Iontophoresis of dexamethasone in the treatment of endotoxin-induced- uveitis in rats

Experimental Eye Research

Volumn 65, Issue 4, 1997, Pages 533-545

  Behar Cohen, Francine F ^a,b,c   Parel, Jean Marie ^b,c,d   Pouliquen, Yves ^b,c   Thillaye Goldenberg, Beatrice ^b,c   Goureau, Olivier ^a   Heydolph, Silke ^a   Courtois, Yves ^a   De Kozak, Yvonne ^b,c  

^a INSERM   (France)

^b CENTRE DE RECHERCHE DES CORDELIERS   (France)

^c HÔTEL DIEU   (France)

^d UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

Author keywords

Drug delivery; EIU; Glucocorticoids; Iontophoresis; Rat; TNF

Indexed keywords

DEXAMETHASONE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CORTICOSTEROID THERAPY; DRUG DELIVERY SYSTEM; IONTOPHORESIS; MALE; NONHUMAN; POSTERIOR EYE CHAMBER; PRIORITY JOURNAL; RAT; TREATMENT OUTCOME; UVEITIS;

EID: 0030700775     PISSN: 00144835     EISSN: None     Source Type: Journal    
DOI: 10.1006/exer.1997.0364     Document Type: Article

References (43)

1. De Kozak, Y., Hicks, D., Chatenoud, L., Bellot, J., Thillaye, B. and Faure, J. P. (1994a). Intraocular TNF-α in Endotoxin and S-Antigen-induced Uveitis: In vitro synthesis of TNF-α by retinal Müller glial and pigment epithelial cells. Regional Immunol. 6, 76-80.
2. De Kozak, Y., Naud, M. C., Bellot, J., Faure, J. P. and Hicks, D. (1994b). Differential tumor necrosis factor expression by resident retinal cells from experimental uveitis-susceptible and -resistant rat strains. J. Neuroimmunol. 55, 11-16.
3. De Vos, A. F., Hoekzema, R. and Kiljstra, A. (1992). Retino-choroidal changes in endotoxin-induced uveitis, a review. Curr. Eye Res. 6, 581-97.
4. De Vos, A. F., van Haren, M. A. C., Verhagen, C., Hoekzema, R. and Kijlstra, A. (1994). Kinetics of intraocular tumor necrosis factor and interleukin-6 in endotoxin-induced uveitis in the rat. Invest. Ophthalmol. Vis. Sci. 35, 1100-6.
5. De Vos, A., Klaren, V. N. A. and Kijlstra, A. (1994). Expression of multiple cytokines and IL-1RA in the uvea and retina during endotoxin-induced uveitis in the rat. Invest. Ophthalmol. Vis. Sci. 35, 3873-7.
6. Ferran, C., Sheenan, K., Dy, M., Schreiber, R., Landais, P., Noel, L. H., Grau, G., Bluestone, J., Bach, J. F. and Chatenoud, L. (1990). Cytokine-related syndrome following injection of anti-CD3 monoclonal antibody: further evidence for transient in vivo T cell activation. Eur. J. Immunol. 20, 509-15.
7. Fiers, W. (1991). Tumor necrosis factor. Characterization at the molecular, cellular and in vivo level. FEBS Lett. 285, 199-212.
8. Geller, D. A., Nussler, A., Di Silvio, M., Lowenstein, C. J., Shapiro, R. A., Stewart, C. W., Simmons, R. L. and Billiar, T. R. (1993). Cytokines, endotoxin and glucorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc. Natl. Acad. Sci. (U.S.A.) 90, 522-6.
9. Goureau, O., Bellot, J., Thillaye, B., Courtois, Y. and De Kozak, Y. (1995). Increased nitric oxide production in endotoxin-induced uveitis, reduction of uveitis by an inhibitor of nitric oxide synthase. J. Immunol. 154, 6518-23.
10. Grewe, M., Gausling, R., Gyufko, K., Hoffmann, R. and Decker, K. (1994). Regulation of the mRNA expression for tumor necrosis factor-alpha in rat liver macrophages. J. Hepatol. 20, 811-18.
11. Herbort, C. P., Okumura, O. A. and Mochizuki, M. (1989). Immunopharmacological analysis of endotoxin-induced-uveitis in rat. Exp. Eye Res. 48, 693-705.
12. Hoekzema, R., Murray, P. I., van Haren, M. A. C., Helle, M. and Kijlstra, A. (1991). Analysis of interleukin-6 in endotoxin induced uveitis. Invest. Ophthalmol. Vis. Sci. 32, 88-95.
13. Hoekzema, R., Verhagen, M. A. C., van Haren, M. and Kiljstra, A. (1992). Endotoxin-induced-uveitis in the rat. Invest. Ophthalmol. Vis. Sci. 33, 532-9.
14. Hooks, J. J., Chan, C. C. and Detrick, B. (1988). Identification of the eye disease. Invest. Ophthalmol. Vis. Sci. 29, 1444-51.
15. Hugues, L. and Maurice, D. (1984). A fresh look at iontophoresis. Arch Ophthalmol. 102, 1825.
16. Jensen, P., Pollycove, M., Aronso, S. B. and Yamamoto, E. (1964). Radio-isotopic measurements of protein transfer between the eyes. Invest. Ophthalmol. Vis. Sci. 3, 676.
17. Jensen, P. Aronson, S. B., Pollycove, M. and Yamamoto, E. (1967). Mechanisms of host response in the eye. Interocular transfer. Arch. Ophthalmol. 77, 814-17.
18. Kasner, L., Chan, C. C., Whitcup, S. and Gery, I. (1993). The paradoxal effect of tumor necrosis factor alpha in endotoxin-induced uveitis. Invest. Ophthalmol. Vis. Sci. 34, 2911-17.
19. Katayama, T. and Fujiwara, H. (1990). Inducing ophthalmitis with interleukin-1. In: Ocular Immunology Today Proceedings of the Fifth International Symposium on the Immunology and Immunopathology of the Eye. Usui M., S. Ohno, and K. Aoki (editors) Excerpta Medica, Tokyo. 73-76.
20. Kogiso, M., Tanouchi, Y., Mimura, Y., Nagasawa, H. and Himeno, K. (1992). Endotoxin-induced uveitis in mice: Induction of uveitis and role of lymphocytes. Jpn J. Ophthalmol. 36, 281-90.
21. Kulkrani, P. S. and Paterson, C. A. (1995). Diclofenac and prednisolone inhibit Endotoxin-induced Uveitis in rabbits. Exp. Eye Res. 61, 767-8.
22. Lam, T. T., Edward, D. P., Zhu, X. and Tso, M. (1989). Transscleral iontophoresis of dexamethasone. Arch. Ophthalmol. 107, 1368-73.
23. Masferrer, J. L., Seibert, B. S. and Needlemen, P. (1990). Selective regulation of cellular cyclooxygenase by Dexamethasone and endotoxin in mice. J. Clin. Invest. 86, 1375-9.
24. McMenamin, P. G. and Crewe, J. (1995). Endotoxin-induced uveitis. Kinetics and phenotype of the inflammatory cell infiltrate and the response of the resident tissue macrophages and dendritics cells in the iris and the ciliary body. Invest. Ophthalmol. Vis. Sci. 36, 1949-59.
25. Morris, S. M. Jr and Billiar, T. R. (1994). New insight into the regulation of inducible nitric oxide synthesis. Am. J. Physiol. 266, E829-39.
26. Morita, M., Kasahara, T., Mukaida, N., Matsushima, K., Nagashima, T., Nishizawa, M. and Yoshida, M. (1993). Induction and regulation of IL-8 and MCAF production in human brain tumour tissues. Eur. Cytokines Network 4, 351-8.
27. Nakamura, S., Yamakawa, T., Sugita, M., Kijima, M., Ishioka, M., Tanaka, S. and Ohno, S. (1994). The role of tumor necrosis factor-alpha in the induction of experimental autoimmune uveoretinitis in mice. Invest. Ophthalmol. Vis. Sci. 35(11), 3884-8.
28. Noye, J. F., George, J. L., Aymard, B., Berrod, J. P., Guedenet, J. C. and Raspiller, A. (1989). Evaluation of the histopathologic effects following subconjunctival injection of corticoids in immediate and retard-actions forms. J. Français Ophthalmol 12, 587-94.
29. Ohia, E. O., Mancino, M. and Kulkarni, P. (1992). Effects of steroids and immunosuppressive drugs on endotoxin-uveitis in rabbits. J. Ocular Pharmacol. 8, 295-307.
30. Pagano, G., Bruno, A., Cavallo-Perin, P., Cesco, L. and Imbimbo, B. (1989). Glucose intolerance after short-term administration of corticosteroids in healthy subjects. Arch. Int. Med. 149, 1098-101.
31. Pfeilschifter, J., Muhl, H., Pignat, W., Marki, F. and Van-den-Bosch, H. (1993). Cytokines regulation of group II phospholipase A2 expression in glomerular mesangial cells. Eur. J. Clin. Pharmacol. 44 Suppl. 1, 7-9.
32. Planck, S. R., Huang, X., Robertson, J. E. and Rosenbaum, J. T. (1994). Cytokine mRNA in rat ocular tissues after endotoxin treatment. Invest. Ophthalmol. Vis. Sci. 35, 924-30.
33. Robyn, G. and Lee, D. A. (1989). Transscleral and trans-corneal iontophoresis of ketoconazole in the rabbit eye. Ophthalmology 96, 724-9.
34. Rosenbaum, J. T., MacDevitt, H. O., Guss, R. B. and Egbert, P. R. (1980). Endotoxin induced uveitis in rats as a model for human disease. Nature (Lond). 286, 611-18.
35. Rosenbaum, J. T., Samples, J. R., Hefeneider, S. H. and Howles, E. L. (1987). Ocular effects of intravitreal interleukin-1. Arch. Ophthalmol. 105, 1117-20.
36. Rosenblum, C., Dengler, R. E., Geoffroy, R. and Rahway, N. J. (1967). Ocular absorption of dexamethasone phosphate disodium by the rabbit. Arch. Ophthalmol. 77, 234-7.
37. Ruiz-Moreno, J. M., Thillaye, B. and de Kozak, Y. (1992). Retino-choroidal changes in endotoxin-induced uveitis. Ophthalmic Res. 24, 162-8.
38. Sartani, G., Silver, P. B., Rizzo, L. V., Chan, C. C., Wiggert, B., Mastorakos, G. and Caspi, R. R. (1996). Anti-tumor necrosis factor alpha therapy suppresses the induction of experimental autoimmune uveoretinitis in mice by inhibiting antigen priming. Invest. Ophthalmol. Vis. Sci. 37, 2211-18.
39. Singh, P. and Maibach, H. I. (1994). Iontophoressi in drug delivery: basic principles and applications. Crit. Rev. Therap. Drug Carrier System 11(2-3), 161-213.
40. Tsuji, F., Sawa, K., Kato, M., Mibu, H. and Shirasawa, E. (1997). The effect of betamethsone derivates on Endotoxin-Induced-Uveitis in rats. Exp. Eye Res. 64, 31-6.
41. Whitworth, J. A. and Gordon, D. (1989). The hypertensive effect of synthetic glucocorticoids in man: role of sodium and volume. J. Hypertens. 7, 537-49.
42. Yang, P., de Vos, A. F. and Kijlstra, A. (1996). Macrophages in the retina of normal Lewis rats and their dynamics after injection of lipopolysaccharide. Invest. Ophthalmol. Vis. Sci. 37, 77-85.
43. Yoshida, M. N., Yoshimura, M., Hangai, M., Tanihara, H. and Honda, Y. (1994). Interleukin-1α, interleukin-1β and tumor necrosis factor gene expression in endotoxin-induced uveitis. Invest. Ophthalmol. Vis. Sci. 35, 1107-13.