메뉴 건너뛰기




Volumn 23, Issue 1, 2010, Pages 199-203

p53 independent radio-sensitization of human lymphoblastoid cell lines by Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin

Author keywords

17 allylamino 17 demethoxygeldanamycin; Heat shock protein 90; p53 status; Radiation

Indexed keywords

HEAT SHOCK PROTEIN 90; PROTEIN P53; TANESPIMYCIN;

EID: 76049120956     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or-00000623     Document Type: Article
Times cited : (10)

References (37)
  • 1
    • 0029887140 scopus 로고    scopus 로고
    • The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding
    • Freeman BC and Morimoto RI: The human cytosolic molecular chaperones hsp90, hsp70 (hsc70) and hdj-1 have distinct roles in recognition of a non-native protein and protein refolding. EMBO J 15: 2969-2979, 1996.
    • (1996) EMBO J , vol.15 , pp. 2969-2979
    • Freeman, B.C.1    Morimoto, R.I.2
  • 2
    • 0141484615 scopus 로고    scopus 로고
    • A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors
    • Kamal A, Thao L, Sensintaffar J, et al: A high-affinity conformation of Hsp90 confers tumour selectivity on Hsp90 inhibitors. Nature 425: 407-410, 2003.
    • (2003) Nature , vol.425 , pp. 407-410
    • Kamal, A.1    Thao, L.2    Sensintaffar, J.3
  • 3
    • 36048975114 scopus 로고    scopus 로고
    • Inhibition of Hsp90 function by ansamycins causes down-regulation of cdc2 and cdc25c and G(2)/M arrest in glioblastoma cell lines
    • Garcia-Morales P, Carrasco-Garcia E, Ruiz-Rico P, et al: Inhibition of Hsp90 function by ansamycins causes down-regulation of cdc2 and cdc25c and G(2)/M arrest in glioblastoma cell lines. Oncogene 26: 7185-7193, 2007.
    • (2007) Oncogene , vol.26 , pp. 7185-7193
    • Garcia-Morales, P.1    Carrasco-Garcia, E.2    Ruiz-Rico, P.3
  • 4
    • 37549060720 scopus 로고    scopus 로고
    • Targeting Cdc37 inhibits multiple signaling pathways and induces growth arrest in prostate cancer cells
    • Gray PJ Jr, Stevenson MA and Calderwood SK: Targeting Cdc37 inhibits multiple signaling pathways and induces growth arrest in prostate cancer cells. Cancer Res 67: 11942-11950, 2007.
    • (2007) Cancer Res , vol.67 , pp. 11942-11950
    • Gray Jr, P.J.1    Stevenson, M.A.2    Calderwood, S.K.3
  • 5
    • 0035793546 scopus 로고    scopus 로고
    • Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90
    • Xu W, Mimnaugh E, Rosser MF, et al: Sensitivity of mature Erbb2 to geldanamycin is conferred by its kinase domain and is mediated by the chaperone protein Hsp90. J Biol Chem 276: 3702-3708, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 3702-3708
    • Xu, W.1    Mimnaugh, E.2    Rosser, M.F.3
  • 6
    • 0030925683 scopus 로고    scopus 로고
    • Steroid receptor interactions with heat shock protein and immunophilin chaperones
    • Pratt WB and Toft DO: Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocr Rev 18: 306-360, 1997.
    • (1997) Endocr Rev , vol.18 , pp. 306-360
    • Pratt, W.B.1    Toft, D.O.2
  • 7
    • 0029145215 scopus 로고
    • Geldanamycin selectively destabilizes and conformationally alters mutated p53
    • Blagosklonny MV, Toretsky J and Neckers L: Geldanamycin selectively destabilizes and conformationally alters mutated p53. Oncogene 11: 933-939, 1995.
    • (1995) Oncogene , vol.11 , pp. 933-939
    • Blagosklonny, M.V.1    Toretsky, J.2    Neckers, L.3
  • 8
    • 34548189523 scopus 로고    scopus 로고
    • Extracellular heat shock protein 90: A role for a molecular chaperone in cell motility and cancer metastasis
    • Tsutsumi S and Neckers L: Extracellular heat shock protein 90: a role for a molecular chaperone in cell motility and cancer metastasis. Cancer Sci 98: 1536-1539, 2007.
    • (2007) Cancer Sci , vol.98 , pp. 1536-1539
    • Tsutsumi, S.1    Neckers, L.2
  • 9
    • 33846861747 scopus 로고    scopus 로고
    • Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitors
    • Powers MV and Workman P: Targeting of multiple signalling pathways by heat shock protein 90 molecular chaperone inhibitors. Endocr Relat Cancer 13 (Suppl 1): S125-S135, 2006.
    • (2006) Endocr Relat Cancer , vol.13 , Issue.SUPPL. 1
    • Powers, M.V.1    Workman, P.2
  • 10
    • 43149087334 scopus 로고    scopus 로고
    • Heat shock proteins: New target in cytoprotective and tumor therapy
    • Bao XQ and Liu GT: Heat shock proteins: new target in cytoprotective and tumor therapy. Yao Xue Xue Bao 43: 234-240, 2008.
    • (2008) Yao Xue Xue Bao , vol.43 , pp. 234-240
    • Bao, X.Q.1    Liu, G.T.2
  • 11
    • 0029812759 scopus 로고    scopus 로고
    • Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin
    • Mimnaugh EG, Chavany C and Neckers L: Polyubiquitination and proteasomal degradation of the p185c-erbB-2 receptor protein-tyrosine kinase induced by geldanamycin. J Biol Chem 271: 22796-22801, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 22796-22801
    • Mimnaugh, E.G.1    Chavany, C.2    Neckers, L.3
  • 12
    • 0031054517 scopus 로고    scopus 로고
    • The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase
    • Stancato LF, Silverstein AM, Owens-Grillo JK, et al: The hsp90-binding antibiotic geldanamycin decreases Raf levels and epidermal growth factor signaling without disrupting formation of signaling complexes or reducing the specific enzymatic activity of Raf kinase. J Biol Chem 272: 4013-4020, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 4013-4020
    • Stancato, L.F.1    Silverstein, A.M.2    Owens-Grillo, J.K.3
  • 13
    • 30344435264 scopus 로고    scopus 로고
    • Heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin potentiates the radiation response of tumor cells grown as monolayer cultures and spheroids by inducing apoptosis
    • Machida H, Nakajima S, Shikano N, et al: Heat shock protein 90 inhibitor 17-allylamino-17-demethoxygeldanamycin potentiates the radiation response of tumor cells grown as monolayer cultures and spheroids by inducing apoptosis. Cancer Sci 96: 911-917, 2005.
    • (2005) Cancer Sci , vol.96 , pp. 911-917
    • Machida, H.1    Nakajima, S.2    Shikano, N.3
  • 14
    • 9144261127 scopus 로고    scopus 로고
    • Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity
    • Bisht KS, Bradbury CM, Mattson D, et al: Geldanamycin and 17-allylamino-17-demethoxygeldanamycin potentiate the in vitro and in vivo radiation response of cervical tumor cells via the heat shock protein 90-mediated intracellular signaling and cytotoxicity. Cancer Res 63: 8984-8995, 2003.
    • (2003) Cancer Res , vol.63 , pp. 8984-8995
    • Bisht, K.S.1    Bradbury, C.M.2    Mattson, D.3
  • 15
    • 33750696349 scopus 로고    scopus 로고
    • Inhibition of homologous recombination repair in irradiated tumor cells pretreated with Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin
    • Noguchi M, Yu D, Hirayama R, et al: Inhibition of homologous recombination repair in irradiated tumor cells pretreated with Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin. Biochem Biophys Res Commun 351: 658-663, 2006.
    • (2006) Biochem Biophys Res Commun , vol.351 , pp. 658-663
    • Noguchi, M.1    Yu, D.2    Hirayama, R.3
  • 16
    • 20044384168 scopus 로고    scopus 로고
    • Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer
    • Goetz MP, Toft D, Reid J, et al: Phase I trial of 17-allylamino-17-demethoxygeldanamycin in patients with advanced cancer. J Clin Oncol 23: 1078-1087, 2005.
    • (2005) J Clin Oncol , vol.23 , pp. 1078-1087
    • Goetz, M.P.1    Toft, D.2    Reid, J.3
  • 17
    • 0028171454 scopus 로고
    • p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents
    • Fan S, el-Deiry WS, Bae I, et al: p53 gene mutations are associated with decreased sensitivity of human lymphoma cells to DNA damaging agents. Cancer Res 54: 5824-5830, 1994.
    • (1994) Cancer Res , vol.54 , pp. 5824-5830
    • Fan, S.1    el-Deiry, W.S.2    Bae, I.3
  • 18
    • 0027109075 scopus 로고
    • Cancer. p53, guardian of the genome
    • Lane DP: Cancer. p53, guardian of the genome. Nature 358: 15-16, 1992.
    • (1992) Nature , vol.358 , pp. 15-16
    • Lane, D.P.1
  • 19
    • 34247485373 scopus 로고    scopus 로고
    • P53-dependent radio-sensitizing effects of Hsp90 inhibitor 17-allylamino-17- demethoxygeldanamycin on human oral squamous cell carcinoma cell lines
    • Shintani S, Zhang T, Aslam A, et al: P53-dependent radio-sensitizing effects of Hsp90 inhibitor 17-allylamino-17- demethoxygeldanamycin on human oral squamous cell carcinoma cell lines. Int J Oncol 29: 1111-1117, 2006.
    • (2006) Int J Oncol , vol.29 , pp. 1111-1117
    • Shintani, S.1    Zhang, T.2    Aslam, A.3
  • 20
    • 0028944890 scopus 로고
    • Altered p53 status correlates with differences in sensitivity to radiation-induced mutation and apoptosis in two closely related human lymphoblast lines
    • Xia F, Wang X, Wang YH, et al: Altered p53 status correlates with differences in sensitivity to radiation-induced mutation and apoptosis in two closely related human lymphoblast lines. Cancer Res 55: 12-15, 1995.
    • (1995) Cancer Res , vol.55 , pp. 12-15
    • Xia, F.1    Wang, X.2    Wang, Y.H.3
  • 21
    • 0027410190 scopus 로고
    • Different cytotoxic and mutagenic responses induced by X-rays in two human lymphoblastoid cell lines derived from a single donor
    • Amundson SA, Xia F, Wolfson K, et al: Different cytotoxic and mutagenic responses induced by X-rays in two human lymphoblastoid cell lines derived from a single donor. Mutat Res 286: 233-241, 1993.
    • (1993) Mutat Res , vol.286 , pp. 233-241
    • Amundson, S.A.1    Xia, F.2    Wolfson, K.3
  • 22
    • 0028144964 scopus 로고
    • Different capacities for recombination in closely related human lymphoblastoid cell lines with different mutational responses to X-irradiation
    • Xia F, Amundson SA, Nickoloff JA, et al: Different capacities for recombination in closely related human lymphoblastoid cell lines with different mutational responses to X-irradiation. Mol Cell Biol 14: 5850-5857, 1994.
    • (1994) Mol Cell Biol , vol.14 , pp. 5850-5857
    • Xia, F.1    Amundson, S.A.2    Nickoloff, J.A.3
  • 23
    • 0019404906 scopus 로고
    • Quantitative assay for mutation in diploid human lymphoblasts using microtiter plates
    • Furth EE, Thilly WG, Penman BW, et al: Quantitative assay for mutation in diploid human lymphoblasts using microtiter plates. Anal Biochem 110: 1-8, 1981.
    • (1981) Anal Biochem , vol.110 , pp. 1-8
    • Furth, E.E.1    Thilly, W.G.2    Penman, B.W.3
  • 24
    • 0029664346 scopus 로고    scopus 로고
    • Chromosomal radiosensitivity in G2-phase lymphocytes as an indicator of cancer predisposition
    • Scott D, Spreadborough AR, Jones LA, et al: Chromosomal radiosensitivity in G2-phase lymphocytes as an indicator of cancer predisposition. Radiat Res 145: 3-16, 1996.
    • (1996) Radiat Res , vol.145 , pp. 3-16
    • Scott, D.1    Spreadborough, A.R.2    Jones, L.A.3
  • 25
    • 0033358577 scopus 로고    scopus 로고
    • Heritability of cellular radiosensitivity: A marker of low-penetrance predisposition genes in breast cancer?
    • Roberts SA, Spreadborough AR, Bulman B, et al: Heritability of cellular radiosensitivity: a marker of low-penetrance predisposition genes in breast cancer? Am J Hum Genet 65: 784-794, 1999.
    • (1999) Am J Hum Genet , vol.65 , pp. 784-794
    • Roberts, S.A.1    Spreadborough, A.R.2    Bulman, B.3
  • 26
    • 0032905029 scopus 로고    scopus 로고
    • Increased chromosomal radiosensitivity in breast cancer patients: A comparison of two assays
    • Scott D, Barber JB, Spreadborough AR, et al: Increased chromosomal radiosensitivity in breast cancer patients: a comparison of two assays. Int J Radiat Biol 75: 1-10, 1999.
    • (1999) Int J Radiat Biol , vol.75 , pp. 1-10
    • Scott, D.1    Barber, J.B.2    Spreadborough, A.R.3
  • 27
    • 9744236616 scopus 로고    scopus 로고
    • Enhanced tumor cell radio-sensitivity and abrogation of G2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin
    • Bull EE, Dote H, Brady KJ, et al: Enhanced tumor cell radio-sensitivity and abrogation of G2 and S phase arrest by the Hsp90 inhibitor 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin. Clin Cancer Res 10: 8077-8084, 2004.
    • (2004) Clin Cancer Res , vol.10 , pp. 8077-8084
    • Bull, E.E.1    Dote, H.2    Brady, K.J.3
  • 28
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr JF, Wyllie AH and Currie AR: Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26: 239-257, 1972.
    • (1972) Br J Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 29
    • 0029166882 scopus 로고
    • Mimosine is a potent clastogen in primary and transformed hamster fibroblasts but not in primary or transformed human lymphocytes
    • Jha AN, Hande PM, Mullenders LH, et al: Mimosine is a potent clastogen in primary and transformed hamster fibroblasts but not in primary or transformed human lymphocytes. Mutagenesis 10: 385-391, 1995.
    • (1995) Mutagenesis , vol.10 , pp. 385-391
    • Jha, A.N.1    Hande, P.M.2    Mullenders, L.H.3
  • 30
    • 0036896782 scopus 로고    scopus 로고
    • Suppression of apoptosis and clonogenic survival in irradiated human lymphoblasts with different TP53 status
    • Schafer J, Bachtler J, Engling A, et al: Suppression of apoptosis and clonogenic survival in irradiated human lymphoblasts with different TP53 status. Radiat Res 158: 699-706, 2002.
    • (2002) Radiat Res , vol.158 , pp. 699-706
    • Schafer, J.1    Bachtler, J.2    Engling, A.3
  • 31
    • 0030915269 scopus 로고    scopus 로고
    • Abrogation of p53 function by HPV16 E6 gene delays apoptosis and enhances mutagenesis but does not alter radiosensitivity in TK6 human lymphoblast cells
    • Yu Y, Li CY and Little JB: Abrogation of p53 function by HPV16 E6 gene delays apoptosis and enhances mutagenesis but does not alter radiosensitivity in TK6 human lymphoblast cells. Oncogene 14: 1661-1667, 1997.
    • (1997) Oncogene , vol.14 , pp. 1661-1667
    • Yu, Y.1    Li, C.Y.2    Little, J.B.3
  • 32
    • 33748363502 scopus 로고    scopus 로고
    • The heat shock protein 90 inhibitor 17-AAG induces cell cycle arrest and apoptosis in mantle cell lymphoma cell lines by depleting cyclin D1, Akt, Bid and activating caspase 9
    • Georgakis GV, Li Y and Younes A: The heat shock protein 90 inhibitor 17-AAG induces cell cycle arrest and apoptosis in mantle cell lymphoma cell lines by depleting cyclin D1, Akt, Bid and activating caspase 9. Br J Haematol 135: 68-71, 2006.
    • (2006) Br J Haematol , vol.135 , pp. 68-71
    • Georgakis, G.V.1    Li, Y.2    Younes, A.3
  • 33
    • 0346996448 scopus 로고    scopus 로고
    • Heat shock protein 90 suppresses tumor necrosis factor alpha induced apoptosis by preventing the cleavage of Bid in NIH3T3 fibroblasts
    • Zhao C and Wang E: Heat shock protein 90 suppresses tumor necrosis factor alpha induced apoptosis by preventing the cleavage of Bid in NIH3T3 fibroblasts. Cell Signal 16: 313-321, 2004.
    • (2004) Cell Signal , vol.16 , pp. 313-321
    • Zhao, C.1    Wang, E.2
  • 34
    • 0026318356 scopus 로고
    • Participation of p53 protein in the cellular response to DNA damage
    • Kastan MB, Onyekwere O, Sidransky D, et al: Participation of p53 protein in the cellular response to DNA damage. Cancer Res 51: 6304-6311, 1991.
    • (1991) Cancer Res , vol.51 , pp. 6304-6311
    • Kastan, M.B.1    Onyekwere, O.2    Sidransky, D.3
  • 35
    • 0035810054 scopus 로고    scopus 로고
    • Regulation of the G2/M transition by p53
    • Taylor WR and Stark GR: Regulation of the G2/M transition by p53. Oncogene 20: 1803-1815, 2001.
    • (2001) Oncogene , vol.20 , pp. 1803-1815
    • Taylor, W.R.1    Stark, G.R.2
  • 36
    • 35548978945 scopus 로고    scopus 로고
    • The impact of a negligent G2/M checkpoint on genomic instability and cancer induction
    • Lobrich M and Jeggo PA: The impact of a negligent G2/M checkpoint on genomic instability and cancer induction. Nat Rev Cancer 7: 861-869, 2007.
    • (2007) Nat Rev Cancer , vol.7 , pp. 861-869
    • Lobrich, M.1    Jeggo, P.A.2
  • 37
    • 34548223252 scopus 로고    scopus 로고
    • An imperfect G2M checkpoint contributes to chromosome instability following irradiation of S and G2 phase cells
    • Krempler A, Deckbar D, Jeggo PA, et al: An imperfect G2M checkpoint contributes to chromosome instability following irradiation of S and G2 phase cells. Cell Cycle 6: 1682-1686, 2007.
    • (2007) Cell Cycle , vol.6 , pp. 1682-1686
    • Krempler, A.1    Deckbar, D.2    Jeggo, P.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.