Safety and efficacy of levetiracetam for critically Ill patients with seizures

Neurocritical Care

Volumn 11, Issue 1, 2009, Pages 34-37

  Nau, Karen M ^a   Divertie, Gavin D ^a   Valentino, Alden K ^a   Freeman, William D ^a  

^a MAYO CLINIC   (United States)

Author keywords

Antiepileptic drugs; Intensive care units; Levetiracetam; Seizures; Status epilepticus

Indexed keywords

BENZODIAZEPINE; CREATININE; ETIRACETAM; FOSPHENYTOIN SODIUM; PHENYTOIN; ANTICONVULSIVE AGENT; DRUG DERIVATIVE; PIRACETAM;

ADULT; ARTICLE; COMBINATION CHEMOTHERAPY; CREATININE BLOOD LEVEL; CRITICAL ILLNESS; DRUG EFFICACY; DRUG SAFETY; FEMALE; HEART ARRHYTHMIA; HEMODYNAMIC STRESS; HEMODYNAMICS; HOSPITAL ADMISSION; HUMAN; LIVER FUNCTION; LOADING DRUG DOSE; MAINTENANCE DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; PRIORITY JOURNAL; PROPHYLAXIS; SEIZURE; SIDE EFFECT; TREATMENT DURATION; AGED; DRUG EFFECT; EPILEPSY; INTENSIVE CARE; KIDNEY; METHODOLOGY; MIDDLE AGED; PHYSIOLOGY; RETROSPECTIVE STUDY;

ADULT; AGED; ANTICONVULSANTS; CRITICAL ILLNESS; EPILEPSY; FEMALE; HUMANS; INTENSIVE CARE; KIDNEY; MALE; MIDDLE AGED; PIRACETAM; RETROSPECTIVE STUDIES;

EID: 70349329265     PISSN: 15416933     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12028-009-9185-0     Document Type: Article

References (15)

1. PN Varelas M Spanaki 2006 Management of seizures in the critically ill Neurologist 12 3 127 39 10.1097/01.nrl.0000195827.34370.63 16688014 10.1097/01.nrl.0000195827.34370.63 (Pubitemid 43756310)
2. T De Smedt R Raedt K Vonck P Boon 2007 Levetiracetam: part II, the clinical profile of a novel anticonvulsant drug CNS Drug Rev 13 1 57 78 10.1111/j.1527-3458.2007.00005.x 17461890 10.1111/j.1527-3458.2007.00005.x (Pubitemid 46705269)
3. MU Farooq B Naravetla A Majid R Gupta JJ Pysh MY Kassab 2007 IV levetiracetam in the management of non-convulsive status epilepticus Neurocrit Care 7 1 36 9 10.1007/s12028-007-0022-z 17657655 10.1007/s12028-007-0022-z (Pubitemid 350242677)
4. JP Szaflarski JM Meckler M Szaflarski LA Shutter MD Privitera SL Yates 2007 Levetiracetam use in critically ill patients Neurocrit Care 7 2 140 7 10.1007/s12028-007-0042-8 17607530 10.1007/s12028-007-0042-8 (Pubitemid 350242663)
5. M Falip M Carreno S Amaro A Donaire R Delgado M Toledo, et al. 2006 Use of levetiracetam in hospitalized patients Epilepsia 47 12 2186 8 10.1111/j.1528-1167.2006.00850.x 17201722 10.1111/j.1528-1167.2006.00850.x 1:CAS:528:DC%2BD2sXhsVSltrs%3D (Pubitemid 44952276)
6. Keppra (levetiracetam) (package insert). Smyrna (GA): USB, Inc.; 2008.
7. PN Patsalos 2000 Pharmacokinetic profile of levetiracetam: toward ideal characteristics Pharmacol Ther 85 2 77 85 10.1016/S0163-7258(99)00052-2 10722121 10.1016/S0163-7258(99)00052-2 1:CAS:528:DC%2BD3cXosFSnsA%3D%3D (Pubitemid 30069478)
8. J French C Arrigo 2005 Rapid onset of action of levetiracetam in refractory epilepsy patients Epilepsia 46 2 324 6 10.1111/j.0013-9580.2005. 31504.x 15679515 10.1111/j.0013-9580.2005.31504.x 1:CAS:528:DC%2BD2MXitFGnt7s%3D (Pubitemid 40194678)
9. D Sirsi JE Safdieh 2007 The safety of levetiracetam Expert Opin Drug Saf 6 3 241 50 10.1517/14740338.6.3.241 17480174 10.1517/14740338.6.3.241 1:CAS:528:DC%2BD2sXkvV2rt7k%3D (Pubitemid 46767632)
10. S Ramael A Daoust C Otoul N Toublanc M Troenaru ZS Lu, et al. 2006 Levetiracetam intravenous infusion: a randomized, placebo-controlled safety and pharmacokinetic study Epilepsia 47 7 1128 35 10.1111/j.1528-1167.2006.00586.x 16886975 10.1111/j.1528-1167.2006.00586.x 1:CAS:528:DC%2BD28XpsFeitro%3D (Pubitemid 44086747)
11. SM Sisodiya JW Sander PN Patsalos 2002 Carbamazepine toxicity during combination therapy with levetiracetam: a pharmacodynamic interaction Epilepsy Res 48 3 217 9 10.1016/S0920-1211(01)00309-6 11904240 10.1016/S0920-1211(01) 00309-6 1:CAS:528:DC%2BD38XitFWms7s%3D (Pubitemid 34252906)
12. D Weintraub R Buchsbaum SR Resor Jr LJ Hirsch 2007 Psychiatric and behavioral side effects of the newer antiepileptic drugs in adults with epilepsy Epilepsy Behav 10 1 105 10 10.1016/j.yebeh.2006.08.008 17079191 10.1016/j.yebeh.2006.08.008 1:STN:280:DC%2BD2s%2Flt1aitg%3D%3D (Pubitemid 46132156)
13. S Ruegg Y Naegelin M Hardmeier DT Winkler S Marsch P Fuhr 2008 Intravenous levetiracetam: treatment experience with the first 50 critically ill patients Epilepsy Behav 12 3 477 80 10.1016/j.yebeh.2008.01.004 18291724 10.1016/j.yebeh.2008.01.004
14. EF Wijdicks FW Sharbrough 1993 New-onset seizures in critically ill patients Neurology 43 5 1042 4 8492924 1:STN:280:DyaK3s3mtFGrtg%3D%3D
15. J Claassen SA Mayer RG Kowalski RG Emerson LJ Hirsch 2004 Detection of electrographic seizures with continuous EEG monitoring in critically ill patients Neurology 62 10 1743 8 15159471 1:STN:280:DC%2BD2c3mtVaqsg%3D%3D