Design of porous microparticles with single-micron size by novel spray freeze-drying technique using four-fluid nozzle

International Journal of Pharmaceutics

Volumn 382, Issue 1-2, 2009, Pages 88-97

  Niwa, Toshiyuki ^a   Shimabara, Hiroko ^a   Kondo, Masahiro ^a   Danjo, Kazumi ^a  

^a MEIJO UNIVERSITY   (Japan)

Author keywords

Four fluid nozzle; Liquid nitrogen; Porous microparticles; Solubilization; Spray freeze drying

Indexed keywords

LIQUID NITROGEN; PHENYTOIN;

ACIDITY; ARTICLE; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; FREEZE DRYING; MICROCRYSTALLINE SUSPENSION; PARTICLE SIZE; POROSITY; PRIORITY JOURNAL;

AEROSOLS; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; EQUIPMENT DESIGN; FREEZE DRYING; HYDROGEN-ION CONCENTRATION; KINETICS; METHYLCELLULOSE; PARTICLE SIZE; PHENYTOIN; POLYMETHACRYLIC ACIDS; POROSITY; SOLUBILITY; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL;

EID: 70350211854     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.08.011     Document Type: Article

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