Phosphatidylinositol Triphosphate Kinase-dependent and c-Jun NH 2-Terminal Kinase-dependent Induction of Telomerase by Calcium Requires Pyk2

Cancer Research

Volumn 64, Issue 1, 2004, Pages 23-26

  Alfonso De Matte, Michelle Y ^a   Kruk, Patricia A ^a,b  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; FOCAL ADHESION KINASE 2; PHOSPHATIDYLINOSITOL 4 PHOSPHATE KINASE; STRESS ACTIVATED PROTEIN KINASE; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

ARTICLE; CALCIUM SIGNALING; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME REGULATION; EPITHELIUM CELL; HUMAN; HUMAN CELL; OVARY; PRIORITY JOURNAL; PROMOTER REGION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANISOMYCIN; CALCIUM; CELL LINE; CHROMONES; DNA-BINDING PROTEINS; EDETIC ACID; ENZYME INDUCTION; ENZYME INHIBITORS; EPITHELIAL CELLS; FEMALE; FOCAL ADHESION KINASE 2; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MORPHOLINES; OVARIAN NEOPLASMS; OVARY; PROTEIN-TYROSINE KINASES; RECOMBINANT PROTEINS; TELOMERASE; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 1642576239     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-03-2820     Document Type: Article

References (18)

1. Stanzione, R., Picascia, A., Chieffi, P., Imbimbo, C., Palmeri, A., Mirone, V., Staibano, S., Franco. R., De Rosa, G., Schlessinger, J., and Tramontano, D. Variations of proline-rich kinase Pyk2 expression correlate with prostate cancer progression. Lab. Investig., 81: 51-59, 2001.
2. Blume-Jensen, P., and Hunter, T. Oncogenic kinase signaling. Nature (Lond.), 411: 355-365, 2001.
3. Zrihan-Licht, S., Fu, Y., Senleman, J., Schinkmann, K., Shaw, L., Keydar, I., Avraham, S., and Avraham, H. RAFTK/Pyk2 kinase mediates the association of p190 RhoGAP with RasGap and is involved in breast cancer cell invasion. Oncogene, 19: 1318-1328, 2000.
4. Tokiwa, G., Dikic, I., Lev, S., and Schlessinger, J. Activation of Pyk2 by stress signals and coupling with JNK signaling pathway. Science, 273: 792-794, 1996.
5. Dikic, I., Tokiwa, G., Lev, S., Courtneidge, S. A., and Schlessinger, J. A role for Pyk2 and Src in linking G-protein-coupled receptors with map kinase activation. Nature (Lond.), 383: 547-550, 1996.
6. Alfonso-De Matte, M. Y., Cheng, J. Q., and Kruk, P. A. Ultraviolet Irradiation- and dimethyl sulfoxide-induced telomerase activity in ovarian epithelial cell lines. Exp. Cell Res., 267: 13-27, 2001.
7. 2-terminal kinase in ovarian surface epithelial cells. Cancer Res., 62: 4575-4578, 2002.
8. Alfonso-De Matte, M. Y., Moses-Soto, H., and Kruk, P. A. Calcium-mediated telomerase activity in ovarian epithelial cells. Arch. Biochem. Biophys., 399: 239-244, 2002.
9. Maines-Bandiera, S. L., Kruk, P. A., and Auersperg, N. Simian virus 40-transformed human ovarian surface epithelial cells escape normal growth controls but retain morphogenetic responses to extracellular matrix. Am. J. Obstet. Gynecol., 167: 729-735, 1992.
10. Vlahos, C. J., Matter. W. F., Hui, K. Y., and Brown, R. F. A specific inhibitor of phosphatidylinositol 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction. J. Biol. Chem., 269: 5241-5248, 1994.
11. Baranick, M., Htun, P., and Shaper, W. Okadaic acid and anisomycin are protective and stimulate the SAPK/JNK pathway. J. Card. Pharm., 34: 182-190, 2000.
12. Takakura, M., Kyo, S., Kanaya, T., Hirano, H., Takeda, J., Yutsudo, M., and Inoue. M. Cloning of human catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. Cancer Res., 59: 551-557, 2000.
13. Hobson, S. A., McNeil, S. E., Lee, F., and Rodland, K. D. Signal transduction mechanisms linking increased extracellular calcium to proliferation in ovarian epithelial cells. Exp. Cell Res., 258: 1-11, 2000.
14. Fathalla, M. F. Incesant ovulation - a factor in ovarian neoplasia? Lancet. 2: 163, 1971.
15. Lowry, S., Russell, H., Hickey, I., and Atkinson, R. Incessant ovulation and ovarian cancer: III. Oral contraceptive use. Int. J. Cancer. 49: 61-65, 1991.
16. Auersperg, N., Edelson, M. I., Mok, S. C., Johnson, S. W., and Hamilton, T. C. The biology of ovarian cancer. Semin. Oncol., 25: 281-304, 1998.
17. Parker, S. L., Tong, T., and Bolder, S. Cancer statistics. Cancer J. Clin., 47: 5-27, 1997.
18. Satoru, K., and Inoue, M. Complex regulatory mechanisms of telomerase activity in normal and cancer cells: how can we apply them for cancer therapy? Oncogene, 21: 688-697, 2002.