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Volumn 12, Issue 2, 2010, Pages 157-167

Improving adeno-associated vector yield in high density insect cell cultures

Author keywords

Adeno associated virus (AAV) vectors; Baculovirus; Fed batch; Gene therapy; High cell density; Insect cells

Indexed keywords

PARVOVIRUS VECTOR;

EID: 76049100861     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.1420     Document Type: Article
Times cited : (31)

References (40)
  • 1
    • 44049094771 scopus 로고    scopus 로고
    • Clinical gene therapy using recombinant adeno-associated virus vectors
    • Mueller C, Flotte TR. Clinical gene therapy using recombinant adeno-associated virus vectors. Gene Ther 2008; 15: 858-863.
    • (2008) Gene Ther , vol.15 , pp. 858-863
    • Mueller, C.1    Flotte, T.R.2
  • 2
    • 34347399599 scopus 로고    scopus 로고
    • Oral vaccination with a viral vector containing Abeta cDNA attenuates age-related Abeta accumulation and memory deficits without causing inflammation in a mouse Alzheimer model
    • Mouri A, Noda Y, Hara H, et al. Oral vaccination with a viral vector containing Abeta cDNA attenuates age-related Abeta accumulation and memory deficits without causing inflammation in a mouse Alzheimer model. FASEB J 2007; 21: 2135-2148.
    • (2007) FASEB J , vol.21 , pp. 2135-2148
    • Mouri, A.1    Noda, Y.2    Hara, H.3
  • 3
    • 44949222522 scopus 로고    scopus 로고
    • Results froma phase I safety trial of hAADC gene therapy for Parkinson disease
    • Eberling JL, Jagust WJ, Christine CW, et al. Results froma phase I safety trial of hAADC gene therapy for Parkinson disease. Neurology 2008; 70: 1980-1983.
    • (2008) Neurology , vol.70 , pp. 1980-1983
    • Eberling, J.L.1    Jagust, W.J.2    Christine, C.W.3
  • 4
    • 34548512049 scopus 로고    scopus 로고
    • Repeated aerosolized AAVCFTR for treatment of cystic fibrosis: A randomized placebo-controlled phase 2B trial
    • Moss RB, Milla C, Colombo J, et al. Repeated aerosolized AAVCFTR for treatment of cystic fibrosis: a randomized placebo-controlled phase 2B trial. Hum Gene Ther 2007; 18: 726-732.
    • (2007) Hum Gene Ther , vol.18 , pp. 726-732
    • Moss, R.B.1    Milla, C.2    Colombo, J.3
  • 5
    • 44049090692 scopus 로고    scopus 로고
    • AAV-mediated gene transfer for the treatment of hemophilia B: Problems and prospects
    • Hasbrouck NC, High KA. AAV-mediated gene transfer for the treatment of hemophilia B: problems and prospects. Gene Ther 2008; 15: 870-875.
    • (2008) Gene Ther , vol.15 , pp. 870-875
    • Hasbrouck, N.C.1    High, K.A.2
  • 6
    • 44249085878 scopus 로고    scopus 로고
    • Safety and efficacy of gene transfer for Leber's congenital amaurosis
    • Maguire AM, Simonelli F, Pierce EA, et al. Safety and efficacy of gene transfer for Leber's congenital amaurosis. N Engl J Med 2008; 358: 2240-2248.
    • (2008) N Engl J Med , vol.358 , pp. 2240-2248
    • Maguire, A.M.1    Simonelli, F.2    Pierce, E.A.3
  • 7
    • 34447134103 scopus 로고    scopus 로고
    • Synoviocyte infection with adeno-associated virus (AAV) is neutralized by human synovial fluid from arthritis patients and depends on AAV serotype
    • Boissier MC, Lemeiter D, Clavel C, et al. Synoviocyte infection with adeno-associated virus (AAV) is neutralized by human synovial fluid from arthritis patients and depends on AAV serotype. Hum Gene Ther 2007; 18: 525-535.
    • (2007) Hum Gene Ther , vol.18 , pp. 525-535
    • Boissier, M.C.1    Lemeiter, D.2    Clavel, C.3
  • 8
    • 0036175095 scopus 로고    scopus 로고
    • Recent advances in recombinant adeno-associated virus vector production
    • Clark KR. Recent advances in recombinant adeno-associated virus vector production. Kidney Int 2002; 61: 9-15.
    • (2002) Kidney Int , vol.61 , pp. 9-15
    • Clark, K.R.1
  • 9
    • 44049108096 scopus 로고    scopus 로고
    • and characterizing AAV-based vectors for use in clinical studies
    • Wright JF. Manufacturing and characterizing AAV-based vectors for use in clinical studies. Gene Ther 2008; 15: 840-848.
    • (2008) Gene Ther , vol.15 , pp. 840-848
    • Manufacturing, W.J.F.1
  • 10
    • 0033054126 scopus 로고    scopus 로고
    • High-titer recombinant adeno-associated virus production utilizing a recombinant herpes simplex virus type I vector expressing AAV-2 Rep and Cap
    • Conway JE, Rhys CM, Zolotukhin I, et al. High-titer recombinant adeno-associated virus production utilizing a recombinant herpes simplex virus type I vector expressing AAV-2 Rep and Cap. Gene Ther 1999; 6: 986-993.
    • (1999) Gene Ther , vol.6 , pp. 986-993
    • Conway, J.E.1    Rhys, C.M.2    Zolotukhin, I.3
  • 11
    • 0036431701 scopus 로고    scopus 로고
    • Insect cells as a factory to produce adeno-associated virus type 2 vectors
    • Urabe M, Ding C, Kotin RM. Insect cells as a factory to produce adeno-associated virus type 2 vectors. Hum Gene Ther 2002; 13: 1935-43.
    • (2002) Hum Gene Ther , vol.13 , pp. 1935-1943
    • Urabe, M.1    Ding, C.2    Kotin, R.M.3
  • 12
    • 13544273326 scopus 로고    scopus 로고
    • Production of recombinant adeno-associated viral vectors using a baculovirus/insect cell suspension culture system: From shake flasks to a 20-L bioreactor
    • Meghrous J, Aucoin MG, Jacob D, et al. Production of recombinant adeno-associated viral vectors using a baculovirus/insect cell suspension culture system: from shake flasks to a 20-L bioreactor. Biotechnol Prog 2005; 21: 154-160.
    • (2005) Biotechnol Prog , vol.21 , pp. 154-160
    • Meghrous, J.1    Aucoin, M.G.2    Jacob, D.3
  • 13
    • 33845207494 scopus 로고    scopus 로고
    • Production of adeno-associated viral vectors in insect cells using triple infection: Optimization of baculovirus concentration ratios
    • Aucoin MG, Perrier M, Kamen AA. Production of adeno-associated viral vectors in insect cells using triple infection: optimization of baculovirus concentration ratios. Biotechnol Bioeng 2006; 95: 1081-92.
    • (2006) Biotechnol Bioeng , vol.95 , pp. 1081-1092
    • Aucoin, M.G.1    Perrier, M.2    Kamen, A.A.3
  • 14
    • 34547619654 scopus 로고    scopus 로고
    • Improving AAV vector yield in insect cells by modulating the temperature after infection
    • Aucoin MG, Perrier M, Kamen AA. Improving AAV vector yield in insect cells by modulating the temperature after infection. Biotechnol Bioeng 2007; 97: 1501-1509.
    • (2007) Biotechnol Bioeng , vol.97 , pp. 1501-1509
    • Aucoin, M.G.1    Perrier, M.2    Kamen, A.A.3
  • 15
    • 36148960860 scopus 로고    scopus 로고
    • Economized large-scale production of high yield of rAAV for gene therapy applications exploiting baculovirus expression system
    • Negrete A, Yang LC, Mendez AF, et al. Economized large-scale production of high yield of rAAV for gene therapy applications exploiting baculovirus expression system. J Gene Med 2007; 9: 938-948.
    • (2007) J Gene Med , vol.9 , pp. 938-948
    • Negrete, A.1    Yang, L.C.2    Mendez, A.F.3
  • 16
    • 36148977618 scopus 로고    scopus 로고
    • Combination of baculovirus-mediated gene delivery and packed-bed reactor for scalable production of adeno-associated virus
    • Huang K-S, Lo W-H, Chung Y-C, et al. Combination of baculovirus-mediated gene delivery and packed-bed reactor for scalable production of adeno-associated virus. Hum Gene Ther 2007; 18: 1161-1170.
    • (2007) Hum Gene Ther , vol.18 , pp. 1161-1170
    • Huang, K.-S.1    Lo, W.-H.2    Chung, Y.-C.3
  • 17
    • 4644346385 scopus 로고    scopus 로고
    • Improving rAAV production and purification: Towards the definition of a scaleable process
    • Blouin V, Brument N, Toublanc EI, et al. Improving rAAV production and purification: towards the definition of a scaleable process. J Gene Med 2004; 6: S223-S228.
    • (2004) J Gene Med , vol.6
    • Blouin, V.1    Brument, N.2    Toublanc, E.I.3
  • 18
    • 36348930054 scopus 로고    scopus 로고
    • Critical assessment of current adeno-associated viral vector production and quantification methods
    • Aucoin MG, Perrier M, Kamen AA. Critical assessment of current adeno-associated viral vector production and quantification methods. Biotechnol Adv 2008; 26: 73-88.
    • (2008) Biotechnol Adv , vol.26 , pp. 73-88
    • Aucoin, M.G.1    Perrier, M.2    Kamen, A.A.3
  • 19
    • 34547115676 scopus 로고    scopus 로고
    • Population kinetics during simultaneous infection of insect cells with two different recombinant baculoviruses for the production of rotavirus-like particles
    • Mena JA, Ramirez OT, Palomares LA. Population kinetics during simultaneous infection of insect cells with two different recombinant baculoviruses for the production of rotavirus-like particles. BMC Biotechnol 2007; 7: 39.
    • (2007) BMC Biotechnol , vol.7 , pp. 39
    • Mena, J.A.1    Ramirez, O.T.2    Palomares, L.A.3
  • 20
    • 0033855097 scopus 로고    scopus 로고
    • A kinetic and statistical-thermodynamic model for baculovirus infection and virus-like particle assembly in suspended insect cells
    • Hu YC, Bentley WE. A kinetic and statistical-thermodynamic model for baculovirus infection and virus-like particle assembly in suspended insect cells. Chem Eng Science 2000; 55: 3991-4008.
    • (2000) Chem Eng Science , vol.55 , pp. 3991-4008
    • Hu, Y.C.1    Bentley, W.E.2
  • 21
    • 28444473059 scopus 로고    scopus 로고
    • Successful production of pseudotyped rAAV vectors using a modified baculovirus expression system
    • Kohlbrenner E, Aslanidi G, Nash K, et al. Successful production of pseudotyped rAAV vectors using a modified baculovirus expression system. Mol Ther 2005; 12: 1217-1225.
    • (2005) Mol Ther , vol.12 , pp. 1217-1225
    • Kohlbrenner, E.1    Aslanidi, G.2    Nash, K.3
  • 22
    • 0141616435 scopus 로고    scopus 로고
    • Virus-like particle production at low multiplicities of infection with the baculovirus insect cell system
    • Maranga L, Brazao TF, Carrondo MJ. Virus-like particle production at low multiplicities of infection with the baculovirus insect cell system. Biotechnol Bioeng 2003; 84: 245-253.
    • (2003) Biotechnol Bioeng , vol.84 , pp. 245-253
    • Maranga, L.1    Brazao, T.F.2    Carrondo, M.J.3
  • 23
    • 44049085243 scopus 로고    scopus 로고
    • Toward exascale production of recombinant adeno-associated virus for gene transfer applications
    • Cecchini S, Negrete A, Kotin RM. Toward exascale production of recombinant adeno-associated virus for gene transfer applications. Gene Ther 2008; 15: 823-830.
    • (2008) Gene Ther , vol.15 , pp. 823-830
    • Cecchini, S.1    Negrete, A.2    Kotin, R.M.3
  • 24
    • 44449114156 scopus 로고    scopus 로고
    • Design of a phase 1/2 trial of intracoronary administration of AAV1/SERCA2a in patients with heart failure
    • Hajjar RJ, Zsebo K, Deckelbaum L, et al. Design of a phase 1/2 trial of intracoronary administration of AAV1/SERCA2a in patients with heart failure. J Card Fail 2008; 14: 355-367.
    • (2008) J Card Fail , vol.14 , pp. 355-367
    • Hajjar, R.J.1    Zsebo, K.2    Deckelbaum, L.3
  • 25
    • 0028719269 scopus 로고
    • Maximization of recombinant protein yield in the insect cell/baculovirus system by one-time addition of nutrients to high-density batch cultures
    • Bedard C, Kamen A, Tom R, et al. Maximization of recombinant protein yield in the insect cell/baculovirus system by one-time addition of nutrients to high-density batch cultures. Cytotechnol 1994; 15: 129-138.
    • (1994) Cytotechnol , vol.15 , pp. 129-138
    • Bedard, C.1    Kamen, A.2    Tom, R.3
  • 26
    • 0034690746 scopus 로고    scopus 로고
    • 7 cells per ml and production of beta-galactosidase at high cell density by fed batch culture. Biotechnol Bioeng 2000; 68: 381-388.
    • 7 cells per ml and production of beta-galactosidase at high cell density by fed batch culture. Biotechnol Bioeng 2000; 68: 381-388.
  • 27
    • 0032123013 scopus 로고    scopus 로고
    • Optimizing fed-batch production of recombinant proteins using the baculovirus expression vector system
    • Chan LCL, Greenfield PF, Reid S. Optimizing fed-batch production of recombinant proteins using the baculovirus expression vector system. Biotechnol Bioeng 1998; 59: 178-188.
    • (1998) Biotechnol Bioeng , vol.59 , pp. 178-188
    • Chan, L.C.L.1    Greenfield, P.F.2    Reid, S.3
  • 28
    • 0027628310 scopus 로고
    • Effects of oxygen/glucose/glutamine feeding on insect cell baculovirus protein expression: A study on epoxide hydrolase production
    • Wang MY, Kwong S, Bentley WE. Effects of oxygen/glucose/glutamine feeding on insect cell baculovirus protein expression: a study on epoxide hydrolase production. Biotechnol Prog 1993; 9: 355-361.
    • (1993) Biotechnol Prog , vol.9 , pp. 355-361
    • Wang, M.Y.1    Kwong, S.2    Bentley, W.E.3
  • 29
    • 0036710633 scopus 로고    scopus 로고
    • Quantitation of baculovirus particles by flow cytometry
    • Shen CF, Meghrous J, Kamen A. Quantitation of baculovirus particles by flow cytometry. J Virol Methods 2002; 105: 321-330.
    • (2002) J Virol Methods , vol.105 , pp. 321-330
    • Shen, C.F.1    Meghrous, J.2    Kamen, A.3
  • 30
    • 0030761489 scopus 로고    scopus 로고
    • 7 cells per ml and improves baculovirus-expressed recombinant protein yields. Biotechnol Lett 1997; 19: 629-632.
    • 7 cells per ml and improves baculovirus-expressed recombinant protein yields. Biotechnol Lett 1997; 19: 629-632.
  • 31
    • 33845223389 scopus 로고    scopus 로고
    • Primary recovery and chromatographic purification of adeno-associated virus type 2 produced by baculovirus/insect cell system
    • Chahal PS, Aucoin MG, Kamen A. Primary recovery and chromatographic purification of adeno-associated virus type 2 produced by baculovirus/insect cell system. J Virol Methods 2007; 139: 61-70.
    • (2007) J Virol Methods , vol.139 , pp. 61-70
    • Chahal, P.S.1    Aucoin, M.G.2    Kamen, A.3
  • 32
    • 26944444283 scopus 로고    scopus 로고
    • A model of the dynamics of insect cell infection at low multiplicity of infection
    • Enden G, Zhang YH, Merchuk JC. A model of the dynamics of insect cell infection at low multiplicity of infection. J Theor Biol 2005; 237: 257-264.
    • (2005) J Theor Biol , vol.237 , pp. 257-264
    • Enden, G.1    Zhang, Y.H.2    Merchuk, J.C.3
  • 33
    • 0025879171 scopus 로고
    • Baculovirus defective interfering particles are responsible for variations in recombinant protein-production as a function of multiplicity of infection
    • Wickham TJ, Davis T, Granados RR, et al. Baculovirus defective interfering particles are responsible for variations in recombinant protein-production as a function of multiplicity of infection. Biotechnol Lett 1991; 13: 483-488.
    • (1991) Biotechnol Lett , vol.13 , pp. 483-488
    • Wickham, T.J.1    Davis, T.2    Granados, R.R.3
  • 34
    • 0141618506 scopus 로고    scopus 로고
    • Spontaneous excision of BAC vector sequences from bacmid-derived baculovirus expression vectors upon passage in insect cells
    • Pijlman GP, Van Schijndel JE, Vlak JM. Spontaneous excision of BAC vector sequences from bacmid-derived baculovirus expression vectors upon passage in insect cells. J Gen Virol 2003; 84: 2669-2678.
    • (2003) J Gen Virol , vol.84 , pp. 2669-2678
    • Pijlman, G.P.1    Van Schijndel, J.E.2    Vlak, J.M.3
  • 35
    • 0034869817 scopus 로고    scopus 로고
    • Comparison of growth and recombinant protein expression in two different insect cell lines in attached and suspension culture
    • Taticek RA, Choi C, Phan SE, et al. Comparison of growth and recombinant protein expression in two different insect cell lines in attached and suspension culture. Biotechnol Prog 2001; 17: 676-684.
    • (2001) Biotechnol Prog , vol.17 , pp. 676-684
    • Taticek, R.A.1    Choi, C.2    Phan, S.E.3
  • 36
    • 0037274314 scopus 로고    scopus 로고
    • Improving glucose and glutamine metabolism of human HEK 293 and Trichoplusia ni insect cells engineered to express a cytosolic pyruvate carboxylase enzyme
    • Elias CB, Carpentier E, Durocher Y, et al. Improving glucose and glutamine metabolism of human HEK 293 and Trichoplusia ni insect cells engineered to express a cytosolic pyruvate carboxylase enzyme. Biotechnol Prog 2003; 19: 90-97.
    • (2003) Biotechnol Prog , vol.19 , pp. 90-97
    • Elias, C.B.1    Carpentier, E.2    Durocher, Y.3
  • 37
    • 2342552941 scopus 로고    scopus 로고
    • Utilization of oxygen uptake rate to assess the role of glucose and glutamine in the metabolism of infected insect cell cultures
    • Palomares LA, Lopez S, Ramirez OT. Utilization of oxygen uptake rate to assess the role of glucose and glutamine in the metabolism of infected insect cell cultures. Biochem Eng Journal 2004; 19: 87-93.
    • (2004) Biochem Eng Journal , vol.19 , pp. 87-93
    • Palomares, L.A.1    Lopez, S.2    Ramirez, O.T.3
  • 38
    • 0030570089 scopus 로고    scopus 로고
    • On-line monitoring of respiration in recombinant-baculovirus infected and uninfected insect cell bioreactor cultures
    • Kamen AA, Bedard C, Tom R, et al. On-line monitoring of respiration in recombinant-baculovirus infected and uninfected insect cell bioreactor cultures. Biotechnol Bioeng 1996; 50: 36-48.
    • (1996) Biotechnol Bioeng , vol.50 , pp. 36-48
    • Kamen, A.A.1    Bedard, C.2    Tom, R.3
  • 39
    • 0034281764 scopus 로고    scopus 로고
    • On-line monitoring of physiological parameters of insect cell cultures during the growth and infection process
    • Zeiser A, Elias CB, Voyer R, et al. On-line monitoring of physiological parameters of insect cell cultures during the growth and infection process. Biotechnol Prog 2000; 16: 803-808.
    • (2000) Biotechnol Prog , vol.16 , pp. 803-808
    • Zeiser, A.1    Elias, C.B.2    Voyer, R.3
  • 40
    • 34548314442 scopus 로고    scopus 로고
    • Process optimization of largescale production of recombinant adeno-associated vectors using dielectric spectroscopy
    • Negrete A, Esteban G, Kotin RM. Process optimization of largescale production of recombinant adeno-associated vectors using dielectric spectroscopy. Appl Microbiol Biotechnol 2007; 76: 761-772.
    • (2007) Appl Microbiol Biotechnol , vol.76 , pp. 761-772
    • Negrete, A.1    Esteban, G.2    Kotin, R.M.3


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