Extracellular β-nicotinamide adenine dinucleotide (β-NAD) promotes the endothelial cell barrier integrity via PKA- and EPAC1/Rac1-dependent actin cytoskeleton rearrangement

Journal of Cellular Physiology

Volumn 223, Issue 1, 2010, Pages 215-223

  Umapathy, Nagavedi S ^a   Zemskov, Evgeny A ^a   Gonzales, Joyce ^a   Gorshkov, Boris A ^a   Sridhar, Supriya ^a   Chakraborty, Trinad ^b   Lucas, Rudolf ^a   Verin, Alexander D ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

^b JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; BACTERIAL TOXIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; LIPOPOLYSACCHARIDE; MEMBRANE PROTEIN; MYOSIN LIGHT CHAIN; NICOTINAMIDE ADENINE DINUCLEOTIDE; PNEUMOLYSIN; PROTEIN EPAC1; PURINERGIC P2Y1 RECEPTOR; PURINERGIC P2Y11 RECEPTOR; RAC1 PROTEIN; THROMBIN; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN;

ARTICLE; CELL INTERACTION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; CYTOSKELETON; ELECTRIC RESISTANCE; ENDOTHELIUM CELL; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PULMONARY ARTERY; SIGNAL TRANSDUCTION; TRANSENDOTHELIAL ELECTRICAL RESISTANCE;

ACTINS; ANTIGENS, CD; BACTERIAL PROTEINS; CADHERINS; CAPILLARY PERMEABILITY; CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYTOSKELETON; ELECTRIC IMPEDANCE; ENDOTHELIAL CELLS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; INTERCELLULAR JUNCTIONS; LIPOPOLYSACCHARIDES; MYOSIN LIGHT CHAINS; MYOSIN-LIGHT-CHAIN PHOSPHATASE; NAD; PHOSPHORYLATION; PULMONARY ARTERY; RAC1 GTP-BINDING PROTEIN; RECEPTORS, PURINERGIC P2; RNA INTERFERENCE; RNA, MESSENGER; SIGNAL TRANSDUCTION; STREPTOLYSINS; THROMBIN; TIME FACTORS;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; POSIBACTERIA;

EID: 75749102978     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22029     Document Type: Article

References (38)

1. Baffert F, Le T, Thurston G, McDonald DM. 2006. Angiopoietin-1 decreases plasma leakage by reducing number and size of endothelial gaps in venules. Am J Physiol Heart Circ Physiol 290:H107-H118.
2. Bai JW, Deng WW, Zhang J, Xu SM, Zhang DX. 2009. Protective effect of myosin light-chain kinase inhibitor on acute lung injury. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 21:215-218.
3. Birukova AA, Smurova K, Birukov KG, Kaibuchi K, Garcia JG, Verin AD. 2004a. Role of Rho GTPases in thrombin-induced lung vascular endothelial cells barrier dysfunction. Microvasc Res 67:64-77.
4. Birukova AA, Smurova K, Birukov KG, Usatyuk P, Liu F, Kaibuchi K, Ricks-Cord A,Natarajan V, Alieva I, Garcia JG, Verin AD. 2004b. Microtubule disassembly induces cytoskeletal remodeling and lung vascular barrier dysfunction: role of Rho-dependent mechanisms. J Cell Physiol 201:55-70.
5. Birukova AA, Zagranichnaya T, Fu P, Alekseeva E, Chen W, Jacobson JR, Birukov KG. 2007. Prostaglandins PGE(2) and PGI(2) promote endothelial barrier enhancement via PKA- and Epac1/Rap1-dependent Rac activation. Exp Cell Res 313:2504-2520.
6. Bruzzone S, Moreschi I, Guida L, Usai C, Zocchi E, De Flora A. 2006. Extracellular NAD+ regulates intracellular calcium levels and induces activation of human granulocytes. Biochem J 393:697-704.
7. De Flora A, Zocchi E, Guida L, Franco L, Bruzzone S. 2004. Autocrine and paracrine calcium signaling by the CD38/NAD+/cyclic ADP-ribose system. Ann NY Acad Sci 1028:176-191.
8. Dudek SM, Camp SM, Chiang ET, Singleton PA, Usatyuk PV, Zhao Y, Natarajan V, Garcia JG. 2007. Pulmonary endothelial cell barrier enhancement by FTY720 does not require the S1P1 receptor. Cell Signal 19:1754-1764.
9. Dudek SM, Garcia JG. 2001. Cytoskeletal regulation of pulmonary vascular permeability. J Appl Physiol 91:1487-1500.
10. Fukuhara S, Sakurai A, Sano H, Yamagishi A, Somekawa S, Takakura N, Saito Y, Kangawa K, Mochizuki N. 2005. Cyclic AMP potentiates vascular endothelial cadherin-mediated cell-cell contact to enhance endothelial barrier function through an Epac-Rap1 signaling pathway. Mol Cell Biol 25:136-146.
11. Garcia JG, Schaphorst KL. 1995. Regulation of endothelial cell gap formation and paracellular permeability. J Investig Med 43:117-126.
12. Iliev AI, Djannatian JR, Nau R, Mitchell TJ, Wouters FS. 2007. Cholesterol-dependent actin remodeling via RhoA and Rac1 activation by the Streptococcus pneumoniae toxin pneumolysin. Proc Natl Acad Sci USA 104:2897-2902.
13. Jaffe AB, Hall A. 2002. Rho GTPases in transformation and metastasis. Adv Cancer Res 84:57-80.
14. Knezevic N, Roy A, Timblin B, Konstantoulaki M, Sharma T, Malik AB, Mehta D. 2007. GDI-1 phosphorylation switch at serine 96 induces RhoA activation and increased endothelial permeability. Mol Cell Biol 27:6323-6333.
15. Koh H, Tasaka S, Hasegawa N, Yamada W, Shimizu M, Nakamura M, Yonemaru M, Ikeda E, Adachi Y, Fujishima S, Yamaguchi K, Ishizaka A. 2007. Protective role of vascular endothelial growth factor in endotoxin-induced acute lung injury in mice. Respir Res 8:60.
16. Kolosova IA, Mirzapoiazova T, Adyshev D, Usatyuk P, Romer LH, Jacobson JR, Natarajan V, Pearse DB, Garcia JG, Verin AD. 2005. Signaling pathways involved in adenosine triphosphate-induced endothelial cell barrier enhancement. Circ Res 97:115-124.
17. Kolosova IA, Mirzapoiazova T, Moreno-Vinasco L, Sammani S, Garcia JG, Verin AD. 2008. Protective effect of purinergic agonist ATPgammaS against acute lung injury. Am J Physiol Lung Cell Mol Physiol 294:L319-L324.
18. Krebs C, Adriouch S, Braasch F, Koestner W, Leiter EH, Seman M, Lund FE, Oppenheimer N, Haag F, Koch-Nolte F. 2005. CD38 controls ADP-ribosyltransferase- 2-catalyzed ADP-ribosylation of T cell surface proteins. J Immunol 174:3298-3305.
19. Lampugnani MG, Zanetti A, Breviario F, Balconi G, Orsenigo F, Corada M, Spagnuolo R, Betson M, Braga V, Dejana E. 2002. VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam. Mol Biol Cell 13:1175-1189.
20. Lum H, Malik AB. 1996. Mechanisms of increased endothelial permeability. Can J Physiol Pharmacol 74:787-800.
21. Marriott HM, Mitchell TJ, Dockrell DH. 2008. Pneumolysin: a double-edged sword during the host-pathogen interaction. Curr Mol Med 8:497-509.
22. Mehta D, Malik AB. 2006. Signaling mechanisms regulating endothelial permeability. Physiol Rev 86:279-367.
23. Moldobaeva A, Welsh-Servinsky LE, Shimoda LA, Stephens RS, Verin AD, Tuder RM, Pearse DB. 2006. Role of protein kinase G in barrier-protective effects of cGMP in human pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol 290: L919-L930.
24. Moreschi I, Bruzzone S, Nicholas RA, Fruscione F, Sturla L, Benvenuto F, Usai C, Meis S, Kassack MU, Zocchi E, De Flora A. 2006. Extracellular NAD+ is an agonist of the human P2Y11 purinergic receptor in human granulocytes. J Biol Chem 281:31419-31429.
25. Mutafova-Yambolieva VN, Hwang SJ, Hao X, Chen H, Zhu MX, Wood JD,Ward SM, Sanders KM. 2007. Beta-nicotinamide adenine dinucleotide is an inhibitory neurotransmitter in visceral smooth muscle. Proc Natl Acad Sci USA 104:16359-16364.
26. Noren NK, Niessen CM, Gumbiner BM, Burridge K. 2001. Cadherin engagement regulates Rho family GTPases. J Biol Chem 276:33305-33308.
27. Pugin J, Verghese G, Widmer MC, Matthay MA. 1999. The alveolar space is the site of intense inflammatory and profibrotic reactions in the early phase of acute respiratory distress syndrome. Crit Care Med 27:304-312.
28. Rabinovitch PS, Torres RM, Engel D. 1986. Simultaneous cell cycle analysis and two-color surface immunofluorescence using 7-amino-actinomycin D and single laser excitation: applications to study of cell activation and the cell cycle of murine Ly-1 B cells. J Immunol 136:2769-2775.
29. Rebecchi MJ, Pentyala SN. 2000. Structure, function, and control of phosphoinositide-specific phospholipase C. Physiol Rev 80:1291-1335.
30. Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A. 1992. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70:401-410.
31. Scheuplein F, Schwarz N, Adriouch S, Krebs C, Bannas P, Rissiek B, Seman M, Haag F, Koch-Nolte F. 2009. NAD+ and ATP released from injured cells induce P2X7-dependent shedding of CD62L and externalization of phosphatidylserine by murine T cells. J Immunol 182:2898-2908.
32. Sells MA, Knaus UG, Bagrodia S, Ambrose DM, Bokoch GM, Chernoff J. 1997. Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr Biol 7:202-210.
33. Venkiteswaran K, Xiao K, Summers S, Calkins CC, Vincent PA, Pumiglia K, Kowalczyk AP. 2002. Regulation of endothelial barrier function and growth by VE-cadherin, plakoglobin, and beta-catenin. Am J Physiol Cell Physiol 283:C811-C821.
34. Verin AD, Birukova A, Wang P, Liu F, Becker P, Birukov K, Garcia JG. 2001. Microtubule disassembly increases endothelial cell barrier dysfunction: role of MLC phosphorylation. Am J Physiol Lung Cell Mol Physiol 281:L565-L574.
35. von Kugelgen I. 2006. Pharmacological profiles of cloned mammalian P2Y-receptor subtypes. Pharmacol Ther 110:415-432.
36. Ware LB, Matthay MA. 2000. The acute respiratory distress syndrome. N Engl J Med 342:1334-1349.
37. Watanabe T, Wang S, Noritake J, Sato K, Fukata M, Takefuji M, Nakagawa M, Izumi N, Akiyama T, Kaibuchi K. 2004. Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration. Dev Cell 7:871-883.
38. Wojciak-Stothard B, Tsang LY, Paleolog E, Hall SM, Haworth SG. 2006. Rac1 and RhoA as regulators of endothelial phenotype and barrier function in hypoxia-induced neonatal pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 290:L1173-L1182.