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Volumn 8, Issue 24, 2009, Pages 2339-2347

Inhibition of mammalian target of rapamycin as a therapeutic strategy in the management of bladder cancer

Author keywords

Bladder cancer; Everolimus; Experimental therapeutics; mTOR

Indexed keywords

EVEROLIMUS; MAMMALIAN TARGET OF RAPAMYCIN; VASCULOTROPIN;

EID: 75749105837     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.8.24.9987     Document Type: Article
Times cited : (69)

References (45)
  • 1
    • 0036310982 scopus 로고    scopus 로고
    • The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation
    • Peng T, Golub TR, Sabatini DM. The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation. Mol Cell Biol 2002; 22:5575-84.
    • (2002) Mol Cell Biol , vol.22 , pp. 5575-5584
    • Peng, T.1    Golub, T.R.2    Sabatini, D.M.3
  • 3
    • 33751162384 scopus 로고    scopus 로고
    • Therapeutic targets: MTOR and related pathways
    • Dancey JE. Therapeutic targets: MTOR and related pathways. Cancer Biol Ther 2006; 5:1065-73.
    • (2006) Cancer Biol Ther , vol.5 , pp. 1065-1073
    • Dancey, J.E.1
  • 4
    • 33644843210 scopus 로고    scopus 로고
    • From Rapa Nui to rapamycin: Targeting PI3K/Akt/mTOR for cancer therapy
    • Georgakis GV, Younes A. From Rapa Nui to rapamycin: targeting PI3K/Akt/mTOR for cancer therapy. Expert Rev Anticancer Ther 2006; 6:131-40.
    • (2006) Expert Rev Anticancer Ther , vol.6 , pp. 131-140
    • Georgakis, G.V.1    Younes, A.2
  • 6
    • 0037312507 scopus 로고    scopus 로고
    • Tor signalling in bugs, brain and brawn
    • Jacinto E, Hall MN. Tor signalling in bugs, brain and brawn. Nat Rev Mol Cell Biol 2003; 4:117-26.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 117-126
    • Jacinto, E.1    Hall, M.N.2
  • 7
    • 0347627139 scopus 로고    scopus 로고
    • mTOR-mediated regulation of translation factors by amino acids
    • Proud CG. mTOR-mediated regulation of translation factors by amino acids. Biochem Biophys Res Commun 2004; 313:429-36.
    • (2004) Biochem Biophys Res Commun , vol.313 , pp. 429-436
    • Proud, C.G.1
  • 8
    • 0037108750 scopus 로고    scopus 로고
    • Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
    • Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci USA 2002; 99:13571-6.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 13571-13576
    • Tee, A.R.1    Fingar, D.C.2    Manning, B.D.3    Kwiatkowski, D.J.4    Cantley, L.C.5    Blenis, J.6
  • 9
    • 33750072949 scopus 로고    scopus 로고
    • mTOR and cancer therapy
    • Easton JB, Houghton PJ. mTOR and cancer therapy. Oncogene 2006; 25:6436-46.
    • (2006) Oncogene , vol.25 , pp. 6436-6446
    • Easton, J.B.1    Houghton, P.J.2
  • 10
    • 23944439945 scopus 로고    scopus 로고
    • Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer
    • Chan S, Scheulen ME, Johnston S, Mross K, Cardoso F, Dittrich C, et al. Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer. J Clin Oncol 2005; 23:5314-22.
    • (2005) J Clin Oncol , vol.23 , pp. 5314-5322
    • Chan, S.1    Scheulen, M.E.2    Johnston, S.3    Mross, K.4    Cardoso, F.5    Dittrich, C.6
  • 11
    • 23944453425 scopus 로고    scopus 로고
    • Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: A North Central Cancer Treatment Group Study
    • Galanis E, Buckner JC, Maurer MJ, Kreisberg JI, Ballman K, Boni J, et al. Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study. J Clin Oncol 2005; 23:5294-304.
    • (2005) J Clin Oncol , vol.23 , pp. 5294-5304
    • Galanis, E.1    Buckner, J.C.2    Maurer, M.J.3    Kreisberg, J.I.4    Ballman, K.5    Boni, J.6
  • 12
    • 33748363166 scopus 로고    scopus 로고
    • A phase 3, randomized, 3-arm study of temsirolimus (TEMSR) or interferon-alpha (IFN) or the combination of TEMSR + IFN in the treatment of first-line, poor-risk patients with advanced renal cell carcinoma (adv RCC)
    • Hudes G, Tomczak MCP, Dutcher J, Figlin R, Kapoor A, Staroslawska E, et al. A phase 3, randomized, 3-arm study of temsirolimus (TEMSR) or interferon-alpha (IFN) or the combination of TEMSR + IFN in the treatment of first-line, poor-risk patients with advanced renal cell carcinoma (adv RCC). J Clin Oncol 2006; 24:18.
    • (2006) J Clin Oncol , vol.24 , pp. 18
    • Hudes, G.1    Tomczak, M.C.P.2    Dutcher, J.3    Figlin, R.4    Kapoor, A.5    Staroslawska, E.6
  • 13
  • 14
    • 60549102667 scopus 로고    scopus 로고
    • Rapamycin inhibits in vitro growth and release of angiogenetic factors in human bladder cancer
    • Fechner G, Classen K, Schmidt D, Hauser S, Muller SC. Rapamycin inhibits in vitro growth and release of angiogenetic factors in human bladder cancer. Urology 2009; 73:665-8.
    • (2009) Urology , vol.73 , pp. 665-668
    • Fechner, G.1    Classen, K.2    Schmidt, D.3    Hauser, S.4    Muller, S.C.5
  • 16
    • 32044439338 scopus 로고    scopus 로고
    • Characterization of a panel of cell lines derived from urothelial neoplasms: Genetic alterations, growth in vivo and the relationship of adenoviral mediated gene transfer to coxsackie adenovirus receptor expression
    • Sabichi A, Keyhani A, Tanaka N, Delacerda J, Lee IL, Zou C, et al. Characterization of a panel of cell lines derived from urothelial neoplasms: genetic alterations, growth in vivo and the relationship of adenoviral mediated gene transfer to coxsackie adenovirus receptor expression. J Urol 2006; 175:1133-7.
    • (2006) J Urol , vol.175 , pp. 1133-1137
    • Sabichi, A.1    Keyhani, A.2    Tanaka, N.3    Delacerda, J.4    Lee, I.L.5    Zou, C.6
  • 17
    • 0029155694 scopus 로고
    • Isolation and characterization of metastatic variants from human transitional cell carcinoma passaged by orthotopic implantation in athymic nude mice
    • Dinney CP, Fishbeck R, Singh RK, Eve B, Pathak S, Brown N, et al. Isolation and characterization of metastatic variants from human transitional cell carcinoma passaged by orthotopic implantation in athymic nude mice. J Urol 1995; 154:1532-8.
    • (1995) J Urol , vol.154 , pp. 1532-1538
    • Dinney, C.P.1    Fishbeck, R.2    Singh, R.K.3    Eve, B.4    Pathak, S.5    Brown, N.6
  • 18
    • 0016671555 scopus 로고
    • Letter: HeLa cells and RT4 cells
    • Franks LM, Rigby C. Letter: HeLa cells and RT4 cells. Science 1975; 188:168.
    • (1975) Science , vol.188 , pp. 168
    • Franks, L.M.1    Rigby, C.2
  • 19
    • 33746637660 scopus 로고    scopus 로고
    • Current development of mTOR inhibitors as anticancer agents
    • Faivre S, Kroemer G, Raymond E. Current development of mTOR inhibitors as anticancer agents. Nat Rev Drug Discov 2006; 5:671-88.
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 671-688
    • Faivre, S.1    Kroemer, G.2    Raymond, E.3
  • 20
    • 0036174289 scopus 로고    scopus 로고
    • Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor
    • Guba M, von Breitenbuch P, Steinbauer M, Koehl G, Flegel S, Hornung M, et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat Med 2002; 8:128-35.
    • (2002) Nat Med , vol.8 , pp. 128-135
    • Guba, M.1    von Breitenbuch, P.2    Steinbauer, M.3    Koehl, G.4    Flegel, S.5    Hornung, M.6
  • 21
    • 0343920277 scopus 로고    scopus 로고
    • Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
    • Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 1996; 380:435-9.
    • (1996) Nature , vol.380 , pp. 435-439
    • Carmeliet, P.1    Ferreira, V.2    Breier, G.3    Pollefeyt, S.4    Kieckens, L.5    Gertsenstein, M.6
  • 22
    • 2942724235 scopus 로고    scopus 로고
    • mTOR inhibition reverses Aktdependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent path-ways
    • Majumder PK, Febbo PG, Bikoff R, Berger R, Xue Q, McMahon LM, et al. mTOR inhibition reverses Aktdependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent path-ways. Nat Med 2004; 10:594-601.
    • (2004) Nat Med , vol.10 , pp. 594-601
    • Majumder, P.K.1    Febbo, P.G.2    Bikoff, R.3    Berger, R.4    Xue, Q.5    McMahon, L.M.6
  • 23
    • 9144233506 scopus 로고    scopus 로고
    • Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells
    • Boulay A, Zumstein-Mecker S, Stephan C, Beuvink I, Zilbermann F, Haller R, et al. Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells. Cancer Res 2004; 64:252-61.
    • (2004) Cancer Res , vol.64 , pp. 252-261
    • Boulay, A.1    Zumstein-Mecker, S.2    Stephan, C.3    Beuvink, I.4    Zilbermann, F.5    Haller, R.6
  • 24
    • 20244365941 scopus 로고    scopus 로고
    • The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation
    • Beuvink I, Boulay A, Fumagalli S, Zilbermann F, Ruetz S, O'Reilly T, et al. The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation. Cell 2005; 120:747-59.
    • (2005) Cell , vol.120 , pp. 747-759
    • Beuvink, I.1    Boulay, A.2    Fumagalli, S.3    Zilbermann, F.4    Ruetz, S.5    O'Reilly, T.6
  • 25
    • 0019870366 scopus 로고
    • New antitumor substances of natural origin
    • Douros J, Suffness M. New antitumor substances of natural origin. Cancer Treat Rev 1981; 8:63-87.
    • (1981) Cancer Treat Rev , vol.8 , pp. 63-87
    • Douros, J.1    Suffness, M.2
  • 26
    • 48649107474 scopus 로고    scopus 로고
    • Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
    • Motzer RJ, Escudier B, Oudard S, Hutson TE, Porta C, Bracarda S, et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 2008; 372:449-56.
    • (2008) Lancet , vol.372 , pp. 449-456
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3    Hutson, T.E.4    Porta, C.5    Bracarda, S.6
  • 27
    • 34249785713 scopus 로고    scopus 로고
    • Chromosomal deletions in bladder cancer: Shutting down pathways
    • Abraham R, Pagano F, Gomella LG, Baffa R. Chromosomal deletions in bladder cancer: shutting down pathways. Front Biosci 2007; 12:826-38.
    • (2007) Front Biosci , vol.12 , pp. 826-838
    • Abraham, R.1    Pagano, F.2    Gomella, L.G.3    Baffa, R.4
  • 28
    • 0041802820 scopus 로고    scopus 로고
    • Targeting mTOR signaling for cancer therapy
    • Huang S, Houghton PJ. Targeting mTOR signaling for cancer therapy. Curr Opin Pharmacol 2003; 3:371-7.
    • (2003) Curr Opin Pharmacol , vol.3 , pp. 371-377
    • Huang, S.1    Houghton, P.J.2
  • 29
    • 0034790016 scopus 로고    scopus 로고
    • mTOR, a novel target in breast cancer: The effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer
    • Yu K, Toral-Barza L, Discafani C, Zhang WG, Skotnicki J, Frost P, et al. mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer. Endocr Relat Cancer 2001; 8:249-58.
    • (2001) Endocr Relat Cancer , vol.8 , pp. 249-258
    • Yu, K.1    Toral-Barza, L.2    Discafani, C.3    Zhang, W.G.4    Skotnicki, J.5    Frost, P.6
  • 30
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005; 307:1098-101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 31
    • 28844434558 scopus 로고    scopus 로고
    • RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes
    • Hresko RC, Mueckler M. mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. J Biol Chem 2005; 280:40406-16.
    • (2005) J Biol Chem , vol.280 , pp. 40406-40416
    • Hresko, R.C.1    Mueckler, M.2    mTOR3
  • 34
    • 0035870281 scopus 로고    scopus 로고
    • p53/p21(CIP1) cooperate in enforcing rapamycin-induced G(1) arrest and determine the cellular response to rapamycin
    • Huang S, Liu LN, Hosoi H, Dilling MB, Shikata T, Houghton PJ. p53/p21(CIP1) cooperate in enforcing rapamycin-induced G(1) arrest and determine the cellular response to rapamycin. Cancer Res 2001; 61:3373-81.
    • (2001) Cancer Res , vol.61 , pp. 3373-3381
    • Huang, S.1    Liu, L.N.2    Hosoi, H.3    Dilling, M.B.4    Shikata, T.5    Houghton, P.J.6
  • 36
    • 1842852634 scopus 로고    scopus 로고
    • Pharmacogenomic profiling of the PI3K/PTEN-AKTmTOR pathway in common human tumors
    • Xu G, Zhang W, Bertram P, Zheng XF, McLeod H. Pharmacogenomic profiling of the PI3K/PTEN-AKTmTOR pathway in common human tumors. Int J Oncol 2004; 24:893-900.
    • (2004) Int J Oncol , vol.24 , pp. 893-900
    • Xu, G.1    Zhang, W.2    Bertram, P.3    Zheng, X.F.4    McLeod, H.5
  • 37
    • 0033000334 scopus 로고    scopus 로고
    • p70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes
    • Brennan P, Babbage JW, Thomas G, Cantrell D. p70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes. Mol Cell Biol 1999; 19:4729-38.
    • (1999) Mol Cell Biol , vol.19 , pp. 4729-4738
    • Brennan, P.1    Babbage, J.W.2    Thomas, G.3    Cantrell, D.4
  • 38
    • 0034722888 scopus 로고    scopus 로고
    • The rapamycin-sensitive signal transduction pathway as a target for cancer therapy
    • Hidalgo M, Rowinsky EK. The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene 2000; 19:6680-6.
    • (2000) Oncogene , vol.19 , pp. 6680-6686
    • Hidalgo, M.1    Rowinsky, E.K.2
  • 39
    • 8344281974 scopus 로고    scopus 로고
    • Targeting the molecular target of rapamycin (mTOR)
    • Rowinsky EK. Targeting the molecular target of rapamycin (mTOR). Curr Opin Oncol 2004; 16:564-75.
    • (2004) Curr Opin Oncol , vol.16 , pp. 564-575
    • Rowinsky, E.K.1
  • 40
    • 1842832314 scopus 로고    scopus 로고
    • Four birds with one stone: RAPA as potential anticancer therapy
    • Blagosklonny MV, Darzynkiewicz Z. Four birds with one stone: RAPA as potential anticancer therapy. Cancer Biol Ther 2002; 1:359-61.
    • (2002) Cancer Biol Ther , vol.1 , pp. 359-361
    • Blagosklonny, M.V.1    Darzynkiewicz, Z.2
  • 41
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxiainducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/ AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, et al. Modulation of hypoxiainducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/ AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 2000; 60:1541-5.
    • (2000) Cancer Res , vol.60 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3    Laughner, E.4    Hanrahan, C.5    Georgescu, M.M.6
  • 42
    • 0034537290 scopus 로고    scopus 로고
    • Autophagy as a regulated pathway of cellular degradation
    • Klionsky DJ, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science 2000; 290:1717-21.
    • (2000) Science , vol.290 , pp. 1717-1721
    • Klionsky, D.J.1    Emr, S.D.2
  • 43
    • 28644451845 scopus 로고    scopus 로고
    • Uncoupling between epidermal growth factor receptor and downstream signals defines resistance to the antiproliferative effect of Gefitinib in bladder cancer cells
    • Kassouf W, Dinney CP, Brown G, McConkey DJ, Diehl AJ, Bar-Eli M, et al. Uncoupling between epidermal growth factor receptor and downstream signals defines resistance to the antiproliferative effect of Gefitinib in bladder cancer cells. Cancer Res 2005; 65:10524-35.
    • (2005) Cancer Res , vol.65 , pp. 10524-10535
    • Kassouf, W.1    Dinney, C.P.2    Brown, G.3    McConkey, D.J.4    Diehl, A.J.5    Bar-Eli, M.6
  • 44
    • 0842289982 scopus 로고    scopus 로고
    • Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy
    • Ciardiello F, Bianco R, Caputo R, Damiano V, Troiani T, Melisi D, et al. Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy. Clin Cancer Res 2004; 10:784-93.
    • (2004) Clin Cancer Res , vol.10 , pp. 784-793
    • Ciardiello, F.1    Bianco, R.2    Caputo, R.3    Damiano, V.4    Troiani, T.5    Melisi, D.6
  • 45
    • 31544464135 scopus 로고    scopus 로고
    • Inhibition of bladder tumor growth by 1,1-bis(3′-indolyl)-1-(p- substitutedphenyl) methanes: A new class of peroxisome proliferatoractivated receptor gamma agonists
    • Kassouf W, Chintharlapalli S, Abdelrahim M, Nelkin G, Safe S, Kamat AM. Inhibition of bladder tumor growth by 1,1-bis(3′-indolyl)-1-(p- substitutedphenyl) methanes: a new class of peroxisome proliferatoractivated receptor gamma agonists. Cancer Res 2006; 66:412-8.
    • (2006) Cancer Res , vol.66 , pp. 412-418
    • Kassouf, W.1    Chintharlapalli, S.2    Abdelrahim, M.3    Nelkin, G.4    Safe, S.5    Kamat, A.M.6


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