Declining prevalence of diabetes mellitus in hereditary haemochromatosis-The result of earlier diagnosis

Diabetes Research and Clinical Practice

Volumn 81, Issue 3, 2008, Pages 316-320

  O'Sullivan, E P ^a   McDermott, J H ^b   Murphy, M S ^c   Sen, S ^d   Walsh, C H ^a  

^a SOUTH INFIRMARY VICTORIA UNIVERSITY HOSPITAL   (Ireland)

^b Royal College of Surgeons in Ireland   (Ireland)

^c UNIVERSITY HOSPITAL GALWAY   (Ireland)

^d NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Diabetes; Hereditary haemochromatosis; Prevalence

Indexed keywords

FERRITIN;

ADULT; ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; FERRITIN BLOOD LEVEL; GENE MUTATION; GENETIC ANALYSIS; HEMOCHROMATOSIS; HUMAN; LIVER BIOPSY; MAJOR CLINICAL STUDY; MALE; PHYSICIAN; PREVALENCE;

DIABETES MELLITUS; DIABETIC ANGIOPATHIES; DIABETIC NEUROPATHIES; DIABETIC RETINOPATHY; FEMALE; FERRITINS; GLUCOSE INTOLERANCE; HEMOCHROMATOSIS; HUMANS; LIVER CIRRHOSIS; MALE; PREVALENCE; PROTEINURIA;

EID: 49049087287     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2008.05.001     Document Type: Article

References (21)

1. Sheldon J.H. Haemochromatosis (1935), Oxford University Press, London
2. Feder J.N., Gnirke A., Thomas W., Tsuchihashi Z., Ruddy D.A., Basava A., et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat. Genet. 13 (1996) 399-408
3. Lassman M.N., Genel M., Wise J.K., Hendler R., and Felig P. Carbohydrate homeostasis and pancreatic islet cell function in thalassaemia. Ann. Intern. Med. 80 (1974) 60-65
4. Rahier J., Loozen S., Goebbels R.M., and Abrahem M. The haemochromatotic human pancreas: a quantitative immunohistochemical and ultrastructural study. Diabetologia 30 (1987) 5-12
5. Tuomainen T.P., Nyyssonen K., Salonen R., Tervahauta A., Korpela H., Lakka T., et al. Body iron stores are associated with serum insulin and blood glucose concentrations: population study in 1,013 eastern Finnish men. Diabetes Care 20 (1997) 426-428
6. Fernandez-Real J.M., Penarroja G., Castro A., Garcia-Bragado F., Hernandez I., and Ricart W. Blood letting in high-ferritin type 2 diabetes: effects on insulin sensitivity and β-cell function. Diabetes 51 (2002) 1000-1004
7. Byrnes V., Ryan E., Mayne P., and Crowe J. Neonatal screening for the HFE mutations in the Irish population. Gut 1 (1999) 527A
8. Merryweather-Clarke A.T., Pointon J.J., Shearman J.D., and Robson K.J. Global prevalence of putative haemochromatosis mutations. J. Med. Genet. 34 (1997) 275-278
9. World Health Organization Expert Committee on Diabetes Mellitus: Second Report, Technical Report 646, World Health Organization, Geneva, Switzerland, 1980.
10. Dymock I.W., Cassar J., Pyke D.A., Oakley W.G., and Williams R. Observations on the pathogenesis, complications and treatment of diabetes in 115 cases of haemochromatosis. Am. J. Med. 52 (1972) 203-210
11. Niederau C., Strohmeyer G., and Stremmel W. Epidemiology, clinical spectrum and prognosis of hemochromatosis. Adv. Exp. Med. Biol. 356 (1994) 293-302
12. Buysschaert M., Paris I., Selvais P., and Hermans M.P. Clinical aspects of diabetes secondary to idiopathic haemochromatosis in French-speaking Belgium. Diabetes Metab. 23 (1997) 308-313
13. Niederau C., Fischer R., Purschel A., Stremmel W., Haussinger D., and Strohmeyer G. Long-term survival in patients with hereditary haemochromatosis. Gastroenterology 110 (1996) 1107-1119
14. Stremmel W., Niederau C., Berger M., Kley H.K., Kruskemper H.L., and Strohmeyer G. Abnormalities in estrogen, androgen, and insulin metabolism in idiopathic hemochromatosis. Ann. NY Acad. Sci. 526 (1988) 209-223
15. McDermott J.H., and Walsh C.H. Hypogonadism in hereditary hemochromatosis. J. Clin. Endocrinol. Metab. 90 (2005) 2451-2455
16. McClain D.A., Abraham D., Rogers J., Brady R., Gault P., Ajioka R., et al. High prevalence of abnormal glucose homeostasis secondary to decreased insulin secretion in individuals with hereditary haemochromatosis. Diabetologia 49 (2006) 1661-1669
17. Jackson H.A., Carter K., Darke C., Guttridge M.G., Ravine D., Hutton R.D., et al. HFE mutations, iron deficiency and overload in 10,500 blood donors. Br. J. Haematol. 114 (2001) 474-484
18. Burt M.J., George P.M., Upton J.D., Collett J.A., Frampton C.M., Chapman T.M., et al. The significance of haemochromatosis gene mutations in the general population: implications for screening. Gut 43 (1998) 830-836
19. Tavill A.S., American Association for the Study of Liver Diseases, American College of Gastroenterology, and American Gastroenterological Association. Diagnosis and management of hemochromatosis. Hepatology 33 (2001) 1321-1328
20. Guyader D., Jacquelinet C., Moirand R., Turlin B., Mendler M.H., Chaperon J., et al. Noninvasive prediction of fibrosis in C282Y homozygous hemochromatosis. Gastroenterology 115 (1998) 929-936
21. Facchini F.S. Effect of phlebotomy on plasma glucose and insulin concentrations. Diabetes Care 21 (1998) 2190