Reaction coordinate of isopenicillin N synthase: Oxidase versus oxygenase activity

Biochemistry

Volumn 49, Issue 6, 2010, Pages 1176-1182

  Brown Marshall, Christina D ^a   Diebold, Adrienne R ^a   Solomon, Edward I ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED H ATOM; BOND ELONGATION; FENTON CHEMISTRY; HETEROLYTIC CLEAVAGE; HOMOLYTIC CLEAVAGE; HYDROPEROXIDES; ISOPENICILLIN N SYNTHASE; NUCLEOPHILIC ATTACK; OXIDASE ACTIVITY; OXYGENASES; REACTION COORDINATES; REACTION PATHWAYS; THIOCARBOXYLATE;

AMIDES; HYDROGEN; HYDROGEN BONDS; OXYGEN; QUANTUM CHEMISTRY;

SUBSTRATES;

AMIDE; BACTERIAL ENZYME; BETA LACTAM; CARBON; CYSTEINE DERIVATIVE; DELTA (ALPHA AMINOADIPOYL) CYSTEINYL ALPHA HYDROXYISOVALERYL ESTER; DELTA (ALPHA AMINOADIPOYL) CYSTEINYL VALINE; ESTER DERIVATIVE; FERROUS ION; FUNGAL ENZYME; HYDROGEN; HYDROPEROXIDE; ISOPENICILLIN N SYNTHETASE; NITROGEN; NUCLEOPHILE; OXIDOREDUCTASE; OXYGEN; OXYGENASE; PEROXIDE; THIAZOLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DENSITY FUNCTIONAL THEORY; ENZYME ACTIVITY; ENZYME BINDING; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; RING CLOSING METATHESIS; SURFACE PROPERTY;

ASPERGILLUS NIDULANS; ELECTRON TRANSPORT; ENZYME ACTIVATION; FERROUS COMPOUNDS; FUNGAL PROTEINS; HYDROGEN BONDING; HYDROLYSIS; OXIDOREDUCTASES; OXYGENASES; PENICILLINS; PEPTIDE SYNTHASES; PEROXIDES; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 76749129792     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi901772w     Document Type: Article

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