The rationale for targeting the NAD/NADH cofactor binding site of parasitic S-adenosyl-L-homocysteine hydrolase for the design of anti-parasitic drugs

Nucleosides, Nucleotides and Nucleic Acids

Volumn 28, Issue 5-7, 2009, Pages 485-503

  Cai, Sumin ^a   Li, Qing Shan ^a   Fang, Jianwen ^a   Borchardt, Ronald T ^a   Kuczera, Krzysztof ^a   Middaugh, C Russell ^a   Schowen, Richard L ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

Anti parasitic drugs; Cofactor site targeting; Enzyme inhibitors; S adenosylhomocysteine

Indexed keywords

3 ACETYLPYRIDINE ADENINE DINUCLEOTIDE; 3 PYRIDINEALDEHYDE ADENINE DINUCLEOTIDE; ADENOSYLHOMOCYSTEINASE; ADENOSYLHOMOCYSTEINASE INHIBITOR; ANTIPARASITIC AGENT; ANTITRYPANOSOMAL AGENT; MUTANT PROTEIN; NEPLANOCIN A; NICOTINAMIDE 1, N6 ETHENOADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE GUANINE DINUCLEOTIDE; NICOTINAMIDE HYPOXANTHINE DINUCLEOTIDE; NICOTINIC ACID ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; RIBAVIRIN; THIONICOTINAMIDE ADENINE DINUCLEOTIDE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; CHAGAS DISEASE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DISSOCIATION CONSTANT; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; ENZYME INACTIVATION; ENZYME KINETICS; ENZYME MECHANISM; HUMAN; NONHUMAN; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN STRUCTURE; PROTEIN TARGETING; REVIEW; SPECIES DIFFERENCE; THERMODYNAMICS; TRYPANOSOMA CRUZI;

ADENOSYLHOMOCYSTEINASE; BINDING SITES; CHAGAS DISEASE; HUMANS; MODELS, MOLECULAR; NAD; PROTEIN BINDING; PROTEIN CONFORMATION; SUBSTRATE SPECIFICITY; THERMODYNAMICS; TRYPANOCIDAL AGENTS; TRYPANOSOMA CRUZI;

EID: 75749126919     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1080/15257770903051031     Document Type: Review

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