Review of pharmacological effects of Glycyrrhiza Radix and its bioactive compounds

Zhongguo Zhongyao Zazhi

Volumn 34, Issue 21, 2009, Pages 2695-2700

  Gao, Xueyan ^a   Wang, Wenquan ^a,b   Wei, Shengli ^a   Li, Weidong ^a,b  

^a BEIJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

Author keywords

Flavonoids; Glycyrrhiza Radix; Pharmacological activities; Triterpene saponins

Indexed keywords

FLAVONOID; GLYCYRRHIZA EXTRACT; GLYCYRRHIZA GLABRA EXTRACT; GLYCYRRHIZA INFLATA EXTRACT; GLYCYRRHIZA URALENSIS EXTRACT; SAPONIN DERIVATIVE; TRITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ANTIVIRAL ACTIVITY; CHINESE MEDICINE; DRUG RESEARCH; GLYCYRRHIZA; GLYCYRRHIZA GLABRA; GLYCYRRHIZA INFLATA; GLYCYRRHIZA URALENSIS; HERBAL MEDICINE; HUMAN IMMUNODEFICIENCY VIRUS; INFLAMMATION; LIVER PROTECTION; MUSCLE SPASM; NEOPLASM; PHYTOTHERAPY; PLANT ROOT; REVIEW; RHIZOME; SARS CORONAVIRUS; SPASMOLYSIS; ULCER; VIRUS INFECTION;

ANIMALS; ANTIOXIDANTS; DRUGS, CHINESE HERBAL; FLAVONOIDS; GLYCYRRHIZA; HUMANS; TRITERPENES;

EID: 76749108132     PISSN: 10015302     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (57)

1. Chinese source
2. Zheng Q Y, Ye M. Chemical analysis of Chinese herbal medicine Can-Cao (licorice) [J]. J Chromatogr A, 2009,1216(11):1954.
3. Marjan N A, Hosseinzadeh H. Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds [J]. Phytother Res, 2008,22:709.
4. Ai-Turki A I, Ei-Ziney M G, Abdel-Salam A M. Chemical and anti-bacterial characterization of aqueous extracts of oregano, marjoram, sage and licorice and their application in milk and labneh [J]. J Food Agr Env, 2008,6(1):39.
5. Park I K. In vivo fungicidal activity of medicinal plant extracts against six phytopathogenic fungi [J]. Int J Pest Manag, 2008,54(1):63.
6. Bodet C, La V D, Cafner S, et al. A licorice extract reduces lipopolysaccharide-induced proinflammatory cytokine secretion by macrophages and whole blood [J]. J Periodontolo, 2008,79(9):1752.
7. Fiore C, Eisenhut M, Krausse R, et al. Antiviral effects of Glycyrrhiza species [J]. Phytother Res, 2008,22(2):141.
8. Rackova L. Mechanism of anti-inflammatory action of liquorice extract and glycyrrhizin [J]. Nat Prod Res, 2007,21(14):1234.
9. Kim J K, Oh S, Kwon H S, et al. Anti-inflammatory effect of roasted licorice extracts on lipopolysaccharide-induced inflammatory responses in murine macrophages [J]. Biochem Bioph Res Co, 2006,345(3):1215.
10. Gol'dberg E D, Amoaova EN, Zueva E P, et al. Licorice preparations improve efficiency of chemotherapy and surgical treatment of transplanted tumors [J]. B Exp Biol Med, 2008,145(2):252.
11. Lee C K, Park K K, Lim S S, et al. Effects of the licorice extract against tumor growth and cisplatin-induced toxicity in a mouse xenograft model of colon cancer [J]. Biol Phann Bull, 2007,30(11):2191.
12. Sharifzadeh M, Shamsa F, Shiran S, et al. A time course analysis of systemic administration of aqueous licorice extract on spatial memory retention in rats [J]. Plants Med, 2008,74(5):485.
13. Lee H J, Yoon M Y, Kim J Y, et al. Antioxidant activity of Glycyrrhiza uralensis Fisch extrats on hydrogen peroxide-induced DNA damage in human leucocytes and cell death in PC12 cells [J]. Food Sci Biotech, 2008,17(2):343.
14. Choi Y J, Lim S S, Jung J Y, et al. Blockade of nitroxidative stress by roasted licorice extracts in high glucose-exposed endothelial cells [J]. J Cardiovasc Pharm, 2008,52(4):344.
15. Visavadiya N P, Narasimhacharya A. Hypocholesterolaemic and antioxidant effects of Glycyrrhiza glabra (Linn) in rats [J]. Mol Nutr Food Res, 2006,50(11):1080.
16. Lee H Y, Jung D Y, Ha H, et al. Induction of growth hormone release by Glycyrrhizae Radix on rat [J]. J Biochem Mol Bio, 2007,40(6):979.
17. Wojcikowski K, Stevenson L, Leach D, et al. Antioxidant capacity of 55 medicinal herbs traditionally used to treat the urinary system: A comparison using a sequential three-solvent extraction process [J]. J Altem Complem Med, 2007,13(1):103.
18. Adamyan T I, Gevorkyan E S, Minasyan S M, et al. Effect of licorice root on peripheral blood indexes upon vibration exposure [J]. Bull Exp Biol Med, 2005,140(2):197.
19. Logemann W, Lauria F, Cudkowicz G, et al. Antileukaemic activity of glycyrrhetinic acid [J]. Nature, 1960,13(187):607.
20. Chinese source
21. 4-induced liver injuries [J]. J Gastroen Hepatol, 2006,21(Suppl.2):154.
22. Zhai D, Zhao Y, Chen X, et al. Protective effect of glycyrrhizin, glycyrrhetic acid and matrine on acute cholestasis induced by alpha-naphthyl isothiocyanate in rats [J]. Planta Med, 2007,73(2):128.
23. Tang B, Qiao H, Meng F, et al. Glycyrrhizin attenuates endotoxin-induced acute liver injury after partial hepatectomy in rats [J]. Bras J Med Biol Res, 2007,40(12):1637.
24. Abe K, Ikeda T, Wake K, et al. Glycyrrhizin prevents of lipopolysaccharide/D-galactosamine-induced liver injury through down-regulation of matrix metalloproteinase-9 in mice [J]. J Pharm Pharma, 2008,60(1):91.
25. Armanini D, Mattarello M J, Fiore C, et al. Licorice reduces Serum testosterone in healthy women [J]. Steroids, 2004,69(11/12):763.
26. Lee C H. Protective mechanism of glycyrrhizin on acute liver injury induced by carbon tetrachloride in mice [J]. Biol Pharm Bull, 2007,30(10):1898.
27. Yoshida T, Abe K, Ikeda T, et al. Inhibitory effect of glycyrrhizin on lipopolysaccharide and D-galactosamine-induced mouse liver injury [J]. Eur J Pharmacol, 2007,576(1/3):136.
28. Harada S. The broad anti-viral agent glycyrrhizin directly modulates the fluidity of plasma membrane and HIV-1 envelope [J]. Biochem J, 2005,392:191.
29. Hibasami H, Iwase H, Yoshioka K, et al. Glycyrrhizin induces apoptosis in human stomach cancer KATO III and human promyelotic leukemia HL-60 cells [J]. Int J Mol Med, 2005,16(2):33.
30. Rahman S, Sultana S. Glycyrrhizin exhibits potential chemopreventive activity on 12-O-tetradecanoyl phorbol-13-acetate-induced cutaneous oxidative stress and tumor promotion in swiss albino mice [J]. J Enzym Inhib Med Chem, 2007,22(3):363.
31. Rahman S, Sultana S. Chemopreventive activity of glycyrrhizin on lead acetate mediated hepatic oxidative stress and its hyperproliferative activity in Wistar rats [J]. Chem Biol Interact, 2006,160(1):61.
32. Amagaya S, Sugishita E, Ogihara Y, et al. Comparative studies of the stereoisomers of glycyrrhetinic acid on anti-inflammatory activities [J]. J Pharmacobiodyn, 1984,7(12):923.
33. Matsui S, Matsumoto H, Sonoda Y, et al. Glycyrrhizin and related compounds down-regulate production of inflammatory chemokines IL-8 and eotaxin 1 in a human lung fibroblast cell line [J]. Int Immunopharmacol, 2004,4(13):1633.
34. Zhang W, Lu C, Liu Z, et al. Therapeutic effect of combined triptolide and glycyrrhizin treatment on rats with collagen induced arthritis [J]. Planta Med, 2007,73(4):336.
35. Nabekura T. Inhibition of P-glycoprotein and multidrug resistance protein 1 by dietary phytochemicals [J]. Cancer Chemoth Pharm, 2008,62(5):867.
36. Li R S, Nakagawa Y, Nakanishi T, et al. Different responsiveness in body weight and hepatic 11 beta-hydroxysteroid dehydrogenase (11 beta-HSD) type 1 mRNA to 11 beta-HSD inhibition by glycyrrhetinic acid treatment in obese and lean Zucker rats [J]. Metabolism, 2004,53(5):600.
37. Ikeda T, Yokomizo K, Okawa M, et al. Anti-herpes virus type 1 activity of oleanane-type triterpenoids [J]. Biol Pharm Bull, 2005,28(9):1779.
38. Tsukahara M, Nishino T, Furuhashi I, et al. Synthesis and inhibitory effect of novel glycyrrhetinic acid derivatives on IL-1 beta-induced prostaglandin E-2 production in normal human dermal fibroblasts [J]. Chem Pharm Bull, 2005,53(9):1103.
39. Gumpricht E, Dahl R, Devereaux M W, et al. Licorice compounds glycyrrhizin and 18β-glycyrrhetinic acid are potent modulators of bile acid-induced cytotoxicity in rat hepatocytes [J]. J Biol Chem, 2005,280:10556.
40. Matsui S, Sonoda Y, Sekiya T, et al. Glycyrrhizin derivative inhibits eotaxin 1 production via STAT6 in human lung fibroblasts [J]. Int Immunopharmacol, 2006,6(3):369.
41. Kim Y W, Ki S H, Lee J R, et al. Liquiritigenin, an aglycone of liquiritin in Glycyrrhizae Radix, prevents acute liver injuries in rats induced by acetaminophen with or without buthionine sulfoximine [J]. Chem Biol Int, 2006,161(2):125.
42. Kwon H M. Blockade of cytokine-induced endothelial cell adhesion molecule expression by licorice isoliquiritigenin through NF-kappa B signal disruption [J]. Exp Biol Mod, 2007,232(2):
43. Jang E Y, Choe E S, Hwang M, et al. Isoliquiritigenin suppresses cocaine-induced extracellular dopamine release in rat brain through GABA(B) receptor [J]. Eur J Pharm, 2008,587(1/3):124.
44. Sato Y, He J X, Nagai H, et al. Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine [J]. Biol Pharm Bull, 2007,30(1):145.
45. Kwon H S, Oh S M, Kim J K, et al. Glabridin, a functional compound of liquorice, attenuates colonic inflammation in mice with dextran sulphate sodium-induced colitis [J]. Clin Exp Immunol, 2008,151(1):165.
46. Kang J S, Yoon Y D, Kang I J C, etal. Glabridin, an isoflavan from licorice root, inhibits inducible nitric-oxide synthase expression and improves survival of mice in experimental model of septic shock [J]. J Pharmacol Exp Ther, 2005,312(3):1187.
47. Cui Y M, Ao M Z, L1 W, et al. Effect of glabridin from Glycyrrhiza glabra on learning and memory in mice [J]. Plants Med, 2008,74(4):377.
48. Somjen D, Katzburg S, Vaya J, et al. Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues [J]. J Steroid Biochem, 2004,91(4/5):241.
49. Choi E M. The licorice root derived isoflavan glabridin increases the function of osteoblastic MC3T3-E1 cells [J]. Biochem Pharmacol, 2005,70(3):363.
50. Cui Y M, Ao M Z, Li W, et al. Anti-inflammatory activity of licochalcone a isolated from Glycyrrhiza inflata [J]. Z Naturforsch C, 2008,63(5/6):361.
51. Yu X Y, Lin S G, Zhou Z W, et al. Role of P-glycoprotein in limiting the brain penetration of glabridin, an active isoflavan from the root of Glycyrrhiza glabra [J]. Pharm Res, 2007,24(9):1668.
52. Yoon G, Kang B Y, Cheon S H. Topoisomerase I inhibition and cytotoxicity of licochalcones A and E from Glycyrrhiza inflata [J]. Arch Pharm Res, 2007,30(3):313.
53. Park J H, Lim H J, Lee K S, et al. Anti-proliferative effect of licochalcone A on vascular smooth muscle cells [J]. Biol Pharm Bull, 2008,31(11):1996.
54. Chang H J, Yoon G, Park J S, et al. Induction of apoptosis by the licochalcone E in endothelial cells via modulation of NF-kappa B and Bcl-2 family [J]. Biol Pharm Bull, 2007,30(12):2290.
55. Kolbe L, Immeyer J, Bat.zer J, et al. Anti-inflammatory efficacy of licochalcone A: correlation of clinical potency and in vitro effects [J]. Arch Derm Res, 2006,298(1):23.
56. Wang W X, Hua X Y, Zhao Z H Y, et al. Antidepressant-like effects of liquiritin and isoliquiritin from Glycyrrhiza uralensis in the forced swimming test and tail suspension test in mice [J]. Prog Neuro Psychoph, 2008,32(5):1179.
57. Kim H J, Seo S H, Lee B G, et al. Identification of tyrosinase inhibitors from Glycyrrhiza uralensis [J]. Plants Med, 2005,71:785.