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Volumn 31, Issue 4, 2010, Pages 332-341

Curcumin inhibits transforming growth factor-β activity via inhibition of smad signaling in HK-2 cells

Author keywords

Curcumin; Fibrosis; HK 2 cells; Microcystin; Smad; TGF 1

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CURCUMIN; MICROCYSTIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECEPTOR REGULATED SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 76549101674     PISSN: 02508095     EISSN: None     Source Type: Journal    
DOI: 10.1159/000287230     Document Type: Article
Times cited : (40)

References (45)
  • 1
    • 0030419494 scopus 로고    scopus 로고
    • Molecular insights into renal interstitial fibrosis
    • Eddy AA: Molecular insights into renal interstitial fibrosis. J Am Soc Nephrol 1996; 7: 2495-2508.
    • (1996) J Am Soc Nephrol , vol.7 , pp. 2495-2508
    • Eddy, A.A.1
  • 2
    • 23144464377 scopus 로고    scopus 로고
    • Rod riguez-Puyol D: The accumulation of extracellular matrix in the kidney: Consequences on cellular function
    • Ruiz-Torres MP, Lopez-Ongil S, Griera M, Diez-Marques ML, Rodriguez-Puyol M, Rod riguez-Puyol D: The accumulation of extracellular matrix in the kidney: consequences on cellular function. J Nephrol 2005; 18: 334-340.
    • (2005) J Nephrol , vol.18 , pp. 334-340
    • Ruiz-Torres, M.P.1    Lopez-Ongil, S.2    Griera, M.3    Diez-Marques, M.L.4    Rodriguez-Puyol, M.5
  • 3
    • 47849127561 scopus 로고    scopus 로고
    • Fibrosis in diabetes complications: Pathogenic mechanisms and circulating and urinary markers
    • Ban CR, Twigg SM: Fibrosis in diabetes complications: pathogenic mechanisms and circulating and urinary markers. Vasc Health Risk Manag 2008; 4: 575-596.
    • (2008) Vasc Health Risk Manag , vol.4 , pp. 575-596
    • Ban, C.R.1    Twigg, S.M.2
  • 4
    • 0346895089 scopus 로고    scopus 로고
    • Tubulo-interstitial changes in glomerulopathy. II. Prognostic significance
    • Okon K: Tubulo-interstitial changes in glomerulopathy. II. Prognostic significance. Pol J Pathol 2003; 54: 163-169.
    • (2003) Pol J Pathol , vol.54 , pp. 163-169
    • Okon, K.1
  • 5
    • 34250733867 scopus 로고    scopus 로고
    • The role of tubular epithelial-mesenchymal transition in progressive kidney disease
    • Burns WC, Kantharidis P, Thomas MC: The role of tubular epithelial-mesenchymal transition in progressive kidney disease. Cells Tissues Organs 2007; 185: 222-231.
    • (2007) Cells Tissues Organs , vol.185 , pp. 222-231
    • Burns, W.C.1    Kantharidis, P.2    Thomas, M.C.3
  • 7
    • 0034030142 scopus 로고    scopus 로고
    • TGF signaling by Smad proteins
    • Miyazono K: TGF signaling by Smad proteins. Cytokine Growth Factor Rev 2000; 11: 15-22.
    • (2000) Cytokine Growth Factor Rev , vol.11 , pp. 15-22
    • Miyazono, K.1
  • 8
    • 24944463244 scopus 로고    scopus 로고
    • Transforming growth factor-beta: A key mediator of fibrosis
    • Mauviel A: Transforming growth factor-beta: a key mediator of fibrosis. Methods Mol Med 2005; 117: 69-80.
    • (2005) Methods Mol Med , vol.117 , pp. 69-80
    • Mauviel, A.1
  • 10
    • 0033752717 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor type 1 is a potential target in renal fibrogenesis
    • Rerolle JP, Hertig A, Nguyen G, Sraer JD, Rondeau EP: Plasminogen activator inhibitor type 1 is a potential target in renal fibrogenesis. Kidney Int 2000; 58: 1841-1850.
    • (2000) Kidney Int , vol.58 , pp. 1841-1850
    • Rerolle, J.P.1    Hertig, A.2    Nguyen, G.3    Sraer, J.D.4    Rondeau, E.P.5
  • 11
    • 0033644283 scopus 로고    scopus 로고
    • Analysis of TGF-beta- mediated synthesis of extracellular matrix components
    • Hocevar BA, Howe PH: Analysis of TGF-beta- mediated synthesis of extracellular matrix components. Methods Mol Biol 2000; 142: 55-65.
    • (2000) Methods Mol Biol , vol.142 , pp. 55-65
    • Hocevar, B.A.1    Howe, P.H.2
  • 12
    • 0031438047 scopus 로고    scopus 로고
    • TGF signalling from cell membrane to nucleus through SMAD proteins
    • Heldin C, Miyazono K, ten Dijke P: TGF signalling from cell membrane to nucleus through SMAD proteins. Nature 1997; 390: 465-471.
    • (1997) Nature , vol.390 , pp. 465-471
    • Heldin, C.1    Miyazono, K.2    Ten Dijke, P.3
  • 13
    • 14844337071 scopus 로고    scopus 로고
    • Transforming growth factor-beta and Smad signaling in kidney diseases
    • Wang W, Koka V, Lan HY: Transforming growth factor-beta and Smad signaling in kidney diseases. Nephrology (Carlton) 2005; 10: 48-56.
    • (2005) Nephrology (Carlton) , vol.10 , pp. 48-56
    • Wang, W.1    Koka, V.2    Lan, H.Y.3
  • 14
    • 0026093041 scopus 로고
    • Pharmacology of Curcuma longa
    • Ammon HP, Wahl MA: Pharmacology of Curcuma longa . Planta Med 1991; 57: 1-7.
    • (1991) Planta Med , vol.57 , pp. 1-7
    • Ammon, H.P.1    Ma, W.2
  • 15
  • 16
    • 51349137454 scopus 로고    scopus 로고
    • Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins
    • Kunnumakkara AB, Anand P, Aggarwal BB: Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett 2008; 269: 199-225.
    • (2008) Cancer Lett , vol.269 , pp. 199-225
    • Kunnumakkara, A.B.1    Anand, P.2    Aggarwal, B.B.3
  • 17
    • 55949095821 scopus 로고    scopus 로고
    • Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells
    • Reuter S, Eifes S, Dicato M, Aggarwal BB, Diederich M: Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells. Biochem Pharmacol 2008; 76: 1340-1351.
    • (2008) Biochem Pharmacol , vol.76 , pp. 1340-1351
    • Reuter, S.1    Eifes, S.2    Dicato, M.3    Aggarwal, B.B.4    Diederich, M.5
  • 18
    • 84934442428 scopus 로고    scopus 로고
    • Cancer chemopreventive effects of curcumin
    • Surh YJ, Chun KS: Cancer chemopreventive effects of curcumin. Adv Exp Med Biol 2007; 595: 149-172.
    • (2007) Adv Exp Med Biol , vol.595 , pp. 149-172
    • Surh, Y.J.1    Chun, K.S.2
  • 19
    • 53449094405 scopus 로고    scopus 로고
    • Anticancer and carcinogenic properties of curcumin: Considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent
    • Lopez-Lazaro M: Anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent. Mol Nutr Food Res 2008; 52(suppl 1):S103-S127.
    • (2008) Mol Nutr Food Res , vol.52 , Issue.SUPPL. 1
    • Lopez-Lazaro, M.1
  • 20
    • 84934436057 scopus 로고    scopus 로고
    • Antioxidant and anti-inflammatory properties of curcumin
    • Menon VP, Sudheer AR: Antioxidant and anti-inflammatory properties of curcumin. Adv Exp Med Biol 2007; 595: 105-125.
    • (2007) Adv Exp Med Biol , vol.595 , pp. 105-125
    • Menon, V.P.1    Sudheer, A.R.2
  • 22
    • 16644381984 scopus 로고    scopus 로고
    • Suppression of protein kinase C and nuclear oncogene expression as possible action mechanisms of cancer chemoprevention by curcumin
    • Lin JK: Suppression of protein kinase C and nuclear oncogene expression as possible action mechanisms of cancer chemoprevention by curcumin. Arch Pharm Res 2004; 27: 683-692.
    • (2004) Arch Pharm Res , vol.27 , pp. 683-692
    • Lin, J.K.1
  • 24
    • 59349120231 scopus 로고    scopus 로고
    • Pharmacological basis for the role of curcumin in chronic diseases: An age-old spice with modern targets
    • Aggarwal BB, Sung B: Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol Sci 2009; 30: 85-94.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 85-94
    • Aggarwal, B.B.1    Sung, B.2
  • 25
    • 0033778209 scopus 로고    scopus 로고
    • Curcumin inhibition of bleomycin-induced pulmonary fibrosis in rats
    • Punithavathi D, Venkatesan N, Babu M: Curcumin inhibition of bleomycin-induced pulmonary fibrosis in rats. Br J Pharmacol 2000; 131: 169-172.
    • (2000) Br J Pharmacol , vol.131 , pp. 169-172
    • Punithavathi, D.1    Venkatesan, N.2    Babu, M.3
  • 26
    • 3042766204 scopus 로고    scopus 로고
    • Curcumin blocks multiple sites of the TGF signaling cascade in renal cells
    • Gaedeke J, Noble NA, Border WA: Curcumin blocks multiple sites of the TGF signaling cascade in renal cells. Kidney Int 2004; 66: 112-120.
    • (2004) Kidney Int , vol.66 , pp. 112-120
    • Gaedeke, J.1    Noble, N.A.2    Border, W.A.3
  • 27
    • 33748891024 scopus 로고    scopus 로고
    • Curcumin, the active principle of turmeric (Curcuma longa) , ameliorates diabetic nephropathy in rats
    • Sharma S, Kulkarni SK, Chopra S: Curcumin, the active principle of turmeric (Curcuma longa) , ameliorates diabetic nephropathy in rats. Clin Exp Pharmacol Physiol 2006; 33: 940-945.
    • (2006) Clin Exp Pharmacol Physiol , vol.33 , pp. 940-945
    • Sharma, S.1    Kulkarni, S.K.2    Chopra, S.3
  • 32
    • 34248663955 scopus 로고    scopus 로고
    • The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: Twenty-something years on
    • Chomczynski P, Sacchi N: The single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction: twenty-something years on. Nat Protoc 2006; 1: 581-585.
    • (2006) Nat Protoc , vol.1 , pp. 581-585
    • Chomczynski, P.1    Sacchi, N.2
  • 34
    • 0031762560 scopus 로고    scopus 로고
    • Characterization of protein serine/threonine phosphatase activities in human lung mast cells and basophils
    • Peirce MJ, Munday MR, Peachell PT: Characterization of protein serine/threonine phosphatase activities in human lung mast cells and basophils. Br J Pharmacol 1998; 125: 1095-1101.
    • (1998) Br J Pharmacol , vol.125 , pp. 1095-1101
    • Peirce, M.J.1    Munday, M.R.2    Peachell, P.T.3
  • 35
    • 33747097252 scopus 로고    scopus 로고
    • Protein kinases and phosphatases as therapeutic targets in cancer
    • Ventura JJ, Nebreda AR: Protein kinases and phosphatases as therapeutic targets in cancer. Clin Transl Oncol 2006; 8: 153-160.
    • (2006) Clin Transl Oncol , vol.8 , pp. 153-160
    • Ventura, J.J.1    Nebreda, A.R.2
  • 36
    • 0347993932 scopus 로고    scopus 로고
    • Epithelial to mesenchymal transition in renal fibrogenesis: Pathologic significance, molecular mechanism, and therapeutic intervention
    • Youhua Liu: Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention. J Am Soc Nephrol 2004; 15: 1-12.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 1-12
    • Liu, Y.1
  • 37
    • 0034785496 scopus 로고    scopus 로고
    • Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis
    • Yang J, Liu Y: Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis. Am J Pathol 2001; 159: 1465-1475.
    • (2001) Am J Pathol , vol.159 , pp. 1465-1475
    • Yang, J.1    Liu, Y.2
  • 38
    • 39349094176 scopus 로고    scopus 로고
    • Arkadia regulates TGF-beta signaling during renal tubular epithelial to mesenchymal cell transition
    • Liu FY, Li XZ, Peng YM, Liu H, Liu YH: Arkadia regulates TGF-beta signaling during renal tubular epithelial to mesenchymal cell transition. Kidney Int 2008; 73: 588-594.
    • (2008) Kidney Int , vol.73 , pp. 588-594
    • Liu, F.Y.1    Li, X.Z.2    Peng, Y.M.3    Liu, H.4    Liu, Y.H.5
  • 39
    • 54049158139 scopus 로고    scopus 로고
    • Transforming growth factor-beta requires its target plasminogen activator inhibitor-1 for cytostatic activity
    • Kortlever RM, Nijwening JH, Bernards R: Transforming growth factor-beta requires its target plasminogen activator inhibitor-1 for cytostatic activity. J Biol Chem 2008; 283: 24308-24313.
    • (2008) J Biol Chem , vol.283 , pp. 24308-24313
    • Kortlever, R.M.1    Nijwening, J.H.2    Bernards, R.3
  • 40
    • 63849095053 scopus 로고    scopus 로고
    • PAI-1 and kidney fibrosis
    • Ma LJ, Fogo AB: PAI-1 and kidney fibrosis. Front Biosci 2009; 14: 2028-2041.
    • (2009) Front Biosci , vol.14 , pp. 2028-2041
    • Ma, L.J.1    Fogo, A.B.2
  • 41
    • 34247539528 scopus 로고    scopus 로고
    • A tale of two proteins: Differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling
    • Brown KA, Pietenpol JA, Moses HL: A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling. J Cell Biochem 2007; 101: 9-33.
    • (2007) J Cell Biochem , vol.101 , pp. 9-33
    • Brown, K.A.1    Pietenpol, J.A.2    Moses, H.L.3
  • 42
    • 68949101788 scopus 로고    scopus 로고
    • Connective tissue growth factor is a Smad2 regulated amplifier of transforming growth factor beta actions in hepatocytes - But without modulating bone morphogenetic protein 7 signaling
    • Gressner OA, Lahme B, Siluschek M, Rehbein K, Weiskirchen R, Gressner AM: Connective tissue growth factor is a Smad2 regulated amplifier of transforming growth factor beta actions in hepatocytes - but without modulating bone morphogenetic protein 7 signaling. Hepatology 2009; 49: 2021-2030.
    • (2009) Hepatology , vol.49 , pp. 2021-2030
    • Gressner, O.A.1    Lahme, B.2    Siluschek, M.3    Rehbein, K.4    Weiskirchen, R.5    Gressner, A.M.6
  • 44
    • 47949130101 scopus 로고    scopus 로고
    • Role of the murine organic anion-transporting polypeptide 1b2 (Oatp1b2) in drug disposition and hepatotoxicity
    • Evers R, Chu XY: Role of the murine organic anion-transporting polypeptide 1b2 (Oatp1b2) in drug disposition and hepatotoxicity. Mol Pharmacol 2008; 74: 309-311.
    • (2008) Mol Pharmacol , vol.74 , pp. 309-311
    • Evers, R.1    Chu, X.Y.2
  • 45
    • 42149136754 scopus 로고    scopus 로고
    • Characterization of organic anion transporting polypeptide 1b2-null mice: Essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR
    • Lu H, Choudhuri S, Ogura K, Csanaky IL, Lei X, Cheng X, Song PZ, Klaassen CD: Characterization of organic anion transporting polypeptide 1b2-null mice: essential role in hepatic uptake/toxicity of phalloidin and microcystin-LR. Toxicol Sci 2008; 103: 35-45.
    • (2008) Toxicol Sci , vol.103 , pp. 35-45
    • Lu, H.1    Choudhuri, S.2    Ogura, K.3    Csanaky, I.L.4    Lei, X.5    Cheng, X.6    Song, P.Z.7    Klaassen, C.D.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.