A nucleotide variant in the promoter region of the interleukin-6 gene associated with decreased bone mineral density

Journal of Human Genetics

Volumn 46, Issue 5, 2001, Pages 267-272

  Ota, N ^a   Nakajima, T ^a   Nakazawa, I ^a   Suzuki, T ^b   Hosoi, T ^b   Orimo, H ^b   Inoue, S ^c   Shirai, Y ^a   Emi, M ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Bone mineral density; Interleukin 6 gene; Osteoporosis; Single nucleotide polymorphism (SNP)

Indexed keywords

ESTROGEN; INTERLEUKIN 6;

AGED; ALLELE; ARTICLE; BONE ATROPHY; BONE DENSITY; BONE MINERAL; ESTROGEN DEFICIENCY; EXON; FEMALE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC LINKAGE; GENOTYPE; HUMAN; OSTEOCLAST; OSTEOPOROSIS; PROMOTER REGION; RESTRICTION MAPPING; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 0035043560     PISSN: 14345161     EISSN: None     Source Type: Journal    
DOI: 10.1007/s100380170077     Document Type: Article

References (39)

1. A polymorphism (G/A transition) in the -78 position of the apolipoprotein A-I promoter increases transcription efficiency
2. A novel polymorphism in the promoter region for human osteocalcin gene: The possibility of a correlation with bone mineral density in postmenopausal Japanese women
3. The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis
4. Reduced bone density and osteoporosis associated with a polymorphic Sp1 site in the collagen type I alpha 1 gene
5. Five familial hypercholesterolemic kindreds in Japan with novel mutation of the LDL receptor gene
6. A novel LDLR mutation, H190Y, in a Utah kindred with familial hypercholesterolemia
7. Association study of parathyroid hormone gene polymorphism and bone mineral density in Japanese postmenopausal women
8. A nucleotide substitution in the promoter of human angiotensinogen is associated with essential hypertension and affects basal transcription in vitro
9. Allelic variation at the interleukin-1 receptor antagonist gene is associated with early postmenopausal bone loss at the spine
10. Association of IL-6 gene alleles with systemic lupus erythematosus (SLE) and with elevated IL-6 expression
11. Allelic variants of human calcitonin receptor: Distribution and association with bone mass in postmenopausal Italian women
12. A genetic association between juvenile rheumatoid arthritis and a novel interleukin-1 alpha polymorphism
13. Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria
14. Juxtaposed regions of extensive and minimal linkage disequilibrium in human Xq25 and Xq28
15. Polymorphism of insulin-like growth factor I gene and bone mineral density
16. Association of bone mineral density with a dinucleotide repeat polymorphism at the calcitonin (CT) locus
17. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis
18. Prediction of bone density from vitamin D receptor alleles
19. Polymorphisms of the interleukin-6 gene are associated with bone mineral density
20. Association of bone mineral density with a polymorphism of the peroxisome proliferator-activated receptor gamma gene: PPAR gamma expression in osteoblasts
21. A novel Nla III polymorphism in the human IL-6 promoter
22. The diagnosis of osteoporosis
23. Linkage of interleukin 6 locus to human osteopenia by sibling pair analysis
24. Interleukin-6 deficient mice are protected from bone loss caused by estrogen depletion
25. Analysis of gene expression in human bone biopsies by polymerase chain reaction: Evidence for enhanced cytokine expression in postmenopausal osteoporosis
26. Interleukin-6: An osteoporotic factor?
27. Association of estrogen receptor dinucleotide repeat polymorphism with osteoporosis
28. Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women
29. Sib pair linkage and association studies between bone mineral density and the interleukin-6 gene locus
30. Genomic structure of the murine IL-6 gene: High degree conservation of potential regulatory sequences between mouse and human
31. Cooperative influence of genetic polymorphisms on interleukin 6 transcriptional regulation
32. The detection of linkage disequilibrium between closely linked markers: RFLPs at the AI-CIII apolipoprotein genes
33. Isolation and mapping of a polymorphic CA repeat sequence at the human interleukin 6 locus
34. Association of radial bone mineral density with CA repeat polymorphism at the interleukin 6 locus in postmenopausal Japanese women
35. Effects of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation
36. Association of a polymorphism of the transforming growth factor-beta 1 gene with genetic susceptibility to osteoporosis in postmenopausal Japanese women
37. Cloning and expression of the human interleukin-6 (BSF/INF-beta-2) receptor
38. Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene