Expression quantitative trait loci and genetic regulatory network analysis reveals that Gabra2 is involved in stress responses in the mouse

Stress

Volumn 12, Issue 6, 2009, Pages 499-506

  Dai, Jiajuan ^a   Wang, Xusheng ^b,c   Chen, Ying ^a   Wang, Xiaodong ^a   Zhu, Jun ^b   Lu, Lu ^a,c  

^a NANTONG UNIVERSITY   (China)

^b ZHEJIANG UNIVERSITY   (China)

^c UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Anxiety; Expression QTL; Gabra2; Genetic regulatory network; Genetical genomics; Hippocampus

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR ALPHA2; CHOLINE KINASE; CHOLINE KINASE ALPHA; DOPAMINE 3 RECEPTOR; GLUTAMATE RECEPTOR; METABOTROPIC RECEPTOR; NEUROLIGIN 1; PROTEIN HOMER 1; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG; 4 AMINOBUTYRIC ACID A RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HIPPOCAMPUS; MALE; MOUSE; NONHUMAN; ODZ4 GENE; PRIORITY JOURNAL; PRKAG2 GENE; QUANTITATIVE TRAIT LOCUS; RECEPTOR GENE; STRAIN DIFFERENCE; STRESS; ANIMAL; DNA MICROARRAY; GENE EXPRESSION PROFILING; GENETICS; MENTAL STRESS; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; GENE EXPRESSION PROFILING; HIPPOCAMPUS; MICE; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; QUANTITATIVE TRAIT LOCI; RECEPTORS, GABA-A; STRESS, PSYCHOLOGICAL;

EID: 75749123116     PISSN: 10253890     EISSN: 16078888     Source Type: Journal    
DOI: 10.3109/10253890802666112     Document Type: Article

References (46)

1. Akman HO, Sampayo JN, Ross FA, Scott JW, Wilson G, Benson L, Bruno C, Shanske S, Hardie DG, Dimauro S. 2007. Fatal infantile cardiac glycogenosis with phosphorylase kinase deficiency and a mutation in the gamma2-subunit of AMP-activated protein kinase. Pediatr Res 62:499-504.
2. Ary AW, Aguilar VR, Szumlinski KK, Kippin TE. 2007. Prenatal stress alters limbo-corticostriatal Homer protein expression. Synapse 61:938-941.
3. Barnard EA, Skolnick P, Olsen RW, Mohler H, Sieghart W, Biggio G, Braestrup C, Bateson AN, Langer SZ. 1998. International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: Classification on the basis of subunit structure and receptor function. Pharmacol Rev 50:291-313.
4. Bonnert TP, McKernan RM, Farrar S, le BourdellesB, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJ, Brown N, Wafford KA, Whiting PJ. 1999. Theta, a novel gamma-aminobutyric acid type A receptor subunit. Proc Natl Acad Sci USA 96:9891-9896.
5. Brem RB, Yvert G, Clinton R, Kruglyak L. 2002. Genetic dissection of transcriptional regulation in budding yeast. Science 296: 752-755.
6. Bremner JD, Narayan M. 1998. The effectsofstress onmemory and the hippocampus throughout the life cycle: Implications for childhood development and aging. Dev Psychopathol 10: 871-885.
7. Bremner JD, Scott TM, Delaney RC, Southwick SM, Mason JW, Johnson DR, Innis RB, McCarthy G, Charney DS. 1993. Deficits in short-term memory in posttraumatic stress disorder. Am J Psychiatr 150:1015-1019.
8. Bystrykh L, Weersing E, Dontje B, Sutton S, Pletcher MT, Wiltshire T, Su AI, Vellenga E, Wang J, Manly KF, Lu L, Chesler EJ, Alberts R, Jansen RC, Williams RW, Cooke MP, de Haan G. 2005. Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'. Nat Genet 37:225-232.
9. Chesler EJ, Lu L, Shou S, QuY, GuJ,WangJ, Hsu HC, Mountz JD, Baldwin NE, Langston MA, Threadgill DW, Manly KF, Williams RW. 2005. Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function. Nat Genet 37:233-242.
10. Chesler EJ, Lu L, Wang J, Williams RW, Manly KF. 2004. WebQTL: Rapid exploratory analysis of gene expression and genetic networks for brain and behavior. Nat Neurosci 7:485-486.
11. Doss S, Schadt EE, Drake TA, Lusis AJ. 2005. Cis-acting expression quantitative trait loci in mice. Genome Res 15: 681-691.
12. Dumas P, Sun Y, Corbeil G, Tremblay S, Pausova Z, Kren V, Krenova D, Pravenec M, Hamet P, Tremblay J. 2000. Mapping of quantitative trait loci (QTL) of differential stress gene expression in rat recombinant inbred strains. J Hypertens 18: 545-551.
13. Edenberg HJ, Dick DM, Xuei X, Tian H, Almasy L, Bauer LO, Crowe RR, Goate A, Hesselbrock V, Jones K, Kwon J, Li TK, Nurnberger JI, Jr., O'Connor SJ, Reich T, Rice J, Schuckit MA, Porjesz B, Foroud T, Begleiter H. 2004. Variations in GABRA2, encoding the alpha 2 subunit of the GABA(A) receptor, are associated with alcohol dependence and with brain oscillations. Am J Hum Genet 74:705-714.
14. Enoch MA, Schwartz L, Albaugh B, Virkkunen M, Goldman D. 2006. Dimensional anxiety mediates linkage of GABRA2 haplotypes with alcoholism. Am J Med Genet B Neuropsychiatr Genet 141:599-607.
15. Freund TF, Buzsaki G. 1996. Interneurons of the hippocampus. Hippocampus 6:347-470.
16. Gautier L, Cope L, Bolstad BM, Irizarry RA. 2004. Affy-Analysis of Affymetrix GeneChip data at the probe level. Bioinformatics 20:307-315.
17. Gould E, Tanapat P, McEwen BS, Flugge G, Fuchs E. 1998. Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress. Proc Natl Acad Sci USA 95:3168-3171.
18. Janardhan S, Srivani P, Sastry GN. 2006. Choline kinase: An important target for cancer. Curr Med Chem 13:1169-1186.
19. Jansen RC, Nap JP. 2001. Genetical genomics: The added value from segregation. Trends Genet 17:388-391.
20. Kandel ER. 2001. The molecular biology of memory storage: A dialogue between genes and synapses. Science 294: 1030-1038.
21. Kim YT, Wu CF. 1996. Reduced growth cone motility in cultured neurons from Drosophila memory mutants with a defective cAMP cascade. J Neurosci 16:5593-5602.
22. Laurie DJ, Seeburg PH, Wisden W. 1992. The distribution of 13 GABAA receptor subunit mRNAs in the rat brain. II. Olfactory bulb and cerebellum. J Neurosci 12:1063-1076.
23. Li H, Lu L, Manly KF, Chesler EJ, Bao L, Wang J, Zhou M, Williams RW, Cui Y. 2005. Inferring gene transcriptional modulatory relations: A genetical genomics approach. Hum Mol Genet 14:1119-1125.
24. Low K, Crestani F, Keist R, Benke D, Brunig I, Benson JA, Fritschy JM, Rulicke T, Bluethmann H, Mohler H, Rudolph U. 2000. Molecular and neuronal substrate for the selective attenuation of anxiety. Science 290:131-134.
25. Lu L, Airey DC, Williams RW. 2001. Complex trait analysis of the hippocampus: Mapping and biometric analysis of two novel gene loci with specific effects on hippocampal structure in mice. J Neurosci 21:3503-3514.
26. Macvanin M, Ballagi A, Hughes D. 2004. Fusidic acid-resistant mutants of Salmonella enterica serovar typhimurium have low levels of heme and a reduced rate of respiration and are sensitive to oxidative stress. Antimicrob Agents Chemother 48: 3877-3883.
27. Mehrabian M, Allayee H, Stockton J, Lum PY, Drake TA, Castellani LW, Suh M, Armour C, Edwards S, Lamb J, Lusis AJ, Schadt EE. 2005. Integrating genotypic and expression data in a segregating mouse population to identify 5-lipoxygenase as a susceptibility gene for obesity and bone traits. Nat Genet 37: 1224-1233.
28. Peirce JL, Chesler EJ, Williams RW, Lu L. 2003. Genetic architecture of the mouse hippocampus: Identification of gene loci with selective regional effects. Genes Brain Behav 2: 238-252.
29. Peirce JL, Lu L, Gu J, Silver LM, Williams RW. 2004. A new set of BXD recombinant inbred lines from advanced intercross populations in mice. BMC Genet 5:7.
30. Ronald J, Akey JM, Whittle J, Smith EN, Yvert G, Kruglyak L. 2005. Simultaneous genotyping, gene-expression measurement, and detection of allele-specific expression with oligonucleotide arrays. Genome Res 15:284-291.
31. Sala M, Perez J, Soloff P, Ucelli di Nemi S, Caverzasi E, Soares JC, Brambilla P. 2004. Stress and hippocampal abnormalities in psychiatric disorders. Eur Neuropsychopharmacol 14:393-405.
32. Schadt EE, Monks SA, Drake TA, Lusis AJ, Che N, Colinayo V, Ruff TG, Milligan SB, Lamb JR, Cavet G, Linsley PS, Mao M, Stoughton RB, Friend SH. 2003. Genetics of gene expression surveyed in maize, mouse and man. Nature 422:297-302.
33. Scheiffele P, Fan J, Choih J, Fetter R, Serafini T. 2000. Neuroligin expressed in nonneuronal cells triggers presynaptic development in contacting axons. Cell 101:657-669.
34. Schwendt M, Jezova D. 2000. Gene expression of two glutamate receptor subunits in response to repeated stress exposure in rat hippocampus. Cell Mol Neurobiol 20:319-329.
35. Soyka M, Preuss UW, Hesselbrock V, Zill P, Koller G, Bondy B. 2008. GABA-A2 receptor subunit gene (GABRA2) polymorphisms and risk for alcohol dependence. J Psychiatr Res 42: 184-191.
36. Steckler T. 2001. The molecular neurobiology of stress-Evidence from genetic and epigenetic models. Behav Pharmacol 12: 381-427.
37. Tarricone BJ, Hingtgen JN, Belknap JK, Mitchell SR, Nurnberger JI, Jr. 1995. Quantitative trait loci associated with the behavioral response of B £ D recombinant inbred mice to restraint stress: A preliminary communication. Behav Genet 25:489-495.
38. Thifault S, Ondrej S, Sun Y, Fortin A, Skamene E, Lalonde R, Tremblay J, Hamet P. 2008. Genetic determinants of emotionality and stress response in AcB/BcA recombinant congenic mice and in silico evidence of convergence with cardiovascular candidate genes. Hum Mol Genet 17:331-344.
39. Tsukada S, Tanaka Y, Maegawa H, Kashiwagi A, Kawamori R, Maeda S. 2006. Intronic polymorphisms within TFAP2B regulate transcriptional activity and affect adipocytokine gene expression in differentiated adipocytes. Mol Endocrinol 20: 1104-1111.
40. Wang XZ, Kuroda M, Sok J, Batchvarova N, Kimmel R, Chung P, Zinszner H, Ron D. 1998. Identification of novel stress-induced genes downstream of chop. Embo J 17:3619-3630.
41. West MA, Kim K, Kliebenstein DJ, van Leeuwen H, Michelmore RW, Doerge RW, St Clair DA. 2007. Global eQTL mapping reveals the complex genetic architecture of transcript-level variation in Arabidopsis. Genetics 175: 1441-1450.
42. Williams RW, Airey DC, Kulkarni A,Zhou G, Lu L. 2001a. Genetic dissection of the olfactory bulbs of mice: QTLs on four chromosomes modulate bulb size. Behav Genet 31:61-77.
43. Williams RW, Gu J, Qi S, Lu L. 2001b. The genetic structure of recombinant inbred mice: High-resolution consensus maps for complex trait analysis. Genome Biol 2:RESEARCH0046.
44. Xi ZX, Gilbert J, Campos AC, Kline N, Ashby CR, Jr., Hagan JJ, Heidbreder CA, Gardner EL. 2004. Blockade of mesolimbic dopamine D3 receptors inhibits stress-induced reinstatement of cocaine-seeking in rats. Psychopharmacology (Berl) 176:57-65.
45. Yvert G, Brem RB, Whittle J, Akey JM, Foss E, Smith EN, Mackelprang R, Kruglyak L. 2003. Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors. Nat Genet 35:57-64.
46. Zhang B, Tomita Y, Qiu Y, He J, Morii E, Noguchi S, Aozasa K. 2007. E74-like factor 2 regulates valosin-containing protein expression. Biochem Biophys Res Commun 356:536-541.