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Volumn 12, Issue 2, 2008, Pages 181-188

Molecular targets in medullary thyroid carcinoma

Author keywords

Medullary thyroid carcinoma; Molecular targets; Prophylactic thyroidectomy; RET activation; RET structure

Indexed keywords


EID: 75749117295     PISSN: 15299120     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (3)

References (85)
  • 1
    • 33645232222 scopus 로고    scopus 로고
    • Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas
    • Adeniran AJ, Zhu Z, Gandhi M, Steward DL, Fidler JP, Giordano TJ, Biddinger PW, Nikiforov YE (2006) Correlation between genetic alterations and microscopic features, clinical manifestations, and prognostic characteristics of thyroid papillary carcinomas. Am J Surg Pathol 30, 216-222.
    • (2006) Am J Surg Pathol , vol.30 , pp. 216-222
    • Adeniran, A.J.1    Zhu, Z.2    Gandhi, M.3    Steward, D.L.4    Fidler, J.P.5    Giordano, T.J.6    Biddinger, P.W.7    Nikiforov, Y.E.8
  • 3
    • 24644456024 scopus 로고    scopus 로고
    • No One-way Street, Cross-Talk between E-cadherin and Receptor Tyrosine kinase RTK Signaling, A Mechanism to Regulate RTK Activity
    • Andl CD, Rustgi AK (2005) No One-way Street, Cross-Talk between E-cadherin and Receptor Tyrosine kinase RTK Signaling, A Mechanism to Regulate RTK Activity. Cancer Biol Ther
    • (2005) Cancer Biol Ther
    • Andl, C.D.1    Rustgi, A.K.2
  • 5
    • 1842426410 scopus 로고    scopus 로고
    • Biological effects of the dual phenotypic Janus mutation of ret cosegregating with both multiple endocrine neoplasia type 2 and Hirschsprung's disease
    • Arighi E, Popsueva A, Degl'innocenti D, Borrello MG, Carniti C, Perala NM, Pierotti MA, Sariola H (2004) Biological effects of the dual phenotypic Janus mutation of ret cosegregating with both multiple endocrine neoplasia type 2 and Hirschsprung's disease. Mol Endocrinol 18, 1004-1017.
    • (2004) Mol Endocrinol , vol.18 , pp. 1004-1017
    • Arighi, E.1    Popsueva, A.2    Degl'innocenti, D.3    Borrello, M.G.4    Carniti, C.5    Perala, N.M.6    Pierotti, M.A.7    Sariola, H.8
  • 6
    • 0028838086 scopus 로고
    • Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations
    • Asai N, Iwashita T, Matsuyama M, Takahashi M (1995) Mechanism of activation of the ret proto-oncogene by multiple endocrine neoplasia 2A mutations. Mol Cell Biol 15, 1613-1619.
    • (1995) Mol Cell Biol , vol.15 , pp. 1613-1619
    • Asai, N.1    Iwashita, T.2    Matsuyama, M.3    Takahashi, M.4
  • 7
    • 33845356681 scopus 로고    scopus 로고
    • Medullary thyroid cancer, therapeutic targets and molecular markers
    • Ball DW (2007) Medullary thyroid cancer, therapeutic targets and molecular markers. Curr Opin Oncol 19, 18-23.
    • (2007) Curr Opin Oncol , vol.19 , pp. 18-23
    • Ball, D.W.1
  • 9
    • 0029823617 scopus 로고    scopus 로고
    • Clinical presentations and RET protooncogene mutations in seven multiple endocrine neoplasia type 2 kindreds
    • Blank RD, Sklar CA, Dimich AB, LaQuaglia MP, Brennan MF (1996) Clinical presentations and RET protooncogene mutations in seven multiple endocrine neoplasia type 2 kindreds. Cancer 78, 1996-2003.
    • (1996) Cancer , vol.78 , pp. 1996-2003
    • Blank, R.D.1    Sklar, C.A.2    Dimich, A.B.3    LaQuaglia, M.P.4    Brennan, M.F.5
  • 11
    • 0031741050 scopus 로고    scopus 로고
    • Molecular analysis of the ret and GDNF genes in a family with multiple endocrine neoplasia type 2A and Hirschsprung disease
    • Borrego S, Eng C, Sanchez B, Saez ME, Navarro E, Antinolo G (1998) Molecular analysis of the ret and GDNF genes in a family with multiple endocrine neoplasia type 2A and Hirschsprung disease. J Clin Endocrinol Metab 83, 3361-3364.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 3361-3364
    • Borrego, S.1    Eng, C.2    Sanchez, B.3    Saez, M.E.4    Navarro, E.5    Antinolo, G.6
  • 12
    • 0028916234 scopus 로고
    • Mutational analysis of multiple endocrine neoplasia type 2A associated with Hirschsprung's disease
    • Borst MJ, VanCamp JM, Peacock ML, Decker RA (1995) Mutational analysis of multiple endocrine neoplasia type 2A associated with Hirschsprung's disease. Surgery 117, 386-391.
    • (1995) Surgery , vol.117 , pp. 386-391
    • Borst, M.J.1    VanCamp, J.M.2    Peacock, M.L.3    Decker, R.A.4
  • 15
    • 0031049753 scopus 로고    scopus 로고
    • The different RET-activating capability of mutations of cysteine 620 or cysteine 634 correlates with the multiple endocrine neoplasia type 2 disease phenotype
    • Carlomagno F, Salvatore G, Cirafici AM, De Vita G, Melillo RM, de Franciscis V, Billaud M, Fusco A, Santoro M (1997) The different RET-activating capability of mutations of cysteine 620 or cysteine 634 correlates with the multiple endocrine neoplasia type 2 disease phenotype. Cancer Res 57, 391-395.
    • (1997) Cancer Res , vol.57 , pp. 391-395
    • Carlomagno, F.1    Salvatore, G.2    Cirafici, A.M.3    De Vita, G.4    Melillo, R.M.5    de Franciscis, V.6    Billaud, M.7    Fusco, A.8    Santoro, M.9
  • 17
    • 0030013621 scopus 로고    scopus 로고
    • C618R mutation in exon 10 of the RET proto-oncogene in a kindred with multiple endocrine neoplasia type 2A and Hirschsprung's disease
    • Caron P, Attie T, David D, Amiel J, Brousset F, Roger P, Munnich A, Lyonnet S (1996) C618R mutation in exon 10 of the RET proto-oncogene in a kindred with multiple endocrine neoplasia type 2A and Hirschsprung's disease. J Clin Endocrinol Metab 81, 2731-2733.
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 2731-2733
    • Caron, P.1    Attie, T.2    David, D.3    Amiel, J.4    Brousset, F.5    Roger, P.6    Munnich, A.7    Lyonnet, S.8
  • 22
    • 49249084044 scopus 로고    scopus 로고
    • RET/PTC-induced cell growth is mediated in part by epidermal growth factor receptor EGFR activation, evidence for molecular and functional interactions between RET and EGFR
    • Croyle M, Akeno N, Knauf JA, Fabbro D, Chen X, Baumgartner JE, Lane HA, Fagin JA (2008) RET/PTC-induced cell growth is mediated in part by epidermal growth factor receptor EGFR activation, evidence for molecular and functional interactions between RET and EGFR. Cancer Res 68, 4183-4191.
    • (2008) Cancer Res , vol.68 , pp. 4183-4191
    • Croyle, M.1    Akeno, N.2    Knauf, J.A.3    Fabbro, D.4    Chen, X.5    Baumgartner, J.E.6    Lane, H.A.7    Fagin, J.A.8
  • 24
    • 32844472474 scopus 로고    scopus 로고
    • Prophylactic thyroidectomy in children who are carriers of a multiple endocrine neoplasia type 2 mutation, description of 20 cases and recommendations based on the literature
    • de Groot JW, Links TP, Rouwe CW, van der Wal JE, Hofstra RM, Plukker JT (2006) Prophylactic thyroidectomy in children who are carriers of a multiple endocrine neoplasia type 2 mutation, description of 20 cases and recommendations based on the literature. Ned Tijdschr Geneeskd 150, 311-318.
    • (2006) Ned Tijdschr Geneeskd , vol.150 , pp. 311-318
    • de Groot, J.W.1    Links, T.P.2    Rouwe, C.W.3    van der Wal, J.E.4    Hofstra, R.M.5    Plukker, J.T.6
  • 25
    • 0031915455 scopus 로고    scopus 로고
    • Occurrence of MEN 2a in familial Hirschsprung's disease, a new indication for genetic testing of the RET proto-oncogene
    • Decker RA, Peacock ML (1998) Occurrence of MEN 2a in familial Hirschsprung's disease, a new indication for genetic testing of the RET proto-oncogene. J Pediatr Surg 33, 207-214.
    • (1998) J Pediatr Surg , vol.33 , pp. 207-214
    • Decker, R.A.1    Peacock, M.L.2
  • 26
    • 0031964670 scopus 로고    scopus 로고
    • Hirschsprung disease in MEN 2A, increased spectrum of RET exon 10 genotypes and strong genotype-phenotype correlation
    • Decker RA, Peacock ML, Watson P (1998) Hirschsprung disease in MEN 2A, increased spectrum of RET exon 10 genotypes and strong genotype-phenotype correlation. Hum Mol Genet 7, 129-134.
    • (1998) Hum Mol Genet , vol.7 , pp. 129-134
    • Decker, R.A.1    Peacock, M.L.2    Watson, P.3
  • 28
    • 0042869892 scopus 로고    scopus 로고
    • Gene therapeutic approaches for medullary thyroid carcinoma treatment
    • Drosten M Putzer BM (2003) Gene therapeutic approaches for medullary thyroid carcinoma treatment. J Mol Med 81, 411-419.
    • (2003) J Mol Med , vol.81 , pp. 411-419
    • Drosten, M.1    Putzer, B.M.2
  • 34
    • 33747633366 scopus 로고    scopus 로고
    • Long-term outcome in 46 gene carriers of hereditary medullary thyroid carcinoma after prophylactic thyroidectomy, impact of individual RET genotype
    • Frank-Raue K, Buhr H, Dralle H, Klar E, Senninger N, Weber T, Rondot S, Hoppner W, Raue F (2006) Long-term outcome in 46 gene carriers of hereditary medullary thyroid carcinoma after prophylactic thyroidectomy, impact of individual RET genotype. Eur J Endocrinol 155, 229-236.
    • (2006) Eur J Endocrinol , vol.155 , pp. 229-236
    • Frank-Raue, K.1    Buhr, H.2    Dralle, H.3    Klar, E.4    Senninger, N.5    Weber, T.6    Rondot, S.7    Hoppner, W.8    Raue, F.9
  • 35
    • 34250805935 scopus 로고    scopus 로고
    • Change in the spectrum of RET mutations diagnosed between 1994 and 2006
    • Frank-Raue K, Rondot S, Schulze E, Raue F (2007) Change in the spectrum of RET mutations diagnosed between 1994 and 2006. Clin Lab 53, 273-282.
    • (2007) Clin Lab , vol.53 , pp. 273-282
    • Frank-Raue, K.1    Rondot, S.2    Schulze, E.3    Raue, F.4
  • 36
    • 0032869135 scopus 로고    scopus 로고
    • Two distinct mutations of the RET receptor causing Hirschsprung's disease impair the binding of signalling effectors to a multifunctional docking site
    • Geneste O, Bidaud C, De Vita G, Hofstra RM, Tartare-Deckert S, Buys CH, Lenoir GM, Santoro M, Billaud M (1999) Two distinct mutations of the RET receptor causing Hirschsprung's disease impair the binding of signalling effectors to a multifunctional docking site. Hum Mol Genet 8, 1989-1999.
    • (1999) Hum Mol Genet , vol.8 , pp. 1989-1999
    • Geneste, O.1    Bidaud, C.2    De Vita, G.3    Hofstra, R.M.4    Tartare-Deckert, S.5    Buys, C.H.6    Lenoir, G.M.7    Santoro, M.8    Billaud, M.9
  • 38
    • 13444311533 scopus 로고    scopus 로고
    • A common haplotype at the 5' end of the RET proto-oncogene, overrepresented in Hirschsprung patients, is associated with reduced gene expression
    • Griseri P, Bachetti T, Puppo F, Lantieri F, Ravazzolo R, Devoto M, Ceccherini I (2005) A common haplotype at the 5' end of the RET proto-oncogene, overrepresented in Hirschsprung patients, is associated with reduced gene expression. Hum Mutat 25, 189-195.
    • (2005) Hum Mutat , vol.25 , pp. 189-195
    • Griseri, P.1    Bachetti, T.2    Puppo, F.3    Lantieri, F.4    Ravazzolo, R.5    Devoto, M.6    Ceccherini, I.7
  • 40
    • 0032723866 scopus 로고    scopus 로고
    • Mutational analysis of the RET proto-oncogene in a kindred with multiple endocrine neoplasia type 2A and Hirschsprung's disease
    • Inoue K, Shimotake T, Inoue K, Tokiwa K (1999) Mutational analysis of the RET proto-oncogene in a kindred with multiple endocrine neoplasia type 2A and Hirschsprung's disease. J Pediatr Surg 34, 1552-1554.
    • (1999) J Pediatr Surg , vol.34 , pp. 1552-1554
    • Inoue, K.1    Shimotake, T.2    Inoue, K.3    Tokiwa, K.4
  • 41
    • 0029798406 scopus 로고    scopus 로고
    • Mechanism of ret dysfunction by Hirschsprung mutations affecting its extracellular domain
    • Iwashita T, Murakami H, Asai N, Takahashi M (1996) Mechanism of ret dysfunction by Hirschsprung mutations affecting its extracellular domain. Hum Mol Genet 5, 1577-1580.
    • (1996) Hum Mol Genet , vol.5 , pp. 1577-1580
    • Iwashita, T.1    Murakami, H.2    Asai, N.3    Takahashi, M.4
  • 42
    • 44449153200 scopus 로고    scopus 로고
    • Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma
    • Jazdzewski K, Murray EL, Franssila K, Jarzab B, Schoenberg DR, de la CA (2008) Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinoma. Proc Natl Acad Sci USA 105, 7269-7274.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 7269-7274
    • Jazdzewski, K.1    Murray, E.L.2    Franssila, K.3    Jarzab, B.4    Schoenberg de la, C.A.5
  • 46
    • 0347481380 scopus 로고    scopus 로고
    • Identification of a surface for binding to the GDNF-GFR alpha 1 complex in the first cadherin-like domain of RET
    • Kjaer S Ibanez CF (2003) Identification of a surface for binding to the GDNF-GFR alpha 1 complex in the first cadherin-like domain of RET. J Biol Chem 278, 47898-47904.
    • (2003) J Biol Chem , vol.278 , pp. 47898-47904
    • Kjaer, S.1    Ibanez, C.F.2
  • 47
    • 0033615042 scopus 로고    scopus 로고
    • The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas
    • Klugbauer S, Rabes HM (1999) The transcription coactivator HTIF1 and a related protein are fused to the RET receptor tyrosine kinase in childhood papillary thyroid carcinomas. Oncogene 18, 4388-4393.
    • (1999) Oncogene , vol.18 , pp. 4388-4393
    • Klugbauer, S.1    Rabes, H.M.2
  • 49
    • 0031038795 scopus 로고    scopus 로고
    • RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2
    • Lorenzo MJ, Gish GD, Houghton C, Stonehouse TJ, Pawson T, Ponder BA, Smith DP (1997) RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2. Oncogene 14, 763-771.
    • (1997) Oncogene , vol.14 , pp. 763-771
    • Lorenzo, M.J.1    Gish, G.D.2    Houghton, C.3    Stonehouse, T.J.4    Pawson, T.5    Ponder, B.A.6    Smith, D.P.7
  • 50
    • 33749545177 scopus 로고    scopus 로고
    • Engineering the recruitment of phosphotyrosine binding domain-containing adaptor proteins reveals distinct roles for RET receptor-mediated cell survival
    • Lundgren TK, Scott RP, Smith M, Pawson T, Ernfors P (2006) Engineering the recruitment of phosphotyrosine binding domain-containing adaptor proteins reveals distinct roles for RET receptor-mediated cell survival. J Biol Chem 281, 29886-29896.
    • (2006) J Biol Chem , vol.281 , pp. 29886-29896
    • Lundgren, T.K.1    Scott, R.P.2    Smith, M.3    Pawson, T.4    Ernfors, P.5
  • 52
    • 34249800946 scopus 로고    scopus 로고
    • Very early manifestation of hereditary medullary thyroid cancer in carriers of intracellulsar-domain RET mutations
    • Machens A Dralle H (2007a) Very early manifestation of hereditary medullary thyroid cancer in carriers of intracellulsar-domain RET mutations. J Pediatr Surg 42, 1153.
    • (2007) J Pediatr Surg , vol.42 , pp. 1153
    • Machens, A.1    Dralle, H.2
  • 53
    • 45349087430 scopus 로고    scopus 로고
    • Familial prevalence and age of RET germline mutations, implications for screening
    • Machens A, Dralle H (2008) Familial prevalence and age of RET germline mutations, implications for screening. Clin Endocrinol 69, 81-7.
    • (2008) Clin Endocrinol , vol.69 , pp. 81-87
    • Machens, A.1    Dralle, H.2
  • 54
    • 34248170296 scopus 로고    scopus 로고
    • Genotype-phenotype based surgical concept of hereditary medullary thyroid carcinoma
    • Machens A, Dralle H, (2007b) Genotype-phenotype based surgical concept of hereditary medullary thyroid carcinoma. World J Surg 31, 957-68.
    • (2007) World J Surg , vol.31 , pp. 957-968
    • Machens, A.1    Dralle, H.2
  • 55
    • 33846537919 scopus 로고    scopus 로고
    • Familial medullary carcinoma prevention, risk evaluation, and RET in children of families with MEN2
    • Moore SW, Appfelstaedt J, Zaahl MG (2007) Familial medullary carcinoma prevention, risk evaluation, and RET in children of families with MEN2. J Pediatr Surg 42, 326-332.
    • (2007) J Pediatr Surg , vol.42 , pp. 326-332
    • Moore, S.W.1    Appfelstaedt, J.2    Zaahl, M.G.3
  • 56
    • 42149115042 scopus 로고    scopus 로고
    • Multiple endocrine neoplasia syndromes, children. Hirschsprung's disease and RET
    • Moore SW, Zaahl MG (2008) Multiple endocrine neoplasia syndromes, children, Hirschsprung's disease and RET. Pediatr Surg Int 24, 521-530.
    • (2008) Pediatr Surg Int , vol.24 , pp. 521-530
    • Moore, S.W.1    Zaahl, M.G.2
  • 60
    • 0030941779 scopus 로고    scopus 로고
    • Distinct pattern of ret oncogene rearrangements in morphological variants of radiationinduced and sporadic thyroid papillary carcinomas in children
    • Nikiforov YE, Rowland JM, Bove KE, Monforte-Munoz H, Fagin JA (1997) Distinct pattern of ret oncogene rearrangements in morphological variants of radiationinduced and sporadic thyroid papillary carcinomas in children. Cancer Res 57, 1690-1694.
    • (1997) Cancer Res , vol.57 , pp. 1690-1694
    • Nikiforov, Y.E.1    Rowland, J.M.2    Bove, K.E.3    Monforte-Munoz, H.4    Fagin, J.A.5
  • 61
    • 0027374562 scopus 로고
    • Expression of c-ret protooncogene during mouse embryogenesis
    • Pachnis V, Mankoo B, Constantini F (1993) Expression of c-ret protooncogene during mouse embryogenesis. Development 119, 1005-1017.
    • (1993) Development , vol.119 , pp. 1005-1017
    • Pachnis, V.1    Mankoo, B.2    Constantini, F.3
  • 65
    • 16944364217 scopus 로고    scopus 로고
    • Cys 618 Arg mutation in the RET proto-oncogene associated with familial medullary thyroid carcinoma and maternally transmitted Hirschsprung's disease suggesting a role for imprinting
    • Peretz H, Luboshitsky R, Baron E, Biton A, Gershoni R, Usher S, Grynberg E, Yakobson E, Lapidot M (1997) Cys 618 Arg mutation in the RET proto-oncogene associated with familial medullary thyroid carcinoma and maternally transmitted Hirschsprung's disease suggesting a role for imprinting. Hum Mutat 10, 155-159.
    • (1997) Hum Mutat , vol.10 , pp. 155-159
    • Peretz, H.1    Luboshitsky, R.2    Baron, E.3    Biton, A.4    Gershoni, R.5    Usher, S.6    Grynberg, E.7    Yakobson, E.8    Lapidot, M.9
  • 66
    • 33745939304 scopus 로고    scopus 로고
    • Apoptotic cell death induction and angiogenesis inhibition in large established medullary thyroid carcinoma xenografts by Ret inhibitor RPI-1
    • Petrangolini G, Cuccuru G, Lanzi C, Tortoreto M, Belluco S, Pratesi G, Cassinelli G, Zunino F (2006) Apoptotic cell death induction and angiogenesis inhibition in large established medullary thyroid carcinoma xenografts by Ret inhibitor RPI-1. Biochem Pharmacol 72, 405-414.
    • (2006) Biochem Pharmacol , vol.72 , pp. 405-414
    • Petrangolini, G.1    Cuccuru, G.2    Lanzi, C.3    Tortoreto, M.4    Belluco, S.5    Pratesi, G.6    Cassinelli, G.7    Zunino, F.8
  • 67
    • 33847681936 scopus 로고    scopus 로고
    • RET Proto-Oncogene in Sardinia. V804M Is the Most Frequent Mutation and May Be Associated with FMTC/MEN-2A Phenotype
    • Pinna G, Orgiana G, Riola A, Ghiani M, Lai ML, Carcassi C, Mariotti S (2007) RET Proto-Oncogene in Sardinia, V804M Is the Most Frequent Mutation and May Be Associated with FMTC/MEN-2A Phenotype. Thyroid 17, 101-104.
    • (2007) Thyroid , vol.17 , pp. 101-104
    • Pinna, G.1    Orgiana, G.2    Riola, A.3    Ghiani, M.4    Lai, M.L.5    Carcassi, C.6    Mariotti, S.7
  • 68
    • 0032541677 scopus 로고    scopus 로고
    • Tyrosine kinase receptoractivated signal transduction pathways which lead to oncogenesis
    • Porter AC Vaillancourt RR (1998) Tyrosine kinase receptoractivated signal transduction pathways which lead to oncogenesis. Oncogene 17, 1343-1352.
    • (1998) Oncogene , vol.17 , pp. 1343-1352
    • Porter, A.C.1    Vaillancourt, R.R.2
  • 69
    • 0032242723 scopus 로고    scopus 로고
    • Molecular genetics of childhood papillary thyroid carcinomas after irradiation, high prevalence of RET rearrangement
    • Rabes HM, Klugbauer S (1998) Molecular genetics of childhood papillary thyroid carcinomas after irradiation, high prevalence of RET rearrangement. Recent Results Cancer Res 154, 248-264.
    • (1998) Recent Results Cancer Res , vol.154 , pp. 248-264
    • Rabes, H.M.1    Klugbauer, S.2
  • 71
    • 0035426416 scopus 로고    scopus 로고
    • GDNF recruits the signaling crew into lipid rafts
    • Saarma M (2001) GDNF recruits the signaling crew into lipid rafts. Trends Neurosci 24, 427-429.
    • (2001) Trends Neurosci , vol.24 , pp. 427-429
    • Saarma, M.1
  • 72
    • 0035866411 scopus 로고    scopus 로고
    • Increased in vivo phosphorylation of ret tyrosine 1062 is a potential pathogenetic mechanism of multiple endocrine neoplasia type 2B
    • Salvatore D, Melillo RM, Monaco C, Visconti R, Fenzi G, Vecchio G, Fusco A, Santoro M (2001) Increased in vivo phosphorylation of ret tyrosine 1062 is a potential pathogenetic mechanism of multiple endocrine neoplasia type 2B. Cancer Res 61, 1426-1431.
    • (2001) Cancer Res , vol.61 , pp. 1426-1431
    • Salvatore, D.1    Melillo, R.M.2    Monaco, C.3    Visconti, R.4    Fenzi, G.5    Vecchio, G.6    Fusco, A.7    Santoro, M.8
  • 74
    • 0028810126 scopus 로고
    • Molecular defects in thyroid carcinomas, role of the RET oncogene in thyroid neoplastic transformation
    • Santoro M, Grieco M, Melillo RM, Fusco A, Vecchio G (1995b) Molecular defects in thyroid carcinomas, role of the RET oncogene in thyroid neoplastic transformation. Eur J Endocrinol 133, 513-522.
    • (1995) Eur J Endocrinol , vol.133 , pp. 513-522
    • Santoro, M.1    Grieco, M.2    Melillo, R.M.3    Fusco, A.4    Vecchio, G.5
  • 77
    • 0142043825 scopus 로고    scopus 로고
    • Management of hereditary thyroid cancer in children
    • Skinner MA (2003) Management of hereditary thyroid cancer in children. Surg Oncol 12, 101-104.
    • (2003) Surg Oncol , vol.12 , pp. 101-104
    • Skinner, M.A.1
  • 78
    • 0033054334 scopus 로고    scopus 로고
    • Co-segregation of MEN2 and Hirschsprung's disease, the same mutation of RET with both gain and loss-of-function?
    • Takahashi M, Iwashita T, Santoro M, Lyonnet S, Lenoir GM, Billaud M (1999) Co-segregation of MEN2 and Hirschsprung's disease, the same mutation of RET with both gain and loss-of-function? Hum Mutat 13, 331-6
    • (1999) Hum Mutat , vol.13 , pp. 331-336
    • Takahashi, M.1    Iwashita, T.2    Santoro, M.3    Lyonnet, S.4    Lenoir, G.M.5    Billaud, M.6
  • 79
    • 0022330363 scopus 로고
    • Activation of a novel human transforming gene, ret, by DNA rearrangement
    • Takahashi M, Ritz J, Cooper GM (1985) Activation of a novel human transforming gene, ret, by DNA rearrangement. Cell 42, 581-588.
    • (1985) Cell , vol.42 , pp. 581-588
    • Takahashi, M.1    Ritz, J.2    Cooper, G.M.3
  • 81
    • 0028781009 scopus 로고
    • Genetics. One gene--four syndromes
    • van Heyningen V (1994) Genetics.One gene--four syndromes. Nature 367, 319-320.
    • (1994) Nature , vol.367 , pp. 319-320
    • van Heyningen, V.1
  • 83
    • 34047276290 scopus 로고    scopus 로고
    • Acidic oligosaccharide sugar chain, a marine-derived oligosaccharide, activates human glial cell line-derived neurotrophic factor signalling
    • Wang XJ, Chen XH, Yang XY, Geng MY, Wang LM (2007) Acidic oligosaccharide sugar chain, a marine-derived oligosaccharide, activates human glial cell line-derived neurotrophic factor signalling. Neurosci Lett 417, 176-180.
    • (2007) Neurosci Lett , vol.417 , pp. 176-180
    • Wang, X.J.1    Chen, X.H.2    Yang, X.Y.3    Geng, M.Y.4    Wang, L.M.5
  • 84
    • 27144467717 scopus 로고    scopus 로고
    • Phosphotyrosine 1062 is critical for the in vivo activity of the Ret9 receptor tyrosine kinase isoform
    • Wong A, Bogni S, Kotka P, de Graaff E, D'Agati V, Costantini F, Pachnis V (2005) Phosphotyrosine 1062 is critical for the in vivo activity of the Ret9 receptor tyrosine kinase isoform. Mol Cell Biol 25, 9661-9673.
    • (2005) Mol Cell Biol , vol.25 , pp. 9661-9673
    • Wong, A.1    Bogni, S.2    Kotka, P.3    de Graaff, E.4    D'Agati, V.5    Costantini, F.6    Pachnis, V.7
  • 85
    • 42249087955 scopus 로고    scopus 로고
    • Serum vascular endothelial growth factor C correlates with lymph node metastases and high-risk tumor profiles in papillary thyroid carcinoma
    • Yu XM, Lo CY, Lam AK, Leung P, Luk JM (2008) Serum vascular endothelial growth factor C correlates with lymph node metastases and high-risk tumor profiles in papillary thyroid carcinoma. Ann Surg 247, 483-489.
    • (2008) Ann Surg , vol.247 , pp. 483-489
    • Yu, X.M.1    Lo, C.Y.2    Lam, A.K.3    Leung, P.4    Luk, J.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.