Frataxin, a molecule of mystery: Trading stability for function in its iron-binding site

Biochemical Journal

Volumn 426, Issue 2, 2010, Pages

  Lane, Darius J R ^a   Richardson, Des R ^b  

^a MONASH UNIVERSITY   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Frataxin; Friedreich's ataxia (FRDA); Iron sulfur cluster; Isu protein; Mitochondrion; Yeast frataxin (Yfh1)

Indexed keywords

DOWNSTREAM EFFECTS; FRATAXIN; FRIEDREICH'S ATAXIAS; IRON BINDING; IRON METABOLISM; IRON-SULFUR CLUSTERS; ISU PROTEIN; METABOLIC ROLES; MITOCHONDRIAL PROTEIN; MOLECULAR FUNCTION; NEGATIVE CHARGE; PROTEIN-PROTEIN INTERACTIONS; STRUCTURAL FLEXIBILITIES;

BINDING ENERGY; BINDING SITES; BIOCHEMISTRY; GENE EXPRESSION; METABOLISM; SULFUR; YEAST;

PROTEINS;

FRATAXIN; IRON;

ARTICLE; BINDING SITE; IRON BINDING CAPACITY; IRON METABOLISM; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY;

FRIEDREICH ATAXIA; HUMANS; IRON; IRON-BINDING PROTEINS; MITOCHONDRIA; PROTEIN BINDING; PROTEIN STABILITY; SACCHAROMYCES CEREVISIAE;

EID: 76549110775     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20091959     Document Type: Article

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