Endothelial nitric oxide synthase activity involves in the protective effect of ascorbic acid against penicillin-induced epileptiform activity

Seizure

Volumn 19, Issue 2, 2010, Pages 102-108

  Yildirim, Mehmet ^a   Ayyildiz, Mustafa ^a   Agar, Erdal ^a  

^a ONDOKUZ MAYIS UNIVERSITY   (Turkey)

Author keywords

7 NI; Ascorbic acid; ECoG; Experimental epilepsy; l Arginine; l NAME

Indexed keywords

7 NITROINDAZOLE; ARGININE; ASCORBIC ACID; ENDOTHELIAL NITRIC OXIDE SYNTHASE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PENICILLIN G;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; ENZYME ACTIVITY; EPILEPSY; EPILEPTIC DISCHARGE; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORIMOTOR CORTEX;

ANALYSIS OF VARIANCE; ANIMALS; ANTIOXIDANTS; ARGININE; ASCORBIC ACID; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG INTERACTIONS; ELECTROENCEPHALOGRAPHY; ENZYME INHIBITORS; EPILEPSY; FREE RADICAL SCAVENGERS; INDAZOLES; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PENICILLINS; RATS; RATS, WISTAR;

EID: 76349102556     PISSN: 10591311     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.seizure.2009.12.005     Document Type: Article

References (64)

1. Dichter M.A. The epilepsies and convulsive disorders. In: Isselbacher K.J. (Ed). Harrison's principles of internal medicine (1994), McGraw-Hill, New York 2223-2233
2. Avanzini G., and Franceschetti S. Cellular biology of epileptogenesis. Lancet 2 (2003) 33-42
3. Braugher J.M., and Hall E.D. Central nervous system trauma and stroke: I. Biochemical considerations for oxygen radical formation and lipid peroxidation. Free Rad Biol Med 6 (1989) 289-301
4. Mori A., Hiramatsu M., Yokoi I., and Edamatsu R. Biochemical pathogenesis of post-traumatic epilepsy. Pav J Biol Sci 25 (1990) 54-62
5. Lapin I.P., Mirzaev S.M., Ryzov I.V., and Oxenkrug G.F. Anticonvulsant activity of melatonin against seizures induced by quinolinate, kainate, glutamate, NMDA, and pentylenetetrazole in mice. J Pineal Res 24 (1998) 215-218
6. Murashima Y.L., Kasamo K., and Suzuki J. Antiepileptic effects of allopurinol on EL mice associated with changes in SOD isoenzyme activities. Epilepsy Res 32 (1998) 254-265
7. Arzimanoglou A., Hirsch E., Nehlig A., Castelnau P., Gressens P., and De Vasconcelos A.P. Epilepsy and neuroprotection: an illustrated review. Epileptic Disord 3 (2002) 173-182
8. Yamamoto N., Kabuto H., Matsumoto S., Ogawa N., and Yokoi I. α-Tocopheryl-l-ascorbate-2-O-phosphate diester, a hydroxyl radical scavenger, prevents the occurrence of epileptic foci in a rat model of post-traumatic epilepsy. Pathophysiology 8 (2002) 205-214
9. Oliveira M.S., Furian A.F., Royes L.F.F., Fighera M.R., De Carvalho J., Fiorenza N.G., et al. Ascorbate modulates pentylenetetrazol-induced convulsions biphasically. Neuroscience 128 (2004) 721-728
10. Foksinski M., Gackowski D., Rozaski R., Siomek A., Guz J., Szpila A., et al. Effects of basal level of antioxidants on oxidative DNA damage in humans. Eur J Nutr 46 3 (2007) 174-180
11. Ayyildiz M., Coskun S., Yildirim M., and Agar E. The effect of ascorbic acid on penicillin-induced epileptiform activity in rats. Epilepsia 48 7 (2007) 1388-1395
12. Tolbert L.C., Thomas T.N., Middaugh L.D., and Zemp J.W. Effect of ascorbic acid on neurochemical, behavioral, and physiological systems mediated by catecholamines. Life Sci 25 (1979) 2189-2195
13. Pierce R.C., Rowlett J.K., Rebec G.V., and Bardo M.T. Ascorbate potentiates amphetamine-induced conditioned place preference and forebrain dopamine release in rats. Brain Res 688 (1995) 21-26
14. Wilson R.L., Kamata K., Wightman R.M., and Rebec G.V. Unilateral, intranigral infusions of amphetamine produce differential changes in unit activity and extracellular levels of ascorbate in the neostriatum of the rat. Brain Res 384 (1986) 342-347
15. Moncada S., Palmer R.M.J., and Higgs E.A. Biosynthesis of nitric oxide from l-arginine. A pathway for the regulation of cell function and communication. Biochem Pharmacol 38 (1989) 1709-1715
16. Garthwaite J. Glutamate, nitric oxide and cell-cell signalling in the nervous system. Trends Neurosci 14 (1991) 60-67
17. Moncada S., Palmer R.M.J., and Higgs E.A. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev 43 (1991) 109-142
18. Kaneko K., Itoh K., Berliner L.J., Miyasaka K., and Fujii H. Consequences of nitric oxide generation in epileptic-seizure rodent models as studied by in vivo EPR. Magn Reson Med 48 (2002) 1051-1056
19. Ferraro G., and Sardo P. Nitric oxide and brain hyperexcitability. In Vivo 18 (2004) 357-366
20. Buisson A., Lackhmeche N., Verrecia C., Plotkine M., and Bolou R.G. Nitric oxide: an endogenous anticonvulsant substance. Neuroreport 4 (1993) 444-446
21. Marangoz C., Ayyildiz M., and Agar E. Evidence that sodium nitroprusside possesses anticonvulsant effects mediated through nitric oxide. Neuroreport 5 (1994) 2454-2456
22. De Sarro G.B., Gareri P., Falconi U., and De Sarro A. 7-Nitroindazole potentiates the antiseizure activity of some anticonvulsants in DBA/2 mice. Eur J Pharmacol 394 (2000) 275-288
23. De Sarro G.B., Donato Di Paola E., De Sarro A., and Vidal M.J. Role of nitric oxide in the genesis of excitatory amino acid-induced seizures from the deep prepiriform cortex. Fundam Clin Pharmacol 5 (1991) 503-511
24. Herberg L.J., Grottick A., and Rose I.C. Nitric oxide synthesis, epileptic seizures and kindling. Psychopharmacol 119 (1995) 115-123
25. Milatovic D., Gupta R.C., and Dettbarn W.-D. Involvement of nitric oxide in kainic acid-induced excitotoxicity in rat brain. Brain Res 957 (2002) 330-337
26. Penix L.P., Davis W., and Subramaniam S. Inhibition of NO synthase increases the severity of kainic acid-induced seizures in rodents. Epilepsy Res 18 (1994) 177-184
27. Ferraro G., Montalbano M.E., and La Grutta V. NO and hippocampal epilepsy: an electrophysiological evidence of a new modulatory system. Epilepsia 38 (1997) 190-191
28. Noh H.S., Kim D.W., Cho G.J., Choi W.S., and Kang S.S. Increased nitric oxide caused by the ketogenic diet reduces the onset time of kainic acid-induced seizures in ICR mice. Brain Res 1075 (2006) 193-200
29. Royes L.F., Fighera M.R., Furian A.F., Oliveira M.S., Fiorenza N.G., Petry J.C., et al. The role of nitric oxide on the convulsive behavior and oxidative stress induced by methylmalonate: an electroencephalographic and neurochemical study. Epilepsy Res 73 3 (2007) 228-237
30. Mulsch A., Busse R., Mordvintcev P.I., Vanin A.F., Nielsen E.O., Scheel-Kruger J., et al. Nitric oxide promotes seizure activity in kainate-treated rats. Neuroreport 5 (1994) 2325-2328
31. Smith S.E., Man C.M., Yip P.K., Tang E., Chapman A.G., and Meldrum B.S. Anticonvulsant effects of 7-nitroindazole in rodents with reflex epilepsy may result from l-arginine accumulation or a reduction in nitric oxide or l-citrulline formation. Br J Pharmacol 119 (1996) 165-173
32. Yasuda H., Fuji M., Fujisawa H., Ito H., and Suzuki M. Changes in nitric oxide synthesis and epileptic activity in the contralateral hippocampus of rats following intrahippocampal kainate injection. Epilepsia 42 (2001) 13-20
33. G-nitroarginine methyl ester, an inhibitor of nitric oxide synthase, upon the anticonvulsive activity of conventional antiepileptic drugs against maximal electroshock in mice. J Neural Transm 105 (1998) 1-12
34. Homayoun H., Khavandgar S., Namiranian K., Gaskari S.A., and Dehpour A.R. The role of nitric oxide in anticonvulsant and proconvulsant effects of morphine in mice. Epilepsy Res 48 (2002) 33-41
35. Bosnak M., Ayyildiz M., Yildirim M., and Agar E. The role of nitric oxide in the anticonvulsant effects of pyridoxine on penicillin-induced epileptiform activity in rats. Epilepsy Res 76 (2007) 49-59
36. Akula K.K., Dhir A., and Kulkarni S.K. Nitric oxide signaling pathway in the anti-convulsant effect of adenosine against pentylenetetrazol-induced seizure threshold in mice. Eur J Pharmacol 587 (2008) 129-134
37. Matsumura N., Kikuchi-Utsumi K., and Nakaki T. Activities of 7-nitroindazole and 1-(2-(trifluoromethylphenyl)-imidazole independent of neuronal nitric-oxide synthase inhibition. J Pharmacol Exp Ther 325 (2008) 357-362
38. Yahyavi-Firouz-Abadi N., Tahsili-Fahadan P., Riazi K., Ghahremani M.H., and Dehpour A.R. Involvement of nitric oxide pathway in the acute anticonvulsant effect of melatonin in mice. Epilepsy Res 68 (2006) 103-113
39. Wyler A.R., and Ward Jr. A.A. Epileptic neurons. In: Lockard J., and Ward Jr. A.A. (Eds). Epilepsy: a window to brain mechanisms (1980), Raven Press, New York 51-68
40. Ayyildiz M., Yildirim M., and Agar E. The effect of vitamin E on penicillin-induced epileptiform activity in rats. Exp Brain Res 174 (2006) 109-113
41. Chavko M., Auker C.R., and McCarron R.M. Relationship between protein nitration and oxidation and development of hyperoxic seizures. Nitric Oxide 9 (2003) 18-23
42. Holmes O., Wallace M.N., and Campbell A.M. Comparison of penicillin epileptogenesis in rat somatosensory and motor cortex. Q J Exp Physiol 72 (1987) 439-452
43. Prince D.A. Topical convulsant drugs and metabolic antagonists. In: Purpura D.P., Penry J.K., Tower D.B., Woodbury D.M., and Walter R.D. (Eds). Experimental models of epilepsy (1972), Raven Press, New York 51-83
44. Matsumoto H., and Ajmonemarsan C. Cellular mechanisms in experimental epileptic seizures. Science 10 144 (1964) 193-194
45. Shin E.J., Suh S.K., Lim Y.K., Jhoo W.K., Hjelle O.P., Ottersen O.P., et al. Ascorbate attenuates trimethyltin-induced oxidative burden and neuronal degeneration in the rat hippocampus by maintaining glutathione homeostasis. Neuroscience 133 (2005) 715-727
46. Przegalinski E., Baran L., and Siwanowicz J. The role of nitric oxide in chemically- and electrically-induced seziures in mice. Neurosci Lett 217 (1996) 145-148
47. Kabuto H., Yokoi I., Habu H., Willmore L.J., Mori A., and Ogawa N. Reduction in nitric oxide synthase activity with development of an epileptogenic focus induced by ferric chloride in the rat brain. Epilepsy Res 25 (1996) 65-68
48. Itoh K., and Watanabe M. Paradoxical facilitation of pentylenetetrazole-induced convulsion susceptibility in mice lacking neuronal nitric oxide synthase. Neuroscience 159 (2009) 735-743
49. Yahyavi-Firouz-Abadi N., Tahsili-Fahadan P., Riazi K., Ghahremani M.H., and Dehpour A.R. Melatonin enhances the anticonvulsant and proconvulsant effects of morphine in mice: role for nitric oxide signaling pathway. Epilepsy Res 75 (2007) 138-144
50. G-nitro-l-arginine differentially affects glutamate or kainate-induced seizures. Neuroreport 7 (1996) 1605-1608
51. Jones P.A., Smith R.A., and Stone T.W. Nitric oxide synthase inhibitors l-NAME and 7-nitroindazole protect rat hippocampus against kainate-induced toxicity. Neurosci Lett 249 (1998) 75-78
52. Homayoun H., Khavandgar S., and Dehpour A.R. Anticonvulsant effects of cyclosporin A on pentylenetetrazole-induced seizure and kindling: modulation by nitricoxidergic system. Brain Res 939 (2002) 1-10
53. Ayyildiz M., Yildirim M., and Agar E. The involvement of nitric oxide in the anticonvulsant effects of α-tocopherol on penicillin-induced epileptiform activity in rats. Epilepsy Res 73 (2007) 166-172
54. Lallement G., Shih T.M., Pernot-Marino I., Baubichon D., Foquin A., and McDonough J.H. The role of nitric oxide in soman-induced seizures, neuropathology, and lethality. Pharmacol Biochem Behav 54 (1996) 731-737
55. Sardo P., D'Agostino S., Rizzo V., Carletti F., Lonobile G., and Ferraro G. In the rat maximal dentate activation model of partial complex epilepsy, the anticonvulsant activity of levetiracetam is modulated by nitric oxide-active drugs. J Neural Transm 116 7 (2009) 831-839
56. Borowicz K.K., Kleinrok Z., and Czuczwar S.J. 7-Nitroindazole, differentially affects the anticonvulsant activity of antiepileptic drugs against amygdala-kindled seizures in rats. Epilepsia 41 (2000) 1112-1118
57. G-nitro-l-arginine impairs the anticonvulsive action of ethosuximide against pentylenetetrazol. Eur J Pharmacol 366 (1999) 137-142
58. Corda M., Orlandi M., Lecca D., Carboni G., Frau V., and Giorgi O. Pentylenetetrazol-induced kindling in rats: effect of GABA function inhibitors. Pharmacol Biochem Behav 40 (1991) 329-333
59. Löscher W. Basic aspects of epilepsy. Curr Opin Neurol Neurosurg 6 2 (1993) 223-232
60. Meldrum B.S. Excitatory amino acid receptors and their role in epilepsy and cerebral ischemia. Ann N Y Acad Sci 757 (1995) 492-505
61. Tsuda A., Ito M., Kishi K., Shiraishi H., Tsuda H., and Mori C. Effect of penicillin on GABA-gated chloride ion influx. Neurochem Res 19 1 (1994) 1-4
62. Jayakumar A.R., Sujatha R., Paul V., Asokan C., Govindasamy S., and Jayakumar R. Role of nitric oxide on GABA, glutamic acid, activities of GABA-T and GAD in rat brain cerebral cortex. Brain Res 837 1-2 (1999) 229-235
63. Li D.P., Chen S.R., Finnegan T.F., and Pan H.L. Signalling pathway of nitric oxide in synaptic GABA release in the rat paraventricular nucleus. J Physiol 554 Pt 1 (2004) 100-110
64. Sershen H., Debler E.A., and Lajtha A. Effect of ascorbic acid on the synaptosomal uptake of [3H]MPP+, [3H]dopamine, and [14C]GABA. J Neurosci Res 17 3 (1987) 298-301