Ascorbate attenuates trimethyltin-induced oxidative burden and neuronal degeneration in the rat hippocampus by maintaining glutathione homeostasis

Neuroscience

Volumn 133, Issue 3, 2005, Pages 715-727

  Shin, E J ^a   Suh, S K ^b   Lim, Y K ^a   Jhoo, W K ^a   Hjelle, O P ^c   Ottersen, O P ^c   Shin, C Y ^d   Ko, K H ^d   Kim, W K ^e   Kim, D S ^b   Chun, W ^a   Ali, S ^f   Kim, H C ^a  

^a Kangwon National University   (South Korea)

^b Korea Food and Drug Administration   (South Korea)

^c UNIVERSITY OF OSLO   (Norway)

^d Seoul National University   (South Korea)

^e Ewha Womans University School of Medicine   (South Korea)

^f CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Ascorbate; Glutathione homeostasis; Hippocampus; Neuronal degeneration; Oxidative burdens; Trimethyltin

Indexed keywords

ASCORBIC ACID; CARBONYL DERIVATIVE; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTATHIONE; HYDROXYL RADICAL; MALONALDEHYDE; TRIMETHYLTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ASTROCYTE; CELL LABELING; CELL LOSS; CONCENTRATION RESPONSE; CONTROLLED STUDY; GLIA CELL; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; NERVE CELL DEGENERATION; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; PYRAMIDAL NERVE CELL; RAT; SEIZURE;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; ASTROCYTES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; EPILEPSY; GLIAL FIBRILLARY ACIDIC PROTEIN; GLUTATHIONE; GLUTATHIONE DISULFIDE; HIPPOCAMPUS; HOMEOSTASIS; HYDROXYL RADICAL; MALONDIALDEHYDE; NERVE DEGENERATION; NEURONS; OXIDATIVE STRESS; RATS; RATS, SPRAGUE-DAWLEY; TRIMETHYLTIN COMPOUNDS;

EID: 20444371352     PISSN: 03064522     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2005.02.030     Document Type: Article

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