Comparative kinetics of cofactor association and dissociation for the human and trypanosomal S-adenosylhomocysteine hydrolases. 2. The role of helix 18 stability

Biochemistry

Volumn 47, Issue 17, 2008, Pages 4983-4991

  Li, Qing Shan ^a   Cai, Sumin ^a   Fang, Jianwen ^a   Borchardt, Ronald T ^a   Kuczera, Krzysztof ^a   Middaugh, C Russell ^a   Schowen, Richard L ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COFACTOR ASSOCIATION; COMPARATIVE KINETICS; HOLOENZYMES; HUMAN ENZYMES;

BINDING SITES; BIOCHEMISTRY; CHEMICAL STABILITY; DISSOCIATION; MOLECULAR DYNAMICS; REACTION KINETICS; THERMODYNAMIC PROPERTIES;

ENZYME ACTIVITY;

ADENOSYLHOMOCYSTEINASE; HOLOENZYME; NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; S ADENOSYLHOMOCYSTEINE;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; DISSOCIATION; ENTHALPY; ENTROPY; ENZYME KINETICS; ENZYME MECHANISM; ENZYME STABILITY; ENZYME STRUCTURE; ENZYME SUBUNIT; HUMAN; LEISHMANIA DONOVANI; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN STRUCTURE; TEMPERATURE DEPENDENCE; THERMODYNAMICS; TRYPANOSOMA CRUZI; ANIMAL; CATALYSIS; CHEMISTRY; CIRCULAR DICHROISM; COMPARATIVE STUDY; DIFFERENTIAL SCANNING CALORIMETRY; ENZYMOLOGY; GENETICS; KINETICS; METABOLISM; MUTATION; PROTEIN SECONDARY STRUCTURE; TEMPERATURE;

HOMO SAPIENS; LEISHMANIA DONOVANI; PLASMODIUM FALCIPARUM; TRYPANOSOMA CRUZI;

ADENOSYLHOMOCYSTEINASE; ANIMALS; CALORIMETRY, DIFFERENTIAL SCANNING; CATALYSIS; CIRCULAR DICHROISM; ENZYME STABILITY; HUMANS; KINETICS; LEISHMANIA DONOVANI; MUTATION; NAD; PLASMODIUM FALCIPARUM; PROTEIN STRUCTURE, SECONDARY; TEMPERATURE; TRYPANOSOMA CRUZI;

EID: 42449119732     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800175g     Document Type: Article

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