Making autophagosomes: Localized synthesis of phosphatidylinositol 3-phosphate holds the clue

Autophagy

Volumn 4, Issue 8, 2008, Pages 1093-1096

  Walker, Simon ^a   Chandra, Priya ^a   Manifava, Maria ^a   Axe, Elizabeth ^a   Ktistakis, Nicholas T ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

Autophagosome; Autophagy; Endoplasmic reticulum; Live imaging; PI3P

Indexed keywords

ADRENOCHROME; AMINO ACID; BINDING PROTEIN; ERBIUM; PHOSPHATIDYLINOSITOL 3 PHOSPHATE; PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOPHAGY; CELL ORGANELLE; DYNAMICS; ENDOPLASMIC RETICULUM; LYSOSOME; MEMBRANE VESICLE; NONHUMAN; PHAGOSOME; PROTEIN DEGRADATION; PROTEIN MALNUTRITION; PROTEIN TRANSPORT; RAT; SYNTHESIS;

EID: 58149097286     PISSN: 15548627     EISSN: 15548635     Source Type: Journal    
DOI: 10.4161/auto.7141     Document Type: Article

References (22)

1. Axe EL, Walker SA, Manifava M, Chandra P, Roderick HL, Habermann A, et al. Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. J Cell Biol 2008; 182:685-701.
2. Mizushima N. Autophagy: process and function. Genes Dev 2007; 21:2861-73.
3. Levine B, Klionsky DJ. Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 2004; 6:463-77.
4. Klionsky DJ. Autophagy: from phenomenology to molecular understanding in less than a decade. Nat Rev Mol Cell Biol 2007; 8:931-7.
5. Suzuki K, Ohsumi Y. Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae. FEBS Lett 2007; 581:2156-61.
6. Xie Z, Klionsky DJ. Autophagosome formation: core machinery and adaptations. Nat Cell Biol 2007; 9:1102-9.
7. Lindmo K, Stenmark H. Regulation of membrane traffic by phosphoinositide 3-kinases. J Cell Sci 2006; 119:605-14.
8. Obara K, Ohsumi Y. Dynamics and function of PtdIns(3)P in autophagy. Autophagy 2008; 4:952-4.
9. Petiot A, Ogier-Denis E, Blommaart EF, Meijer AJ, Codogno P. Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells. J Biol Chem 2000; 275:992-8.
10. Kihara A, Noda T, Ishihara N, Ohsumi Y. Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J Cell Biol 2001; 152:519-30.
11. Byfield MP, Murray JT, Backer JM. hVps34 is a Nutrient-regulated lipid kinase required for activation of p70 S6-kinase. J Biol Chem 2005; 280:33076-82.
12. Juhász G, Hill JH, Yan Y, Sass M, Baehrecke EH, Backer JM, et al. The class III PI(3)K Vps34 promotes autophagy and endocytosis but not TOR signaling in Drosophila. J Cell Biol 2008; 181:655-66.
13. Blommaart EF, Krause U, Schellens JP, Vreeling-Sindelarova H, Meijer AJ. The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur J Biochem 1997; 243:240-6.
14. Juhász G, Neufeld TP. Autophagy: a forty-year search for a missing membrane source. PLoS Biol 2006; 4:e36.
15. Reunanen H, Hirsimaki P. Studies on vinblastine-induced autophagocytosis in mouse liver. IV. Origin of membranes. Histochemistry 1983; 79:59-67.
16. Dunn WA, Jr. Studies on the mechanisms of autophagy: formation of the autophagic vacuole. J Cell Biol 1990; 110:1923-33.
17. Ueno T, Muno D, Kominami E. Membrane markers of endoplasmic reticulum preserved in autophagic vacuolar membranes isolated from leupeptin-administered rat liver. J Biol Chem 1991; 266:18995-9.
18. Mizushima N, Yamamoto A, Hatano M, Kobayashi Y, Kabeya Y, Suzuki K, et al. Dissection of autophagosome formation using Apg5-deficient mouse embryonic stem cells. J Cell Biol 2001; 152:657-68.
19. Reggiori F, Klionsky DJ. Autophagosomes: biogenesis from scratch? Curr Opin Cell Biol 2005; 17:415-22.
20. Gillooly DJ, Morrow IC, Lindsay M, Gould R, Bryant NJ, Gaullier JM, et al. Localization of phosphatidylinositol 3-phosphate in yeast and mammalian cells. EMBO J 2000; 19:4577-88.
21. Ridley SH, Ktistakis N, Davidson K, Anderson KE, Manifava M, Ellson CD, et al. FENS-1 and DFCP1 are FYVE domain-containing proteins with distinct functions in the endosomal and Golgi compartments. J Cell Sci 2001; 114:3991-4000.
22. Caro LH, Plomp PJ, Leverve XM, Meijer AJ. A combination of intracellular leucine with either glutamate or aspartate inhibits autophagic proteolysis in isolated rat hepatocytes. Eur J Biochem 1989; 181:717-20.