Novel α-KTx peptides from the venom of the scorpion Centruroides elegans selectively blockade Kv1.3 over IKCa1 K+ channels of T cells

Toxicon

Volumn 46, Issue 4, 2005, Pages 418-429

  Olamendi Portugal, Timoteo ^a   Somodi, Sándor ^b   Fernández, Juan Antonio ^a   Zamudio, Fernando Z ^a   Becerril, Baltazar ^a   Varga, Zoltán ^b   Panyi, Gyorgy ^b   Gáspár, Rezso ^b   Possani, Lourival D ^a  

^a INSTITUTO DE BIOTECNOLOGÍA   (Mexico)

^b UNIVERSITY OF DEBRECEN   (Hungary)

Author keywords

KTx; Centruroides elegans; Kv1.3 channel; Scorpion toxin; T lymphocytes

Indexed keywords

CALCIUM ACTIVATED POTASSIUM CHANNEL; SCORPION VENOM; VOLTAGE GATED POTASSIUM CHANNEL;

AMIDATION; AMINO ACID SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CHROMATOGRAPHY; DISULFIDE BOND; DRUG SELECTIVITY; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; ISOLATION AND PURIFICATION; MOLECULAR WEIGHT; PATCH CLAMP; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; SCORPION; T LYMPHOCYTE; WHOLE CELL;

AMINO ACID SEQUENCE; ANIMALS; BAYES THEOREM; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROPHYSIOLOGY; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INTERMEDIATE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; KV1.3 POTASSIUM CHANNEL; MASS SPECTROMETRY; MEXICO; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; ORGANOPHOSPHORUS COMPOUNDS; PEPTIDES; PHYLOGENY; SCORPION VENOMS; SCORPIONS; SEQUENCE ANALYSIS, PROTEIN; T-LYMPHOCYTES;

CENTRUROIDES ELEGANS; SCORPIONES;

EID: 24044456713     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2005.06.001     Document Type: Article

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