Improved dissolution of an insoluble drug using a 4-fluid nozzle spray-drying technique

Chemical and Pharmaceutical Bulletin

Volumn 52, Issue 9, 2004, Pages 1066-1070

  Chen, Richer ^a   Tagawa, Maya ^a   Hoshi, Noboru ^b   Ogura, Toshihiro ^b   Okamoto, Hirokazu ^c   Danjo, Kazumi ^c  

^a Mingtai Chemical Co Ltd   (Taiwan)

^b Nisshin Kasei Co Ltd   (Japan)

^c MEIJO UNIVERSITY   (Japan)

Author keywords

Amorphous; Hydroxypropylmethylcellulose (HPMC); Solubility; Spray drying; Tolubutamide

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE; TOLBUTAMIDE; ANTIDIABETIC AGENT; DRUG CARRIER; DRUG DERIVATIVE; METHYLCELLULOSE;

ACIDITY; ARTICLE; ATOM; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG RELEASE; DRUG SOLUBILITY; LIQUID; MORPHOLOGY; PARTICLE SIZE; SCANNING ELECTROCHEMICAL MICROSCOPY; SOLID; SPRAY DRYING; X RAY DIFFRACTION; CHEMICAL MODEL; CHEMISTRY; CRYSTALLIZATION; DRUG DOSAGE FORM; INSTRUMENTATION; KINETICS; PHARMACEUTICS; SCANNING ELECTRON MICROSCOPY; SOLUBILITY;

CRYSTALLIZATION; DOSAGE FORMS; DRUG CARRIERS; HYPOGLYCEMIC AGENTS; KINETICS; METHYLCELLULOSE; MICROSCOPY, ELECTRON, SCANNING; MODELS, CHEMICAL; PARTICLE SIZE; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; TOLBUTAMIDE;

EID: 16644366133     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.52.1066     Document Type: Article

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