-
1
-
-
0036310982
-
The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation
-
Peng T, Golub TR, Sabatini DM. The immunosuppressant rapamycin mimics a starvation-like signal distinct from amino acid and glucose deprivation. Mol Cell Biol 2002; 22:5575-84.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 5575-5584
-
-
Peng, T.1
Golub, T.R.2
Sabatini, D.M.3
-
3
-
-
33751162384
-
Therapeutic targets: MTOR and related pathways
-
Dancey JE. Therapeutic targets: MTOR and related pathways. Cancer Biol Ther 2006; 5:1065-73.
-
(2006)
Cancer Biol Ther
, vol.5
, pp. 1065-1073
-
-
Dancey, J.E.1
-
4
-
-
33644843210
-
From Rapa Nui to rapamycin: Targeting PI3K/Akt/mTOR for cancer therapy
-
Georgakis GV, Younes A. From Rapa Nui to rapamycin: targeting PI3K/Akt/mTOR for cancer therapy. Expert Rev Anticancer Ther 2006; 6:131-40.
-
(2006)
Expert Rev Anticancer Ther
, vol.6
, pp. 131-140
-
-
Georgakis, G.V.1
Younes, A.2
-
6
-
-
0037312507
-
Tor signalling in bugs, brain and brawn
-
Jacinto E, Hall MN. Tor signalling in bugs, brain and brawn. Nat Rev Mol Cell Biol 2003; 4:117-26.
-
(2003)
Nat Rev Mol Cell Biol
, vol.4
, pp. 117-126
-
-
Jacinto, E.1
Hall, M.N.2
-
7
-
-
0347627139
-
mTOR-mediated regulation of translation factors by amino acids
-
Proud CG. mTOR-mediated regulation of translation factors by amino acids. Biochem Biophys Res Commun 2004; 313:429-36.
-
(2004)
Biochem Biophys Res Commun
, vol.313
, pp. 429-436
-
-
Proud, C.G.1
-
8
-
-
0037108750
-
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
-
Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J. Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci USA 2002; 99:13571-6.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 13571-13576
-
-
Tee, A.R.1
Fingar, D.C.2
Manning, B.D.3
Kwiatkowski, D.J.4
Cantley, L.C.5
Blenis, J.6
-
9
-
-
33750072949
-
mTOR and cancer therapy
-
Easton JB, Houghton PJ. mTOR and cancer therapy. Oncogene 2006; 25:6436-46.
-
(2006)
Oncogene
, vol.25
, pp. 6436-6446
-
-
Easton, J.B.1
Houghton, P.J.2
-
10
-
-
23944439945
-
Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer
-
Chan S, Scheulen ME, Johnston S, Mross K, Cardoso F, Dittrich C, et al. Phase II study of temsirolimus (CCI-779), a novel inhibitor of mTOR, in heavily pretreated patients with locally advanced or metastatic breast cancer. J Clin Oncol 2005; 23:5314-22.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5314-5322
-
-
Chan, S.1
Scheulen, M.E.2
Johnston, S.3
Mross, K.4
Cardoso, F.5
Dittrich, C.6
-
11
-
-
23944453425
-
Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: A North Central Cancer Treatment Group Study
-
Galanis E, Buckner JC, Maurer MJ, Kreisberg JI, Ballman K, Boni J, et al. Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study. J Clin Oncol 2005; 23:5294-304.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5294-5304
-
-
Galanis, E.1
Buckner, J.C.2
Maurer, M.J.3
Kreisberg, J.I.4
Ballman, K.5
Boni, J.6
-
12
-
-
33748363166
-
A phase 3, randomized, 3-arm study of temsirolimus (TEMSR) or interferon-alpha (IFN) or the combination of TEMSR + IFN in the treatment of first-line, poor-risk patients with advanced renal cell carcinoma (adv RCC)
-
Hudes G, Tomczak MCP, Dutcher J, Figlin R, Kapoor A, Staroslawska E, et al. A phase 3, randomized, 3-arm study of temsirolimus (TEMSR) or interferon-alpha (IFN) or the combination of TEMSR + IFN in the treatment of first-line, poor-risk patients with advanced renal cell carcinoma (adv RCC). J Clin Oncol 2006; 24:18.
-
(2006)
J Clin Oncol
, vol.24
, pp. 18
-
-
Hudes, G.1
Tomczak, M.C.P.2
Dutcher, J.3
Figlin, R.4
Kapoor, A.5
Staroslawska, E.6
-
13
-
-
34249779568
-
Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma
-
Hudes G, Carducci M, Tomczak P, Dutcher J, Figlin R, Kapoor A, et al. Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma. N Engl J Med 2007; 356:2271-81.
-
(2007)
N Engl J Med
, vol.356
, pp. 2271-2281
-
-
Hudes, G.1
Carducci, M.2
Tomczak, P.3
Dutcher, J.4
Figlin, R.5
Kapoor, A.6
-
14
-
-
60549102667
-
Rapamycin inhibits in vitro growth and release of angiogenetic factors in human bladder cancer
-
Fechner G, Classen K, Schmidt D, Hauser S, Muller SC. Rapamycin inhibits in vitro growth and release of angiogenetic factors in human bladder cancer. Urology 2009; 73:665-8.
-
(2009)
Urology
, vol.73
, pp. 665-668
-
-
Fechner, G.1
Classen, K.2
Schmidt, D.3
Hauser, S.4
Muller, S.C.5
-
15
-
-
58649090201
-
Effect of sirolimus on urinary bladder cancer T24 cell line
-
Pinto-Leite R, Botelho P, Ribeiro E, Oliveira PA, Santos L. Effect of sirolimus on urinary bladder cancer T24 cell line. J Exp Clin Cancer Res 2009; 28:3.
-
(2009)
J Exp Clin Cancer Res
, vol.28
, pp. 3
-
-
Pinto-Leite, R.1
Botelho, P.2
Ribeiro, E.3
Oliveira, P.A.4
Santos, L.5
-
16
-
-
32044439338
-
Characterization of a panel of cell lines derived from urothelial neoplasms: Genetic alterations, growth in vivo and the relationship of adenoviral mediated gene transfer to coxsackie adenovirus receptor expression
-
Sabichi A, Keyhani A, Tanaka N, Delacerda J, Lee IL, Zou C, et al. Characterization of a panel of cell lines derived from urothelial neoplasms: genetic alterations, growth in vivo and the relationship of adenoviral mediated gene transfer to coxsackie adenovirus receptor expression. J Urol 2006; 175:1133-7.
-
(2006)
J Urol
, vol.175
, pp. 1133-1137
-
-
Sabichi, A.1
Keyhani, A.2
Tanaka, N.3
Delacerda, J.4
Lee, I.L.5
Zou, C.6
-
17
-
-
0029155694
-
Isolation and characterization of metastatic variants from human transitional cell carcinoma passaged by orthotopic implantation in athymic nude mice
-
Dinney CP, Fishbeck R, Singh RK, Eve B, Pathak S, Brown N, et al. Isolation and characterization of metastatic variants from human transitional cell carcinoma passaged by orthotopic implantation in athymic nude mice. J Urol 1995; 154:1532-8.
-
(1995)
J Urol
, vol.154
, pp. 1532-1538
-
-
Dinney, C.P.1
Fishbeck, R.2
Singh, R.K.3
Eve, B.4
Pathak, S.5
Brown, N.6
-
18
-
-
0016671555
-
Letter: HeLa cells and RT4 cells
-
Franks LM, Rigby C. Letter: HeLa cells and RT4 cells. Science 1975; 188:168.
-
(1975)
Science
, vol.188
, pp. 168
-
-
Franks, L.M.1
Rigby, C.2
-
19
-
-
33746637660
-
Current development of mTOR inhibitors as anticancer agents
-
Faivre S, Kroemer G, Raymond E. Current development of mTOR inhibitors as anticancer agents. Nat Rev Drug Discov 2006; 5:671-88.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 671-688
-
-
Faivre, S.1
Kroemer, G.2
Raymond, E.3
-
20
-
-
0036174289
-
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: Involvement of vascular endothelial growth factor
-
Guba M, von Breitenbuch P, Steinbauer M, Koehl G, Flegel S, Hornung M, et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat Med 2002; 8:128-35.
-
(2002)
Nat Med
, vol.8
, pp. 128-135
-
-
Guba, M.1
von Breitenbuch, P.2
Steinbauer, M.3
Koehl, G.4
Flegel, S.5
Hornung, M.6
-
21
-
-
0343920277
-
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
-
Carmeliet P, Ferreira V, Breier G, Pollefeyt S, Kieckens L, Gertsenstein M, et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 1996; 380:435-9.
-
(1996)
Nature
, vol.380
, pp. 435-439
-
-
Carmeliet, P.1
Ferreira, V.2
Breier, G.3
Pollefeyt, S.4
Kieckens, L.5
Gertsenstein, M.6
-
22
-
-
2942724235
-
mTOR inhibition reverses Aktdependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent path-ways
-
Majumder PK, Febbo PG, Bikoff R, Berger R, Xue Q, McMahon LM, et al. mTOR inhibition reverses Aktdependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent path-ways. Nat Med 2004; 10:594-601.
-
(2004)
Nat Med
, vol.10
, pp. 594-601
-
-
Majumder, P.K.1
Febbo, P.G.2
Bikoff, R.3
Berger, R.4
Xue, Q.5
McMahon, L.M.6
-
23
-
-
9144233506
-
Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells
-
Boulay A, Zumstein-Mecker S, Stephan C, Beuvink I, Zilbermann F, Haller R, et al. Antitumor efficacy of intermittent treatment schedules with the rapamycin derivative RAD001 correlates with prolonged inactivation of ribosomal protein S6 kinase 1 in peripheral blood mononuclear cells. Cancer Res 2004; 64:252-61.
-
(2004)
Cancer Res
, vol.64
, pp. 252-261
-
-
Boulay, A.1
Zumstein-Mecker, S.2
Stephan, C.3
Beuvink, I.4
Zilbermann, F.5
Haller, R.6
-
24
-
-
20244365941
-
The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation
-
Beuvink I, Boulay A, Fumagalli S, Zilbermann F, Ruetz S, O'Reilly T, et al. The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation. Cell 2005; 120:747-59.
-
(2005)
Cell
, vol.120
, pp. 747-759
-
-
Beuvink, I.1
Boulay, A.2
Fumagalli, S.3
Zilbermann, F.4
Ruetz, S.5
O'Reilly, T.6
-
25
-
-
0019870366
-
New antitumor substances of natural origin
-
Douros J, Suffness M. New antitumor substances of natural origin. Cancer Treat Rev 1981; 8:63-87.
-
(1981)
Cancer Treat Rev
, vol.8
, pp. 63-87
-
-
Douros, J.1
Suffness, M.2
-
26
-
-
48649107474
-
Efficacy of everolimus in advanced renal cell carcinoma: A double-blind, randomised, placebo-controlled phase III trial
-
Motzer RJ, Escudier B, Oudard S, Hutson TE, Porta C, Bracarda S, et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet 2008; 372:449-56.
-
(2008)
Lancet
, vol.372
, pp. 449-456
-
-
Motzer, R.J.1
Escudier, B.2
Oudard, S.3
Hutson, T.E.4
Porta, C.5
Bracarda, S.6
-
27
-
-
34249785713
-
Chromosomal deletions in bladder cancer: Shutting down pathways
-
Abraham R, Pagano F, Gomella LG, Baffa R. Chromosomal deletions in bladder cancer: shutting down pathways. Front Biosci 2007; 12:826-38.
-
(2007)
Front Biosci
, vol.12
, pp. 826-838
-
-
Abraham, R.1
Pagano, F.2
Gomella, L.G.3
Baffa, R.4
-
28
-
-
0041802820
-
Targeting mTOR signaling for cancer therapy
-
Huang S, Houghton PJ. Targeting mTOR signaling for cancer therapy. Curr Opin Pharmacol 2003; 3:371-7.
-
(2003)
Curr Opin Pharmacol
, vol.3
, pp. 371-377
-
-
Huang, S.1
Houghton, P.J.2
-
29
-
-
0034790016
-
mTOR, a novel target in breast cancer: The effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer
-
Yu K, Toral-Barza L, Discafani C, Zhang WG, Skotnicki J, Frost P, et al. mTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer. Endocr Relat Cancer 2001; 8:249-58.
-
(2001)
Endocr Relat Cancer
, vol.8
, pp. 249-258
-
-
Yu, K.1
Toral-Barza, L.2
Discafani, C.3
Zhang, W.G.4
Skotnicki, J.5
Frost, P.6
-
30
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005; 307:1098-101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
31
-
-
28844434558
-
RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes
-
Hresko RC, Mueckler M. mTOR.RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes. J Biol Chem 2005; 280:40406-16.
-
(2005)
J Biol Chem
, vol.280
, pp. 40406-40416
-
-
Hresko, R.C.1
Mueckler, M.2
mTOR3
-
32
-
-
12944271053
-
Cancer statistics, 2005
-
Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, Ghafoor A, et al. Cancer statistics, 2005. CA Cancer J Clin 2005; 55:10-30.
-
(2005)
CA Cancer J Clin
, vol.55
, pp. 10-30
-
-
Jemal, A.1
Murray, T.2
Ward, E.3
Samuels, A.4
Tiwari, R.C.5
Ghafoor, A.6
-
34
-
-
0035870281
-
p53/p21(CIP1) cooperate in enforcing rapamycin-induced G(1) arrest and determine the cellular response to rapamycin
-
Huang S, Liu LN, Hosoi H, Dilling MB, Shikata T, Houghton PJ. p53/p21(CIP1) cooperate in enforcing rapamycin-induced G(1) arrest and determine the cellular response to rapamycin. Cancer Res 2001; 61:3373-81.
-
(2001)
Cancer Res
, vol.61
, pp. 3373-3381
-
-
Huang, S.1
Liu, L.N.2
Hosoi, H.3
Dilling, M.B.4
Shikata, T.5
Houghton, P.J.6
-
35
-
-
1042267229
-
Determinants of rapamycin sensitivity in breast cancer cells
-
Noh WC, Mondesire WH, Peng J, Jian W, Zhang H, Dong J, et al. Determinants of rapamycin sensitivity in breast cancer cells. Clin Cancer Res 2004; 10:1013-23.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 1013-1023
-
-
Noh, W.C.1
Mondesire, W.H.2
Peng, J.3
Jian, W.4
Zhang, H.5
Dong, J.6
-
36
-
-
1842852634
-
Pharmacogenomic profiling of the PI3K/PTEN-AKTmTOR pathway in common human tumors
-
Xu G, Zhang W, Bertram P, Zheng XF, McLeod H. Pharmacogenomic profiling of the PI3K/PTEN-AKTmTOR pathway in common human tumors. Int J Oncol 2004; 24:893-900.
-
(2004)
Int J Oncol
, vol.24
, pp. 893-900
-
-
Xu, G.1
Zhang, W.2
Bertram, P.3
Zheng, X.F.4
McLeod, H.5
-
37
-
-
0033000334
-
p70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes
-
Brennan P, Babbage JW, Thomas G, Cantrell D. p70(s6k) integrates phosphatidylinositol 3-kinase and rapamycin-regulated signals for E2F regulation in T lymphocytes. Mol Cell Biol 1999; 19:4729-38.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 4729-4738
-
-
Brennan, P.1
Babbage, J.W.2
Thomas, G.3
Cantrell, D.4
-
38
-
-
0034722888
-
The rapamycin-sensitive signal transduction pathway as a target for cancer therapy
-
Hidalgo M, Rowinsky EK. The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene 2000; 19:6680-6.
-
(2000)
Oncogene
, vol.19
, pp. 6680-6686
-
-
Hidalgo, M.1
Rowinsky, E.K.2
-
39
-
-
8344281974
-
Targeting the molecular target of rapamycin (mTOR)
-
Rowinsky EK. Targeting the molecular target of rapamycin (mTOR). Curr Opin Oncol 2004; 16:564-75.
-
(2004)
Curr Opin Oncol
, vol.16
, pp. 564-575
-
-
Rowinsky, E.K.1
-
40
-
-
1842832314
-
Four birds with one stone: RAPA as potential anticancer therapy
-
Blagosklonny MV, Darzynkiewicz Z. Four birds with one stone: RAPA as potential anticancer therapy. Cancer Biol Ther 2002; 1:359-61.
-
(2002)
Cancer Biol Ther
, vol.1
, pp. 359-361
-
-
Blagosklonny, M.V.1
Darzynkiewicz, Z.2
-
41
-
-
0034654174
-
Modulation of hypoxiainducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/ AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
-
Zhong H, Chiles K, Feldser D, Laughner E, Hanrahan C, Georgescu MM, et al. Modulation of hypoxiainducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/ AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res 2000; 60:1541-5.
-
(2000)
Cancer Res
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
Chiles, K.2
Feldser, D.3
Laughner, E.4
Hanrahan, C.5
Georgescu, M.M.6
-
42
-
-
0034537290
-
Autophagy as a regulated pathway of cellular degradation
-
Klionsky DJ, Emr SD. Autophagy as a regulated pathway of cellular degradation. Science 2000; 290:1717-21.
-
(2000)
Science
, vol.290
, pp. 1717-1721
-
-
Klionsky, D.J.1
Emr, S.D.2
-
43
-
-
28644451845
-
Uncoupling between epidermal growth factor receptor and downstream signals defines resistance to the antiproliferative effect of Gefitinib in bladder cancer cells
-
Kassouf W, Dinney CP, Brown G, McConkey DJ, Diehl AJ, Bar-Eli M, et al. Uncoupling between epidermal growth factor receptor and downstream signals defines resistance to the antiproliferative effect of Gefitinib in bladder cancer cells. Cancer Res 2005; 65:10524-35.
-
(2005)
Cancer Res
, vol.65
, pp. 10524-10535
-
-
Kassouf, W.1
Dinney, C.P.2
Brown, G.3
McConkey, D.J.4
Diehl, A.J.5
Bar-Eli, M.6
-
44
-
-
0842289982
-
Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy
-
Ciardiello F, Bianco R, Caputo R, Damiano V, Troiani T, Melisi D, et al. Antitumor activity of ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor, in human cancer cells with acquired resistance to antiepidermal growth factor receptor therapy. Clin Cancer Res 2004; 10:784-93.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 784-793
-
-
Ciardiello, F.1
Bianco, R.2
Caputo, R.3
Damiano, V.4
Troiani, T.5
Melisi, D.6
-
45
-
-
31544464135
-
Inhibition of bladder tumor growth by 1,1-bis(3′-indolyl)-1-(p- substitutedphenyl) methanes: A new class of peroxisome proliferatoractivated receptor gamma agonists
-
Kassouf W, Chintharlapalli S, Abdelrahim M, Nelkin G, Safe S, Kamat AM. Inhibition of bladder tumor growth by 1,1-bis(3′-indolyl)-1-(p- substitutedphenyl) methanes: a new class of peroxisome proliferatoractivated receptor gamma agonists. Cancer Res 2006; 66:412-8.
-
(2006)
Cancer Res
, vol.66
, pp. 412-418
-
-
Kassouf, W.1
Chintharlapalli, S.2
Abdelrahim, M.3
Nelkin, G.4
Safe, S.5
Kamat, A.M.6
|