Discovery of novel benzimidazolones as potent non-nucleoside reverse transcriptase inhibitors active against wild-type and mutant HIV-1 strains

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 7, 2007, Pages 1956-1960

  Barreca, Maria Letizia ^a   Rao, Angela ^a   Luca, Laura De ^a   Iraci, Nunzio ^a   Monforte, Anna Maria ^a   Maga, Giovanni ^b   Clercq, Erik De ^c   Pannecouque, Christophe ^c   Balzarini, Jan ^c   Chimirri, Alba ^a  

^a UNIVERSITY OF MESSINA   (Italy)

^b CNR   (Italy)

^c REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Anti HIV; Molecular modeling; NNRTI; Pharmacophore

Indexed keywords

BENZIMIDAZOLE DERIVATIVE; EFAVIRENZ; NEVIRAPINE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MOLECULAR MODEL; NONHUMAN; VIRUS MUTANT; VIRUS STRAIN; WILD TYPE;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANTI-RETROVIRAL AGENTS; BENZOXAZINES; CELL LINE; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; ENZYME INHIBITORS; HIV-1; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MUTATION; NEVIRAPINE; REVERSE TRANSCRIPTASE INHIBITORS;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 33847618875     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.01.025     Document Type: Article

References (12)

1. Balzarini J. Curr. Top. Med. Chem. 4 (2004) 921
2. Das K., Lewi P.J., Hughes S.H., and Arnold E. Prog. Biophys. Mol. Biol. 88 (2005) 209
3. Barreca M.L., Rao A., De Luca L., Zappala M., Monforte A.M., et al. J. Med. Chem. 48 (2005) 3433
4. Hopkins A.L., Ren J., Tanaka H., Baba M., Okamato M., et al. J. Med. Chem. 42 (1999) 4500
5. Chan J.H., Hong J.S., Hunter III R.N., Orr G.F., Cowan J.R., et al. J. Med. Chem. 44 (2001) 1866
6. Silvestri R., De Martino G., La Regina G., Artico M., Massa S., et al. J. Med. Chem. 46 (2003) 2482
7. Williams T.M., Ciccarone T.M., MacTough S.C., Rooney C.S., Balani S.K., et al. J. Med. Chem. 36 (1993) 1291
8. The PyMOL Molecular Graphics System; v 0.99; DeLano Scientific: San Carlos, CA, USA, 2002.
9. Morris G.M., Goodsell D.S., Halliday R.S., Huey R., Hart W.E., Belew R.K., and Olson A.J. J. Comput. Chem. 19 (1998) 1639
10. Barreca M.L., Balzarini J., Chimirri A., De Clercq E., De Luca L., et al. J. Med. Chem. 45 (2002) 5410
11. Ren J., Milton J., Weaver K.L., Short S.A., Stuart D.I., et al. Structure 8 (2000) 1089
12. Wallace A.C., Laskowski R.A., and Thornton J.M. Protein Eng. 8 (1995) 127