Transport characteristics of mouse concentrative nucleoside transporter 1

International Journal of Pharmaceutics

Volumn 388, Issue 1-2, 2010, Pages 168-174

  Niitani, Miho ^a   Nishida, Kentaro ^a   Okuda, Hiroto ^a   Nagai, Katsuhito ^a   Fujimoto, Sadaki ^a   Nagasawa, Kazuki ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Concentrative nucleoside transporter 1; Mouse; Nucleoside analogue; Substrate specificity

Indexed keywords

3' DEOXYURIDINE; BROXURIDINE; COMPLEMENTARY DNA; CYTARABINE; DEOXYURIDINE; GEMCITABINE; NUCLEOSIDE ANALOG; NUCLEOSIDE TRANSPORTER; NUCLEOSIDE TRANSPORTER 1; SODIUM; UNCLASSIFIED DRUG; URIDINE; URIDINE DERIVATIVE; ZALCITABINE; ZIDOVUDINE;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CELL STRAIN COS7; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME SPECIFICITY; GENETIC TRANSFECTION; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TRANSPORT;

ANIMALS; BIOLOGICAL TRANSPORT; CERCOPITHECUS AETHIOPS; COS CELLS; HUMANS; MALE; MEMBRANE TRANSPORT PROTEINS; MICE; MODELS, ANIMAL; NUCLEOSIDES; SODIUM; SPECIES SPECIFICITY; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 76549112989     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.12.057     Document Type: Article

References (23)

1. Baldwin S.A., Yao S.Y., Hyde R.J., Ng A.M., Foppolo S., Barnes K., Ritzel M.W., Cass C.E., and Young J.D. Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes. J. Biol. Chem. 280 (2005) 15880-15887
2. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
3. Cass C.E., Young J.D., and Baldwin S.A. Recent advances in the molecular biology of nucleoside transporters of mammalian cells. Biochem. Cell Biol. 76 (1998) 761-770
4. Chang C., Swaan P.W., Ngo L.Y., Lum P.Y., Patil S.D., and Unadkat J.D. Molecular requirements of the human nucleoside transporters hCNT1, hCNT2, and hENT1. Mol. Pharmacol. 65 (2004) 558-570
5. Gerstin K.M., Dresser M.J., and Giacomini K.M. Specificity of human and rat orthologs of the concentrative nucleoside transporter, SPNT. Am. J. Physiol. Renal Physiol. 283 (2002) F344-F349
6. Graham K.A., Leithoff J., Coe I.R., Mowles D., Mackey J.R., Young J.D., and Cass C.E. Differential transport of cytosine-containing nucleosides by recombinant human concentrative nucleoside transporter protein hCNT1. Nucleosides Nucleotides Nucleic Acids 19 (2000) 415-434
7. Gray J.H., Owen R.P., and Giacomini K.M. The concentrative nucleoside transporter family, SLC28. Pflugers Arch. 447 (2004) 728-734
8. Kato R., Maeda T., Akaike T., and Tamai I. Nucleoside transport at the blood-testis barrier studied with primary-cultured sertoli cells. J. Pharmacol. Exp. Ther. 312 (2005) 601-608
9. Kong W., Engel K., and Wang J. Mammalian nucleoside transporters. Curr. Drug Metab. 5 (2004) 63-84
10. + nucleoside cotransporters hCNT1 and hCNT2. J. Biol. Chem. 274 (1999) 24475-24484
11. Nagai K., Nagasawa K., and Fujimoto S. Transport mechanisms for adenosine and uridine in primary-cultured rat cortical neurons and astrocytes. Biochem. Biophys. Res. Commun. 334 (2005) 1343-1350
12. Nagasawa K., Nagai K., Ishimoto A., and Fujimoto S. Transport mechanism for lovastatin acid in bovine kidney NBL-1 cells: kinetic evidences imply involvement of monocarboxylate transporter 4. Int. J. Pharm. 262 (2003) 63-73
13. +-nucleoside transporters. Cancer Chemother. Pharmacol. 46 (2000) 394-402
14. Peng L., Huang R., Yu A.C., Fung K.Y., Rathbone M.P., and Hertz L. Nucleoside transporter expression and function in cultured mouse astrocytes. Glia 52 (2005) 25-35
15. +-nucleoside cotransporter proteins (hCNT3 and mCNT3) broadly selective for purine and pyrimidine nucleosides (system cib). J. Biol. Chem. 276 (2001) 2914-2927
16. +/nucleoside cotransporter hCNT1 affect permeant selectivity and cation coupling. Biochemistry 46 (2007) 1684-1693
17. +-coupled nucleoside transporter (hCNT1) produced in Xenopus oocytes. J. Physiol. 558 (2004) 807-823
18. Soler C., Valdes R., Garcia-Manteiga J., Xaus J., Comalada M., Casado F.J., Modolell M., Nicholson B., MacLeod C., Felipe A., Celada A., and Pastor-Anglada M. Lipopolysaccharide-induced apoptosis of macrophages determines the up-regulation of concentrative nucleoside transporters Cnt1 and Cnt2 through tumor necrosis factor-alpha-dependent and -independent mechanisms. J. Biol. Chem. 276 (2001) 30043-30049
19. Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K., Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F., Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L., Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E., Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C., Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J., Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H., Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W., Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G., Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Krzywinski M.I., Skalska U., Smailus D.E., Schnerch A., Schein J.E., Jones S.J., and Marra M.A. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 16899-16903
20. Yao S.Y., Cass C.E., and Young J.D. Transport of the antiviral nucleoside analogs 3′-azido-3′-deoxythymidine and 2′,3′-dideoxycytidine by a recombinant nucleoside transporter (rCNT) expressed in Xenopus laevis oocytes. Mol. Pharmacol. 50 (1996) 388-393
21. Yao S.Y., Ng A.M., Ritzel M.W., Gati W.P., Cass C.E., and Young J.D. Transport of adenosine by recombinant purine- and pyrimidine-selective sodium/nucleoside cotransporters from rat jejunum expressed in Xenopus laevis oocytes. Mol. Pharmacol. 50 (1996) 1529-1535
22. Zhang J., Smith K.M., Tackaberry T., Visser F., Robins M.J., Nielsen L.P., Nowak I., Karpinski E., Baldwin S.A., Young J.D., and Cass C.E. Uridine binding and transportability determinants of human concentrative nucleoside transporters. Mol. Pharmacol. 68 (2005) 830-839
23. Zhang J., Visser F., Vickers M.F., Lang T., Robins M.J., Nielsen L.P., Nowak I., Baldwin S.A., Young J.D., and Cass C.E. Uridine binding motifs of human concentrative nucleoside transporters 1 and 3 produced in Saccharomyces cerevisiae. Mol. Pharmacol. 64 (2003) 1512-1520