Potentially amyloidogenic conformational intermediates populate the unfolding landscape of transthyretin: Insights from molecular dynamics simulations

Protein Science

Volumn 19, Issue 2, 2010, Pages 202-219

  Rodrigues, J Rui ^a,c   Simões, Carlos J V ^a,b   Silva, Cândida G ^a,b   Brito, Rui M M ^a,b  

^a UNIVERSITY OF COIMBRA   (Portugal)

^b UNIVERSITY OF COIMBRA   (Portugal)

^c POLYTECHNIC INSTITUTE OF LEIRIA   (Portugal)

Author keywords

Amyloid; Amyloidogenic intermediates; L55P TTR; Molecular dynamics; Protein misfolding; Protein unfolding; Transthyretin

Indexed keywords

PREALBUMIN;

ALZHEIMER DISEASE; AMYLOIDOSIS; ARTICLE; CREUTZFELDT JAKOB DISEASE; FAMILIAL AMYLOID POLYNEUROPATHY; HUMAN; HUNTINGTON CHOREA; HYDROGEN BOND; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN FOLDING; SIMULATION;

AMYLOID; CRYSTALLOGRAPHY, X-RAY; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MUTATION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PREALBUMIN; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

EID: 76749161776     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.289     Document Type: Article

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