N-linked glycosylation is essential for the stability but not the signaling function of the interleukin-6 signal transducer glycoprotein 130

Journal of Biological Chemistry

Volumn 285, Issue 3, 2010, Pages 1781-1789

  Waetzig, Georg H ^a   Chalaris, Athena ^b   Rosenstiel, Philip ^b   Suthaus, Jan ^b   Holland, Christin ^a   Karl, Nadja ^a   Uriarte, Lorena Vallés ^a   Till, Andreas ^b   Scheller, Jürgen ^b   Grötzinger, Joachim ^b   Schreiber, Stefan ^b,c   Rose John, Stefan ^b   Seegert, Dirk ^a  

^a CONARIS Research Institute AG ^*  (Germany)

^b UNIVERSITY OF KIEL   (Germany)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACES; CYTOKINES; EXTRACELLULAR DOMAINS; FUSION PROTEINS; GLYCOSYLATED; IN-VITRO; INTERLEUKIN-6; N-GLYCOSYLATION; N-GLYCOSYLATION SITES; N-LINKED GLYCANS; N-LINKED GLYCOSYLATION; PLASMA MEMBRANES; POTENTIAL SITES; PROTEASOMES; PROTEIN STRUCTURES; SIGNAL TRANSDUCERS; SIGNALING FUNCTIONS; TARGET SIGNALS; TRANSDUCING; WILD TYPES;

AMINO ACIDS; CELL MEMBRANES; ESTERIFICATION; GLYCOPROTEINS; GLYCOSYLATION; PROTEINS; TRANSDUCERS;

SIGNALING;

ASPARAGINASE; GLUTAMINE; GLYCOPROTEIN; GLYCOPROTEIN 130; HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G1; INTERLEUKIN 6; INTERLEUKIN 6 RECEPTOR; PROTEASOME; STAT3 PROTEIN; UNCLASSIFIED DRUG; GLYCOPROTEIN 130, HUMAN; GLYCOPROTEIN GP 130; IMMUNOGLOBULIN G; LIGAND; NITROGEN; OXYGEN;

ANIMAL CELL; ARTICLE; CELL MEMBRANE TRANSPORT; CELL SURFACE; CONTROLLED STUDY; EMBRYO; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN GLYCOSYLATION; PROTEIN STABILITY; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; WILD TYPE; ANIMAL; CELL LINE; CHEMISTRY; CRICETULUS; GENE DELETION; GENETICS; GLYCOSYLATION; HAMSTER; METABOLISM; MOUSE;

ANIMALS; CELL LINE; CRICETINAE; CRICETULUS; CYTOKINE RECEPTOR GP130; GLYCOPROTEINS; GLYCOSYLATION; HUMANS; IMMUNOGLOBULIN G; INTERLEUKIN-6; LIGANDS; MICE; NITROGEN; OXYGEN; PROTEIN STABILITY; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; SEQUENCE DELETION; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR;

EID: 76249113764     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.075952     Document Type: Article

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