Synthesis and evaluation of the α-glucosidase inhibitory activity of 3-[4-(phenylsulfonamido)benzoyl]-2H-1-benzopyran-2-one derivatives

European Journal of Medicinal Chemistry

Volumn 45, Issue 3, 2010, Pages 1250-1255

  Wang, Shaojie ^a   Yan, Jufang ^b   Wang, Xiaoyan ^a   Yang, Zhuo ^a   Lin, Fengwei ^a   Zhang, Tingjian ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b Drug Screening Center   (China)

Author keywords

Glucosidase inhibitor; 3 4 (Phenylsulfonamido)benzoyl 2H 1 benzopyran 2 one; Chalcone

Indexed keywords

3 [4 (4 METHYLPHENYLSULFONAMIDO)BENZOYL] 2H 1 BENZOPYRAN 2 ONE; 3 [4 (PHENYLSULFONAMIDO)BENZOYL] 2H 1 BENZOPYRAN 2 ONE; 3 [4 (PHENYLSULFONAMIDO)BENZOYL] 2H 1 BENZOPYRAN 2ONE; 6 BROMO 3 [4 (4 METHYLPHENYLSULFONAMIDO)BENZOYL] 2H 1 BENZOPYRAN 2 ONE; 6 BROMO 3 [4 (PHENYLSULFONAMIDO)BENZOYL] 2H 1 BENZOPYRAN 2 ONE; 6 CHLORO 3 [4 (4 METHYLPHENYLSULFONAMIDO)BENZOYL] 2H 1 BENZOPYRAN 2 ONE; 6 CHLORO 3 [4 (PHENYLSULFONAMIDO)BENZOYL] 2H 1 BENZOPYRAN 2 ONE; 6 FLUORO 3 [4 (4 METHYLPHENYLSULFONAMIDO)BENZOYL] 2H 1 BENZOPYRAN 2 ONE; 6 FLUORO 3 [4 (PHENYLSULFONAMIDO)BENZOYL] 2H 1 BENZOPYRAN 2 ONE; 6,7 DIMETHOXY 3 [4 (4 METHYLPHENYLSULFONAMIDO)BENZOYL 2H 1 BENZOPYRAN 2 ONE; 6,8 DIBROMO 3 [4 (4 METHYLPHENYLSULFONAMIDO)BENZOYL] 2H 1 BENZOPYRAN 2 ONE; 6,8 DIBROMO 3 [4 (PHENYLSULFONAMIDO)BENZOYL] 2H 1 BENZOPYRAN 2 ONE; 6,8 DITERTBUTYL 3 [4 (4 METHYLPHENYLSULFONAMIDO)BENZOYL] 2H 1 BENZOPYRAN 2 ONE; 6,8 DITERTBUTYL 3 [4 (PHENYLSULFONAMIDO)BENZOYL] 2H 1 BENZOPYRAN 2 ONE; 7 DIETHYLAMINO 3 [4 (4 METHYLPHENYLSULFONAMIDO)BENZOYL] 2H 1 BENZOPYRAN 2 ONE; 7 DIETHYLAMINO 3 [4 (PHENYLSULFONAMIDO)BENZOYL] 2H 1 BENZOPYRAN 2 ONE; 7 DIMETHOXY 3 [4 (PHENYLSULFONAMIDO)BENZOYL] 2H 1 BENZOPYRAN 2 ONE; 7 HYDROXY 3 [4 (4 METHYLPHENYLSULFONAMIDO)BENZOYL] 2H 1 BENZOPYRAN 2 ONE; 7 HYDROXY 3 [4 (PHENYLSULFONAMIDO)BENZOYL] 2H 1 BENZOPYRAN 2 ONE; 7 HYDROXY 6 METHOXY 3 [4 (4 METHYLPHENYLSULFONAMIDO)BENZOYL] 2H 1 BENZOPYRAN 2 ONE; 7 HYDROXY 6 METHOXY 3 [4 (PHENYLSULFONAMIDO)BENZOYL] 2H 1 BENZOPYRAN 2 ONE; 7 METHOXY 3 [4 (4 METHYLPHENYLSULFONAMIDO)BENZOYL] 2H 1 BENZOPYRAN 2 ONE; 7 METHOXY 3 [4 (PHENYLSULFONAMIDO)BENZOYL] 2H 1 BENZOPYRAN 2 ONE; ALPHA GLUCOSIDASE INHIBITOR; BENZENE DERIVATIVE; BENZOPYRAN DERIVATIVE; CHALCONE DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION;

ALPHA-GLUCOSIDASES; BENZOPYRANS; COUMARINS; DRUG DESIGN; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; SULFONAMIDES;

EID: 75849129602     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.12.031     Document Type: Article

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