy. Endocr. Relat. Cancer 16 (2009) 835-844