The role of cigarette smoking and statins in the development of postmenopausal osteoporosis: A pilot study utilizing the marshfield clinic personalized medicine cohort

Osteoporosis International

Volumn 21, Issue 3, 2010, Pages 467-477

  Giampietro, P F ^a,e   McCarty, C ^a   Mukesh, B ^b   McKiernan, F ^a   Wilson, D ^a   Shuldiner, A ^c   Liu, J ^c   Levasseur, J ^a,d   Ivacic, L ^a   Kitchner, T ^a   Ghebranious, N ^a  

^a MARSHFIELD CLINIC   (United States)

^b ALCON RESEARCH LTD   (United States)

^c UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF WISCONSIN MADISON   (United States)

^e UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

Author keywords

Cigarette; Gene environment interaction; IL6; LRP5; Osteoporosis; Smoking

Indexed keywords

APOLIPOPROTEIN E; COLLAGEN TYPE 1; COLLAGEN TYPE 1 ALPHA; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INTERLEUKIN 6; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

AGED; ARTICLE; BODY MASS; BONE DENSITY; CAUCASIAN; CIGARETTE SMOKING; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DRUG USE; ENVIRONMENTAL FACTOR; FEMALE; GENE FREQUENCY; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOLECULAR INTERACTION; PILOT STUDY; POPULATION BASED CASE CONTROL STUDY; POSTMENOPAUSE; POSTMENOPAUSE OSTEOPOROSIS; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM;

AGED; BODY MASS INDEX; BONE DENSITY; EPIDEMIOLOGIC METHODS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INTERLEUKIN-6; LDL-RECEPTOR RELATED PROTEINS; MIDDLE AGED; OSTEOPOROSIS, POSTMENOPAUSAL; POLYMORPHISM, SINGLE NUCLEOTIDE; POSTMENOPAUSE; SMOKING; WISCONSIN;

EID: 76549136887     PISSN: 0937941X     EISSN: 14332965     Source Type: Journal    
DOI: 10.1007/s00198-009-0981-3     Document Type: Article

References (56)

1. Anonymous 1993 Consensus development conference: diagnosis, prophylaxis and treatment of osteoporosis Am J Med 94 646 650 10.1016/0002-9343(93)90218-E (Pubitemid 23166713)
2. J Smith K Shoukri 2000 Diagnosis of osteoporosis Clin Cornerstone 2 22 33 10.1016/S1098-3597(00)90003-6 1:STN:280:DC%2BD3M%2FksFChsg%3D%3D 10938989
3. TV Nguyen J Blangero JA Eisman 2000 Genetic epidemiological approaches to the search for osteoporosis genes J Bone Miner Res 15 392 401 10.1359/jbmr.2000.15.3.392 1:CAS:528:DC%2BD3cXitFaksbY%3D 10750553
4. C Cooper G Campion LJ Melton III 1992 Hip fractures in the elderly: a worldwide projection Osteoporos Int 2 285 289 10.1007/BF01623184 1:STN:280:DyaK3s%2Fktlyrtw%3D%3D 1421796
5. RA Evans GM Marel EK Lancaster, et al. 1988 Bone mass is low in relatives of osteoporotic patients Ann Intern Med 109 870 873 1:STN:280: DyaL1M%2FkvVKkug%3D%3D 3190041
6. NA Pocock JA Eisman JL Hopper, et al. 1987 Genetic determinants of bone mass in adults. A twin study J Clin Invest 80 706 710 10.1172/JCI113125 1:STN:280:DyaL2szgvVyjtQ%3D%3D 3624485
7. H Shen RR Recker HW Deng 2003 Molecular and genetic mechanisms of osteoporosis: implication for treatment Curr Mol Med 3 737 757 10.2174/1566524033479375 1:CAS:528:DC%2BD3sXpvVarsLY%3D 14682495 (Pubitemid 37536879)
8. AW Kung QY Huang 2007 Genetic and environmental determinants of osteoporosis J Musculoskelet Neuronal Interact 7 26 32 1:CAS:528: DC%2BD2sXmsVGmsbg%3D 17396003
9. KD Ward RC Klesges 2001 A meta-analysis of the effects of cigarette smoking on bone mineral density Calcif Tissue Int 68 259 270 10.1007/BF02390832 1:CAS:528:DC%2BD3MXlsVyrurY%3D 11683532
10. O Johnell B Gullberg JA Kanis, et al. 1995 Risk factors for hip fracture in European women: the MEDOS Study. Mediterranean osteoporosis study J Bone Miner Res 10 1802 1815 10.1002/jbmr.5650101125 1:STN:280:DyaK287lsFKmtQ%3D%3D 8592959
11. M Herrmann J Peter Schmidt N Umanskaya, et al. 2007 The role of hyperhomocysteinemia as well as folate, vitamin B(6) and B(12) deficiencies in osteoporosis: a systematic review Clin Chem Lab Med 45 1621 1632 10.1515/CCLM.2007.362 1:CAS:528:DC%2BD1cXjtV2jtg%3D%3D 18067447 (Pubitemid 350232987)
12. EJ Waugh MA Lam GA Hawker, et al. 2009 Risk factors for low bone mass in healthy 40-60 year old women: a systematic review of the literature Osteoporos Int 20 1 21 10.1007/s00198-008-0643-x 1:STN:280:DC%2BD1cjms1OktQ%3D%3D 18523710
13. C McCarty R Wilke P Giampietro, et al. 2005 Marshfield Clinic Personalized Medicine Research Project (PMRP): design, methods and recruitment for a large population-based biobank Personalized Med 2 49 79 10.1517/17410541.2.1.49 http://www.marshfieldclinic.org/chg/pages/Proxy.aspx? Content=MCRF-Centers-PMRP-Pubs-McCartyMethodsCHG0522122553.1.pdf
14. ES Leib EM Lewiecki N Binkley, et al. 2004 Official positions of the international society for clinical densitometry J Clin Densitom 7 1 6 10.1385/JCD:7:1:1 14742881 (Pubitemid 38223458)
15. RA Wilke MW Carillio MD Ritchie 2005 Pacific symposium on biocomputing-computational approaches for pharmacogenetics Pharmacogenomics 6 111 113 10.1517/14622416.6.2.111 15882130 (Pubitemid 40613178)
16. E Sirohi P Peissig 2005 Study of effect of drug lexicons on medication extraction from electronic medical records DA Altman RB L Hunter TA Jung TE Klein (eds) Pacific symposium on biocomputing World Scientific Singapore 308 318 10.1142/9789812702456-0029 http://helix-web.stanford.edu/psb05/sirohi.pdf Sirohi E, Peissig P (2005) Study of effect of drug lexicons on medication extraction from electronic medical records. In: Altman RB DA, Hunter L, Jung TA, Klein TE (eds) Pacific symposium on biocomputing. World Scientific, Singapore, pp 308-318 http://helix-web.stanford.edu/psb05/sirohi.pdf
17. Y Gong RB Slee N Fukai, et al. 2001 LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development Cell 107 513 523 10.1016/S0092- 8674(01)00571-2 1:CAS:528:DC%2BD3MXovVCnsb4%3D 11719191 (Pubitemid 33152786)
18. RD Little JP Carulli RG Del Mastro, et al. 2002 A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone mass trait Am J Hum Genet 70 11 19 10.1086/338450 1:CAS:528:DC%2BD38XlvVKhtw%3D%3D 11741193 (Pubitemid 34031693)
19. VK Yadav JH Ryu N Suda, et al. 2008 LRP5 controls bone formation by inhibiting serotonin synthesis in the duodenum Cell 135 825 837 10.1016/j.cell.2008.09.059 1:CAS:528:DC%2BD1cXhsV2jtr%2FP 19041748
20. MA Koay PY Woon Y Zhang, et al. 2004 Influence of LRP5 polymorphisms on normal variation in BMD J Bone Miner Res 19 1619 1627 10.1359/JBMR.040704 1:CAS:528:DC%2BD2cXovFWmsbk%3D 15355556 (Pubitemid 41094324)
21. X Liu T Kohyama T Kobayashi, et al. 2003 Cigarette smoke extract inhibits chemotaxis and collagen gel contraction mediated by human bone marrow osteoprogenitor cells and osteoblast-like cells Osteoporos Int 14 235 242 1:CAS:528:DC%2BD3sXlslOlsL8%3D 12730796
22. M Akhter A Manolides D Cullen RR Recker 2008 LRP5 G171V mutation and tobacco smoke related bone fragility J Bone Miner Res 23 S454 Abstracts
23. AM Kenny KM Prestwood 2000 Osteoporosis. Pathogenesis, diagnosis and treatment in older adults Rheum Dis Clin North Am 26 569 591 10.1016/S0889-857X(05)70157-5 1:STN:280:DC%2BD3cvkt1Gquw%3D%3D 10989513
24. R Pacifici 1996 Estrogen, cytokines and the pathogenesis of postmenopausal osteoporosis J Bone Miner Res 11 1043 1051 10.1002/jbmr. 5650110802 1:CAS:528:DyaK28XlvVWisrc%3D 8854239
25. K Tsukamato H Yoshida S Watanabe, et al. 1999 Association of radial bone mineral density with CA repeat polymorphism at the interleukin 6 locus in postmenopausal Japanese women J Hum Genet 44 148 151 10.1007/s100380050132 (Pubitemid 29219898)
26. TL Yang H Shen DH Xiong, et al. 2007 Epistatic interactions between genomic regions containing the COL1A1 gene and genes regulating osteoclast differentiation may influence femoral neck bone mineral density Ann Hum Genet 71 152 159 10.1111/j.1469-1809.2006.00313.x 1:CAS:528:DC%2BD2sXlt1aitb8%3D 17331078 (Pubitemid 46656494)
27. SF Lei FY Deng SM Xiao, et al. 2005 Association and haplotype analyses of the COL1A2 and ER-alpha gene polymorphisms with bone size and height in Chinese Bone 36 533 541 10.1016/j.bone.2004.11.002 1:CAS:528:DC%2BD2MXisFGrtL0%3D 15777651 (Pubitemid 40403851)
28. X Li GP He B Zhang, et al. 2008 Interactions of interleukin-6 gene polymorphisms with calcium intake and physical activity on bone mass in pre-menarche Chinese girls Osteoporos Int 19 1629 1637 10.1007/s00198-008-0613-3 1:CAS:528:DC%2BD1cXht1anurbM 18418640
29. Y Yamada F Ando N Niino H Shimokata 2003 Association of polymorphisms of interleukin-6, osteocalcin and vitamin D receptor genes, alone or in combination with bone mineral density in community dwelling Japanese women and men J Clin Endocrinol Metab 88 3372 3378 10.1210/jc.2002-021449 1:CAS:528: DC%2BD3sXlslaiur0%3D 12843190 (Pubitemid 36877519)
30. SL Ferrari L Ahn-Luong P Garnero, et al. 2003 Two promoter polymorphisms regulating interleukin-6 gene expression are associated with circulating levels of C-reactive protein and markers of bone resorption in postmenopausal women J Clin Endocrinol Metab 88 255 259 10.1210/jc.2002-020092 1:CAS:528: DC%2BD3sXkvVCjsw%3D%3D 12519862 (Pubitemid 36115175)
31. U Styrkarsdottir JB Cazier A Kong, et al. 2003 Linkage of osteoporosis to chromosome 20p12 and association to BMP2 PLoS Biol 1 E69 10.1371/journal.pbio. 0000069 14691541 (Pubitemid 39112134)
32. SC Manolagas RL Jilka 1995 Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis N Engl J Med 332 305 311 10.1056/NEJM199502023320506 1:STN:280:DyaK2M7hsFOiuw%3D%3D 7816067
33. RE Murray F McGuigan SF Grant, et al. 1997 Polymorphisms of the interleukin-6 gene are associated with bone mineral density Bone 21 89 92 10.1016/S8756-3282(97)00081-1 1:CAS:528:DyaK2sXkslamsbs%3D 9213013 (Pubitemid 27341744)
34. DJ Maron S Fazio MF Linton 2000 Current perspectives on statins Circulation 101 207 213 1:CAS:528:DC%2BD3cXptFKlug%3D%3D 10637210
35. G Mundy R Garrett S Harris, et al. 1999 Stimulation of bone formation in vitro and in rodents by statins Science 286 1946 1949 10.1126/science.286.5446. 1946 1:CAS:528:DyaK1MXnvFSiu78%3D 10583956
36. KA Chan SE Andrade M Boles, et al. 2000 Inhibitors of hydroxymethylglutaryl-coenzyme A reductase and risk of fracture among older women Lancet 355 2185 2188 10.1016/S0140-6736(00)02400-4 1:CAS:528: DC%2BD3cXltVCntrc%3D 10881890
37. L Rejnmark ML Olsen SP Johnsen, et al. 2004 Hip fracture risk in statin users-a population-based Danish case-control study Osteoporos Int 15 452 458 15205716
38. WA Ray JR Daugherty MM Griffin 2002 Lipid-lowering agents and the risk of hip fracture in a Medicaid population Inj Prev 8 276 279 10.1136/ip.8.4.276 1:STN:280:DC%2BD38jjvVWqsQ%3D%3D 12460961
39. N Ota T Nakajima I Nakazawa, et al. 2001 A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density J Hum Genet 46 267 272 10.1007/s100380170077 1:CAS:528: DC%2BD3MXjslKks74%3D 11355017
40. A Viitanen M Kärkkäinen K Laitinen, et al. 1996 Common polymorphism of the vitamin D receptor gene is associated with variation of peak bone mass in young Finns Calcif Tissue Int 59 231 234 10.1007/s002239900113 1:CAS:528:DyaK28XlvFCntbs%3D 8781042 (Pubitemid 26353013)
41. JM Zmuda JA Cauley RE Ferrell 2000 Molecular epidemiology of vitamin D receptor gene variants Epidemiol Rev 22 203 217 1:STN:280:DC%2BD3M3gtl2rtg%3D%3D 11218372
42. C Gross TR Eccleshall PJ Malloy, et al. 1996 The presence of a polymorphism at the translation initiation site of the vitamin D receptor gene is associated with low bone mineral density in postmenopausal Mexican-American women J Bone Miner Res 11 1850 1855 1:CAS:528:DyaK2sXjtVCmtQ%3D%3D 8970885
43. JP Ioannidis SH Ralston ST Bennett, et al. 2004 Differential genetic effects of ESRI gene polymorphisms on osteoporosis outcomes JAMA 292 2105 2114 10.1001/jama.292.17.2105 1:CAS:528:DC%2BD2cXpsVeku7g%3D 15523071 (Pubitemid 39435101)
44. HW Deng J Li JL Li, et al. 1998 Change of bone mass in postmenopausal Caucasian women with and without hormone replacement therapy is associated with vitamin D receptor and estrogen receptor genotypes Hum Genet 103 576 585 10.1007/s004390050872 1:CAS:528:DyaK1cXnsVOht78%3D 9860300 (Pubitemid 28548480)
45. AG Uitterlinden H Burger Q Huang, et al. 1998 Relation of alleles of the collagen type Ialpha1 gene to bone density and the risk of osteoporotic fractures in postmenopausal women N Engl J Med 338 1016 1021 10.1056/NEJM199804093381502 1:STN:280:DyaK1c7otFOqug%3D%3D 9535665 (Pubitemid 28180402)
46. BL Langdahl M Carstens L Stenkjaer EF Eriksen 2003 Polymorphisms in the transforming growth factor beta 1 gene and osteoporosis Bone 32 297 310 10.1016/S8756-3282(02)00971-7 1:CAS:528:DC%2BD3sXit12gsLs%3D 12667558 (Pubitemid 36349534)
47. M Shiraki Y Shiraki C Aoki, et al. 1997 Association of bone mineral density with apolipoprotein E phenotype J Bone Miner Res 12 1438 1445 10.1359/jbmr.1997.12.9.1438 1:CAS:528:DyaK2sXmt1WksLo%3D 9286760 (Pubitemid 27375387)
48. SL Ferrari S Deutsch C Baudoin, et al. 2005 LRP5 gene polymorphisms and idiopathic osteoporosis in men Bone 37 770 775 10.1016/j.bone.2005.06.017 1:CAS:528:DC%2BD2MXhtlShsrbO 16168727 (Pubitemid 41773486)
49. JB van Meurs TA Trikalinos SH Ralston, et al. 2008 Large-scale analysis of association between LRP5 and LRP6 variants and osteoporosis JAMA 299 1277 1290 10.1001/jama.299.11.1277 18349089
50. JB Richards F Rivadeneira M Inouye, et al. 2008 Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study Lancet 371 1505 1512 10.1016/S0140-6736(08)60599-1 1:CAS:528:DC%2BD1cXlsFGisr0%3D 18455228
51. L Agueda M Bustamante S Jurado, et al. 2008 A haplotype-based analysis of the LRP5 gene in relation to osteoporosis phenotypes in Spanish postmenopausal women J Bone Miner Res 23 1954 1963 10.1359/jbmr.080806 1:CAS:528: DC%2BD1MXosVylsbY%3D 18684085
52. QY Huang H Shen HY Deng, et al. 2003 Linkage and association of the CA repeat polymorphism of the IL6 gene, obesity-related phenotypes, and bone mineral density (BMD) in two independent Caucasian populations J Hum Genet 48 430 437 10.1007/s10038-003-0053-z 1:CAS:528:DC%2BD3sXnt1ShsL8%3D 12898289 (Pubitemid 37221559)
53. D Feng H Ishibashi S Yamamoto, et al. 2003 Association between bone loss and promoter polymorphism in the IL6 gene in elderly Japanese women with hip fracture J Bone Miner Metab 21 225 228 1:CAS:528:DC%2BD3sXnt1ygu7Y%3D 12811627
54. HW Chung JS Seo SE Hur, et al. 2003 Association of interleukin-6 promoter variant with bone mineral density in pre-menopausal women J Hum Genet 48 243 248 10.1007/s10038-003-0020-8 1:CAS:528:DC%2BD3sXjvF2lt7Y%3D 12768442 (Pubitemid 36759487)
55. JJ Magaña R Gómez B Cisneros, et al. 2008 Association of interleukin-6 gene polymorphisms with bone mineral density in Mexican women Arch Med Res 39 618 624 10.1016/j.arcmed.2008.05.006 18662595 (Pubitemid 352033613)
56. K Yamasaki T Taga Y Hirata, et al. 1988 Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor Science 241 825 828 10.1126/science.3136546 1:CAS:528:DyaL1MXitFSmur4%3D 3136546