New thalidomide analogues derived through Sonogashira or Suzuki reactions and their TNF expression inhibition profiles

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 2, 2010, Pages 650-662

  Stewart, Scott G ^a   Braun, Carlos J ^a   Ng, Sze Ling ^a   Polomska, Marta E ^a   Karimi, Mahdad ^a   Abraham, Lawrence J ^a  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

Author keywords

Sonogashira reaction; Suzuki reaction; Thalidomide; TNF expression inhibition; Tumour necrosis factor (TNF)

Indexed keywords

(2,6 DIOXOPIPERIDIN 3 YL) 4 PARA TOLYLISOINDOLE 1,3 DIONE; (2,6 DIOXOPIPERIDIN 3 YL) 4 PHENYLISOINDOLE 1,3 DIONE; 2 (2,6 DIOXOPIPERIDIN 3 YL) 4 (3 HYDROXY 3 METHYL BUT 1 YNYL)ISOINDOLINE 1,3 DIONE; 2 (2,6 DIOXOPIPERIDIN 3 YL) 4 (3 HYDROXYPROP 1 YNYL)ISOINDOLINE 1,3 DIONE; 2 (2,6 DIOXOPIPERIDIN 3 YL) 4 (4 HYDROXYPHENYL)ISOINDOLINE 1,3 DIONE; 2 (2,6 DIOXOPIPERIDIN 3 YL) 4 (4 ISOBUTYLPHENYL)ISOINDOLINE 1,3 DIONE; 2 (2,6 DIOXOPIPERIDIN 3 YL) 4 (4 ISOPROPOXYPHENYL)ISOINDOLINE 1,3 DIONE; 2 (2,6 DIOXOPIPERIDIN 3 YL) 4 IODOISOINDOLE 1,3 DIONE; 2 (2,6 DIOXOPIPERIDIN 3 YL) 4 PHENYLETHYNYLISO ISOINDOLINE 1,3 DIONE; 2 (2,6 DIOXOPIPERIDIN 3 YL) 5 (3 HYDROXY 3 METHYLBUT 1 YNYL)ISOINDOLINE 1,3 DIONE; 2 (2,6 DIOXOPIPERIDIN 3 YL) 5 (3 HYDROXYPROP 1 YNYL)ISOINDOLINE 1,3 DIONE; 2 (2,6 DIOXOPIPERIDIN 3 YL) 5 (4 HYDROXYPHENYL)ISOINDOLINE 1,3 DIONE; 2 (2,6 DIOXOPIPERIDIN 3 YL) 5 (4 ISOBUTYLPHENYL)ISOINDOLINE 1,3 DIONE; 2 (2,6 DIOXOPIPERIDIN 3 YL) 5 (4 ISOPROPOXYPHENYL)ISOINDOLINE 1,3 DIONE; 2 (2,6 DIOXOPIPERIDIN 3 YL) 5 [3 (METHYLAMINO)PROP 1 YNYL]ISOINDOLINE 1,3 DIONE; 2 (2,6 DIOXOPIPERIDIN 3 YL) 5 PARA TOLYLISOINDOLE 1,3 DIONE; 2 (2,6 DIOXOPIPERIDIN 3 YL) 5 PHENYLETHYNYLISOINDOLE 1,3 DIONE; 2 (2,6 DIOXOPIPERIDIN 3 YL) 5 PHENYLISOINDOLE 1,3 DIONE; 3 [2 (2,6 DIOXOPIPERIDIN 3 YL) 1,3 DIOXOISOINDOLIN 5 YL]ISOINDOLINE 1,3 DIONE; 4 (2,6 DIOXOPIPERIDIN 3 YL) 1,3 DIOXOISOINDOLIN 4 YL)BENZAMIDE; 4 (3,3 DIMETHYLBUT 1 YNYL) 2 (2,6 DIOXOPIPERIDIN 3 YL)ISOINDOLINE 1,3 DIONE; 4 (4 ACETYLPHENYL) 2 (2,6 DIOXOPIPERIDIN 3 YL)ISOINDOLINE 1,3 DIONE; 4 [2 (2,6 DIOXOPIPERIDIN 3 YL) 1,3 DIOXOISOINDOLIN 5 YL]BENZAMIDE; 5 (3,3 DIMETHYLBUT 1 YNYL) 2 (2,6 DIOXOPIPERIDIN 3 YL)ISOINDOLINE 1,3 DIONE; 5 (4 ACETYLPHENYL) 2 (2,6 DIOXOPIPERIDIN 3 YL)ISOINDOLINE 1,3 DIONE; 5 BROMO 2 (2,6 DIOXOPIPERIDIN 3 YL) ISOINDOLE 1,3 DIONE; 6 [2 (2,6 DIOXOPIPERIDIN 3 YL) 1,3 DIOXOISOINDOLI 4 YL]HEX 5 YNENITRILE; 6 [2 (2,6 DIOXOPIPERIDIN 3 YL) 1,3 DIOXOISOINDOLI 5 YL]HEX 5 YNENITRILE; THALIDOMIDE DERIVATIVE; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG INHIBITION; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IMMUNOMODULATION; POLYMERASE CHAIN REACTION; PROTEIN EXPRESSION; SONOGASHIRA REACTION; STRUCTURE ACTIVITY RELATION; SUZUKI REACTION; T LYMPHOCYTE;

CELL DEATH; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION PROFILING; HUMANS; MOLECULAR STRUCTURE; POLYMERASE CHAIN REACTION; RNA, MESSENGER; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THALIDOMIDE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 76449098891     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2009.12.001     Document Type: Article

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