Intramyocellular lipids: Effect of age, obesity, and exercise

Physician and Sportsmedicine

Volumn 37, Issue 1, 2009, Pages 20-26

  Franklin, Ruth M ^a   Kanaley, Jill A ^a  

^a SYRACUSE UNIVERSITY   (United States)

Author keywords

Intramyocellular lipids; Magnetic resonance imaging; Metabolic syndrome; Skeletal muscle; Spectroscopy

Indexed keywords

INTRAMYOCELLULAR LIPID; LIPID; UNCLASSIFIED DRUG;

AGED; AGING; ARTICLE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; EXERCISE; FEMALE; HEART INFARCTION; HISTOCHEMISTRY; HUMAN; MALE; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR MAGNETIC RESONANCE IMAGING; OBESITY; PROTON NUCLEAR MAGNETIC RESONANCE; SKELETAL MUSCLE;

AGE FACTORS; AGING; DIABETES MELLITUS, TYPE 2; EXERCISE; HUMANS; LIPID METABOLISM; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; METABOLIC SYNDROME X; MUSCLE FIBERS, SKELETAL; MUSCLE, SKELETAL; OBESITY; OVERWEIGHT;

EID: 75849152287     PISSN: 00913847     EISSN: None     Source Type: Journal    
DOI: 10.3810/PSM.2009.04.1679     Document Type: Article

References (52)

1. Flegal K, Carroll M, Ogden C, Johnson C. Prevalence and trends in obesity among US adults, 1999-2000. JAMA. 2002;288(14):1723-1727.
2. Johnson LW, Weinstock RS. The metabolic syndrome: concepts and controversy. Mayo Clin Proc. 2006;81(12):1615-1620.
3. Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA. 2002;287(3):356-359.
4. American Heart Association. Heart disease and stroke statistics. Dallas, TX: AHA; 2007 update.
5. Koopman R, Manders RJ, Jonkers RA, Hul GB, Kuipers H, van Loon LI. Intramyocellular lipid and glycogen content are reduced following resistance exercise in untrained healthy males. Eur J Appl Physiol. 2006;96(5): 525-534.
6. Boesch C, Slotboom J, Hoppeler H, Kreis R. In vivo determination of intra-inyocellular lipids in human muscle by means of localized 1H-MR-spectroscopy. Magn Reson Med. 1997;37(4):484-493.
7. Goodpaster BH, Theriault R, Watkins SC, Kelley DE. Intramuscular lipid content is increased in obesity and decreased by weight loss. Metabolism. 2000;49(4):467-472.
8. Kovanikaya A, Mittelman SD, Ward A, Geffner ME, Dorey F, Gilsanz V. Obesity and fat quantification in lean tissues using three-point Dixon MR imaging. Pediatr Radiol 2005;35(6):601-607.
9. Krssak M, Falk Petersen K, Dresner A. Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia. 1999;42(1):113-116.
10. Bachmann OP, Dahl DB, Brechtel K, et al. Effects of intravenous and dietary lipid challenge on intramyocellular lipid content and the relation with insulin sensitivity in humans. Diabetes. 2001;50(11):2579-2584.
11. Goodpaster BH, Kelley DE, Wing RR, Meier A, Thaete FL. Effects of weight loss on regional fat distribution and insulin sensitivity in obesity. Diabetes. 1999;48(4):839-847.
12. Wolfe RR, Peters EJ, Klein S, Holland OB, Rosenblatt J, Gary H. Effect of short-term tasting on lipolytic responsiveness in normal and obese human subjects. Am J Physiol. 1987;252(2 pt 1):E189-E196.
13. DeFronzo RA. Dysfunctional tat cells, lipotoxicity and type 2 diabetes. Int J Clin Pract Suppl. 2004;(143):9-21.
14. Tarnopolsky MA, Rennie CD, Robertshaw HA, Fedak-Tamopolsky SN, Devries MC, Hainadeh MJ. Influence of endurance exercise training and sex on intramyocellular lipid and mitochondrial structure, substrate use, and mitochondrial enzyme activity. Am J Physiol Regul Integr Comp Phiysiol. 2007;292(3):R1271-R1278.
15. Goodpaster BH, He J, Watkins S, Kelley DE. Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J Clin Endocrinol Metab. 2001;86(12):5755-5761.
16. van Loon LJ, Koopman R, Manders R, van der Weegen W, van Kranenburg GP, Keizer HA. Intramyocellular lipid content in type 2 diabetes patients compared with overweight sedentary men and highly trained endurance athletes. Am J Physiol Endocrinol Metab. 2004;287(3):E558-E565.
17. Goodpaster BH, Brown NF. Skeletal muscle lipid and its association with insulin resistance: what is the role for exercise? Exerc Sport Sci Rev. 2005;33(3):150-154.
18. Machann J, Häring H, Schick F, Stumvoll M. Intramyocellular lipids and insulin resistance. Diabetes Obes Metab. 2004;6(4):239-248.
19. Tainura Y, Tanaka Y, Sato F, et al. Effects of diet and exercise on muscle and liver intracellular lipid contents and insulin sensitivity in type 2 diabetic patients. J Clin Endocrinol Metab. 2005;90(6):3191-3196.
20. Bayliss-High O. Theory and Practice of Histological Techniques. Edinburgh, UK: Churchill Livingstone; 1977:168-185.
21. Koopman R, Schaart G, Hesselink MK. Optimisation of oil red O staining permits combination with immunofluorescence and automated quantifiaction of lipids. Histochem Cell Biol. 2001;116(1):63-68.
22. Schrauwen-Hinderling VB, Hesselink MK, Schrauwen P, Kooi ME. Intramyocellular lipid content in human skeletal muscle. Obesity (Silver Spring). 2006;14(3):357-367.
23. Watt MJ, Heigenhauser GJ, Spriet LL. Intramuscular triacylglycerol utilization in human skeletal muscle during exercise: is there a controversy? J Appl Physiol. 2002;93(4):1185-1195.
24. Thornell LE, Carlsson E, Kugelberg E, Grove BK. Myofibrillar M-band structure and composition of physiologically defined rat motor units. Am J Physiol. 1987;253(3 pt 1):C456-C468.
25. Goodpaster BH, Stenger VA, Boada F, et al. Skeletal muscle lipid concentration quantified by magnetic resonance imaging. Am J Clin Nutr. 2004;79(5):748-754.
26. Rico-Sanz J, Moosavi M, Thomas EL, et al. In vivo evaluation of the effects of continuous exercise on skeletal muscle triglycerides in trained humans. Lipids. 2000;35(12):1313-1318.
27. Schrauwen-Hinderling VB, Schrauwen R Hesselnk MK, et al. The increase in intramyocellular lipid content is a very early response to training. J Clin Endocrinol Metab. 2003-88(4):1610-1616.
28. Cree MG, Newcomer BR, Katsanos CS, et al. Intramuscular and liver triglyceride are increased in the elderly. J Clin Endocrinol Metab. 2004;89(8):3864-3871.
29. Krssak M, Petersen KF, Bergeron R, et al. Intramuscular glycogen and intramyocellular lipid utilization during prolonged exercise and recovery time in man: a 13C and 1H nuclear magnetic resonance spectroscopy study. J Clin Endocrinol Metab. 2000;85(2):748-754.
30. van Loon LJ, Koopman R, Stegen JH, Wagenmakers AJ, Keizer HA, Saris WH. Intramyocellular lipids form an important substrate source during moderate intensity exercise in endurance-trained males in a fasted state. J Physiol. 2003;553(pt 2):611-625.
31. Johnson NA, Stannard SR, Mehalski K, et al. Intramyocellular triacylglycerol in prolonged cycling with high- and low-carbohydrate availability. J Appl physiol. 2003;94(4):1365-1372.
32. Larson-Meyer DE, Newcomer BR, Hunter GR. Influence of endurance running and recovery diet on intramyocellular lipid content in women: a 1H NMR study. Am J Physiol Endocrinol Metab. 2002;282(1):E95-E106.
33. White LJ, Ferguson MA, McCoy S, Kim H. Intramyocellular lipid changes in men and women during aerobic exercise: a (1)H-magnetic resonance spectroscopy study. J Clin Endocrinol Metab. 2003;88(12):5638-5643.
34. Rico-Sanz J, Hajnal JV, Thomas EL, Mierisová S, Ala-Korpela M, Bell JD. Intracellular and extracellular skeletal muscle triglyceride metabolism during alternating intensity exercise in humans. J Physiol. 1998;510(pt2):615-622.
35. Gan SK, Kriketos AD, Ellis BA, Thompson CH, Kraegen EW, Chisholm DJ. Changes in aerobic capacity and visceral fat but not myocyte lipid levels predict increased insulin action after exercise in overweight and obese men. Diabetes Care. 2003;26(6):1706-1713.
36. Gollnick PD, Piehl K, Saltin B. Selective glycogen depletion pattern in human muscle fibres after exercise of varying intensity and at varying pedalling rates. J Physiol. 1974;241(1):45-57.
37. Decombaz J, Schmitt B, Ith M, et al. Postexercise fat intake repletes intramyocelular lipids but no taster in trained than in sedentary subjects. Am J Physiol Regul Integr Comp Physiol. 2001;281(3):R760-R769.
38. van Loon LJ, Schrauwen-Hinderling VB, Koopman R, et al. Influence of prolonged endurance cycling and recovery diet on intramuscular triglyceride content in trained males. Am J Physiol Endocrinol Metab. 2003;285(4):E804-E811.
39. Pruchnic R, Katsiaras A, He J, Kelley DE, Winters C, Goodpaster BH. Exercise training increases intramyocellular lipid and oxidative capacity in older adults. Am J Physiol Endocrinol Metab. 2004;287(5):E857-E862.
40. He J, Goodpaster BH, Kelley DE. Effects of weight loss and physical activity on muscle lipid content and droplet size. Obes Res. 2004;12(5):761-769.
41. Petersen KF, Befroy D, Dutbur S, et al. Mitochondrial dysfunction in the elderly: possible role in insulin resistance. Science. 2003;300(5622): 1140-1142.
42. Boesch C, Machann J, Vermathen P, Schick F. Role of proton MR for the study of muscle lipid metabolism. NMR Biomed. 2006;19(7):968-988.
43. Ukropcova B, Sereda O, dejonge L, et al. Family history of diabetes links impaired substrate switching and reduced mitochondrial content in skeletal muscle. Diabetes. 2007;56(3):720-726.
44. Dubé JJ, Amati F, Stetanovic-Racic M, Toledo FG, Sauers SE, Goodpaster BH. Exercise-induced alterations in intramyocellular lipids and insulin resistance: the athlete's paradox revisited. Am J Physiol Endocrinol Metab. 2008;294(5):E882-E888.
45. Solomon TP, Sistrun SN, Krishnan RK, et al. Exercise and diet enhance fat oxidation and reduce insulin resistance in older obese adults. J Appl Physiol. 2008;104(5):1313-1319.
46. Forouhi NG, Jenkinson G, Thomas EL, et al. Relation of triglyceride stores in skeletal muscle cells to central obesity and insulin sensitivity in European and South Asian men. Diabetologia. 1999;42(8):932-935.
47. Watt MJ, Heigenhauser GJ, Dyck DJ, Spriet LL. Intramuscular triacylglycerol, glycogen and acetyl group metabolism during 4 h of moderate exercise in man. J Physiol. 2002;541(pt 3):969-978.
48. White LJ, Robergs RA, Sibbett WL, Ferguson MA, McCoy S, Brooks WM. Effects of intermittent cycle exercise on intramyocellular lipid use and recovery. Lipids. 2003;38:9-13.
49. Fröberg SO, Mossfeldt F. Effect of prolonged strenuous exercise on the concentration of triglycerides, phospholipids and glycogen in muscle of man. Acta Physiol Scand. 1971;82(2):167-171.
50. Steffensen CH, Roepstorff C, Madsen M, Kiens B. Myocellular triacylglycerol breakdown in females but not in males during exercise. Am J Physiol Endocrinol Metab. 2002;282(3):E634-E642.
51. Roepstortf C, Steffensen CH, Madsen M, et al. Gender differences in substrate utilization during submaximal exercise in endura nee-trained subjects. Am J Physiol Endocrinol Metab. 2002;282(2):E435-E447.
52. Zehnder M, Ith M, Kreis R, Saris W, Boutellier U, Boesch C. Gender-specific usage of intramyocellular lipids and glycogen during exercise. Med Sci Sports Exerc. 2005;37(9):1517-1524.