Effects of dinuclear copper(II) complexes with 6-(benzylamino)purine derivatives on AhR and PXR dependent expression of cytochromes P450 CYP1A2 and CYP3A4 genes in primary cultures of human hepatocytes

Toxicology in Vitro

Volumn 24, Issue 2, 2010, Pages 425-429

  Dvořák, Zdeněk ^a   Vrzal, Radim ^a   Štarha, Pavel ^a   Klanicová, Alena ^a   Trávníček, Zdeněk ^a  

^a PALACKÝ UNIVERSITY   (Czech Republic)

Author keywords

Cytochrome P450; Dinuclear copper(II) complexes; Gene induction; Human hepatocytes

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 6 (BENZYLAMINO)PURINE DERIVATIVE; AROMATIC HYDROCARBON RECEPTOR; COPPER COMPLEX; CYTOCHROME P450 1A2; CYTOCHROME P450 3A4; LUCIFERASE; MESSENGER RNA; PREGNANE X RECEPTOR; PURINE DERIVATIVE; RIFAMPICIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CELL PROTECTION; CELL STRAIN HEPG2; CHEMICAL COMPOSITION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIOXIN RESPONSIVE ELEMENT; DNA STRUCTURE; DRUG CYTOTOXICITY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME INDUCTION; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; INCUBATION TIME; MALE; PLASMID; REPORTER GENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSCRIPTION INITIATION;

ADULT; AGED; BENZYL COMPOUNDS; CELLS, CULTURED; COPPER; CYTOCHROME P-450 CYP1A2; CYTOCHROME P-450 CYP3A; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEPATOCYTES; HUMANS; MALE; MIDDLE AGED; MOLECULAR STRUCTURE; PURINES; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, STEROID; RNA, MESSENGER;

EID: 76549103373     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2009.10.012     Document Type: Article

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