10 mM glucosamine prevents activation of proADAMTS5 (aggrecanase-2) in transfected cells by interference with post-translational modification of furin

Osteoarthritis and Cartilage

Volumn 18, Issue 3, 2010, Pages 455-463

  McCulloch, D R ^a,b   Wylie, J D ^a   Longpre, J M ^c   Leduc, R ^c   Apte, S S ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b DEAKIN UNIVERSITY   (Australia)

^c UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

ADAMTS; Aggrecanase; Catabolism; Furin; Glucosamine

Indexed keywords

A DISINTEGRIN LIKE AND METALLOPROTEASE DOMAIN WITH THROMBOSPONDIN TYPE 1 MOTIF 5; AGGRECANASE; AGGRECANASE 2; ENZYME PRECURSOR; FURIN; GLUCOSAMINE; METALLOPROTEINASE; UNCLASSIFIED DRUG; ADAM PROTEIN; ADAMTS5 PROTEIN, HUMAN;

ARTICLE; CATABOLISM; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; GENE ACTIVATION; GENE FUNCTION; GENETIC TRANSFECTION; GLYCOSYLATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PROCESSING; SITE DIRECTED MUTAGENESIS; WESTERN BLOTTING; CELL CULTURE; DRUG EFFECT; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STATISTICS;

ADAM PROTEINS; BLOTTING, WESTERN; CELLS, CULTURED; FURIN; GLUCOSAMINE; HUMANS; PROTEIN PROCESSING, POST-TRANSLATIONAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STATISTICS AS TOPIC;

EID: 76549117397     PISSN: 10634584     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.joca.2009.10.014     Document Type: Article

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